New York Times–bestselling author The author of The Brain Fog Fix presents “a smart, science-based way to heal anxiety and insomnia” through nutrition, CBT techniques, mindfulness, breathwork, and more (Daniel Amen, New York Times–bestselling author). Are you anxious, frazzled, exhausted? Do you find yourself constantly worrying? Do you feel like you’re “running on empty”? Do you have trouble sleeping? Like millions of people living today, your brain has become drained. These days, it seems like everything in our day-to-day lives —from our increasingly unpredictable world, the smart phones we can’t stop using, to the processed foods we eat all day long, to the many hours we spend at our jobs —is setting us up to feel drained. The short-term effects of becoming drained are uncomfortable, but the long-term effects can be life-threatening. Left untreated, it can quadruple your risk of high blood pressure —the #1 cause of preventable death. Finding natural solutions to anxiety and insomnia is becoming increasingly vital as sleeping pills, antianxiety medications, and hospitalizations have seen a dramatic spike recently. More and more people are desperate to heal their drained brains. In his latest book, Dr. Mike Dow offers a 2-week plan designed to help you naturally balance your brain. He explains what drains modern brains, which groups are wired for it, and provides clinically proven tools to help you feel less drained. Dr. Mike offers nutritional tips, recipes, cognitive behavioral tools, supplements, breathing techniques, self-hypnosis, and mindfulness. Stress hormones like cortisol and adrenaline go down as feel-good neurotransmitters like GABA and serotonin rise.
Is stress preventing you from enjoying your daily life? Do you find that you’re becoming more distracted or forgetful? Are "the blues" sapping your spirits? Or do you simply feel not quite like yourself? If you want to reclaim you focus, memory, and joy, you’re not alone. There are millions of people fighting against the epidemic of brain fog that’s sweeping the nation. The good news: It’s not an irreparable condition; rather it’s a side effect of modern-day living. Many of the foods we eat and the habits we have do not support our brains. We no longer get what we need in order to produce essential brain chemicals that keep us energized, calm, focused, optimistic, and inspired. And even worse, our choices could lead to long-term problems, like dementia, Alzheimer’s disease, depression, and anxiety. Sadly, if you look at the way most of us live, it seems almost as though we’ve chosen a lifestyle deliberately intended to undermine our brain chemistry and our health. Fortunately, there is a solution. The Brain Fog Fix is an easy-to-follow three-week program designed to help naturally restore three of your brain’s most crucial hormones: serotonin, dopamine, and cortisol. Rebalancing these chemicals will in turn enable the rest of your brain’s chemistry to reach optimal levels. Each week of the program focuses on a different element of your life: • In week 1, you’ll improve your mood by modifying your diet and using cognitive strategies to overcome pitfall thought patterns. • In week 2, you’ll increase your energy by focusing on sleep, exercise, and memory-boosting games. • In week 3, you’ll enhance your spirit through practices that help you connect to something larger than yourself and enable you to rediscover your joy in life. By the end of this simple program, you’ll be thinking more clearly, remembering more accurately, learning more quickly, and unleashing the floodgates of your creativity. And you’ll simply feel better – for now and in the long term.
Presents a novel approach to conducting meta-analysis using structural equation modeling. Structural equation modeling (SEM) and meta-analysis are two powerful statistical methods in the educational, social, behavioral, and medical sciences. They are often treated as two unrelated topics in the literature. This book presents a unified framework on analyzing meta-analytic data within the SEM framework, and illustrates how to conduct meta-analysis using the metaSEM package in the R statistical environment. Meta-Analysis: A Structural Equation Modeling Approach begins by introducing the importance of SEM and meta-analysis in answering research questions. Key ideas in meta-analysis and SEM are briefly reviewed, and various meta-analytic models are then introduced and linked to the SEM framework. Fixed-, random-, and mixed-effects models in univariate and multivariate meta-analyses, three-level meta-analysis, and meta-analytic structural equation modeling, are introduced. Advanced topics, such as using restricted maximum likelihood estimation method and handling missing covariates, are also covered. Readers will learn a single framework to apply both meta-analysis and SEM. Examples in R and in Mplus are included. This book will be a valuable resource for statistical and academic researchers and graduate students carrying out meta-analyses, and will also be useful to researchers and statisticians using SEM in biostatistics. Basic knowledge of either SEM or meta-analysis will be helpful in understanding the materials in this book.
Leukaemia Diagnosis Authoritative reference on classifying and diagnosing leukaemia, with practical guidance on using various laboratory techniques included Leukaemia Diagnosis is a practical reference on the principles of leukaemia diagnosis and classification that illustrates and explains in a user-friendly way how different laboratory techniques are used to achieve an accurate interpretation. To aid in reader comprehension, over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma are included, supplemented by histological, cytogenetic and immunophenotyping images. This newly revised and updated Sixth Edition includes recent developments, highlights the growing importance of molecular genetics, and incorporates the recent 5th edition of the WHO guidelines and the International Consensus Classification for leukaemia diagnosis and classification throughout the text. Information on cytogenetic and molecular genetic abnormalities in leukaemia is also included, along with characteristic immunophenotypic characteristics of different categories of leukaemia. Written by world-renowned authors in the field, Barbara Bain and Mike Leach, Leukaemia Diagnosis covers sample topics such as: The nature of leukaemia, cytology, cytochemistry, and the morphological classification of acute leukaemia, with an index of commonly used abbreviations Immunophenotyping and cytogenetic/molecular genetic analysis, and integration of morphological, immunophenotypic and genetic information with the WHO classifications Acute lymphoblastic leukaemia, acute leukaemia of ambiguous lineage, and the myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms Chronic myeloid leukaemias, lymphoid leukaemias of mature B, T, and natural killer cells, and leukaemia diagnosis in resource-poor countries The Sixth Edition of Leukaemia Diagnosis is a highly valuable resource for trainee haematologists and laboratory scientists in haematology and related disciplines. The text also serves as a useful reference and teaching aid for those who already have expertise in this field.
Within the context of reigniting post crisis macroeconomic growth, income inequality has emerged as a topic of significant interest for both academics and policymakers (Bastagli, Coady, and Gupta, 2012) This study builds on past literature on fiscal decentralization suggesting that redistribution is most effectively carried out at sub-central levels of government. Using the IMF’s multi-sector Government Finance Statistics Yearbook database, this paper tests the impact of decentralized redistribution on income inequality for a globally representative sample of countries since 1980. The findings suggest that the decentralization of government expenditure can help achieve a more equal distribution of income. However, several conditions need to be fulfilled: i) the government sector needs to be sufficiently large, ii) decentralization should be comprehensive, including redistributive government spending, and, iii) decentralization on the expenditure side should be accompanied by adequate decentralization on the revenue side, such that subnational governments rely primarily on their own revenue sources as opposed to intergovernmental transfers.
A pioneering book that takes us beyond economic debate to show how inequality is returning us to a past dominated by empires, dynastic elites, and ethnic divisions. The economic facts of inequality are clear. The rich have been pulling away from the rest of us for years, and the super-rich have been pulling away from the rich. More and more assets are concentrated in fewer and fewer hands. Mainstream economists say we need not worry; what matters is growth, not distribution. In The Return of Inequality, acclaimed sociologist Mike Savage pushes back, explaining inequality’s profound deleterious effects on the shape of societies. Savage shows how economic inequality aggravates cultural, social, and political conflicts, challenging the coherence of liberal democratic nation-states. Put simply, severe inequality returns us to the past. By fracturing social bonds and harnessing the democratic process to the strategies of a resurgent aristocracy of the wealthy, inequality revives political conditions we thought we had moved beyond: empires and dynastic elites, explosive ethnic division, and metropolitan dominance that consigns all but a few cities to irrelevance. Inequality, in short, threatens to return us to the very history we have been trying to escape since the Age of Revolution. Westerners have been slow to appreciate that inequality undermines the very foundations of liberal democracy: faith in progress and trust in the political community’s concern for all its members. Savage guides us through the ideas of leading theorists of inequality, including Marx, Bourdieu, and Piketty, revealing how inequality reimposes the burdens of the past. At once analytically rigorous and passionately argued, The Return of Inequality is a vital addition to one of our most important public debates.
Now in its 2nd edition, An Introduction to Western Medical Acupuncture provides a broad evidence-based approach to acupuncture when used as part of modern medicine. Illustrated throughout it gives the practitioner an essential guide for deciding where and how to treat conditions with acupuncture, and how to avoid known risks associated with it. Ultimately it provides the practitioner with a tool to develop safe and effective practice. For this edition the text has been revised, updated and extensively re-written. A new chapter brings together the understanding of how pain is recognised by the nervous system, and how acupuncture can influence these pathways. This is followed by six chapters providing detailed explanations of the effects and mechanisms of acupuncture, organised according to three recognised treatment approaches – needling to produce local changes, to generate effects at the level of the spinal segment, and to modify the overall function of the nervous system. The chapters on the evidence from research have been also updated. - An explanation of the various mechanisms of acupuncture linked to how they can best be activated by needling. - Learn the principles of treatment rather than any 'cook-book' approach. - Clear and objective discussion of the evidence for the effectiveness and the risks of acupuncture. - Thorough and detailed description of all aspects of clinical practice. - Reference section for quickly reminding the practitioner of the best approach to treating many problems.
New in paperback: New York Times best-selling author offers a groundbreaking approach to activate the subconscious brain to set yourself free from your past and create a terrific future. "This well-researched and scientific look at your subconscious brain will provide you with the practical tools you need to help you achieve your wildest dreams." -- Dr. Mercola, New York Times best-selling author of Fat for Fuel and founder of Mercola.com Can you remember a time in your life when you felt absolutely confident, happy, and free? Imagine what your life would be like if you could live in that space . . . In this book, Dr. Mike Dow shares a groundbreaking, life-changing program he created: Subconscious Visualization Technique (SVT). Now, if you think the subconscious brain is some woo-woo pseudoscience, prepare to have your mind blown. The cutting-edge research, protocol, and audio tracks Mike offers will help you speak directly to your subconscious brain and tap into your greatest strengths, gifts, and resources. His program, the first of its kind, starts with cognitive behavioral therapy (CBT), then incorporates various types of subconscious tools: mindfulness, guided visualization, audio-visual entrainment, and bilateral stimulation of the brain and body. Your subconscious can change the way you digest food, help you access memories and repressed feelings, boost your immune system, and activate mindbody healing so that you don't have to constantly treat your symptoms. Some examples of syndromes that SVT can treat include chronic pain, fibromyalgia, leaky gut, irritable bowel syndrome (IBS), migraines, anxiety disorders, and more! SVT helps you access the best parts of yourself and move into your true self. In short, your subconscious brain can change your life!
Outreach in the community is the treatment of choice for the severely mentally ill in the community. It involves taking services directly to patients rather than requiring them to attend clinics and hospitals. This approach is a significant addition to routine mental health care practice and addresses the needs of marginalized communities and those that struggle to attend appointments. Outreach in Community Mental Health Care: A Manual for Practitioners has been fully updated since the last edition, providing readers with an in-depth, practical guide to mental health care in the community setting today. It addresses the significant changes in mental health service organizations over the years, including the various new teams devised and the importance of central planning and targets. The authors Tom Burns and Mike Firn are pioneers in this field of research and are active in community outreach as practitioners, researchers, and supervisors. In 29 chapters they cover key discussions in conceptual issues, health and social care practice, management and development, which provides readers with an insight into the reality of community outreach work.
A human being consists of a mammalian component and a multiplicity of microbes, collectively referred to as the "microbiota" or "microbiome," with which it has a symbiotic relationship. The microbiota is comprised of a variety of communities, the composition of each being dependent on the body site it inhabits. This community variation arises because the numerous locations on a human being provide very different environments, each of which favors the establishment of a distinct microbial community. Each community consists of bacteria, fungi and viruses with, in some cases, archaea and/or protozoa. It is increasingly being recognized that the indigenous microbiota plays an important role in maintaining the health of its human host. However, changes in the overall composition of a microbial community at a body site, or an increase in the proportion of a particular species in that community, can result in disease or other adverse consequences for the host. The Human Microbiota in Health and Disease: An Ecological and Community-Based Approach describes the nature of the various communities inhabiting humans as well as the important roles they play in human health and disease. It discusses techniques used to determine microbial community composition and features a chapter devoted to the many factors that underlie this mammalian–microbe symbiosis. Uniquely, the book adopts an ecological approach to examining the microbial community’s composition at a particular body site and why certain factors can shift a community from a eubiotic to a dysbiotic state. The book is for undergraduates and postgraduates on courses with a module on the indigenous microbiota of humans. It will also be useful to scientists, clinicians, and others seeking information on the human microbiota and its role in health and disease.
“Shines a light on institutions that are teaching students, young and old, how to rebuild our economy and put America back to work” (President Bill Clinton). It’s a statistic that’s sure to surprise: Close to forty-five percent of postsecondary students in the United States today did not enroll in college directly out of high school, and many attend only part-time. Following a tradition of self-improvement as old as the Republic, the “nontraditional” college student is becoming the norm. Back to School is the first book to look at the schools that serve a growing population of “second-chancers,” exploring what higher education—in the fullest sense of the term—can offer our rapidly changing society and why it is so critical to support the institutions that make it possible for millions of Americans to better their lot in life. In the anecdotal style of his bestselling Possible Lives, Mike Rose crafts rich and moving vignettes of people in tough circumstances who find their way, who get a second . . . or third . . . or even fourth chance, and who, in a surprising number of cases, reinvent themselves as educated, engaged citizens. Rose reminds us that our nation’s economic and civic future rests heavily on the health of the institutions that serve millions of everyday people—not simply the top twenty universities listed in U.S. News and World Report—and paints a vivid picture of the community colleges and adult education programs that give so many a shot at reaching their aspirations. “Thoughtful and surprising.” —The Washington Post “Inspiring stories of older Americans attending secondary schools.” —Kirkus Reviews
This volume gives language teachers, software designers, and researchers who wish to use technology in second or foreign language education the information they need to absorb what has been achieved so far and to make sense of it. It is designed to enable the kind of critical reading of a substantial literature that leads to a balanced and detailed knowledge of the field. Chapter by chapter, the book builds, through description, analysis, examples, and discussion, a detailed picture of modern CALL. In this book, the label “CALL” is interpreted broadly to include technology-enhanced language learning, Web-enhanced language learning, and information and communication technologies for language learning. The work is distinguished by its attention to a range of languages rather than just English. The authors first set the scene and introduce major areas of interest and growth in CALL, and then look in depth at seven important dimensions: design, evaluation, computer-mediated communication, theory, research, practice, and technology. Chapters on each of these topics include a description that reviews the recent literature, identifies themes, and presents representative projects that illustrate the dimension, followed by a discussion that provides in-depth analysis, and a conclusion offering suggestions for further work. Detailed references and links connect the description and discussion with original works and primary sources so the reader can follow up easily on areas of personal interest. Two concluding chapters discuss how the various dimensions might be brought together, the first from a practical point of view, the second with a view to the development of CALL as a whole.
Bayesian analysis of complex models based on stochastic processes has in recent years become a growing area. This book provides a unified treatment of Bayesian analysis of models based on stochastic processes, covering the main classes of stochastic processing including modeling, computational, inference, forecasting, decision making and important applied models. Key features: Explores Bayesian analysis of models based on stochastic processes, providing a unified treatment. Provides a thorough introduction for research students. Computational tools to deal with complex problems are illustrated along with real life case studies Looks at inference, prediction and decision making. Researchers, graduate and advanced undergraduate students interested in stochastic processes in fields such as statistics, operations research (OR), engineering, finance, economics, computer science and Bayesian analysis will benefit from reading this book. With numerous applications included, practitioners of OR, stochastic modelling and applied statistics will also find this book useful.
Built upon the two original books by Mike Crisfield and their own lecture notes, renowned scientist René de Borst and his team offer a thoroughly updated yet condensed edition that retains and builds upon the excellent reputation and appeal amongst students and engineers alike for which Crisfield's first edition is acclaimed. Together with numerous additions and updates, the new authors have retained the core content of the original publication, while bringing an improved focus on new developments and ideas. This edition offers the latest insights in non-linear finite element technology, including non-linear solution strategies, computational plasticity, damage mechanics, time-dependent effects, hyperelasticity and large-strain elasto-plasticity. The authors' integrated and consistent style and unrivalled engineering approach assures this book's unique position within the computational mechanics literature. Key features: Combines the two previous volumes into one heavily revised text with obsolete material removed, an improved layout and updated references and notations Extensive new material on more recent developments in computational mechanics Easily readable, engineering oriented, with no more details in the main text than necessary to understand the concepts. Pseudo-code throughout makes the link between theory and algorithms, and the actual implementation. Accompanied by a website (www.wiley.com/go/deborst) with a Python code, based on the pseudo-code within the book and suitable for solving small-size problems. Non-linear Finite Element Analysis of Solids and Structures, 2nd Edition is an essential reference for practising engineers and researchers that can also be used as a text for undergraduate and graduate students within computational mechanics.
Written by a leading geographer of climate, this book offers a unique guide to students and general readers alike for making sense of this profound, far-reaching, and contested idea. It presents climate change as an idea with a past, a present, and a future. In ten carefully crafted chapters, Climate Change offers a synoptic and inter-disciplinary understanding of the idea of climate change from its varied historical and cultural origins; to its construction more recently through scientific endeavour; to the multiple ways in which political, social, and cultural movements in today’s world seek to make sense of and act upon it; to the possible futures of climate, however it may be governed and imagined. The central claim of the book is that the full breadth and power of the idea of climate change can only be grasped from a vantage point that embraces the social sciences, humanities, and natural sciences. This vantage point is what the book offers, written from the perspective of a geographer whose career work on climate change has drawn across the full range of academic disciplines. The book highlights the work of leading geographers in relation to climate change; examples, illustrations, and case study boxes are drawn from different cultures around the world, and questions are posed for use in class discussions. The book is written as a student text, suitable for disciplinary and inter-disciplinary undergraduate and graduate courses that embrace climate change from within social science and humanities disciplines. Science students studying climate change on inter-disciplinary programmes will also benefit from reading it, as too will the general reader looking for a fresh and distinctive account of climate change.
Examines the "democratic deficit" present in Confederation today and applies to it these foundational principles: expanding Canadians' freedom of choice; challenging Canadians to accept greater personal responsibility; and deepening Canada's practice of federal democracy.
What's really in your food? Award-winning investigative journalist and clean food activist Mike Adams, the "Health Ranger," is founder and editor of Natural News, one of the top health news websites in the world, reaching millions of readers each month. Now, in Food Forensics, Adams meticulously tests groceries, fast foods, dietary supplements, spices, and protein powders for heavy metals and toxic elements that could be jeopardizing your health. To conduct this extensive research, Adams built a state-of-the-art laboratory with cutting-edge scientific instruments. Publishing results of metal concentrations for more than 800 different foods, Food Forensics is doing the job the FDA refuses to do: testing off-the-shelf foods and sharing the findings so the public can make informed decisions about what they consume or avoid. In Food Forensics, you'll discover little-known truths about other toxic food ingredients such as polysorbate 80, MSG, sodium nitrite, pesticides, and weed killers such as glyphosate. Adams reveals stunning, never-before-reported details of heavy metals found in recycled human waste used on crops and in parks, and he explains how industrial pollution causes mercury, lead, and cadmium to end up in your favorite protein powders. This book will forever change your view of food safety, regulation, and manufacturing. When you know what's really in your food, you can start making changes to protect yourself against serious diseases like cancer, all while maximizing your natural immune defenses against infection and disease.
This new edition of The Economics of Tourism reflects the tremendous changes that have occurred in the tourism sector in the last twelve years. It recognizes that the nature of tourism demand and supply is being transformed by innovations in information communication technologies, market liberalization and climate change. Paralleling this, there is much greater interest in the study of tourism by both students and researchers in mainstream economics. The text is now in four parts covering: demand; supply; national, regional and international matters and environmental issues. The concluding chapter appraises the state of the economic research into tourism. The increased interest in tourism has engendered the development of new methods of analysis and the refinement of established ones. Accordingly, the book has been extensively restructured, revised and expanded with two new chapters: chapter six of the first edition is now broken down into two and a new chapter has been added on environmental issues to take account of new developments, critically review the associated literature and consider future trends in tourism economics research. The reader-friendliness of the book has also been enhanced in various ways, such as the extensive chapter cross-referencing to refresh the reader’s memory and the inclusion of a detailed list of abbreviations. The Economics of Tourism will continue to make accessible for the non-specialist, the application and relevance of economics to tourism. Extensively revised and updated, including research and case studies the textbook will be an indispensable resource for both students and researchers.
The Martin Luther King Memorial on the National Mall of Washington, DC, is dedicated to the first person of color, first person for peace, and first person with no public or government position, etc. The values this person represents—democracy, justice, equal rights, hope, and love—are ever more relevant to the advance of human civilization of our own society and those of the whole world. The unique memorial style also sets it apart from all the other memorials on the National Mall of Washington, DC. Its central piece, the Stone of Hope, is the first granite statue, the tallest, and installed outdoor. It was designed, carved, and installed by a Chinese master sculptor, Lei Yixin. You may want to know who first initiated this project. Who managed the operation of the memorial development project? Whose design was finally selected? Who is Lei Yixin? How and why he was chosen to be the sculptor of record? How did he design and build the massive Stone of Hope and the Mountains of Despair out of granite? Where did he create those art pieces? And from where did they ship the stone to Washington DC? How did he install this central piece of the memorial? This book will give you all above and more answers you would like to know.
Being in a foreign country, immersed in the great atmosphere of western culture, what is still in my heart is the quintessence of China, and the DNA of Chinese culture still flows in my blood. The United States is a multi-ethnic country, and the cultural essence of various ethnic groups blooms here like the flowers of spring. Chinese calligraphy, the gem of Chinese culture with a history of 3,000 years and the genius of the world that has shocked the history of art, has been splendid in this melting pot! The sages said: There are at least two aspects in life, one is life and the other is spirit. Once one settles in a foreign place, there will be spiritual pursuits; cultural factors will become active, childhood dreams will come into life, and flowers will bloom in the cradle of multiculturalism... In the educational world dominated by western culture, eastern culture and Chinese culture are not featured prominently, especially in art departments in universities. I am honored to be a practitioner and inheritor of Chinese calligraphy, and I am a frequent guest speaker in various schools and museums in New England, such as Harvard and Wellesley universities, giving lectures, demonstrations and exhibitions, etc. These invitations compensate for the neglect of Chinese calligraphy in the main curriculum and allow students to witness the creative process of Chinese calligraphy as an art form. In Asian art departments of western universities, there are capable people who study Chinese calligraphy theories from the perspective of westerners, but only a few who are capable of doing calligraphy. To answer this need I felt compelled to take up a teaching role, shuttling between colleges, high schools, and elementary schools.
Reporting on China has long been one of the most challenging and crucial of journalistic assignments. Foreign correspondents have confronted war, revolution, isolation, internal upheaval, and onerous government restrictions as well as barriers of language, culture, and politics. Nonetheless, American media coverage of China has profoundly influenced U.S. government policy and shaped public opinion not only domestically but also, given the clout and reach of U.S. news organizations, around the world. This book tells the story of how American journalists have covered China—from the civil war of the 1940s through the COVID-19 pandemic—in their own words. Mike Chinoy assembles a remarkable collection of personal accounts from eminent journalists, including Stanley Karnow, Seymour Topping, Barbara Walters, Dan Rather, Melinda Liu, Nicholas Kristof, Joseph Kahn, Evan Osnos, David Barboza, Amy Qin, and Megha Rajagopalan, among dozens of others. They share behind-the-scenes stories of reporting on historic moments such as Richard Nixon’s groundbreaking visit in 1972, China’s opening up to the outside world and its emergence as a global superpower, and the crackdowns in Tiananmen Square and Xinjiang. Journalists detail the challenges of covering a complex and secretive society and offer insight into eight decades of tumultuous political, economic, and social change. At a time of crisis in Sino-American relations, understanding the people who have covered China for the American media and how they have done so is crucial to understanding the news. Through the personal accounts of multiple generations of China correspondents, Assignment China provides that understanding.
On-treatment verification imaging has developed rapidly in recent years and is now at the heart of image-guided radiation therapy (IGRT) and all aspects of radiotherapy planning and treatment delivery. This is the first book dedicated to just this important topic, which is written in an accessible manner for undergraduate and graduate therapeutic radiography (radiation therapist) students and trainee medical physicists and clinicians. The later sections of the book will also help established medical physicists, therapeutic radiographers, and radiation therapists familiarise themselves with developing and cutting-edge techniques in IGRT. Features: Clinically focused and internationally applicable; covering a wide range of topics related to on-treatment verification imaging for the study of IGRT Accompanied by a library of electronic teaching and assessment resources for further learning and understanding Authored by experts in the field with over 18 years’ experience of pioneering the original forms of on-treatment verification imaging in radiotherapy (electronic portal imaging) in clinical practice, as well as substantial experience of teaching the techniques to trainees
The success of transplantation to treat human diseases has greatly increased the demand for organs and tissues. Xenotransplantation, the use of animals as donors, is viewed increasingly as a solution to this problem. The pig-to-NHP model has become the standard for preclinical studies of cell and tissue xenotransplantation prior to starting a clinical trial. This is A Compilation of Cell and Tissue Xenotransplantation Studies (1838-2022): A Promising Approach for the Treatment of Diseases and a collection of reminiscences by surgeons and scientists who made significant research contributions toward achieving successful transplantation of animal cells and tissues into humans. It records the works of the world’s leading researchers in this field which will impact the future medical care of patients with diabetes, liver failure, neurodegenerative disorders, corneal blindness, etc. It also provides a comprehensive overview of applications of cellular and tissue xenotransplantation for a range of diseases especially those that result from tissue loss or dysfunction. The importance of the decellularization technique in animal tissues and organs as implantable biomaterials in the field of regenerative medicine and tissue engineering is also highlighted. Essential reading for physicians, scientists, and lay persons with an interest in xenotransplantation; those caring for patients with life-threatening diseases; and also those interested in understanding the potential of genetic and tissue engineering in science and medicine. This book charts a historical record of the research which has contributed to the advancement of medicine called “the next great medical revolution.” Many believe we are on the threshold of clinical trials using genetically modified animals as organ donors. If successful, the benefits of clinical xenotransplantation will be enormous and will represent one of the greatest advances in modern medicine.
This handbook focuses on different aspects of anti-aging and both preventive and regenerative medicine. It includes analysis of the paradigm of ageing and concepts of anti-aging medicine. Standards and technologies are highlighted in over twenty chapters all authored by international experts in regenerative medicine. Topics covered include: • Ageing, aging, and anti-aging: A Decalogue for anti-aging medicine • Lessons from Sicilian centenarians for anti-aging medicine • Molecular biomarkers and genetic aspects of aging • Future of peptides in clinical practice • Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection • Tissue-specific autoantibodies in preventive medicine • Chronic stress as a psycho-neuro-immunological dysfunction • Gut-associated immune system and its health implications • Regenerative medicine with platelet-rich-plasma • Alzheimer’s disease: Preventive and anti-aging neurology • Autistic spectrum disorder and mitochondrial medicine • Integrative hormonal approach in anti-aging medicine • Preventive cardiology and phlebology • Aesthetic and anti-aging medicine • Preventive ophthalmology • Preventive oncology • Nutrition in healthy aging • Physical activity and fitness paradigms for anti-aging and longevity Recommended reading for clinicians working in anti-aging medicine as well as ageing people. The authors hope it will set a new “standard of anti-aging medicine” and as a tool in planning for the inevitable challenges we all will face caring for ageing patients and creating preventive-health programs.
An insider’s guide to doing business in the fastest growing market in the world—China! Did you know? —Americans have bought $185 billion worth of Chinese goods. —China’s economy is growing at an astounding rate of 9 percent a year. —The trade gap between the U.S. and China has been growing by more than 25 percent per year. Whether you work for a company doing business in China, or are an entrepreneur looking to export your goods and services, An American’s Guide to Doing Business in China teaches you the practicalities and the pitfalls of dealing with this complex market. While there are undeniable opportunities in the Chinese market, there is also a great deal of hype—and very real political and cultural differences that make doing business in China extremely challenging. Written by an industry expert with more than two decades of experience, An American’s Guide to Doing Business in China is an authoritative and accessible guide covering all aspects of doing business in China, including: • Finding manufacturing partners • Negotiating contracts and agreements • Choosing a location and hiring employees This practical work also teaches you how to navigate Chinese culture and customs, market and advertise to Chinese consumers, and find the hottest opportunities. An American’s Guide to Doing Business in China is what you need to succeed in the world’s biggest market.
This thought-provoking book examines gang history in the region encompassing West Texas, Southern New Mexico, and Northern Chihuahua, Mexico. Known as the El Paso-Juárez borderland region, the area contains more than three million people spanning 130 miles from east to west. From the badlands--the historically notorious eastern Valle de Juárez--to the Puerto Palomas port of entry at Columbus, New Mexico, this area has become more militarized and politicized than ever before. Mike Tapia examines this region by exploring a century of historical developments through a criminological lens and by studying the diverse subcultures on both sides of the law. Tapia looks extensively at the role of history and geography on criminal subculture formation in the binational urban setting of El Paso-Juárez, demonstrating the region's unique context for criminogenic processes. He provides a poignant case study of Homeland Security and the apparent lack of drug-war spillover in communities on the US-Mexico border.
The crash of the Indian plate into Asia is the biggest known collision in geological history, and it continues today. The result is the Himalaya and Karakoram - one of the largest mountain ranges on Earth. The Karakoram has half of the world's highest mountains and a reputation as being one of the most remote and savage ranges of all. In this beautifully illustrated book, Mike Searle, a geologist at the University of Oxford and one of the most experienced field geologists of our time, presents a rich account of the geological forces that were involved in creating these mountain ranges. Using his personal accounts of extreme mountaineering and research in the region, he pieces together the geological processes that formed such impressive peaks.
The use of electronically scanned phased arrays is increasing in systems such as radar, wireless networks, and satellite ground terminals. An important and necessary component for these systems is the transmit receive (T/R) module, which provides the amplification and electronic beam steering that is required for proper function. This new resource presents a comprehensive overview of all design, fabrication, integration, and implementation issues associated with T/R modules for radar and communications. This book provides engineers and researchers with practical designs and 44 examples of analysis, circuits, and components used in T/R modules. It also provides a solid explanation of the theory for how T/R modules operate and how they can be optimized. In addition, this book shows how the latest technical advances in silicon germanium (SiGe) and gallium nitride (GaN) are allowing levels of performance that were previously unachievable. The book concludes with informative chapters on testing, cost considerations, and the future of next generation T/R modules.
Volume III of the present work on Statius' Thebaid and Achilleid is divided into two parts. The first part offers a sketch of the history of the textual transmission, a complete list of manuscripts, discussion of various previous editions, exposition of the views about the manuscripts which underly the present edition, and an orthographical index. The second part comprises a secondary apparatus, which tabulates further evidence from the manuscripts and all conjectures not recorded in the primary apparatus.
During the past decade, raising the productivity of women became an integral element of the World Bank�s overall strategy for reducing poverty and achieving sustainable growth. The number and scope of Bank projects to provide women with enterprise development, financial services, and social intermediation services grew accordingly. This paper reviews 27 such projects in East and South Asia and provides a succinct assessment of successes, failures, and surprises. The authors identify patterns and trends in the design of projects, examine the reasons for such trends, and draw lessons about how such projects can be more effective in delivering financial services to women in these countries. Many of these women are an increasingly vital source--or the sole source--of income for their families, but they are often overlooked in the implementation of small development projects. The authors draw eight key lessons for future Bank projects to provide enterprise development and financial services. They recommend that such projects be considered one element of a coordinated country-specific strategy for poverty alleviation.
Haematology Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis. Using a novel format of visual case studies, this text mimics ‘real life’ for the practising diagnostic haematologist – using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work. Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.
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