Mike S. Lee's Books

Integrated Strategies for Drug Discovery Using Mass Spectrometry

By: Mike S. Lee

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Integrated Strategies for Drug Discovery Using Mass Spectrometry

By: Mike S. Lee

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

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Page Count

576

Publisher

John Wiley & Sons

Published Date

ISBN 10

0471721026

ISBN 13

9780471721024

LC/MS Applications in Drug Development

By: Mike S. Lee

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LC/MS Applications in Drug Development

By: Mike S. Lee

Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases. In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include: Proteomics Glycoprotein Mapping Natural Products Dereplication Lead Identification Screening Open-Access LC/MS In Vitro Drug Screening Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.

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Page Count

256

Publisher

John Wiley & Sons

Published Date

ISBN 10

0471405205

ISBN 13

9780471405207

Trading Nation

Advancing Australia's Interests in world markets

By: Mike Adams,Nicolas Brown,Ron Wickes

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Trading Nation

Advancing Australia's Interests in world markets

By: Mike Adams,Nicolas Brown,Ron Wickes

From wool and gold to minerals and manufacturing, Trading Nation reviews the history of Australia’s trade and trade policy since Federation. The book tackles a number of key questions which are central to the nation’s future. What is the future of our trade in minerals, agriculture, manufacturing and services? How can trade policy help address our faltering productivity? Is the Doha Round of multilateral trade negotiations dead and, if not, what can be done to conclude it? What can we expect from new free trade agreements? Is there more we could be doing in trade policy with Europe, India and Latin America? This comprehensive book also looks ahead at the options for Australia’s future trade and trade policy.

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Page Count

322

Publisher

UNSW Press

Published Date

ISBN 10

1742241514

ISBN 13

9781742241517

Biological Psychology

By: Suzanne Higgs,Alison Cooper,Jonathan Lee,Mike Harris

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Biological Psychology

By: Suzanne Higgs,Alison Cooper,Jonathan Lee,Mike Harris

Written to guide undergraduate students new to brain and behaviour through the key biological concepts that determine how we act, Biological Psychology provides a comprehensive introduction to the subject. It includes detailed coverage of sensation, movement, sleep, eating and emotions, with further chapters on the biological basis of psychological disorders and the effects of drug-taking. Uniquely, the authors emphasize the importance of learning and memory as a key thread throughout and include advanced chapters on key research areas that push discussion further and encourage critical thinking, making this book appropriate for undergraduates studying biological psychology at any level. Key features include: ‘Spotlights’ offering insights into key areas of research that expose the most important developing issues in the field today A clear structure including roadmaps and key points for each chapter to ease navigation through the book and understanding of the links between concepts Full colour presentation to bring the topics to life through clear and comprehensive illustrations and diagrams A companion website at study.sagepub.com/higgs with a range of materials for instructors and students

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Page Count

505

Publisher

SAGE

Published Date

ISBN 10

1473908981

ISBN 13

9781473908987

Clinical Insights for Image-Guided Radiotherapy

Prostate

By: Mike Kirby,Kerrie-Anne Calder

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Clinical Insights for Image-Guided Radiotherapy

Prostate

By: Mike Kirby,Kerrie-Anne Calder

This book provides a clinical insight into image-guided radiation therapy (IGRT) for prostate cancer. It starts by setting the clinical scene, discussing immobilisation and standard IGRT practice and then considering important developments like IGRT with non-ionising radiation, adaptive radiotherapy, particle therapy, margins, hypofractionation, clinical outcomes, AI and training. Good IGRT requires both technical and clinical focus. So, in complement to our first study guide on IGRT, this book now brings together key, clinical insights into IGRT for Prostate Cancer patients, with a view to helping the professional learn more about ‘how-to’ undertake IGRT for these patients more accurately, effectively and safely, throughout the whole course of a patient’s treatment with radiation. This clinical insight guide will be of interest to newly qualified radiation therapists, therapeutic radiographers, medical dosimetrists, medical physicists, radiotherapy physicists and clinical oncologists. It will also be of use for trainees and can be used alongside continuing competency and clinical training within real clinical departments and radiation therapy centres worldwide. This is the first in a forthcoming series of clinical insights, each tackling a different treatment area. Further areas in the series will be: Head and Neck; Thorax; Breast; Pelvis; and the Brain. Key Features: • Internationally applicable, clinically focused, up-to-date and evidence based. · Accompanied by suitable electronic multimedia resources. · Authored by experts with decades of experience of pioneering electronic portal imaging and IGRT in clinical practice, pedagogic research and substantial experience of teaching/supervising students, trainees and qualified therapists/medical physicists at bachelors, postgraduate and doctoral levels. Mike Kirby and Kerrie-Anne Calder are well-respected authors and radiotherapy professionals, who have worked in radiotherapy physics/radiotherapy clinical and academic practice for nearly 35 years and 25 years respectively. Mike Kirby is a Senior Lecturer in Radiotherapy Physics at the University of Liverpool, UK, and an Honorary Lecturer at the University of Manchester, UK. He holds graduate and postgraduate qualifications in medical physics and has in total over 200 books, papers, oral and poster presentations to his name in the field of radiotherapy. Dr. Kirby holds professional membership of the Institute of Physics and Engineering in Medicine, the American Association of Physicists in Medicine, the American Society for Radiation Oncology, the European Society for Radiotherapy and Oncology and the British Institute of Radiology, is a Fellow of the Higher Education Academy and the British Institute of Radiology in the UK. Kerrie-Anne Calder is a Lecturer at the University of Liverpool, UK, where she educates undergraduate and post graduate students in many aspects of radiotherapy with a special interest and role in imaging training. Kerrie-Anne has graduate and postgraduate qualifications in radiotherapy, education and academic practice, is a member of the Society and College of Radiographers, and is a Fellow of the Higher Education Academy in the UK. She was a clinical and professional lead in IGRT (on-treatment verification imaging) within the NHS in the UK for over ten years.

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Page Count

165

Publisher

CRC Press

Published Date

ISBN 10

1040043747

ISBN 13

9781040043745

Sustainable Gold Mining Wastewater Treatment by Sorption Using Low-Cost Materials

UNESCO-IHE PhD Thesis

By: Mike Agbesi Acheampong

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Sustainable Gold Mining Wastewater Treatment by Sorption Using Low-Cost Materials

UNESCO-IHE PhD Thesis

By: Mike Agbesi Acheampong

Sorption technique was employed to remove heavy metals from gold mining effluent using natural and plant materials for sustainability. An assessment of the effluent quality of a gold mining company in Ghana indicated that arsenic, copper and cyanide were the major pollutants in the process effluent. Arsenic and copper were successfully removed from the effluent by the studied materials. The research showed that the down-flow fixed-bed treatment configuration is an ideal system for the simultaneous removal of copper and arsenic from low concentration gold mining effluent, in addition to other heavy metals present in very low concentrations.

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Page Count

189

Publisher

CRC Press

Published Date

ISBN 10

1000150178

ISBN 13

9781000150179

The RF and Microwave Handbook - 3 Volume Set

By: Mike Golio

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The RF and Microwave Handbook - 3 Volume Set

By: Mike Golio

By 1990 the wireless revolution had begun. In late 2000, Mike Golio gave the world a significant tool to use in this revolution: The RF and Microwave Handbook. Since then, wireless technology spread across the globe with unprecedented speed, fueled by 3G and 4G mobile technology and the proliferation of wireless LANs. Updated to reflect this tremendous growth, the second edition of this widely embraced, bestselling handbook divides its coverage conveniently into a set of three books, each focused on a particular aspect of the technology. Six new chapters cover WiMAX, broadband cable, bit error ratio (BER) testing, high-power PAs (power amplifiers), heterojunction bipolar transistors (HBTs), as well as an overview of microwave engineering. Over 100 contributors, with diverse backgrounds in academic, industrial, government, manufacturing, design, and research reflect the breadth and depth of the field. This eclectic mix of contributors ensures that the coverage balances fundamental technical issues with the important business and marketing constraints that define commercial RF and microwave engineering. Focused chapters filled with formulas, charts, graphs, diagrams, and tables make the information easy to locate and apply to practical cases. The new format, three tightly focused volumes, provides not only increased information but also ease of use. You can find the information you need quickly, without wading through material you don’t immediately need, giving you access to the caliber of data you have come to expect in a much more user-friendly format.

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2208

Publisher

CRC Press

Published Date

ISBN 10

1439833230

ISBN 13

9781439833230

Dacie and Lewis Practical Haematology E-Book

By: Barbara J. Bain,Imelda Bates,Mike A Laffan

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Dacie and Lewis Practical Haematology E-Book

By: Barbara J. Bain,Imelda Bates,Mike A Laffan

For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You'll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. - A unique section on haematology in under-resourced laboratories. - Ideal as a laboratory reference or as a comprehensive exam study tool. - diagnosis, molecular testing, blood transfusion- and much more. - Complete coverage of the latest advances in the field. - An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.

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Page Count

599

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0702069256

ISBN 13

9780702069253

Omnidirectional Tilt-Rotor Flying Robots for Aerial Physical Interaction

Modelling, Control, Design and Experiments

By: Karen Bodie,Maximilian Brunner,Mike Allenspach

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Omnidirectional Tilt-Rotor Flying Robots for Aerial Physical Interaction

Modelling, Control, Design and Experiments

By: Karen Bodie,Maximilian Brunner,Mike Allenspach

This book deals with the study of tilt-rotor omnidirectional aerial robots and their application to aerial physical interaction tasks. Omnidirectional aerial robots possess decoupled translational and rotational dynamics, which are important for stable and sustained aerial interaction. The additional ability to dynamically re-orient thrust vectors opens the door to a wide array of possible morphologies and system capabilities. Through modeling, control, prototype design, and experimental evaluation, this book presents a comprehensive methodology and examples for the development of a novel tilt-rotor aerial manipulator. This work serves as a guide for envisioning and constructing innovative systems that will advance the frontier of aerial manipulation.

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Page Count

230

Publisher

Springer Nature

Published Date

ISBN 10

3031454979

ISBN 13

9783031454974

Physical Activity Epidemiology

By: Rod K. Dishman,Gregory W. Heath,Mike D. Schmidt,I-Min Lee

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Physical Activity Epidemiology

By: Rod K. Dishman,Gregory W. Heath,Mike D. Schmidt,I-Min Lee

Physical Activity Epidemiology, Third Edition, provides a discussion of current studies showing the influence of physical activity on disease. Updated with extensive new content in alignment with the 2018 Physical Activity Guidelines Advisory Committee Scientific Report, the third edition benefits from the expertise of authors Rod Dishman, Gregory Heath, Michael Schmidt, and I-Min Lee. These authors offer insight gained from their professional experiences, which include leadership roles within the Centers for Disease Control and Prevention, contributions to the 2008 Physical Activity Guidelines for Americans, and a combined 1,000 peer-reviewed articles in high-impact journals across each of their disciplines. Physical Activity Epidemiology, Third Edition, explores how physical activity can enhance quality of life. The text summarizes the available knowledge, examines the methods used to obtain these findings, considers the implications for public health, and outlines the important questions that remain. Readers will find comprehensive discussions of these topics: Part I introduces physical activity epidemiology and provides an extensive background in research methods as well as physical activity measurement and surveillance. Part II focuses on the evidence that physical activity protects against premature death from all causes and inhibits the development of coronary heart disease and stroke. Part III offers population-based studies and clinical experiments providing evidence that physical activity plays a role in the prevention of hypertension, dyslipidemia, and obesity. Part IV compiles the latest data on two chronic diseases that are increasing in prevalence worldwide: type 2 diabetes and osteoporosis. Part V describes the evidence that physical activity is associated with reduced risks of certain cancers and explores the use of immunotherapy in cancer treatment. Part VI addresses mental health and the promotion of a safe, physically active lifestyle among all segments of the population. The third edition of this text offers expanded coverage of the measurement of sedentary behavior; the effects of physical activity on osteoporosis and bone health, cancers, and inflammatory diseases; and the potential of exercise to complement immunotherapy in cancer treatment. More than 200 tables and figures highlight information in an easy-to-understand visual format. Physical Activity Epidemiology, Third Edition, examines the methodology and findings of classic and contemporary studies and then helps students analyze the results. The special Strength of the Evidence sections summarize the findings to determine the extent to which correlation and causation can be proven. Chapter objectives, chapter summaries, sidebars, and a glossary assist students in finding key information. Instructors will find a test package, image bank, and downloadable learning activities to assist with student comprehension. Physical Activity Epidemiology, Third Edition, offers a comprehensive presentation of significant studies, discusses how these studies contribute to understanding the relationship between activity and disease prevention, and explores how this information can be used in leading global society toward increased health and longevity.

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Page Count

673

Publisher

Human Kinetics

Published Date

ISBN 10

1492593028

ISBN 13

9781492593027

Dacie and Lewis Practical Haematology

Expert Consult: Online and Print

By: Barbara J. Bain,Imelda Bates,Mike A Laffan,S. Mitchell Lewis

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Dacie and Lewis Practical Haematology

Expert Consult: Online and Print

By: Barbara J. Bain,Imelda Bates,Mike A Laffan,S. Mitchell Lewis

Highly Commended at 2012 BMA awards in Internal Medicine Category. Recognized worldwide as the standard reference work, Dacie & Lewis Practical Haematology is a must have reference for any haematology laboratory. It covers all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as the tried and true manual methods of measurement. It discusses the principles of each test, possible causes of error, the rationale for choosing one method over another and the interpretation, significance and clinical relevance of these findings. Each chapter conforms to a template, providing quick access to key information

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Page Count

1649

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0702050253

ISBN 13

9780702050251

Population Movements and the Third World

By: Mike Parnwell

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Population Movements and the Third World

By: Mike Parnwell

The interrelationship between migration and development is complex. The causes of migration stem from the uneveness of the development process and the effects exert a powerful influence on the pattern and process of development. This volume explores both the concepts and facts behind the main forms of population movement in the third world today, particularly rural-urban migration. Examining the causes and consequences of migration, the author assesses the implications for planning and policy-makers.

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Page Count

173

Publisher

Routledge

Published Date

ISBN 10

1134914385

ISBN 13

9781134914388

Leukaemia Diagnosis

By: Barbara J. Bain,Mike Leach

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Leukaemia Diagnosis

By: Barbara J. Bain,Mike Leach

Leukaemia Diagnosis Authoritative reference on classifying and diagnosing leukaemia, with practical guidance on using various laboratory techniques included Leukaemia Diagnosis is a practical reference on the principles of leukaemia diagnosis and classification that illustrates and explains in a user-friendly way how different laboratory techniques are used to achieve an accurate interpretation. To aid in reader comprehension, over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma are included, supplemented by histological, cytogenetic and immunophenotyping images. This newly revised and updated Sixth Edition includes recent developments, highlights the growing importance of molecular genetics, and incorporates the recent 5th edition of the WHO guidelines and the International Consensus Classification for leukaemia diagnosis and classification throughout the text. Information on cytogenetic and molecular genetic abnormalities in leukaemia is also included, along with characteristic immunophenotypic characteristics of different categories of leukaemia. Written by world-renowned authors in the field, Barbara Bain and Mike Leach, Leukaemia Diagnosis covers sample topics such as: The nature of leukaemia, cytology, cytochemistry, and the morphological classification of acute leukaemia, with an index of commonly used abbreviations Immunophenotyping and cytogenetic/molecular genetic analysis, and integration of morphological, immunophenotypic and genetic information with the WHO classifications Acute lymphoblastic leukaemia, acute leukaemia of ambiguous lineage, and the myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms Chronic myeloid leukaemias, lymphoid leukaemias of mature B, T, and natural killer cells, and leukaemia diagnosis in resource-poor countries The Sixth Edition of Leukaemia Diagnosis is a highly valuable resource for trainee haematologists and laboratory scientists in haematology and related disciplines. The text also serves as a useful reference and teaching aid for those who already have expertise in this field.

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Page Count

660

Publisher

John Wiley & Sons

Published Date

ISBN 10

1394218583

ISBN 13

9781394218585

Texas Almanac and State Industrial Guide

By: Mike Kingston (ed)

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Texas Almanac and State Industrial Guide

By: Mike Kingston (ed)

An almanac of miscellaneous facts about the state of Texas.

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Page Count

676

Published Date

ISBN 10

0914511181

ISBN 13

9780914511182

Functionalization of Polyolefins

By: T. C. Mike Chung

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Functionalization of Polyolefins

By: T. C. Mike Chung

Polyolefins are the most widely used commercial polymers and their functionalization has been a long standing scientific challenge and an industrially important area. In recent decades significant progress has been made in the area, with exciting results reported in many journals. Functionalization of Polyolefins is the first book to summarize the significant experimental results on the functionalization of polyolefins and classify them into several chemical methods (shown in each chapter of this book). The book also provides an update on the functional polyolefin materials available today. The two key subject categories covered are: - Chemical approaches in the functionalization of polyolefins - New available polyolefin materials and their potential applications The book includes: - The historic development and future prospects for polyolefins - Functionalization chemistry, classified into four general approaches - Chemical approaches with experimental results - Functionalization approaches The book provides an invaluable reference for researchers in industry and academia interested in functionalization chemistry and polymers. It has been developed through Professor Chung's own teaching experience, both at Pennsylvania State University and on short courses. It is therefore ideally suited as a core text for advanced polymer chemistry and courses on polyolefins and polymers, as well as being a useful supplementary reference for introductory courses on polyolefin chemistry and materials. T.C. Mike Chung is Professor of Polymer Science in the Materials Science and Engineering Department, Pennsylvania State University, USA. He is one of the most experienced people in the field of polyolefin functionalization, with a wide-ranging knowledge gained through many years of experience both in academia and industry. - Shows the available functionalisation approaches with a discussion of their scope and limitations - Written by one of the most experienced people in this field

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Page Count

290

Publisher

Elsevier

Published Date

ISBN 10

0080477933

ISBN 13

9780080477930

Mount Pleasant Cemetery

An Illustrated Guide: Second Edition, Revised and Expanded

By: Mike Filey

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Mount Pleasant Cemetery

An Illustrated Guide: Second Edition, Revised and Expanded

By: Mike Filey

Established in 1876, Mount Pleasant Cemetery has a rich and textured history. It is the keeper of thousands of stories, each of which has contributed to the history of our city, province, and country. Many of Canada’s most beloved figures rest there - William Lyon Mackenzie King, Foster Hewitt, Glenn Gould, and Timothy Eaton are just a few. Other, less known historical figures are buried there also - the first Canadian soldier killed in First World War and victims of the 1949 Noronic disaster. Along with a fascinating account of the cemetery’s history, this illustrated guide includes descriptions of the remarkable monuments and the beautiful horticultural features. Accompanying maps detailing their locations make this book a perfect companion for a walking tour through the grounds.

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Page Count

240

Publisher

Dundurn

Published Date

ISBN 10

1554882338

ISBN 13

9781554882335

Book's by Mike S. Lee

Integrated Strategies for Drug Discovery Using Mass Spectrometry

Integrated Strategies for Drug Discovery Using Mass Spectrometry

LC/MS Applications in Drug Development

LC/MS Applications in Drug Development

Trading Nation

Trading Nation

Biological Psychology

Biological Psychology

Clinical Insights for Image-Guided Radiotherapy

Clinical Insights for Image-Guided Radiotherapy

Sustainable Gold Mining Wastewater Treatment by Sorption Using Low-Cost Materials

Sustainable Gold Mining Wastewater Treatment by Sorption Using Low-Cost Materials

The RF and Microwave Handbook - 3 Volume Set

The RF and Microwave Handbook - 3 Volume Set

Dacie and Lewis Practical Haematology E-Book

Dacie and Lewis Practical Haematology E-Book

Omnidirectional Tilt-Rotor Flying Robots for Aerial Physical Interaction

Omnidirectional Tilt-Rotor Flying Robots for Aerial Physical Interaction

Physical Activity Epidemiology

Physical Activity Epidemiology

Dacie and Lewis Practical Haematology

Dacie and Lewis Practical Haematology

Population Movements and the Third World

Population Movements and the Third World

Leukaemia Diagnosis

Leukaemia Diagnosis

Texas Almanac and State Industrial Guide

Texas Almanac and State Industrial Guide

Functionalization of Polyolefins

Functionalization of Polyolefins

Mount Pleasant Cemetery

Mount Pleasant Cemetery

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