Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis.Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds
This textbook on the digestive system was developed in collaboration with medical students to meet both students' and teachers' needs and objectives. It is currently the official gastroenterology textbook for undergraduate students in all French medical schools in Canada, and is also used in Europe and Africa. An updated and improved 3rd edition was published in French in 2020; this translation and update make the book available in English for the first time. The text features contributions from GI experts from Quebec, France, French Africa, and from key Canadian GI experts. The first part of the book covers the eight main organs of the digestive system, while the second half discusses the major clinical diseases and symptoms that affect the digestive system. This book is comprehensive and well-organized, and features color-coded and beautifully designed figures and tables that make the book helpful and accessible to students.
Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis.Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds
Life or movie: Which comes first?" is a glimpse into an aspiring screenwriter's mind as he tries to figure out the inner workings of high concept movies. The author starts out with the premise that there are very easy rules that govern storytelling, rules which are universal and tolerate no exceptions. That is how he was led to discard traditional perspectives of movie analysis one after the other (Field, Campbell, Jung, Freud) which all proved to be unfaithful to observable facts. The author proposes then a change of paradigm and a different look at storytelling: fiction is like magic; you cannot explain it or it will break the spell, ruin the magic. But when you think about it, there are no two rational ways of making a rabbit appear from a hat.
We all live in the fiction of our Founding Event. It is every man's mission to discover what his Founding Event is, in order to escape the Matrix of Trauma. This essay explains how to reach it and how to avoid further trauma in future generations.
Reviews the emerging field of geodesic methods and features the following: explanations of the mathematical foundations underlying these methods; discussion on the state of the art algorithms to compute shortest paths; review of several fields of application, including medical imaging segmentation, 3-D surface sampling and shape retrieval
I sleep on the Mountain, next to my secret cave. All night I dream about walking in the desert. Somehow, I wake up at the foot of Mont Royal s cross." The story of a Montreal homeless man, anguished by disturbing images, who realizes he s a time-travel fugitive hunted by the CIA for his link to pre-Christian writings. With the help of a sixteenth century New-France explorer, an underground society inhabited by mysterious children, ex-agents, homeless and Aboriginal friends, Gabriel Norson is ready to battle a Draconian empire that has matured for eons on Earth. As Gabriel reads these sacred texts on Mont Royal, a lysergic kaleidoscope of events ignites that may dismantle the foundation of faith upon this planet.
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