The authors explore and explain current techniques for handling the specialised data that describes geographical phenomena in a study that will be of great value to computer scientists and geographers working with spatial databases.
Retinal Pharmacotherapy is the first comprehensive book devoted to pharmacologic agents and their rationale and mechanisms of action in selected retinal and uveitic diseases. Drs. Quan Dong Nguyen, Eduardo Buchele Rodrigues, Michel Eid Farah, and William F. Mieler lead an international team of expert contributors to present up-to-date knowledge of new drugs on the market, the science behind the drugs, evidence of how the drugs work, and the reasons why they are effective or not. This user-friendly, all-in-one reference provides you with easy access to practical information on the effective and appropriate use of pharmacologic agents in the management of retinal diseases. Covers all new and existing retinal drugs to keep you current in this expanding area of the treatment of retinal diseases. Discusses the background behind retinal drugs and the various pathways of how they work so you can make thoroughly informed clinical decisions. Presents 400 color photographs and line drawings that illustrate disease appearance before and after treatment and clarify difficult key concepts. Features contributors from Europe, North America, South America, the Middle East, Asia, and Australia for an international approach. Identifies and emphasizes key points clearly in each chapter to improve comprehension and make finding information easier.
This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Networks of Modernity: Germany in the Age of the Telegraph, 1830-1880 offers a fresh perspective on the history of Germany by investigating the origins and impact of the 'communications revolution' that transformed state and society during the nineteenth century. It focuses upon the period 1830-1880, exploring the interactions between the many different actors who developed, administered, and used one of the most important technologies of the period-the electric telegraph. It reveals the channels through which scientific and technical knowledge circulated across Central Europe during the 1830s and 1840s, stimulating both collaboration and confrontation between the scientists, technicians, businessmen, and bureaucrats involved in bringing the telegraph to life. It highlights the technology's impact upon the conduct of trade, finance, news distribution, and government in the tumultuous decades that witnessed the 1848 revolutions, the wars of unification, and the establishment of the Kaiserreich in 1871. Following the telegraph lines themselves, it weaves together the changes which took place at a local, regional, national, and eventually global level, revisiting the technology's impact upon concepts of space and time, and highlighting the importance of this period in laying the foundations for Germany's experience of a profoundly ambiguous, networked modernity.
Few other civilizations rival Ancient Egypt in its power to capture the modern imagination, and Cleopatra VII, monarch at the end of the Ptolemaic period, has always been preeminent among its cast of characters. Coming to power just before the unstable state was about to be absorbed into an autocratic empire, Cleopatra oversaw not only Egypt's progress as an influential regional power but also the fragile peace of its ethnically mixed population.Michel Chauveau looks at many facets of life under this queen and her dynasty, drawing on such sources as firsthand accounts, numismatics, and Greek, Demotic, and hieroglyphic inscriptions. His use of such sources helps to free the narrative of dependence on later (and usually hostile) Greek and Roman historians. By taking up such subjects as funeral customs, language and writing, social class structure, religion, and administration, he affords the reader an unprecedented and comprehensive picture of Greek and Egyptian life in both the cities and the countryside.Originally published in French in 1997, Egypt in the Age of Cleopatra fulfills a long-standing need for an accessible introduction to the social, economic, religious, military, and cultural history of Ptolemaic Egypt.
This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology - Includes the major toxins of both basic and clinical interest are described in depth - Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology - Evolutionary and functional aspects of bacterial toxins evaluated and summarized - Toxin applications in cell biology presented - Therapy (cancer therapy, dystonias) discussed - Vaccines (native and genetically engineered vaccines) featured - Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. - Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity - Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field - Describes wholly new concepts, including the linking of metabolic pathways with epigenetics - Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases
An approachable guide to an invaluable radiofrequency communication toolkit Software-defined radio (SDR), which emerged in the 1990s, has become a core development method in certain high-profile fields, including military and space communications. High cost and problems with hardware availability, however, prevented this technology from being widely disseminated. The advent of low-cost hardware beginning in the 2010s, however, has made GNU Radio—the leading open-source software toolkit for developing SDR systems—an increasingly viable and even critical tool for a new generation of radiofrequency communication engineers. Communication Systems Engineering with GNU Radio provides an accessible overview of this toolkit and its applications. Beginning with the fundamentals of using GNU radio for digital signal processing, the volume then moves to the practicalities of decoding data and the advantages of accessing raw data normally unavailable in hardware-defined radiofrequency receivers. The result is a potentially crucial tool for engineers looking to adopt this cost-effective and flexible standard for transmitting and processing radiofrequency signals. Readers will also find: A careful balance of radio communications theory with GNU Radio practicalities Practical implementation examples employing well-developed open-source GNU Radio platforms Extensive accompanying documentation and explanation Communication Systems Engineering with GNU Radio is ideal for graduate and undergraduate students in communications systems courses, as well as professionals working in SDR.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction - Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle - Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol
A comprehensive review of evidence-based medicine for the food animal practitioner! Topics include: evidence-based veterinary medicine: principles, applications and perceptions in veterinary medicine, systemic review in the evidence-based veterinary medicine: material and methods, evidence related to the use of ancillary drugs in bovine respiratory disease (anti-inflammatory and others: are they justified or not?, evidence-based use of prokinetic drugs for abomasal disorders in calves and cows, what is the best therapeutic option between intramammary and systemic antibiotic treatment and between intramammary antibiotics?, evidence-based management of infectious certifiable diseases, evidence-based veterinary medicine concerning vaccinal efficiency against clostridial diseases in calves, evidence based therapeutical options for hepatic lipidosis in dairy cows : dextrose, insulin, and others?, and evidence based effectiveness concerning vaccination against mannheimia haemolytica, pasteurella multocida and histophilus somni in feedlot cattle, and much more!
In this Element, a framework is proposed in which it is assumed that visual selection is the result of the interaction between top-down, bottom-up and selection-history factors. The Element discusses top-down attentional engagement and suppression, bottom-up selection by abrupt onsets and static singletons as well as lingering biases due to selection-history entailing priming, reward and statistical learning. We present an integrated framework in which biased competition among these three factors drives attention in a winner-take-all-fashion. We speculate which brain areas are likely to be involved and how signals representing these three factors feed into the priority map which ultimately determines selection.
To observe the tenth anniversary of the founding of the Ramanujan Mathematical Society, an international conference on Discrete Mathematics and Number Theory was held in January 1996 in Tiruchirapalli, India. This volume contains proceedings from the number theory component of that conference. Papers are divided into four groups: arithmetic algebraic geometry, automorphic forms, elementary and analytic number theory, and transcendental number theory. This work deals with recent progress in current aspects of number theory and covers a wide variety of topics.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Highlights recent advances in opioid addiction - Includes Neurocircuitry, Cellular and Molecular neurobiological mechanisms of opioid addiction - Defines opioid abuse and addiction potential, including biological tolerance
Hydrotreating processes in petroleum refining were introduced more than 50 years ago for the removal of sulfur and nitrogen. The sulfided cobalt-molybdenum catalyst, together with its near relatives, is still widely used. Two oil crises made it clear that pretroleum reserves are not inexhaustible and we shall be compelled to exploid less satisfactory sources with high sulfur and nitrogen making hydrotreating even more important. This review is particularly timely for the reason that only recently has a detailed understanding of process chemistry and catalyst structure been obtained. The authors concentrate on the catalytic chemistry of the processes, dealing in some detail with the structure of the most important types of catalysts and the relationship of structure to activity.
Comprehensive coverage of the background and design requirements for plastic and seismic design of steel structures Thoroughly revised throughout, Ductile Design of Steel Structures, Second Edition, reflects the latest plastic and seismic design provisions and standards from the American Institute of Steel Construction (AISC) and the Canadian Standard Association (CSA). The book covers steel material, cross-section, component, and system response for applications in plastic and seismic design, and provides practical guidance on how to incorporate these principles into structural design. Three new chapters address buckling-restrained braced frame design, steel plate shear wall design, and hysteretic energy dissipating systems and design strategies. Eight other chapters have been extensively revised and expanded, including a chapter presenting the basic seismic design philosophy to determine seismic loads. Self-study problems at the end of each chapter help reinforce the concepts presented. Written by experts in earthquake-resistant design who are active in the development of seismic guidelines, this is an invaluable resource for students and professionals involved in earthquake engineering or other areas related to the analysis and design of steel structures. COVERAGE INCLUDES: Structural steel properties Plastic behavior at the cross-section level Concepts, methods, and applications of plastic analysis Building code seismic design philosophy Design of moment-resisting frames Design of concentrically braced frames Design of eccentrically braced frames Design of steel energy dissipating systems Stability and rotation capacity of steel beams
Ensure ductile behavior in any steel structure Engineer earthquake resistant structures using today's most advanced ductile steel design techniques. This guide gives you the latest seismic-resistant design criteria--based on research into the recent Northridge and Kobe earthquakes. You get fingertip access to the ductile properties of steel. . .essential data on the plastic behavior of cross-sections. . .and systematic methods and applications of plastic analysis. This time-saving resource walks you through the seismic design of ductile braced frames and moment resisting frames. . .provides the special detailing requirements needed to ensure satisfactory plastic behavior. . .gives you an overview of special steel-based energy dissipation systems. . .and much more.
The authors explore and explain current techniques for handling the specialised data that describes geographical phenomena in a study that will be of great value to computer scientists and geographers working with spatial databases.
Geographical Information Systems are becoming increasingly important to geologists, geographers, and urban and environmental planners, amongst others. Although there is an increasing number of such systems available on the market, many questions of a theoretical nature need to be addressed, because of the inherently large amounts of data and the lack of appropriate models and languages. Also, there is a need for flexible and efficient usage of GIS, thus permitting their application in a broad range of new areas, such as navigation systems for transport and the automotive industry. ESPRIT Working Groups provide a structure that enables researchers to meet, interact and share research results, thus providing a platform for ad dressing fertile research areas with significant industrial promise. This par ticular volume is the result of a workshop organised by the "Basic GOODS" Working Group. The challenge has been to define richer and more powerful data definition and manipulation languages, and also to develop new and efficient algorithms. The challenge has been met, as presented in this volume, and the Working Group has succeeded in laying a good foundation for future research and eventual applications. We look forward to seeing the results of the recently launched "AMUSING" project, which will build on this foundation.
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