Printed Pandemonium is a fresh take on one of the most violent political upheavals in early modern history: the popular riots, the political murders and the brutal purifications of local governments in the Dutch Republic during the so-called ‘Year of Disaster’ 1672. Printed Pandemonium gives an insight into the relationship between political event and political communication in the early modern world. The popular revolts of 1672 were the work of ‘normal’ citizens who rioted and killed, but also politically participated by reading, writing and debating hundreds of different pamphlets and petitions that were put on the market during that momentous year. In total somewhere between one and two million pamphlets flooded the Dutch Republic in 1672. This study is the first analysis of all these pamphlets.
This book provides for the first time an insider’s view into ITER, the biggest fusion reactor in the world, which is currently being constructed in southern France. Now in its second edition, it updates readers on all developments at ITER and those at competing fusion initiatives worldwide, at the National Ignition Facility (US), the Joint European Torus (EU) and the tens of start-ups funded by private ventures. The author also shares his personal experience with this unique big science project. Aimed at bringing the “energy of the stars” to earth, ITER is funded by the major economic powers (China, the EU, India, Japan, Korea, Russia and the USA). Often presented as a “nuclear but green” energy source, fusion could play an important role in the future electricity supply. But as delays accumulate and budgets continue to grow, ITER is currently a star partially obscured by clouds. Will ITER save humanity by providing a clean, safe and limitless source of energy, or is it merely a political showcase of cutting-edge technology? Is ITER merely an ambitious research project and partly a PR initiative driven by some politically connected scientists? In any case, ITER has already helped spur on rival projects in the USA, Canada and the UK. This book offers readers a behind-the-scenes look at this controversial project, which France snatched from Japan, and introduces them to a world of superlatives: with the largest magnets in the world, the biggest cryogenic plant and tremendous computing power, ITER is one of the most fascinating, and most international, scientific and technological endeavours of our time.
Annotated guide to the Dutch archives on Ghana and West Africa in the "Nationaal Archief" offering a comprehensive overview of available sources. Part I: description of archival materials. Part II: historical overview of the Dutch in Ghana and selected themes from Ghana's history. With bibliography and index.
A diary kept by a boy in the 1790s sheds new light on the rise of autobiographical writing in the 19th century and sketches a panoramic view of Europe in the Age of Enlightenment. The French Revolution and the Batavian Revolution in the Netherlands provide the backdrop to this study, which ranges from changing perceptions of time, space and nature to the thought of Jean-Jacques Rousseau and its influence on such far-flung fields as education, landscape gardening and politics. The book describes the high expectations people had of science and medicine, and their disappointment at the failure of these new branches of learning to cure the world of its ills.
In-vivo imaging markers of neuronal changes related to Alzheimer’s disease (AD) are ideally suited to be employed as diagnostic markers for early and differential diagnosis of AD as well as for the assessment of neurobiological effects of medical treatments in clinical trials. Novel molecular imaging techniques enable in-vivo detection of cerebral amyloid pathology, whereas magnetic resonance imaging (MRI)-based techniques, such as volumetric MRI and diffusion tensor imaging (DTI), provide structural lesion markers that allow tracking disease progression from preclinical through predementia to clinically manifest stages of AD. However, a widespread clinical use of these imaging biomarkers is hampered by considerable multi-centric variability related to differences in scanner hardware and acquisition protocols, but also by the lack of internationally agreed upon standards for analytic design and employed quantitative metrics. Several strategies for reducing multicenter variability in imaging measures have been proposed, including homogenization of the acquisition settings across scanner platforms, stringent quality assurance procedures, and artifact removal by means of post-acquisition image processing techniques. In addition, selection of appropriate statistical models to account for remaining multicenter variability in the data can further improve the accuracy and reproducibility of study results. The first projects for international standardization of image analysis methods and derived quantitative metrics have emerged recently for volumetric MRI measures. In contrast, the standardization and establishment of DTI-derived measures within a multicenter context are less well developed. Although molecular imaging techniques are already widely used in multicenter settings, sources of variability across sites and appropriate methods to reduce multicenter effects are still not explored in detail. Comparability of neuroimaging measures as AD biomarkers in worldwide clinical settings will finally depend on the establishment of internationally agreed upon standards for image acquisition, quality assurance, and employed quantitative metrics.
Headache syndromes rank amongst the most common presenting symptoms in general practice and neurology, affecting up to 15% of the adult population. Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Headache Syndromes provides clinicians with a definitive resource for diagnosing and managing patients with primary and secondary forms of headaches, either as isolated complaints or as part of a more complex syndrome. Split into 7 key sections with 59 chapters, this comprehensive work discusses the scientific basis and practical management of headache syndromes in a logical format. Each chapter is written by international experts in neurology who share their research and extensive experience by providing a wealth of practical advice for use in clinical situations. In addition, all content is up-to-date and chapters incorporate discussions on the latest International Classification of Headache Disorders 3rd edition when relevant.
Printed Pandemonium is a fresh take on one of the most violent political upheavals in early modern history: the popular riots, the political murders and the brutal purifications of local governments in the Dutch Republic during the so-called ‘Year of Disaster’ 1672. Printed Pandemonium gives an insight into the relationship between political event and political communication in the early modern world. The popular revolts of 1672 were the work of ‘normal’ citizens who rioted and killed, but also politically participated by reading, writing and debating hundreds of different pamphlets and petitions that were put on the market during that momentous year. In total somewhere between one and two million pamphlets flooded the Dutch Republic in 1672. This study is the first analysis of all these pamphlets.
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