The type of material considered for publication includes drafts of original papers or monographs, technical reports of high quality and broad interest, advanced-level lectures, reports of meetings, provided they are of exceptional interest and focused on a single topic.
In just few years, case-based reasoning has evolved from a research topic studied at a small number of specialized academic labs into an industrial-strength technology applied in various fields. The INRECA methodology presented in detail in this monograph provides a data analysis framework for developing case-based reasoning solutions for successful applications in real-world industrial contexts. The book is divided into parts on: - smarter business with case-based decision support; - developing case-based applications using the INRECA methodology; and - using the methodology in various application domains. The book provides a self-contained introduction to case-based reasoning applications that address both R&D professionals and general IT managers interested in this powerful new technology. In this second edition, improvements and updates have been incorporated throughout the text. Particularly useful is the systematic coverage of experience factory applications at various steps; and, of course, the references have been extended substantially.
In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood within the molecular paradigm. What has happened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molecular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational biology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics. Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution.
Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology. A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg. This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry. An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research.
In just few years, case-based reasoning has evolved from a research topic studied at a small number of specialized academic labs into an industrial-strength technology applied in various fields. The INRECA methodology presented in detail in this monograph provides a data analysis framework for developing case-based reasoning solutions for successful applications in real-world industrial contexts. The book is divided into parts on: - smarter business with case-based decision support; - developing case-based applications using the INRECA methodology; and - using the methodology in various application domains. The book provides a self-contained introduction to case-based reasoning applications that address both R&D professionals and general IT managers interested in this powerful new technology. In this second edition, improvements and updates have been incorporated throughout the text. Particularly useful is the systematic coverage of experience factory applications at various steps; and, of course, the references have been extended substantially.
The type of material considered for publication includes drafts of original papers or monographs, technical reports of high quality and broad interest, advanced-level lectures, reports of meetings, provided they are of exceptional interest and focused on a single topic.
Dalila est une jeune orpheline tanzanienne témoin d'un drame odieux. Vous allez me dire, ce n'est pas terrible pour commencer à franchir les obstacles d'un début d'existence. Mais en plus d'être spectatrice de cet acte ignoble, elle se retrouve détentrice d'un secret (et d'une promesse associée) qui l'oblige en son âme et conscience à voyager vers Paris quoiqu'il se passe. Vous êtes d'accord, elle ne se facilite pas du tout la vie d'autant plus qu'elle se fait accompagner par un drôle de vieux paysan ougandais aussi bougon que naïf, Moses. Ça serait à mourir de rire si les gens nombreux rencontrés sur le chemin du couple ne s'en mêlaient pas pour des raisons impérieuses toutes très différentes. Mais quel est donc ce secret inavouable ? Et pourquoi ces hommes et ces femmes se démènent-ils tant pour l'aider ou lui mettre des bâtons dans les roues ? Tout à la fois aventure humaine et leçon de vie : ce conte noir moderne ne vous laissera pas indifférent !
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