« Safety Man, le parfait compagnon de la femme urbaine ! Conçu comme un élément visuel dissuasif, Safety Man ressemble à un homme grandeur nature qui pèserait 80 kilos, mesurerait 1 mètre 80, donnant ainsi aux autres l'impression que, seule chez vous ou au volant de votre voiture, vous êtes protégée. » C'est ce que Sandy pouvait lire sur la notice de ce qui n'aurait dû rester finalement... qu'un jouet dans son carton ! Cette nouvelle est extraite du livre Parmi les disparus. Temps de lecture estimé : à partir de 20 minutes.
Lorsque Gus Orviston, jeune prodige de la pêche à la mouche, claque la porte de la demeure familiale, il sait qu'il n'y remettra plus les pieds. Finies les ridicules querelles de ses parents, à lui la liberté et les eaux sauvages de l'Oregon. Sur son chemin, l'attendent de drôles d'oiseaux : un vieil Indien, un philosophe et son chien savant Descartes, une souris qui chante, un cadavre et une énigmatique " pêcheuse " qui l'enverra au cœur de la nuit remonter la rivière en compagnie d'une femelle saumon. Invitation à la philosophie de la vie, célébration de la nature et de la liberté, l'autobiographie de Gus Orviston, assurément l'un des personnages les plus attachants de la littérature américaine contemporaine, est unique d'irrévérence, d'humour et d'intelligence. Ce premier roman, devenu un livre-culte aux Etats-Unis, a imposé d'emblée David James Duncan aux côtés de Richard Brautigan et de John Irving.
Un veuf élève deux filles, Anna et Claire, avec l'aide de Cooper, un jeune travailleur agricole, dans un ranch californien. Lorsque Anna s'éprend de Cooper, la colère du père éclate et la famille se disperse. Claire devient détective pour un cabinet d'avocats et Cooper joueur de poker professionnel alors qu'Anna, professeur de littérature, s'installe dans la ferme d'un poète oublié, Lucien Segura, dans le Gers. Un roman à la structure éclatée, où le destin des protagonistes se reflète, à un siècle de distance, dans celui de la famille Segura. [SDM].
La légende dit qu'en 1931, le célèbre musicien noir Robert Johnson vendit son âme au Diable en échange d'une guitare enchantée et d'un talent extraordinaire pour le blues. Présumé mort depuis plus d'un demi-siècle, il réapparaît aujourd'hui sur un réserve indienne de l'Etat de Washington, à la recherche d'une vieille femme auprès de qui se sont succédé Marvin Gaye, Jimi Hendrix et Janis Joplin. Celle-ci ne représente-t-elle pas pour lui le dernier espoir d'être libéré du pacte diabolique ? Toujours est-il qu'il finit par " oublier " sa guitare à bord du pick-up d'un jeune Indien qui l'a pris en stop. L'instrument magique pourrait encore faire des prodiges... C'est ainsi que naissent les " Coyote Springs ", un groupe de rock cent pour cent indien dont l'ascension, des réserves à Manhattan, sera fulgurante. Faut-il voir dans cette équipée tragi-comique, l'œuvre du " Gentleman " ou Sherman Alexie lui aurait-il vendu son âme ?
A magisterial history of the artists and writers who left Weimar when the Nazis came to power In 1933 thousands of intellectuals, artists, writers, militants and other opponents of the Nazi regime fled Germany. They were, in the words of Heinrich Mann, “the best of Germany,” refusing to remain citizens in this new state that legalized terror and brutality. Exiled across the world, they continued the fight against Nazism in prose, poetry, painting, architecture, film and theater. Weimar in Exile follows these lives, from the rise of national socialism to their return to a ruined homeland, retracing their stories, struggles, setbacks and rare victories. The dignity in exile of Walter Benjamin, Ernst Bloch, Bertolt Brecht, Alfred Döblin, Hanns Eisler, Heinrich Mann, Thomas Mann, Anna Seghers, Ernst Toller, Stefan Zweig and many others provides a counterpoint to the story of Germany under the Nazis.
The purpose of this book is to present the state of knowledge concerning nutrition and point out directions for future work for the Echinodermata, an ancient group which shows great diversity in form and function, and whose feeding activities can have great environmental impact.
The Handbook of Clinical Interviewing with Children is one of three interrelated handbooks on the topic of interviewing for specific populations. It presents a combination of theory and practice plus concern with diagnostic entities for readers who work, or one day will work, with children (and their parents and teachers) in clinical settings. The volume begins with general issues (structured versus unstructured interview strategies, developmental issues when working with children, writing up the intake interview, etc.), moves to a section on major disorders with special relevance for child populations (conduct disorders, attention-deficit hyperactivity disorder, learning disorders, etc.), and concludes with a section addressing special populations.
In the present volume and in the preceding one we have stretched our normal pattern of reviews by including articles of more major proportions than any we have published before. As a consequence each of these two vol umes contains only three review articles. From the beginning of this series it has been our aim, as editors, to achieve variation in the scope, style, and length of individual articles sufficient to match the needs of the individual topic, rather than to restrain the authors within rigid limits. We feel that the two major articles of Vols. 5 and 6 are entirely justified and do not repre sent unnecessary exuberance on the part of the authors. The article by Michaudon on fission is the first comprehensive account of the developments in this subject, which have placed it in the center of the stage of nuclear physics during the past few years. The discovery of fission isomerism and its dramatic manifestations in the intermediate structure of the neutron cross sections for fissionable isotopes are among the most im portant and interesting events to occur in nuclear physics. These events came as a surprise, and reaffirmed that the strength of nuclear physics lies in the combination of ingenious experiments with simple ideas.
The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, another pathway associated with the hyperpolarization of both endothelial and vascular smooth muscle cells contributes also to endothelium-dependent relaxations (EDHF-mediated responses). These responses involve an increase in the intracellular Ca concentration of the endothelial cells followed by the opening of Ca-activated K channels of small and intermediate conductances (SKCa and IKCa). These channels show a distinct subcellular distribution, suggesting that their activation could be elicited by distinct stimuli. Following KCa activation, the endothelial hyperpolarization can be conducted to the underlying smooth muscle cells by electrical coupling through myo-endothelial gap junctions. In addition, the potassium efflux can lead to the accumulation of potassium ions in the intercellular space and the subsequent activation of smooth muscle Kir2.1 and/or Na/K-ATPase. The hyperpolarization of the smooth muscle cells produces vascular relaxation, predominantly by closing voltage-gated calcium channels, and vasodilatation. EDHFmediated responses are altered in various pathologies or, conversely, act as a compensating mechanism when other endothelial pathways are impaired. A better characterization of EDHF-mediated responses should allow determining whether or not new drugable targets can be identified within this endothelial pathway for the treatment of cardiovascular diseases. Table of Contents: Endothelium-Dependent Hyperpolarizations: The Classical "EDHF" Pathway / Conclusion / References
Main headings: I. Basic concepts of pulsatile arterial hemodynamics. - II. Pathophysiological mechanisms. - III. Arterial stiffness, wave reflections, cardiovascular risk and end-organ damage. - IV. Clinical aspects of arterial stiffness and wave reflections. - V. Therapeutic aspects of arterial stiffness and wave reflections.
Liberal constitutionalism has come under sharp attack as globalization led to a confluence of huge disparities in wealth, identity-based alienation triggered by mass migration, and accompanying erosions of democracy. Liberal constitutionalism has also been challenged by illiberal populists who have adapted its framework to mask their aim to subvert its core values. These developments bring the nexus between the constitution and justice to the fore--and in particular that concerning distributive justice in its three dimensions of redistribution, recognition, and representation. The book provides a systematic account of the central role of distributive justice in the normative legitimation of liberal constitutions. Because what distributive justice requires is highly contested, and constitutions are supposed to be susceptible of garnering a consensus among those they govern, constitutions only ought to guarantee essential but limited aspects of justice. Drawing on Rawls's insight that distributive justice calls for "constitutional essentials", the book advances the thesis that liberal constitutions must incorporate certain "justice essentials". The book is divided into three parts. Part one examines the combination of current legal, economic, political, and ideological developments that pose challenges to the normative viability of liberal constitutionalism. Part two offers a rereading of the relevant philosophical and jurisprudential literature that sheds crucial theoretical light on the relationship between constitution and justice. This rereading draws on key figures in both the analytic and the continental traditions. Finally, part three makes the case for a thoroughly pluralistic approach being optimal in the quest for a constitution's justice essentials
Thinking Critically About the Kennedy Assassination uses the tools of critical thinking, historical research, and philosophical inquiry to debunk the many myths and conspiracy theories surrounding JFK’s shocking and untimely death. As we approach the 60th anniversary of the violent public assassination of President John F. Kennedy, over half of all Americans surveyed continue to believe that he was killed by a conspiracy involving multiple assassins. Through its reasoned and detailed analysis of the content and evolution of JFK conspiracy narratives, this book also serves as a comprehensive case study of paranoid reasoning and modern mythmaking. The book’s opening chapters lay out the "official" academic consensus concerning the Kennedy assassination (better known as the "Lone Gunman Theory") and discuss the origins of popular interpretations of Kennedy’s life and death, such as the nostalgic myth of "Camelot," the unsympathetic "Irish Mafia" narrative, and the many conspiracy theories critical of both. Subsequent sections scrutinize the alleged motives of leading conspiracy suspects, the ballistic, forensic, and medical evidence related to JFK’s murder, and the most popular "proofs" of an enduring government cover- up. The book concludes that no clear evidence exists to suggest that JFK was the victim of a conspiracy and ends with a discussion of the causes and consequences of paranoid thinking in contemporary public discourse. This volume will appeal to students of history, politics, psychology, and cultural and media studies, and to a broader audience interested in American history, critical thinking, and conspiracy thinking.
This book provides the theoretical background required for modelling photonic crystals and their optical properties, while presenting the large variety of devices where photonic crystals have found application. As such, it aims at building bridges between optics, electromagnetism and solid state physics. This second edition includes the most recent developments of two-dimensional photonic crystal devices, as well as some of the last results reported on metamaterials.
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Over the years enormous effort was invested in proving ergodicity, but for a number of reasons, con?dence in the fruitfulness of this approach has waned. — Y. Ben-Menahem and I. Pitowsky [1] Abstract The basic motivation behind the present text is threefold: To give a new explanation for the emergence of thermodynamics, to investigate the interplay between quantum mechanics and thermodynamics, and to explore possible ext- sions of the common validity range of thermodynamics. Originally, thermodynamics has been a purely phenomenological science. Early s- entists (Galileo, Santorio, Celsius, Fahrenheit) tried to give de?nitions for quantities which were intuitively obvious to the observer, like pressure or temperature, and studied their interconnections. The idea that these phenomena might be linked to other ?elds of physics, like classical mechanics, e.g., was not common in those days. Such a connection was basically introduced when Joule calculated the heat equ- alent in 1840 showing that heat was a form of energy, just like kinetic or potential energy in the theory of mechanics. At the end of the 19th century, when the atomic theory became popular, researchers began to think of a gas as a huge amount of bouncing balls inside a box.
Konrad Michel, a leading psychiatrist and acclaimed expert, draws on decades of experience to offer necessary new ways of understanding—and preventing—suicide. After one of his first patients died by suicide, Michel devoted himself to researching self-harm. Writing vividly and personally, he recounts more than forty years of working with and learning from suicidal patients. Michel shows that suicide is not just a consequence of mental illness but an action related to a person’s life story. Drawing on hundreds of interviews with suicidal patients, he argues that suicide and suicide attempts occur when someone experiences extreme emotional pain that severely impairs the ability to think and act rationally. Based on this understanding, Michel and his colleagues developed a person-centered approach to treatment that overcomes the limitations of the traditional medical model. Through a brief therapy, patients find a personally meaningful narrative understanding of their suicidal thoughts and impulses. People at risk can learn to recognize their vulnerabilities in order to manage potentially life-threatening situations and keep themselves safe. Michel emphasizes the importance of communication: medical professionals need to connect with patients as individuals to identify specific warning signs. Both compassionate and rigorous, this book provides vital insight into suicide prevention and shows how changing attitudes will help save lives. It includes practical advice for people at risk, with special emphasis on young people, as well as for relatives and health professionals.
The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, another pathway associated with the hyperpolarization of both endothelial and vascular smooth muscle cells contributes also to endothelium-dependent relaxations (EDHF-mediated responses). These responses involve an increase in the intracellular Ca concentration of the endothelial cells followed by the opening of Ca-activated K channels of small and intermediate conductances (SKCa and IKCa). These channels show a distinct subcellular distribution, suggesting that their activation could be elicited by distinct stimuli. Following KCa activation, the endothelial hyperpolarization can be conducted to the underlying smooth muscle cells by electrical coupling through myo-endothelial gap junctions. In addition, the potassium efflux can lead to the accumulation of potassium ions in the intercellular space and the subsequent activation of smooth muscle Kir2.1 and/or Na/K-ATPase. The hyperpolarization of the smooth muscle cells produces vascular relaxation, predominantly by closing voltage-gated calcium channels, and vasodilatation. EDHFmediated responses are altered in various pathologies or, conversely, act as a compensating mechanism when other endothelial pathways are impaired. A better characterization of EDHF-mediated responses should allow determining whether or not new drugable targets can be identified within this endothelial pathway for the treatment of cardiovascular diseases. Table of Contents: Endothelium-Dependent Hyperpolarizations: The Classical "EDHF" Pathway / Conclusion / References
The advances made in vascular biology in the last 25 years have considerably changed the perception that one could have of the endothelial cells. Once considered as a diffusion barrier preventing the access of the blood cells to the vascular matrix, the endothelium is now recognized as playing a major role in the control of blood fluidity, platelet aggregation, and vascular tone, but also in immunology, inflammation, angiogenesis, and for serving as a metabolizing and an endocrine organ. -- from the preface Cardiovascular diseases, so prevalent in the Western world during the twentieth century, could well become the scourge of the twenty-first century in emerging countries as well as the West. Endothelial dysfunction linked to an imbalance in the synthesis and/or release of contracting and relaxing factors is often evoked to explain the initiation of the cardiovascular pathology or its development and perpetuation. Two decades ago, when nitric oxide was demonstrated to mediate endothelium-dependent relaxations, the vascular world seemed convinced that nitric oxide was the ultimate and sole explanation for such relaxations. However not everyone agreed. EDHF: The Complete Story is the work of two leading researchers who did not accept that simple conclusion, but instead continued to search, along with others, for a deeper understanding of the ways in which endothelial cells communicate with the underlying smooth muscle to signal it to hyperpolarize. Now with most, if not all, of those ways, uncovered, the authors offer this summary as way of bringing closure to the quest. This monograph reports on the work of many researchers. It summarizes the significant recent discoveries concerning endothelium-dependent hyperpolarizations, which are likely to play a much more important role in cardiovascular physiology and pathology than was originally foreseen Extensively illustrated with original diagrams and schematics that summarize the different steps of endothelium-dependent hyperpolarization, the text is designed for vascular biologists, and cardiologists, as well as graduate students looking to gain an understanding of the intimate functioning of the blood vessel wall.
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