This book provides an exhaustive review of the current state of the art in the management of prostate cancer, from screening to treatment. A particular feature is the emphasis placed on the value of a multidisciplinary approach. The opening chapters address basic aspects including epidemiology, biology, and chemoprevention. The role of individual and mass screening is carefully appraised, and diagnosis, clinical work-up, and the role of active surveillance are discussed in detail. Subsequent chapters are devoted to each of the therapies that may be employed, including open and robotic laparoscopic radical prostatectomy, the various forms of radiation therapy, high-intensity focused ultrasound, cryotherapy, hormonal therapy, and targeted therapies and vaccination. Up-to-date data from clinical trials are included. The editors are members of the EORTC who have coordinated phase III EORTC trials and have worldwide reputations.
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
The northern Italian, ‘Padanian’ identity, fostered by the Lega Nord, is rooted in the long-standing tradition, in political and scholarly discourse, of casting regional differences within Italy in terms of a North-South geographic divide. Trying to come to terms, in the late 1980s and 1990s, with Italy’s (real or presumed) inadequacies – such as inefficient government, corruption, and organized crime – this imagined geography acquired political centrality in that the North became associated with the virtues of modernity and the South with the vices of un-modernity. It was not only politicians but also social scientists, who fostered and perpetuated this conceptualization of the North-South divide, thus imposing a normative hierarchy between the two parts of the country. In response to this discourse many scholars, both in Italy and abroad, have started to question this perception of the South as a “backward” and implicitly inferior society. Starting from this critical tradition, Michel Huysseune provides a new, systematic, and interdisciplinary approach that re-interprets the premises behind Italy’s imagined geography of modernity. He moves beyond an understanding of the South as a “backward” and implicitly inferior society and problematizes normative notions of modernity, thus offering a new perspective on the North-South divide, which has a significance well beyond the case of Italy.
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
What happened between two people on a cliff’s edge on the French coast is at the heart of “a tantalizing puzzle” in this twisting noir thriller (Kirkus Reviews). In the town of Yport, during a run along Europe’s tallest cliff, Jamal notices a red scarf hanging on a fence. Then he sees the woman, her dress torn, her back to the void, her eyes fixed on his own. Jamal holds the scarf out to her like a buoy. A few seconds later, the stranger’s lifeless body is found lying on the icy pebbles of the empty beach below. Around her neck, the red scarf. Everyone thinks he pushed her. He only wanted to save her. That’s Jamal’s version. Do you believe it? “One of France’s most ingenious crime writers.” —The Sunday Times Acclaim for Michel Bussi’s novels “Wonderfully ingenious and altogether satisfying.” —The New York Times Book Review “Harlan Coben fans will enjoy [the] intriguing characters and twisty conclusion.” —Library Journal “A well-constructed literary thriller with a strong sense of place and deep understanding of human nature.” —Kirkus Reviews
The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, another pathway associated with the hyperpolarization of both endothelial and vascular smooth muscle cells contributes also to endothelium-dependent relaxations (EDHF-mediated responses). These responses involve an increase in the intracellular Ca concentration of the endothelial cells followed by the opening of Ca-activated K channels of small and intermediate conductances (SKCa and IKCa). These channels show a distinct subcellular distribution, suggesting that their activation could be elicited by distinct stimuli. Following KCa activation, the endothelial hyperpolarization can be conducted to the underlying smooth muscle cells by electrical coupling through myo-endothelial gap junctions. In addition, the potassium efflux can lead to the accumulation of potassium ions in the intercellular space and the subsequent activation of smooth muscle Kir2.1 and/or Na/K-ATPase. The hyperpolarization of the smooth muscle cells produces vascular relaxation, predominantly by closing voltage-gated calcium channels, and vasodilatation. EDHFmediated responses are altered in various pathologies or, conversely, act as a compensating mechanism when other endothelial pathways are impaired. A better characterization of EDHF-mediated responses should allow determining whether or not new drugable targets can be identified within this endothelial pathway for the treatment of cardiovascular diseases. Table of Contents: Endothelium-Dependent Hyperpolarizations: The Classical "EDHF" Pathway / Conclusion / References
This book provides the theoretical background required for modelling photonic crystals and their optical properties, while presenting the large variety of devices where photonic crystals have found application. As such, it aims at building bridges between optics, electromagnetism and solid state physics. This second edition includes the most recent developments of two-dimensional photonic crystal devices, as well as some of the last results reported on metamaterials.
Headache syndromes rank amongst the most common presenting symptoms in general practice and neurology, affecting up to 15% of the adult population. Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Headache Syndromes provides clinicians with a definitive resource for diagnosing and managing patients with primary and secondary forms of headaches, either as isolated complaints or as part of a more complex syndrome. Split into 7 key sections with 59 chapters, this comprehensive work discusses the scientific basis and practical management of headache syndromes in a logical format. Each chapter is written by international experts in neurology who share their research and extensive experience by providing a wealth of practical advice for use in clinical situations. In addition, all content is up-to-date and chapters incorporate discussions on the latest International Classification of Headache Disorders 3rd edition when relevant.
The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, another pathway associated with the hyperpolarization of both endothelial and vascular smooth muscle cells contributes also to endothelium-dependent relaxations (EDHF-mediated responses). These responses involve an increase in the intracellular Ca concentration of the endothelial cells followed by the opening of Ca-activated K channels of small and intermediate conductances (SKCa and IKCa). These channels show a distinct subcellular distribution, suggesting that their activation could be elicited by distinct stimuli. Following KCa activation, the endothelial hyperpolarization can be conducted to the underlying smooth muscle cells by electrical coupling through myo-endothelial gap junctions. In addition, the potassium efflux can lead to the accumulation of potassium ions in the intercellular space and the subsequent activation of smooth muscle Kir2.1 and/or Na/K-ATPase. The hyperpolarization of the smooth muscle cells produces vascular relaxation, predominantly by closing voltage-gated calcium channels, and vasodilatation. EDHFmediated responses are altered in various pathologies or, conversely, act as a compensating mechanism when other endothelial pathways are impaired. A better characterization of EDHF-mediated responses should allow determining whether or not new drugable targets can be identified within this endothelial pathway for the treatment of cardiovascular diseases. Table of Contents: Endothelium-Dependent Hyperpolarizations: The Classical "EDHF" Pathway / Conclusion / References
Main headings: I. Basic concepts of pulsatile arterial hemodynamics. - II. Pathophysiological mechanisms. - III. Arterial stiffness, wave reflections, cardiovascular risk and end-organ damage. - IV. Clinical aspects of arterial stiffness and wave reflections. - V. Therapeutic aspects of arterial stiffness and wave reflections.
Professor Jean Richard is the doyen of crusade historians. Although also well-known as one of the most distinguished historians of Burgundy, he has through publications which have been appearing for over half a century established himself as the greatest living scholar working on crusading and the Latin East. His book on twelfth-century Tripoli, published in 1945, is still the standard work on the county. In the 1950s he, and Joshua Prawer, provided a revolutionary approach towards the constitution and institutions of the kingdom of Jerusalem. He went on to pave the way for an entirely new understanding of the kingdom of Cyprus. In the 1960s he was one of a few historians who were sign-posting a more empathetic view of the ideology of crusading and the motivation of crusaders, and he developed his ideas further in recent monographs on Saint Louis and on the crusades in general. His work on Catholic missions to Asia and the role of the papacy in those enterprises is generally regarded as setting standards which few can approach. To celebrate his eightieth birthday thirty-nine colleagues have contributed articles in fields which themselves illustrate Professor Richard’s breadth of interest: the crusades, the military orders, and the Latin settlements on the Levantine mainland and the island of Cyprus.
Critical reflections by established academics on the crisis of multiculturalism that occurred in Great Britain, Netherlands and Canada. It provides an occasion to develop a sophisticated understanding of societies characterized by religious, ethnic and cultural diversity.
Let the Author's Handbook of Styles for Life Science Journals save you time and trouble by providing a one-stop resource for all your manuscript writing requirements. No more plowing through your journal collection or wandering the library stacks to get those elusive journal pages containing instructions to authors. This unique book contains all the information you need to know: whether the journal will consider your manuscript; the journal's submission address; how to construct the abstract, illustrations, tables, and references; and specific information on copyright, multiple authorship, statistical analyses, and page charges. The Author's Handbook of Styles for Life Science Journals gives all this information for 440 of the most important English-language, life science journals. Titles were selected from the "Journal Rankings by Times Cited" list in the Science Citation Index Journal Citation Report. Because this report is heavily weighted toward the medical sciences, other life science journals are incorporated into the book based on general level of prestige and reputation. In addition, some new titles that promise to be important to their fields, like Nature Medicine and Emerging Infectious Diseases are also included. Organized by journal title, the handbook's entries are uniformly arranged to allow direct comparison between journals. Information is presented in an easy-to-use, easy-to-read format with clear and explicitly stated instructions. The Author's Handbook of Styles for Life Science Journals gives authors in the life sciences all the information necessary for the correct and complete compilation of a manuscript for submission to their journal of choice.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction are detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Psychostimulants, Volume 2 in the series, explores the molecular and cellular systems in the brain responsible for psychostimulant addiction, including both direct/indirect sympathomimetics and nonsympathomimetics. This volume introduces the readers to the history of psychostimulant use. The authors clearly differentiate the neurobiological effects into three distinct stages of the addiction cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Highlights recent advances in psychostimulant addiction Includes neurocircuitry, cellular and molecular neurobiological mechanisms of psychostimulant addiction Defines the abuse and addiction potentials of both direct and indirect sympathomimetics and nonsympathomimetics
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