The Doyle, Carbone, and Roth families immigrate to the United States from Europe for a variety of reasons: the 1850 potato famine in Ireland, religious freedom, and persecution of the mafia in Sicily by Mussolini in 1925. It is the appearance of Oscar Klein, an orphan from Philadelphia, which brings them all together in the post-depression, pre-World War II era of the late 1930s to 1940s. Oscar Klein is a kid of the streets without formal education, but he becomes the driving force and innovator. His ideas shape, mold, and secure the future of his colleagues, Patrick Doyle and Anthony Carbone. Together they create KCD Incorporated, purchase taxi medallions, and own and operate parking garages, private clubs, and restaurants. Oscar marries Mildred Stein—a wedding not to be missed at the Plaza Hotel attended by the New York City elite, including Anthony’s father, Luca Carbone, the Mafia Don and head of the Cosa Nostra in New York. Together they build success and give back to the community. However, with accomplishments come unavoidable heartbreak and misfortune, illness, drug addiction, and death. Follow the saga of four families that combines historical events with the personal dramas of its characters.
The Doyle, Carbone, and Roth families immigrate to the United States from Europe for a variety of reasons: the 1850 potato famine in Ireland, religious freedom, and persecution of the mafia in Sicily by Mussolini in 1925. It is the appearance of Oscar Klein, an orphan from Philadelphia, which brings them all together in the post-depression, pre-World War II era of the late 1930s to 1940s. Oscar Klein is a kid of the streets without formal education, but he becomes the driving force and innovator. His ideas shape, mold, and secure the future of his colleagues, Patrick Doyle and Anthony Carbone. Together they create KCD Incorporated, purchase taxi medallions, and own and operate parking garages, private clubs, and restaurants. Oscar marries Mildred Stein—a wedding not to be missed at the Plaza Hotel attended by the New York City elite, including Anthony’s father, Luca Carbone, the Mafia Don and head of the Cosa Nostra in New York. Together they build success and give back to the community. However, with accomplishments come unavoidable heartbreak and misfortune, illness, drug addiction, and death. Follow the saga of four families that combines historical events with the personal dramas of its characters.
For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Pediatric Hematology & Oncology Secrets, 2nd Edition, offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. This highly regarded resource features the Secrets' popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style – making inquiry, reference, and review quick, easy, and enjoyable. - The proven Secrets Series® format gives you the most return for your time – succinct, easy to read, engaging, and highly effective. - Fully revised and updated, including discussions of supportive care of children with cancer and psychosocial aspects of care. - New chapters on Precision Medicine and Systems Biology; Health Equity and Disparities in Pediatric and Adolescent/Young Adult Oncology; Transfusion Medicine; Neoplastic Hematopathology; Hemophagocytic Lymphohistiocytosis; and more. - Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams. - Bulleted lists, mnemonics, practical tips from global leaders in the field – all providing a concise overview of important board-relevant content. - Portable size makes it easy to carry with you for quick reference or review anywhere, anytime.
The Babies Hospital, now known as Morgan Stanley Children's Hospital, was founded in 1887 by Drs. Sarah and Julia McNutt in a brownstone on Fifty-Fifth Street and Lexington Avenue. The hospital is the first freestanding children's hospital in New York City and the fourth oldest in the United States. However, the hospital traces its roots to the establishment of the Vagelos College of Physicians and Surgeons of Columbia University, then King's College, more than 250 years ago. In 1929, the hospital relocated to a new 204-bed facility as part of the Columbia-Presbyterian Medical Center. The New York Times referred to the new Babies Hospital as "the last word in hospital design and equipment." Under the leadership of Rustin Mcintosh from 1931 to 1960, the hospital became a beacon for discovery and innovation, assembled a department of noted subspecialists, and was one of the first children's hospitals to develop programs in neonatology, surgery, radiology, neurology, hematology-oncology, and psychiatry. Michael Weiner, MD, Hettinger professor of pediatrics at Columbia University Irving Medical Center, is a vice chair of pediatrics, former director of the Division of Pediatric Oncology, and an author of Living Cancer: Stories of an Oncologist, Father, Survivor and a Philanthropist. Stephen E. Novak has been the head of Archives & Special Collections at Columbia's Augustus C. Long Health Sciences Library since 1997. The images in the book come from the rich photographic resources of the library.
To date (2013), we have witnessed over 100 years of research on Alzheimer’s disease (AD). In the past century, this gave new and deep insights into its pathophysiology. However, no new treatment with an innovative mode of action has found its way to the patients since the first targeted therapies with cholinergic drugs like Tacrin. So far A-beta and related targets have shown negative results in pivotal Phase III studies, after showing promising trends in Phase II. Thus the question arises as to whether A-beta is the wrong target for disease-modifying treatments, or whether other substantial changes to clinical development plans need to be made, e.g. including patients at risk of developing AD instead of those already experiencing symptoms. Alternative targets and study design options like enrichment strategies, however, do not evolve as an easy alternative solution.
Alzheimer’s disease (AD) confers an additional risk of death. The magnitude of this impact is related to the person’s underlying mortality and current AD stage. When planning clinical trials, estimating the number of deaths prior to study initiation, and periodically during the study as participants are enrolled, assists in providing an informative context, particularly if there are few life events. Additionally, deaths have the potential to introduce a bias, thus, equal follow-up needs to ensure for participants assigned to either active or placebo, particularly if the period of observation for safety events extends beyond the end of the study. During AD clinical trials, patients discontinue for reasons other than death and at substantially high rates, which has the potential to introduce significant bias. Planning and incorporating strategies to improve retention and identify successful techniques should be an integral part of the study process.
Multiple Imputation and its Application The most up-to-date edition of a bestselling guide to analyzing partially observed data In this comprehensively revised Second Edition of Multiple Imputation and its Application, a team of distinguished statisticians delivers an overview of the issues raised by missing data, the rationale for multiple imputation as a solution, and the practicalities of applying it in a multitude of settings. With an accessible and carefully structured presentation aimed at quantitative researchers, Multiple Imputation and its Application is illustrated with a range of examples and offers key mathematical details. The book includes a wide range of theoretical and computer-based exercises, tested in the classroom, which are especially useful for users of R or Stata. Readers will find: A comprehensive overview of one of the most effective and popular methodologies for dealing with incomplete data sets Careful discussion of key concepts A range of examples illustrating the key ideas Practical advice on using multiple imputation Exercises and examples designed for use in the classroom and/or private study Written for applied researchers looking to use multiple imputation with confidence, and for methods researchers seeking an accessible overview of the topic, Multiple Imputation and its Application will also earn a place in the libraries of graduate students undertaking quantitative analyses.
While New Jersey now frequently appears near the top in listings of America’s healthiest states, this has not always been the case. The fluctuations in the state’s overall levels of health have less to do with the lifestyle choices of individual residents and more to do with broader structural issues, ranging from pollution to urban design to the consolidation of the health care industry. This book uses the past fifty years of New Jersey history as a case study to illustrate just how much public policy decisions and other upstream factors can affect the health of a state’s citizens. It reveals how economic and racial disparities in health care were exacerbated by bad policies regarding everything from zoning to education to environmental regulation. The study further chronicles how New Jersey struggled to deal with public health crises like the AIDS epidemic and the crack epidemic. Yet it also explores how the state has developed some of the nation’s most innovative responses to public health challenges, and then provides policy suggestions for how we might build an even healthier New Jersey.
This book explains how the U.S. federal system manages environmental health issues, with a unique focus on risk management and human health outcomes. Building on a generic approach for understanding human health risk, this book shows how federalism has evolved in response to environmental health problems, political and ideological variations in Washington D.C, as well as in-state and local governments. It examines laws, rules and regulations, showing how they stretch or fail to adapt to environmental health challenges. Emphasis is placed on human health and safety risk and how decisions have been influenced by environmental health information. The authors review different forms of federalism, and analyse how it has had to adapt to ever evolving environmental health hazards, such as global climate change, nanomaterials, nuclear waste, fresh air and water, as well as examining the impact of robotics and artificial intelligence on worker environmental health. They demonstrate the process for assessing hazard information and the process for federalism risk management, and subsequently arguing that human health and safety should receive greater attention. This book will be essential reading for students and scholars working on environmental health and environmental policy, particularly from a public health, and risk management viewpoint, in addition to practitioners and policymakers involved in environmental management and public policy.
A practical guide to analysing partially observed data. Collecting, analysing and drawing inferences from data is central to research in the medical and social sciences. Unfortunately, it is rarely possible to collect all the intended data. The literature on inference from the resulting incomplete data is now huge, and continues to grow both as methods are developed for large and complex data structures, and as increasing computer power and suitable software enable researchers to apply these methods. This book focuses on a particular statistical method for analysing and drawing inferences from incomplete data, called Multiple Imputation (MI). MI is attractive because it is both practical and widely applicable. The authors aim is to clarify the issues raised by missing data, describing the rationale for MI, the relationship between the various imputation models and associated algorithms and its application to increasingly complex data structures. Multiple Imputation and its Application: Discusses the issues raised by the analysis of partially observed data, and the assumptions on which analyses rest. Presents a practical guide to the issues to consider when analysing incomplete data from both observational studies and randomized trials. Provides a detailed discussion of the practical use of MI with real-world examples drawn from medical and social statistics. Explores handling non-linear relationships and interactions with multiple imputation, survival analysis, multilevel multiple imputation, sensitivity analysis via multiple imputation, using non-response weights with multiple imputation and doubly robust multiple imputation. Multiple Imputation and its Application is aimed at quantitative researchers and students in the medical and social sciences with the aim of clarifying the issues raised by the analysis of incomplete data data, outlining the rationale for MI and describing how to consider and address the issues that arise in its application.
Highly regarded by anesthesiologists, residents, and nurse anesthetists, Essence of Anesthesia Practice, 4th Edition by Drs. Lee A. Fleisher, Michael F. Roizen, and Jeffrey Roizen, is a trusted resource for point-of-care anesthesia management. Concise, easy-to-find summaries cover a single clinical topic for both common and rare conditions. A renewed focus on diseases and drugs makes this edition even more useful when formulating anesthesia plans and mastering the core knowledge of anesthesia practice. - Features a unique, easy-to-follow, consistent format that covers a single clinical topic on each page, with a review of its problems, causes, comorbidities, and anesthesia implications. - Helps you understand the interactions of common drugs and alternative medicine so that you can develop effective anesthesia plans. - Includes more than 105 new disease topics (with more coverage of rarer diseases) and new drug information featuring 20 new drugs that patients take on an outpatient basis. - Offers fresh insights on nearly 550 topics – many authored by new contributors to this edition. - Keeps you current with the latest perioperative anesthetic implications including anticipated problems, drug interactions, and special concerns. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
With at least one case presentation for each of the mental disorders catalogued in DSM-5 -- and multiple cases for nearly half of the disorders -- Learning DSM-5® by Case Example has been meticulously designed to aid practitioners and students of all levels in psychology, psychiatry, social work, counseling, and psychiatric nursing develop internalized prototypes of DSM-5 disorders by first describing each disorder in relatable terms and subsequently illustrating how these symptom constellations manifest in real-life settings using clinical case material. The nearly 200 cases featured in this guide are drawn from the clinical experience of well over 100 clinicians, many of whom are well-known experts in particular areas of diagnosis and treatment. Sensitive to the fact that one of the hallmarks of mental disorders is the wide range of presentations that are encountered in a real-world setting, many of the disorders described include multiple cases that vary in symptom presentation, gender, age, clinical course, associated impairment in psychosocial functioning, and developmental factors, thus giving readers an appreciation for the heterogeneity typical of these disorders. Each case is complemented by a discussion that elaborates the ways in which the case conforms to the DSM-5 prototype or highlights those features of the case that illustrate the heterogeneity. With definitions of potentially unfamiliar medical and psychiatric terms, Learning DSM-5® by Case Example is an accessible resource for readers of all disciplines. And because it guides the reader through the organizational structure of DSM-5, it is also an ideal reference for courses on psychopathology or abnormal psychology.
Offering a state-of-the-art, authoritative summary of the most relevant scientific and clinical advances in the field, Principles and Practice of Movement Disorders provides the expert guidance you need to diagnose and manage the full range of these challenging conditions. Superb summary tables, a large video library, and a new, easy-to-navigate format help you find information quickly and apply it in your practice. Based on the authors' popular Aspen Course of Movement Disorders in conjunction with the International Parkinson and Movement Disorder Society, this 3rd Edition is an indispensable resource for movement disorder specialists, general neurologists, and neurology residents. - Explores all facets of movement disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. - Provides the essential information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. - Reflects recent advances in areas such as the genetics of Parkinsonian and other movement disorders, diagnostic brain imaging, new surgical approaches to patients with movement disorders, and new treatment guidelines for conditions such as restless legs syndrome. - Features a reader-friendly, full-color format, with plentiful diagrams, photographs, and tables. - Includes access to several hundred updated, professional-quality video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses.
Concise, thorough, and easy to use, Handbook of Nephrology and Hypertension 7th Edition, provides authoritative guidance on diagnosing and treating patients with a wide range of kidney disorders and hypertension, including coverage of dialysis and transplantation. Lead editor Dr. Christopher Wilcox and his team of section editors Drs. Michael Choi, Limeng Chen, Winfred N. Williams, and Mark S. Segal oversee a group of expert authors, both faculty and fellows, who focus on common problems and challenges in this complex field. Brief, focused chapters contain abundant figures and algorithms and have been updated to reflect new findings in renal cystic diseases, new drugs used for hypertension, transplantation and renal protection, and much more.
In your practice, you require advanced knowledge of the obstetrical, medical, genetic and surgical complications of pregnancy and their effects on the mother and fetus. With both basic science and clinical information, six new chapters, and an updated color design, you need look no further than the 6th edition of this long-time best seller. Includes both basic science and clinical information to give you comprehensive knowledge of the biology of pregnancy. Acts as an excellent resource for OB/GYNs studying for their Maternal-Fetal Medicine boards — and for practitioners who need quick access to practical information. Provides an updated and focused reference list to keep you up to date on the standards of care in maternal-fetal medicine today. Keeps you current with a new section: Disorders at the Maternal-Fetal Interface...and 6 new chapters: Biology of Parturition, Developmental Origins of Health and Disease, Intrapartum Assessment of Fetal Health, Pathogenesis of Pre-term Birth, Maternal and Fetal Infectious Disorders, and Benign Gynecological Conditions of Pregnancy. Features over 50% new authorship with increased focus on international perspectives. Includes the following hot topics in Maternal-Fetal Medicine: o Biology of Parturition o Fetal Growth o Prenatal Genetic Screening and Diagnosis o Fetal Cardiac Malformations and Arrhythmias o Thyroid Disease and Pregnancy o Management of Depression and Psychoses during Pregnancy and the Puerperium Focuses on evidence based medicine, the current best practice in MFM for diagnosing and treating high risk pregnancies. Includes new illustrations and an updated, color design.
Order the AUDIOLOGY, 3-Volume Set and save $49.90! Now updated for a Second Edition! Designed as the complete reference for practitioners in the 21st century, these three books not only include foundation-building sections in anatomy, physiology, diagnosis, treatment, and practice management, but also cover such cutting-edge topics as otoacoustic emissions, functional brain imaging, genetic components, neonatal screening, pharmacology, infection control, and much more! It is the only current audiology text to address pressing issues of practice management, with checklists for the growing number of specialists moving into private practice. Highlights of this outstanding work include: Incisive coverage of otoacoustic emissions, radiology, brain imaging, and pharmacology Each volume comes complete with sections on principles, applications, and future directions The first comprehensive treatment in an audiology textbook of business and practice management issues for hearing health professionals Pearls, pitfalls, special considerations, and controversial issues emphasize key points and clarify important information For comprehensive coverage of everything today's audiologist needs to know, these books are unparalleled. Practicing audiologists will turn to them often in daily practice and look to them for tips on how to make their practice more efficient. The audiology graduate student will rely on these books for thorough, state-of-the-art information.
The Insider's Guide to Acing the Neurology Boards-- Written by Physicians Who Passed! Apply the proven First Aid formula for Neurology Board success! 4 STAR DOODY'S REVIEW! "This is a nice, concise review of high-yield neurology and psychiatry topics focused on preparing for neurology board examinations. It can easily be read or reviewed in a short period of time, and the tables and graphics are also helpful. 4 Stars."--Doody's Review Service First Aid for the Neurology Boards is a unique guide for success on the Neurology Boards, in-training exams, and recertification. You will find hundreds of frequently-tested facts based on feedback from students who just passed the exam along with mini-cases essential for oral board preparation.The books is written by recent test-takers and reviewed by top faculty so you know you are studying the most up-to-date, relevant information possible. Features Hundreds of high-yield facts, mnenomics, clinical images, and summary tables help you ace the boards and in-service exams Covers must-know neurology AND psychiatry topics in one complete volume Written by recent, successful test-takers and reviewed by faculty so you know you're studying the most relevant, up-to-date material possible Integrated mini-cases highlight frequently tested scenarios and classic patient presentations Great for in-service and board exams and the perfect refresher before recertification The Content You Need to Excel on the Boards: Guide to the ABPN Examination, Neurology Topics: Neuroanatomy, Neuropharmacology, Neuroimmunology, Neurodegenerative Disorders, Headache and Pain, Neuro-oncology, Neuro-ophthalomology and Neuro-otology, Stroke and Neurocritical Care, Neurological Infections, Neuromuscular Disease, Pediatric Neurology and Neurogenetics, Seizures, Epilepsy, and Sleep Disorders, Psychiatry Topics: Substance Abuse and Dependence, Delirium, Anxiety Disorders, Somatoform Disorders, Bipolar Disorder, Major Depressive Disorder, Primary Psychotic Disorders. Visit www.FirstAidfortheBoards.com and www.FirstAidTeam.com
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