Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Police are required to obey the law. While that seems obvious, courts have lost track of that requirement due to misinterpreting the two constitutional provisions governing police conduct: the Fourth and Fourteenth Amendments. The Fourth Amendment forbids "unreasonable searches and seizures" and is the source of most constitutional constraints on policing. Although that provision technically applies only to the federal government, the Fourteenth Amendment, ratified in the wake of the Civil War, has been deemed to apply the Fourth Amendment to the States. This book contends that the courts’ misinterpretation of these provisions has led them to hold federal and state law enforcement mistakenly to the same constitutional standards. The Fourth Amendment was originally understood as a federalism, or “states’ rights,” provision that, in effect, required federal agents to adhere to state law when searching or seizing. Thus, applying the same constraint to the States is impossible. Instead, the Fourteenth Amendment was originally understood in part as requiring that state officials (1) adhere to state law, (2) not discriminate, and (3) not be granted excessive discretion by legislators. These principles should guide judicial review of modern policing. Instead, constitutional constraints on policing are too strict and too forgiving at the same time. In this book, Michael J.Z. Mannheimer calls for a reimagination of what modern policing could look like based on the original understandings of the Fourth and Fourteenth Amendments.
The only combined organic photochemistry and photobiology handbookAs spectroscopic, synthetic and biological tools become more and more sophisticated, photochemistry and photobiology are merging-making interdisciplinary research essential. Following in the footsteps of its bestselling predecessors, the CRC Handbook of Organic Photochemistry and Pho
Object-Oriented Design with Applications has long been the essential reference to object-oriented technology, which, in turn, has evolved to join the mainstream of industrial-strength software development. In this third edition--the first revision in 13 years--readers can learn to apply object-oriented methods using new paradigms such as Java, the Unified Modeling Language (UML) 2.0, and .NET. The authors draw upon their rich and varied experience to offer improved methods for object development and numerous examples that tackle the complex problems faced by software engineers, including systems architecture, data acquisition, cryptoanalysis, control systems, and Web development. They illustrate essential concepts, explain the method, and show successful applications in a variety of fields. You'll also find pragmatic advice on a host of issues, including classification, implementation strategies, and cost-effective project management. New to this new edition are An introduction to the new UML 2.0, from the notation's most fundamental and advanced elements with an emphasis on key changes New domains and contexts A greatly enhanced focus on modeling--as eagerly requested by readers--with five chapters that each delve into one phase of the overall development lifecycle. Fresh approaches to reasoning about complex systems An examination of the conceptual foundation of the widely misunderstood fundamental elements of the object model, such as abstraction, encapsulation, modularity, and hierarchy How to allocate the resources of a team of developers and mange the risks associated with developing complex software systems An appendix on object-oriented programming languages This is the seminal text for anyone who wishes to use object-oriented technology to manage the complexity inherent in many kinds of systems. Sidebars Preface Acknowledgments About the Authors Section I: Concepts Chapter 1: Complexity Chapter 2: The Object Model Chapter 3: Classes and Objects Chapter 4: Classification Section II: Method Chapter 5: Notation Chapter 6: Process Chapter 7: Pragmatics Chapter 8: System Architecture: Satellite-Based Navigation Chapter 9: Control System: Traffic Management Chapter 10: Artificial Intelligence: Cryptanalysis Chapter 11: Data Acquisition: Weather Monitoring Station Chapter 12: Web Application: Vacation Tracking System Appendix A: Object-Oriented Programming Languages Appendix B: Further Reading Notes Glossary Classified Bibliography Index
As communities continue to undergo rapid demographic shifts that modify their composition, culture, and collective values, police departments serving those communities must evolve accordingly in order to remain effective. The Future of Policing: A Practical Guide for Police Managers and Leaders provides concrete instruction to agencies on how to pr
From its founding one hundred years ago by a group of dedicated women working to better life and opportunity in their fledgling metropolis, the Dallas Public Library has provided essential services to the people of Dallas. In The Dallas Public Library, Michael V. Hazel presents the centennial history of this landmark institution, from its genesis as a single library with a staff of five, to a central library and twenty-two branch libraries with a staff of more than five hundred. This is the story of committed leaders like May Dickson Exall, who persuaded Andrew Carnegie to give $50,000 to build Dallas's first free public library, and director Cleora Clanton, who stretched a shoestring budget to provide service to all citizens of Dallas at a time when minorities were often shunned and intellectual freedom challenged. It is also the story of beloved director Lillian Bradshaw, who built a major central library facility and a network of branches that reflect the interests of the neighborhoods they serve. More than just a repository of books, the Dallas Public Library has offered many people a place for lifelong learning, practical skills development, pursuit of personal interests, and recreation. Through the years, the library has grown and changed with the city of Dallas and is ready once again--as technology drives the information market--to adapt its services to meet the needs of Dallas citizens. This is the centennial history of a landmark institution, from its genesis as a single library with a staff of five to a central library and twenty-two branch libraries with a staff of more than five hundred. Richly illustrated with two hundred black-and-white photographs and ten color plates.
This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.
Fully revised and restructured, the sixth edition of World War II: A Global History offers students a concise and yet thorough textbook that examines history’s bloodiest conflict. The chapters alternate between chronological chapters on Europe and Asia-Pacific and thematic chapters on innovations, home fronts, brutal regimes, and logistics. This textbook includes the following features: A lively narrative of facts, events, people, and ideas that incorporates thoughtful analysis New material and restructured content on global factors that affected the causes, conduct, and consequences of World War II Balanced pace that does not bog readers down in too many details yet gives them sufficient depth and breadth for context Chapters, sections, and sidebars arranged in ways that can complement lectures and assignments Fifty new photographs that illustrate the human condition and weaponry during World War II. Global in focus, by blending both geographic and thematic chapters to ensure readers gain a comprehensive understanding of impact of the war worldwide, this is the perfect volume for all students of the biggest global conflict of the twentieth century.
Many scientists find themselves working in the laboratory without sufficient background in current biotechnology methods. Others want to keep up with the revolution in biotechnology and the flood of new methodologies. This book provides a solution for both: a multidisciplinary approach to the methods essential to biotechnical development. C
This book is a critique of western systematic theology. It borrows insights from India and other traditions; it is not a synthesis of religious traditions. The book includes two parts, method and systematics. It examines the traditional topics of systematic theology '- topics such as the existence and nature of God, revelation and reason, religious ethics and human practice, the relation of God to the world, Christology, and eschatology - and allows these topics to grow in conversation with India and to change according to dialogical insights. The book is prompted by a perceived need to cross the boundaries between western and Indian worldviews in a systematic and comprehensive way. The purpose of the book is to enable scholars worldwide to extend their theological resources and to look anew at the problems and prospects of a comparative, systematic theology.
This book constitutes the refereed proceedings of the 7th International Conference on Intelligent Data Analysis, IDA 2007, held in Ljubljana, Slovenia. The 33 revised papers were carefully reviewed and selected from almost 100 submissions. The book covers all current aspects of this interdisciplinary field, including statistics, machine learning, data mining, classification and pattern recognition, clustering, applications, modeling, and interactive dynamic data visualization.
This fully updated and expanded second edition of a highly popular text book focuses on the structure and mechanism in carbohydrate chemistry and biochemistry. Carbohydrates play important roles in biological systems as energy sources, as structural materials, and as informational structures (when they are often attached to proteins or lipids). Their chemical reactivity and conformational behaviour is governed by mechanistic and stereochemical rules, which apply as much to enzymic as to non-enzymic reactivity. The same principles of reactivity and conformation govern changes brought about in the process industries, such as pulp, paper and food. Extensively referenced with citations and a detailed index, the book contains everything the reader needs to know to start a carbohydrate research project with one of the real strengths being the treatment and integration of the important physical-chemical principles and methods (though lead references only are given to the finer points of carbohydrate synthesis). The book is suitable for both researchers who are new to the subject and those more established as well as a readership from diverse backgrounds and interests, including chemists, biochemists, food scientists and technologists involved with the processing of polysaccharides in the paper, textile, cosmetics, biofuels and other industries.
Offering a state-of-the-art, authoritative summary of the most relevant scientific and clinical advances in the field, Principles and Practice of Movement Disorders provides the expert guidance you need to diagnose and manage the full range of these challenging conditions. Superb summary tables, a large video library, and a new, easy-to-navigate format help you find information quickly and apply it in your practice. Based on the authors' popular Aspen Course of Movement Disorders in conjunction with the International Parkinson and Movement Disorder Society, this 3rd Edition is an indispensable resource for movement disorder specialists, general neurologists, and neurology residents. - Explores all facets of movement disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. - Provides the essential information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. - Reflects recent advances in areas such as the genetics of Parkinsonian and other movement disorders, diagnostic brain imaging, new surgical approaches to patients with movement disorders, and new treatment guidelines for conditions such as restless legs syndrome. - Features a reader-friendly, full-color format, with plentiful diagrams, photographs, and tables. - Includes access to several hundred updated, professional-quality video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses.
Since its inception in 1865, the Detroit Police Department has been a trailblazer and pioneer in adopting revolutionary advances in law enforcement that are essential to policing today. The Detroit Police Department was among the first police departments to put its officers on bicycles and developed one of the earliest motorized forces using motorcycles, ultimately becoming the first department to utilize Harley Davidson motorcycles. Of its firsts, arguably the most important and synonymous with the city of Detroit being recognized as the "Automotive Capital of the World" is the department's deployment of its first patrol car in 1909. This photographic book highlights the Detroit Police Department's rich history, resplendent with groundbreaking advancements in the field of law enforcement. Over the years, many of the issues that proved challenging to large metropolitan cities, such as urban unrest, school busing, labor disputes, crime, and poverty, also produced challenges for the department. This book illustrates how the department met those challenges and continued to serves its community with the utmost professionalism, respect, and pride. The vision of the Detroit Police Department is "building a safer Detroit through community partnerships," a with the unquestioned dedication and hard work exhibited by Detroit's fi nest, this vision has become a reality.
How could producing 25 percent of U.S. electricity and motor-vehicle transportation fuels from renewables by the year 2025 affect U.S. consumer energy expenditures and CO2 emissions? This report finds that reaching 25 percent renewables with limited impact on expenditures requires significant progress in renewable-energy technologies and biomass production. Without substantial innovation in these areas, expenditures could increase considerably.
As this volume indicates, the issues facing black America are diverse, and the tools needed to understand these phenomena cross disciplinary boundaries. In this anthology, the authors address a wide range of topics including race, gender, class, sexual orientation, globalism, migration, health, politics, culture, and urban issues-from a diversity of disciplinary perspectives.
J. Howard Wert's Lost History of the 209Th Regiment, Pennsylvania Volunteer Infantry, 1864-1865, Including the Defense of Bermuda Hundred, the Battle of Fort Stedman and the Storming of Petersburg with Additional Documents
J. Howard Wert's Lost History of the 209Th Regiment, Pennsylvania Volunteer Infantry, 1864-1865, Including the Defense of Bermuda Hundred, the Battle of Fort Stedman and the Storming of Petersburg with Additional Documents
Glorious Recollections: J. Howard Wert's Lost History of the 209th Regiment, Pennsylvania Volunteer Infantry, 1864-1865, including the Battles of Bermuda Hundred, Fort Stedman, and Petersburg is a Civil War regimental history originally written in 1894. It was not published at the time and has now been edited and supplemented for today's readers. Wert's text is both a detailed history and a devoted memoir. It describes his regiment's actions in the closing months of the war, particularly its participation in the battles of Bermuda Hundred, Fort Stedman, and Petersburg, and, after the war, its marching in the Grand Review. On the same pages, Wert also shows Civil War memory and veteran pride taking shape. The editors have supplemented Wert's manuscript with introductory and interpretive essays, personal documents from the soldiers, reminiscences from unit reunions, a biographical sketch of its commander, a collective portrait of one of its companies, and the rosters of the entire regiment. The publication of this regimental history, previously unknown, adds to our understanding of Pennsylvania soldiers serving late in the war. Many of them had prior service while others were enlisting for the first time, such as Wert himself. This history also deepens our understanding of J. Howard Wert, one of Pennsylvania's most productive historians, novelists, poets and educators in the late 19th century. His account of a notorious Harrisburg neighborhood, the "Old Eighth Ward," has been republished recently; his "lost world" science fiction novel, Alecto and Ebony, is being prepared for publication; his Civil War poetry has been well-known for over a century; his collection of Battle of Gettysburg artifacts is world famous; and with this book his accomplishment as a military historian comes to light.
In this report, RAND researchers assess the potential future production levels, production costs, greenhouse gases, and other environmental implications of synthetic crude oil from oil sands and fuels produced via coal liquefaction relative to conventional petroleum-based transportation fuels. The findings indicate the potential cost-competitiveness of these alternative fuels and potential economic-environmental trade-offs from their deployment.
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