Ronald J. Furlong of the United Kingdom per the short term with this method of biologic fixation formed the first clinical implantation of a hydroxy of total joint implants has withstood the test of time. apatite-coated (HA) hip implant in 1985, about 18 Our thanks are due to the authors of chapters in this volume for the effort they made to write and years ago. This was followed in 1986 by other HA submit their work to us in a timely fashion. These clinical implantations conducted by the ARTRO Group in France and Rudolf Geesink in the Nether authors, working in Europe, the United States, lands. Following these pioneers, many thousands of Japan, and Australia, do not all use English as their first language. Many made great efforts to provide HA-coated hip implants of various designs, from us with English language documents. Where we various implant manufacturers, have been implanted felt the language was unclear, we made only those worldwide, by many surgeons at many institutions. minor changes needed to facilitate understanding. The coating technology has expanded to include the For manuscripts submitted in a language other than revision setting in the hip, as well as unicompart English, we employed professional interpretation, mental knees, total knees, shoulders, and an assort and then made editorial changes if the content was ment of minor joint implants. unclear to us.
RNA plays a central, and until recently, somewhat underestimated role in the genetics underlying all forms of life on earth. This versatile molecule not only plays a crucial part in the synthesis of proteins from a DNA template, but is also intrinsically involved in the regulation of gene expression, and in catalysis.This landmark text provides a systematic overview of the exciting and rapidly moving field of RNA biology. For the secondedition of Molecular Biology of RNA more introductory material has been incorporated at the beginning of the text, while new material has been included throughout - particularly in relation to RNA bindingdomains, non-coding RNAs, and the connection between RNA biology and epigenetics. Finally, a new closing chapter discusses how exciting new technologies are being used to explore current topical areas of research.
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