Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.
Every step in the business bankruptcy litigation process is covered in Aspen Publishers' Bankruptcy Litigation Manual, from the drafting of the first pleadings through the appellate process. In fact, by making the Bankruptcy Litigation Manual a part of your working library, you not only get detailed coverage of virtually all the topics and issues you must consider in any bankruptcy case, you also get field-tested answers to questions you confront every day, such as: How to stay continuing litigation against a corporate debtor's non-debtor officers? What are the limits on suing a bankruptcy trustee? Is the Deprizio Doctrine still alive? Does an individual debtor have an absolute right to convert a case from Chapter 7 to Chapter 13? What prohibitions exist on cross-collateralization in financing disputes? Are option contracts "executory" for bankruptcy purposes? When, and under what circumstances, may a bankruptcy court enjoin an administrative proceeding against a Chapter 11 debtor? What are the current standards for administrative priority claims? When must a creditor assert its setoff rights? When can a remand order issued by a district court be reviewed by a court of appeals? What are the limits on challenging pre-bankruptcy real property mortgage foreclosures as fraudulent transfers? Can an unsecured lender recover contract-based legal fees incurred in post- bankruptcy litigation on issues of bankruptcy law? Is there a uniform federal limitation on perfecting security interests that primes a longer applicable state law period, thus subjecting lenders to a preference attack? Do prior bankruptcy court orders bar a plaintiff's later state court suit and warrant removal of the action in federal court? Michael L. Cook, a partner at Schulte Roth & Zabel LLP in New York and former long-time Adjunct Professor at New York University School of Law, has gathered together some of the country's top bankruptcy litigators to contribute to Bankruptcy Litigation Manual.
Focusing on the mid-eighteenth century, this book provides the first clear view of the press of London, where the dominant patterns of organization and content of the English press were worked out.
This book provides a good foundation for understanding influences on children’s health and development. The volume brings together in a single reference source the world’s leading thinkers on children’s health and development. It sets out the basic concepts that underpin the study of child development and response to impairments to development, including attachment, changes in brain structure, and resilience. The book explores the idea of life-course development, explaining how experiences at each stage in a person’s life shapes his or her future. It goes on to example the relative contribution of societal, neighbourhood, school, family and individual influences to child well-being. This includes a look at the way these forces interact, such as when genes shape environments, and vice versa. The book summarises the evidence on the incidence and consequences of impairments to children’s health and development, covering both the majority of typical children and the minority who experience significant problems.
Fr. Michael Kwatera, OSB, helps deacons comprehend, share, and effectively perform their ministry by providing both spiritual and functional support. This short work is directed to al deacons, both permanent and transitional, in the hope that it will promote their formation for service within the church's Eucharist, other sacramental rites, and communal prayer. Contents include explanations of the deacon's role in various church situations and liturgies - such as confirmation and marriage - as well as outside of the Mass setting, such as ministering to the sick. With Petitions for Deacons from Ancient Liturgies and historical background, this book provides an interesting and informative look at the deacon's role in the Catholic Church. Fr. Michael Kwatera, OSB, PhD, is director of Oblates for Saint John's Abbey, Collegeville, Minnesota. He's a teacher and practitioner of Christian liturgy and the author of several Liturgical Press books, including Come to the Feast: Liturgical Ministry of, by, and for Everybody.
Every step in the business bankruptcy litigation process is covered inAspen Publishers' Bankruptcy Litigation Manual, from thedrafting of the first pleadings through the appellate process. In fact, bymaking the Bankruptcy Litigation Manual a part of your workinglibrary, you not only get detailed coverage of virtually all the topics andissues you must consider in any bankruptcy case, you also getfield-tested answers to questions you confront every day, such as:How to stay continuing litigation against a corporate debtor's non-debtorofficers?What are the limits on suing a bankruptcy trustee?Is the Deprizio Doctrine still alive?Does an individual debtor have an absolute right to convert a case fromChapter 7 to Chapter 13?What prohibitions exist on cross-collateralization in financing disputes?Are option contracts "executory" for bankruptcy purposes?When, and under what circumstances, may a bankruptcy court enjoin anadministrative proceeding against a Chapter 11 debtor?What are the current standards for administrative priority claims?When must a creditor assert its setoff rights?When can a remand order issued by a district court be reviewed by a court ofappeals?What are the limits on challenging pre- bankruptcy real propertymortgage foreclosures as fraudulent transfers?Can an unsecured lender recover contract-based legal fees incurred in post-bankruptcy litigation on issues of bankruptcy law ?Is there a uniform federal limitation on perfecting security interests thatprimes a longer applicable state law period, thus subjecting lenders to apreference attack?Do prior bankruptcy court orders bar a plaintiff's later state courtsuit and warrant removal of the action in federal court?Michael L. Cook, a partner at Schulte Roth & Zabel LLP in New York andformer long-time Adjunct Professor at New York University School of Law, hasgathered together some of the country's top bankruptcy litigators tocontribute to Bankruptcy Litigation Manual.Contributing Authors:Jay Alix, Southfield, MINeal Batson, Alston & Bird, LLP, Atlanta, GAKenneth K. Bezozo, Haynes and Boone, New York, NYSusan Block-Lieb, Fordham University School of Law, Newark, NJPeter W. Clapp, Valle Makoff, LLP, San Francisco, CADennis J. Connolly, Alston & Bird, LLP, Atlanta, GADavid N. Crapo, Gibbons P.C., Newark, NJKaren A. Giannelli, Gibbons P.C., Newark, NJDavid M. Hillman, Schulte Roth & Zabel, LLP, New York, NYAlfred S. Lurey, Kilpatrick & Stockton, Atlanta, GAGerald Munitz, Butler Rubin, Salterelli & Boyd, LLP, Chicago, ILRobert L. Ordin, Retired Bankruptcy Court JudgeStephen M. Pezanosky, Haynes and Boone, LLP, Partner and Chair of BankruptcySection, Fort Worth, TXRobin E. Phelan, Haynes and Boone, LLP Dallas, TXDaniel H. Squire, Wilmer Cutler Pickering Hale and Dorr, LLP, Washington, DCMichael L. Temin, Fox Rothschild, LLP, Philadelphia, PASheldon S. Toll, Law Office ofSheldon S. Toll, Southfield, MIJason H. Watson, Alston & Bird, LLP, Atlanta, GAKit Weitnauer, Alston & Bird, LLP, Atlanta, GAWritten by Mr. Cook and nineteen other experts, Bankruptcy LitigationManual provides authoritative, up-to-date information on virtuallyevery aspect of the bankruptcy litigation process, from discovery throughappeal.
From the physician behind the wildly popular NutritionFacts website, How Not to Die reveals the groundbreaking scientific evidence behind the only diet that can prevent and reverse many of the causes of disease-related death. The vast majority of premature deaths can be prevented through simple changes in diet and lifestyle. In How Not to Die, Dr. Michael Greger, the internationally-renowned nutrition expert, physician, and founder of NutritionFacts.org, examines the fifteen top causes of premature death in America-heart disease, various cancers, diabetes, Parkinson's, high blood pressure, and more-and explains how nutritional and lifestyle interventions can sometimes trump prescription pills and other pharmaceutical and surgical approaches, freeing us to live healthier lives. The simple truth is that most doctors are good at treating acute illnesses but bad at preventing chronic disease. The fifteen leading causes of death claim the lives of 1.6 million Americans annually. This doesn't have to be the case. By following Dr. Greger's advice, all of it backed up by strong scientific evidence, you will learn which foods to eat and which lifestyle changes to make to live longer. History of prostate cancer in your family? Put down that glass of milk and add flaxseed to your diet whenever you can. Have high blood pressure? Hibiscus tea can work better than a leading hypertensive drug-and without the side effects. Fighting off liver disease? Drinking coffee can reduce liver inflammation. Battling breast cancer? Consuming soy is associated with prolonged survival. Worried about heart disease (the number 1 killer in the United States)? Switch to a whole-food, plant-based diet, which has been repeatedly shown not just to prevent the disease but often stop it in its tracks. In addition to showing what to eat to help treat the top fifteen causes of death, How Not to Die includes Dr. Greger's Daily Dozen -a checklist of the twelve foods we should consume every day.Full of practical, actionable advice and surprising, cutting edge nutritional science, these doctor's orders are just what we need to live longer, healthier lives.
In addition to filling a need within the field of parental behavior, this book contributes importantly to the growing area of emotional and motivational neuroscience. A major part of neuroscience research at the whole organism level has been focused on cognitive neuroscience, with an emphasis on the neurobiology of learning and memory, but there has been a recent upsurge in research which is attempting to define the neural basis of basic motivational and emotional systems which regulate such behaviors as food intake, aggression, reproduction, reward-seeking behaviors, and anxiety-related behaviors. In this book the emphasis is on the research findings obtained from rodents, sheep and primates. The authors' goal, of course, was to provide a foundation that may help us understand the neurobiology of human parental behavior. Indeed, the last chapter attempts to integrate the non-human research data with some human data in order to make some inroads toward an understanding of postpartum depression, child abuse, and child neglect. Clearly, motivational and emotional neuroscience has close ties to psychiatry, and this connection will be very evident in the final chapter. By understanding the neurobiology of parental behavior we are also delving into neurobiological factors which may have an impact on core human characteristics involved in sociality, social attachment, nurturing behavior, and love. In this very violent world, it is hard to conceive of a group of characteristics that are more worthy of study.
From 'audet IX to Zytchin III, this book covers it all. This is the ultimate reference book for all Star Trek fans! Added to this edition are 128 new pages. This addendum highlights the latest episodes of Star Trek: Deep Space Nine®, Star Trek: Voyager® and the newest feature film, Star Trek: Insurrection™. The thousands of photos and hundreds of illustrations place the Star Trek universe at your fingertips. Planets and stars, weapons and ships, people and places are just part of the meticulous research and countless cross-reference that fill this book.
Organic Synthesis 5e provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature.? There have been advancements in organic reactions, particularly organometallic reactions, and there is a need to show how these advancements have influenced current organic synthesis. The goal is to revise and update the examples of reaction examples taken from the synthesis literature from about 2017-2023. The reactions illustrate those that are used most often in modern organic synthesis, but recent examples will show their current relevance.? Where new approaches and new reactions have been developed for organic synthesis, examples will be added as new material. - Provides new content, reaction examples, and study problems from recent research? - Features improved organization, new art, and new chapter content on process chemistry and green organic chemistry - Includes revised homework for each chapter, with new examples and questions?
Perhaps the most significant development of the Georgian theater was its multiplication of ethnic, colonial, and provincial character types parading across the stage. In Theatrical Nation, Michael Ragussis opens up an archive of neglected plays and performances to examine how this flood of domestic and colonial others showcased England in general and London in particular as the center of an increasingly complex and culturally mixed nation and empire, and in this way illuminated the shifting identity of a newly configured Great Britain. In asking what kinds of ideological work these ethnic figures performed and what forms were invented to accomplish this work, Ragussis concentrates on the most popular of the "outlandish Englishmen," the stage Jew, Scot, and Irishman. Theatrical Nation understands these stage figures in the context of the government's controversial attempts to merge different ethnic and national groups through the 1707 Act of Union with Scotland, the Jewish Naturalization Bill of 1753, and the Act of Union with Ireland of 1800. Exploring the significant theatrical innovations that illuminate the central anxieties shared by playhouse and nation, Ragussis considers how ethnic identity was theatricalized, even as it moved from stage to print. By the early nineteenth century, Anglo-Irish and Scottish novelists attempted to deconstruct the theater's ethnic stereotypes while reimagining the theatricality of interactions between English and ethnic characters. An important shift took place as the novel's cross-ethnic love plot replaced the stage's caricatured male stereotypes with the beautiful ethnic heroine pursued by an English hero.
Every step in the business bankruptcy litigation process is covered in Aspen Publishersand’ Bankruptcy Litigation Manual, from the drafting of the first pleadings through the appellate process. In fact, by making the Bankruptcy Litigation Manual a part of your working library, you not only get detailed coverage of virtually all the topics and issues you must consider in any bankruptcy case, you also get field-tested answers to questions you confront every day, such as: How to stay continuing litigation against a corporate debtorand’s non-debtor officers? What are the limits on suing a bankruptcy trustee? Is the Deprizio Doctrine still alive? Does an individual debtor have an absolute right to convert a case from Chapter 7 to Chapter 13? What prohibitions exist on cross-collateralization in financing disputes? Are option contracts and“executoryand” for bankruptcy purposes? When, and under what circumstances, may a bankruptcy court enjoin an administrative proceeding against a Chapter 11 debtor? What are the current standards for administrative priority claims? When must a creditor assert its setoff rights? When can a remand order issued by a district court be reviewed by a court of appeals? What are the limits on challenging pre-bankruptcy real property mortgage foreclosures as fraudulent transfers? Can an unsecured lender recover contract-based legal fees incurred in post- bankruptcy litigation on issues of bankruptcy law? Is there a uniform federal limitation on perfecting security interests that primes a longer applicable state law period, thus subjecting lenders to a preference attack? Do prior bankruptcy court orders bar a plaintiffand’s later state court suit and warrant removal of the action in federal court? Michael L. Cook, a partner at Schulte Roth and& Zabel LLP in New York and former long-time Adjunct Professor at New York University School of Law, has gathered together some of the countryand’s top bankruptcy litigators to contribute to Bankruptcy Litigation Manual. Contributing Authors: Jay Alix, Southfield, MI Neal Batson, Alston and& Bird, LLP, Atlanta, GA Kenneth K. Bezozo, Haynes and Boone, New York, NY Susan Block-Lieb, Fordham University School of Law, Newark, NJ Peter W. Clapp, Valle Makoff, LLP, San Francisco, CA Dennis J. Connolly, Alston and& Bird, LLP, Atlanta, GA David N. Crapo, Gibbons P.C., Newark, NJ Karen A. Giannelli, Gibbons P.C., Newark, NJ David M. Hillman, Schulte Roth and& Zabel, LLP, New York, NY Alfred S. Lurey, Kilpatrick and& Stockton, Atlanta, GA Gerald Munitz, Butler Rubin, Salterelli and& Boyd, LLP, Chicago, IL Robert L. Ordin, Retired Bankruptcy Court Judge Stephen M. Pezanosky, Haynes and Boone, LLP, Partner and Chair of Bankruptcy Section, Fort Worth, TX Robin E. Phelan, Haynes and Boone, LLP Dallas, TX Daniel H. Squire, Wilmer Cutler Pickering Hale and Dorr, LLP, Washington, DC Michael L. Temin, Fox Rothschild, LLP, Philadelphia, PA Sheldon S. Toll, Law Office ofSheldon S. Toll, Southfield, MI Jason H. Watson, Alston and& Bird, LLP, Atlanta, GA Kit Weitnauer, Alston and& Bird, LLP, Atlanta, GA Written by Mr. Cook and nineteen other experts, Bankruptcy Litigation Manual provides authoritative, up-to-date information on virtually every aspect of the bankruptcy litigation process, from discovery through appeal.
Written in accord with the Catechism of the Catholic Church and rooted in the sound catechetical principles of the National Catechetical Directory, these texts present a well-defined curriculum model that stresses clear objectives, careful organization, and creative methods and evaluation procedures to check the attainment of goals. Very flexible, allowing teachers to select materials to highlight and stress, each text can be implemented on various grade levels for a quarter, a semester, or a full year depending on the length and frequency of class meetings.This text begins with a discussion of the wonders of God's love in such things as creation, the incarnation, forgiveness and salvation, followed by a call to respond to this love through faith and loving service. A chapter on signs, symbols, and sacraments gives a solid foundation for understanding Catholic sacramental theology. This prepares the way for a discussion of each of the seven sacraments that covers the historical developments, the way the sacrament is celebrated today, and the ways students can live the reality of each of the sacraments in their lives.
Clint Eastwood has been Hollywood's most consistently successful male star since the golden days of the studio era. He has established himself as a respected director whose work includes at least two of the great western films of the last quarter century, one an Oscar winner, as well as a number of deeply personal works which hardly fit the mode of the action hero. This book analyses all of Eastwood's films as director and includes information about his acting career, as well as tracing the influences of Leone, Siegel and others on his work.
Here's a one-of-a-kind sourcebook on who's who and what's what in American business today. Arranged alphabetically by type of company, it offers a diverse assortment of listings crucial in reaching CEOs, VPs, and other key executives in the nation's top 1,000 companies.
Composition and the Rhetoric of Science: Engaging the Dominant Discourse calls for instructors of first-year writing courses to employ primary scientific discourse in their teaching and for rhetoricians of science to think about teaching scientific discourse as a literacy skill. Author Michael J. Zerbe argues that inclusion of scientific discourse is crucial because of this rhetoric’s status as the dominant discourse in western culture. The volume draws on Lyotard, Žižek, Foucault, and Althusser to argue that while important theorists such as these have recognized the dominance of scientific discourse, rhetoric and composition has not—to its detriment. The textillustrates that scientific discourse remains a miniscule part of the enterprise of rhetoric and composition and thus the field is not fulfilling its mission of providing students with the writing and reading skills they need to live and work in a science- and technology-dependent society. Zerbe provides an analysis of science popularizations and demonstrates how these works can be used to contextualize primary scientific research. He also presents three pedagogical scenarios, each built around a carefully chosen, accessible example of scientific discourse, that demonstrate how articles from scientific journals can be used in writing courses. Only by gaining a meaningful fluency in this discourse—one that is not offered by science textbooks—can a more sophisticated scientific literacy be assured. Composition and the Rhetoric of Science effectively explores the relatively limited amount of work done in rhetoric and composition on scientific discourse and questions this state of affairs. Zerbe presents for the first time cultural studies and science literacy as gateways for incorporating scientific discourse into first-year writing courses.
A scholarly and imaginative reconstruction of the voyage Daniel Defoe took from the pillory to literary immortality, The Shortest Way with Defoe contends that Robinson Crusoe contains a secret satire, written against one person, that has gone undetected for 300 years. By locating Defoe's nemesis and discovering what he represented and how Defoe fought him, Michael Prince's book opens the way to a new account of Defoe's emergence as a novelist. The book begins with Defoe’s conviction for seditious libel for penning a pamphlet called The Shortest Way with the Dissenters (1702). A question of biography segues into questions of theology and intellectual history and of formal analysis; these questions in turn require close attention to the early reception of Defoe's works, especially by those who hated or suspected him. Prince aims to recover the way of reading Defoe that his enemies considered accurate. Thus, the book rethinks the positions represented in Defoe's ambiguous alternation and mimicking of narrative and editorial voices in his tracts, proto-novels, and novels. By examining Defoe's early publications alongside Robinson Crusoe, Prince shows that Defoe traveled through nonrealist, nonhistorical genres on the way to discovering the form of prose fiction we now call the novel. Moreover, a climate (or figure) of extreme religious intolerance and political persecution required Defoe always to seek refuge in literary disguise. And, religious convictions aside, Defoe's practice as a writer found him inhabiting forms known for their covert deism.
A reconstruction of Shaw's life from his days as a young playwright and novelist up to his death in 1984. Despite a prevailing pedestrian tone and lapses into gossip column journals, a chilling and, at times, insightful portrait of the man and his social milieu emerges forcefully. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR
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