This introductory statistics textbook conveys the essential concepts and tools needed to develop and nurture statistical thinking. It presents descriptive, inductive and explorative statistical methods and guides the reader through the process of quantitative data analysis. In the experimental sciences and interdisciplinary research, data analysis has become an integral part of any scientific study. Issues such as judging the credibility of data, analyzing the data, evaluating the reliability of the obtained results and finally drawing the correct and appropriate conclusions from the results are vital. The text is primarily intended for undergraduate students in disciplines like business administration, the social sciences, medicine, politics, macroeconomics, etc. It features a wealth of examples, exercises and solutions with computer code in the statistical programming language R as well as supplementary material that will enable the reader to quickly adapt all methods to their own applications.
Now in its second edition, this introductory statistics textbook conveys the essential concepts and tools needed to develop and nurture statistical thinking. It presents descriptive, inductive and explorative statistical methods and guides the reader through the process of quantitative data analysis. This revised and extended edition features new chapters on logistic regression, simple random sampling, including bootstrapping, and causal inference. The text is primarily intended for undergraduate students in disciplines such as business administration, the social sciences, medicine, politics, and macroeconomics. It features a wealth of examples, exercises and solutions with computer code in the statistical programming language R, as well as supplementary material that will enable the reader to quickly adapt the methods to their own applications.
The Daubert trilogy of U.S. Supreme Court cases has established that scientific expert testimony must be based on science grounded in empirical research. As such, greater scrutiny is being placed on questioned document examination generally, and handwriting comparison in particular. Bridging the gap between theory and practice, The Neuroscience of Handwriting: Applications in Forensic Document Examination examines the essential neuroscientific principles underlying normal and pathological hand motor control and handwriting. Topics discussed include: Fundamental principles in the neuroanatomy and neurochemistry of hand motor control and their application to research in handwriting The epidemiology, pathophysiology, and motor characteristics of neurogenerative diseases such as Parkinson’s, Huntington’s, Alzheimer’s, multiple sclerosis, essential tremor, and motor neuron disease and their effects on handwriting Psychotropic medications prescribed for depression, bipolar disorder, and psychosis; their mechanisms of action; and their effect on motor behavior and handwriting The impact of substance abuse on handwriting An overview of the aging process and its effects on motor control and handwriting The kinematic approach and new findings on the kinematic analyses of genuine, disguised, and forged signatures The authors’ laboratory research on authentic and forged signatures An essential resource for professionals and researchers in the forensic documentation examination and legal communities, this volume provides a window on the scientific process of signature and handwriting authentication, integrating the extensive research on neural processes and exploring how disease, medication, and advanced age alter these processes.
Based on the premise that many, if not most, reactions in organic chemistry can be explained by variations of fundamental acid–base concepts, Organic Chemistry: An Acid–Base Approach provides a framework for understanding the subject that goes beyond mere memorization. Using several techniques to develop a relational understanding, it helps students fully grasp the essential concepts at the root of organic chemistry. This new edition was rewritten largely with the feedback of students in mind and is also based on the author’s classroom experiences using the previous editions. Highlights of the Third Edition Include: Extensively revised chapters that improve the presentation of material. Features the contributions of more than 65 scientists, highlighting the diversity in organic chemistry. Features the current work of over 30 organic chemists, highlighting the diversity in organic chemistry. Many new reactions are featured that are important in modern organic chemistry. Video lectures are provided in a .mov format, accessible online as a ‘built-in’ ancillary for the book. Instructor and Student Resources —includes scientist images and solutions manual for instructors. The third edition of Organic Chemistry: An Acid–Base Approach constitutes a significant improvement upon a unique introductory technique to organic chemistry. The reactions and mechanisms it covers are the most fundamental concepts in organic chemistry that are applied to industry, biological chemistry, biochemistry, molecular biology, and pharmacy. Using an illustrated conceptual approach rather than presenting sets of principles and theories to memorize, it gives students a more concrete understanding of the material.
Landmark Experiments in Molecular Biology critically considers breakthrough experiments that have constituted major turning points in the birth and evolution of molecular biology. These experiments laid the foundations to molecular biology by uncovering the major players in the machinery of inheritance and biological information handling such as DNA, RNA, ribosomes, and proteins. Landmark Experiments in Molecular Biology combines an historical survey of the development of ideas, theories, and profiles of leading scientists with detailed scientific and technical analysis. Includes detailed analysis of classically designed and executed experiments Incorporates technical and scientific analysis along with historical background for a robust understanding of molecular biology discoveries Provides critical analysis of the history of molecular biology to inform the future of scientific discovery Examines the machinery of inheritance and biological information handling
The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
When unexpected grief brings two families together, how do they start their journey to healing? Join Michael and Gina Spehn--bestselling authors and founders of the New Day Foundation--as they tell their story of resilience, remembrance, and reliance on their shared faith. Matt Kell and Cathy Spehn had known each other since grade school. As adults, they each got married, lived in their hometown, and attended the same church. Their kids even attended school together. Matt died at home on Christmas Day after a three-year battle with cancer, leaving behind his wife, Gina, and two young boys. After attending Matt's inspirational funeral and reaching out to Gina with offers of support, Cathy was diagnosed with inoperable brain cancer. She died only 17 days later, leaving behind her husband, Michael, and three young children. In her final hours, Cathy instructed Michael to call Gina Kell. The Color of Rain illuminates the stepping stones of loss and healing that ultimately led to a joyful new life for Michael, Gina, and their five children. Their path to becoming a modern-day Brady Bunch was paved with grief, laughter, and the willingness to be restored to a new and even better life despite the inevitable resistance they faced. As you learn more about Michael and Gina's story, you'll learn: The importance of keeping God at the center of your marriage How they navigated becoming a blended family The life-changing power of faith, even on your darkest days As their dual first-person narrative reveals what it is like to walk through loss and love simultaneously, you'll have an intimate look at how Michael and Gina lived, lost, and ultimately persevered through extraordinary circumstances. Praise for The Color of Rain: "The Color of Rain is a testament to God's restoration and grace. Even in our suffering, there is beauty. It rarely makes sense, but it's always true: 'He makes all things beautiful, in His time.'" --Katie Davis, New York Times bestselling author of Kisses from Katie "Michael and Gina Spehn's The Color of Rain is not only an instant bestseller but also an instant classic, certain to be pressed into the hands of hundreds of thousands of grieving men and women by their closest friends, for it is a book that is painfully honest about the depths of sorrow but also full of the joy of the hard path back from near despair. It is another reminder that God is there, however dark the day, and that he will comfort those who call on him." --Hugh Hewitt, bestselling author and radio host
Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching. Winner, 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association Fully revised and updated throughout, and organized into 19 chapters for a more cogent and versatile presentation of concepts Includes reaction examples taken from literature research reported between 2010-2015 Features new full-color art and new chapter content on process chemistry and green organic chemistry Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Solutions Manual for qualified course instructors
Crime Scene Investigation offers an innovative approach to learning about crime scene investigation, taking the reader from the first response on the crime scene to documenting crime scene evidence and preparing evidence for courtroom presentation. It includes topics not normally covered in other texts, such as forensic anthropology and pathology, arson and explosives, and the electronic crime scene. Numerous photographs and illustrations complement text material, and a chapter-by-chapter fictional narrative also provides the reader with a qualitative dimension of the crime scene experience.
Volume II of two, from the Thermodymaics Research Centre, this includes Thermodynamic Functions of the Substances in the Ideal Gas State; and Empirical Functions for Thermodynamical Properties of Ideal Gases.
What's for dinner?" has always been a complicated question. The locavore movement has politicized food and challenged us to rethink the answer in new and radical ways. These days, questions about where our food comes from have moved beyond 100-mile-dieters into the mainstream. Celebrity chefs Jamie Oliver and Alice Waters, alternative food gurus such as Michael Pollan, and numerous other popular and academic commentators have all talked about the importance of understanding the sources and transformation of food on a human scale. In The Politics of the Pantry, Michael Mikulak interrogates these narratives - what he calls "storied food" - in food culture. As with any story, however, it is important to ask: who is telling it? Who is the audience? What assumptions are being made? Mikulak examines competing narratives of food, pleasure, sustainability, and value that have emerged from the growing sustainable food movement as well as food's past and present relationship to environmentalism in order to understand the potential and the limits of food politics. He also considers whether or not sustainable food practices can address questions about health, environmental sustainability, and local economic development, while at the same time articulating an ethical globalization. An innovative blend of academic analysis, poetic celebration, and autobiography, The Politics of the Pantry provides anyone interested in the future of food and the emergence of a green economy with a better understanding of how what we eat is transforming the world.
The emergence of a common security and foreign policy has been one of the most contentious issues accompanying the integration of the European Union. In this book, Michael Smith examines the specific ways foreign policy cooperation has been institutionalized in the EU, the way institutional development affects cooperative outcomes in foreign policy, and how those outcomes lead to new institutional reforms. Smith explains the evolution and performance of the institutional procedures of the EU using a unique analytical framework, supported by extensive empirical evidence drawn from interviews, case studies, official documents and secondary sources. His perceptive and well-informed analysis covers the entire history of EU foreign policy cooperation, from its origins in the late 1960s up to the start of the 2003 constitutional convention. Demonstrating the importance and extent of EU foreign/security policy, the book will be of interest to scholars, researchers and policy-makers.
The Compendium of Organic Synthetic Methods series facilitates the working chemist's search for the most useful functional group transformations in organic chemistry. Drawn from an exhaustive survey of the literature, Compendium of Organic Synthetic Methods, Volume 12 contains both functional group transformations and carbon-carbon bond-forming reactions. Author Michael Smith adheres to stringent criteria for listing reactions, including real synthetic utility and reagents that are either readily available or easily prepared and handled in the laboratory. A clear organizational scheme-chemical transformations classified first by reacting functional group of starting material, then by functional group formed-allows for quick reference and information retrieval. Compendium of Organic Synthetic Methods, Volume 12 provides an unparalleled source of information on the methods, reactions, and transformations in contemporary organic chemistry for the working chemist and student alike.
Crystal Structure Refinement is a mixture of textbook and tutorial. As A Crystallographers Guide to SHELXL it covers advanced aspects of practical crystal structure refinement, which have not been much addressed by textbooks so far. After an introduction to SHELXL in the first chapter, a brief survey of crystal structure refinement is provided. Chapters three and higher address the various aspects of structure refinement, from the treatment of hydrogen atoms to the assignment of atom types, to disorder, to non-crystallographic symmetry and twinning. One chapter is dedicated to the refinement of macromolecular structures and two short chapters deal with structure validation (one for small molecule structures and one for macromolecules). In each of the chapters the book gives refinement examples, based on the program SHELXL, describing every problem in detail. It comes with a CD-ROM with all files necessary to reproduce the refinements.
Problems in Organic Synthesis provides over 100 new and challenging problems, designed to aid in the mastery of organic synthesis. While written to be a companion text to Modern Organic Synthesis, it can serve as a supplement to any organic synthesis course. Problems in Organic Synthesis features chemistry from the current literature and addresses recent advances in the field. It provides full problems and detailed answers, along with corresponding literature references, to create a contemporary context for appreciating the art of organic synthesis.
Multiple Imputation and its Application The most up-to-date edition of a bestselling guide to analyzing partially observed data In this comprehensively revised Second Edition of Multiple Imputation and its Application, a team of distinguished statisticians delivers an overview of the issues raised by missing data, the rationale for multiple imputation as a solution, and the practicalities of applying it in a multitude of settings. With an accessible and carefully structured presentation aimed at quantitative researchers, Multiple Imputation and its Application is illustrated with a range of examples and offers key mathematical details. The book includes a wide range of theoretical and computer-based exercises, tested in the classroom, which are especially useful for users of R or Stata. Readers will find: A comprehensive overview of one of the most effective and popular methodologies for dealing with incomplete data sets Careful discussion of key concepts A range of examples illustrating the key ideas Practical advice on using multiple imputation Exercises and examples designed for use in the classroom and/or private study Written for applied researchers looking to use multiple imputation with confidence, and for methods researchers seeking an accessible overview of the topic, Multiple Imputation and its Application will also earn a place in the libraries of graduate students undertaking quantitative analyses.
The Compendium of Organic Synthetic Methods serves as a handy desktop reference for organic chemists to browse new reactions and transformations of interest, facilitating the search for functional group transformations in the original literature of organic chemistry. Volume 13 contains both functional group transformations and carbon-carbon bond forming reactions from the literature in the years 2005-8. It presents examples of published reactions for the preparation of monofunctional compounds. The Compendium of Organic Synthetic Methods series facilitates the search for quality, selected functional group transformations, organized by reacting functional group of starting material and functional group formed, with full references to each reaction Presents examples of published reactions for the preparation of monofunctional compounds from the literature of 2005-8 Provides a handy reference and a valuable tool to the working organic chemist, allowing a quick check of known organic transformations Stringent criteria for inclusion of reactions, including real synthetic utility of reactions, reagents readily available or easily prepared and handled in the laboratory
Personalized medicine is a medical paradigm that emphasizes systematic use of individual patient information to optimize that patient's health care, particularly in managing chronic conditions and treating cancer. In the statistical literature, sequential decision making is known as an adaptive treatment strategy (ATS) or a dynamic treatment regime (DTR). The field of DTRs emerges at the interface of statistics, machine learning, and biomedical science to provide a data-driven framework for precision medicine. The authors provide a learning-by-seeing approach to the development of ATSs, aimed at a broad audience of health researchers. All estimation procedures used are described in sufficient heuristic and technical detail so that less quantitative readers can understand the broad principles underlying the approaches. At the same time, more quantitative readers can implement these practices. This book provides the most up-to-date summary of the current state of the statistical research in personalized medicine; contains chapters by leaders in the area from both the statistics and computer sciences fields; and also contains a range of practical advice, introductory and expository materials, and case studies.
Rousell examines the rich and complex nuances of the science of surprise and shows us how we can use it strategically to enrich lives. Random events transform us. After studying formative events, moments that define us, for over three decades, Michael Rousell discovered that most of them took place during a spark of surprise. This breakthrough launched a fascinating journey from neuroscience to stand-up comedy. Rousell draws on research from a wide variety of brain science disciplines (cognition, motivation, neuroscience, psychology, artificial intelligence, persuasion, evolution, and learning), then examines those who already use surprise strategically (comedians, film directors, entertainers, magicians, and novelists). This examination illustrates the hidden, yet critical features inherent in surprise, while demystifying the complexities. Surprise evolved as a mechanism to instantly change our beliefs. Rousell shows how surprising events produce invisible influence because they open a window to spontaneous belief change with no warning or conscious awareness. You’ll see how seemingly minor features of surprise create profound differences and can be used to strategically enrich lives, create positive mindsets, and maximize influence.
Phylogenomics: A Primer, Second Edition is for advanced undergraduate and graduate biology students studying molecular biology, comparative biology, evolution, genomics, and biodiversity. This book explains the essential concepts underlying the storage and manipulation of genomics level data, construction of phylogenetic trees, population genetics, natural selection, the tree of life, DNA barcoding, and metagenomics. The inclusion of problem-solving exercises in each chapter provides students with a solid grasp of the important molecular and evolutionary questions facing modern biologists as well as the tools needed to answer them.
Spoken Dialogue Technology provides extensive coverage of spoken dialogue systems, ranging from the theoretical underpinnings of the study of dialogue through to a detailed look at a number of well-established methods and tools for developing spoken dialogue systems. The book enables students and practitioners to design and test dialogue systems using several available development environments and languages, including the CSLU toolkit, VoiceXML, SALT, and XHTML+ voice. This practical orientation is usually available otherwise only in reference manuals supplied with software development kits. The latest research in spoken dialogue systems is presented along with extensive coverage of the most relevant theoretical issues and a critical evaluation of current research prototypes. A dedicated web site containing supplementary materials, code, links to resources will enable readers to develop and test their own systems (). Previously such materials have been difficult to track down, available only on a range of disparate web sites and this web site provides a unique and useful reference source which will prove invaluable.
The Reformation's legacy, religious identities and the history of minority communities are all subjects of growing importance in Reformation studies and are addressed in this case study of the Netherlandic Mennonite community living in and around Hamburg after the Thirty Years War.
Crime Scene Investigation offers an innovative approach to learning about crime scene investigation, taking the reader from the first response on the crime scene to documenting crime scene evidence and preparing evidence for courtroom presentation. It includes topics not normally covered in other texts, such as forensic anthropology and pathology, entomology, arson and explosives, and the electronic crime scene. Numerous photographs and illustrations complement text material, and a chapter-by-chapter fictional narrative also provides the reader with a qualitative dimension of the crime scene experience.
In 1890 the Lauerman brothers opened a general store in the lumber-boom town of Marinette, Wisconsin. The business prospered, and soon the brothers abandoned their small quarters on Main Street for a magnificent department store on Dunlap Square in the heart of Marinette. Thanks to the Lauermans’ devotion to offering diverse merchandise, superior customer service, and loyalty to their employees, the store would remain a lively, vital part of the Marinette fabric for one hundred years. This book traces the history of the Lauerman enterprise and its importance to the community of Marinette and dozens of counties in northern Wisconsin and the UP. The author takes readers on a tour of the store’s most memorable and delightful features, from the plethora of merchandise offered to the record-listening booths to the famous frosted malt cones. Along the way we hear the recollections of dozens of former customers and employees whose memories form a unique tapestry of family, business, and community story. As it brings to life the people who worked and shopped at Lauermans, Something for Everyone will have readers fondly recalling their own favorite shopping destinations during the golden age of department stores.
Trace the development of a pioneering college of pharmacy! This fascinating book recounts the history of the first college of pharmacy west of the Alleghenies. Pharmaceutical Education in the Queen City tells the tale from its beginnings as the Cincinnati College of Pharmacy in 1850 to its status as a college of the University of Cincinnati and into the twenty-first century. Through the specific history of the school, its founders, and its dedicated faculty and students, the remarkable progress of pharmacy as a profession is mirrored here. In the mid-nineteenth century, most aspiring pharmacists in the United States had to apprentice themselves to practicing druggists. Though a formal school had already been established in Philadelphia, followed by schools in the other large eastern cities, young men in the West who wanted to learn the profession faced great difficulties. Few pharmacists had any formal training in chemistry, anatomy, or other sciences, and they could not teach what they did not themselves know. Pharmaceutical Education in the Queen City discusses the fascinating facts of pharmacy history, including: the influence of German settlers on pharmacy standards the reasons nineteenth-century women faced less opposition in becoming pharmacists than in becoming doctors how admissions standards changed as high school diplomas and college degrees became more widespread how colleges of pharmacy met the emergency demands of World War I and World War II the effects of high technology on pharmacy education Pharmaceutical Education in the Queen City offers a fresh look at the history of pharmacy education in the United States as well as in Cincinnati. Well researched and entertainingly written, this book will help you appreciate the rapid changes in the profession of pharmacy.
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