This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.
Published in 1997, This book offers an up-to-date guide to the Green parties of Western Europe as the optimism of the 1980s confronts the ‘Green fatigue’ of the 1990s. The approach is both thematic and comparative. Green politics in Europe is located in its historical and cultural context. There is a comparative analysis of the principal ideological questions , policy issues and strategic dilemmas that have confronted the European Greens. There are national profiles of Green politics throughout the European Union. The conclusion addresses the critical issue of political change in post industrial societies. It discusses the contribution of Green parties to the ‘New Politics’ and assesses their likely impact on post-modern politics
Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging.Methuselah Flies: ? is a tightly edited distillation of twenty years of work by many scientists? contains the original publications regarding the longer-lived fruit flies? offers commentaries on each of the topics covered ? new, short essays that put the individual research papers in a wider context? gives full access to the original data ? captures the scientific significance of postponed aging for a wide academic audienc
Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakthroughs that built the evolutionary biology of aging as a leading scientific field. Following the evolutionary study of aging from its humble origins to the present, the book's chapters treat the field's breakthroughs one at a time. Users will find a concise and accessible analysis of the science of aging viewed through an evolutionary lens. Building upon widely-cited studies conducted by author Michael Rose, this book covers 30 subsequent years of growth and development within the field.The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures. - Reviews cell-molecular theories of aging in the light of evolutionary biology - Offers an evolutionary analysis of prospects for mitigating aging not commonly discussed within private and public sectors - Provides readers with a radically different perspective on contemporary biological gerontology, specifically through the lens of evolutionary biology
The eye disease known as macular degeneration affects millions of people. But it doesn't have to go unchecked. Doctors Marc and Michael Rose show how you can prevent, halt and even reverse the progress of macular degeneration and other eye problems.
The conquest of aging is now within our grasp. It hasn't arrived yet, writes Michael R. Rose, but a scientific juggernaut has started rolling and is picking up speed. A long tomorrow is coming. In The Long Tomorrow, Rose offers us a delightfully written account of the modern science of aging, spiced with intriguing stories of his own career and leavened with the author's engaging sense of humor and rare ability to make contemporary research understandable to nonscientists. The book ranges from Rose's first experiments while a graduate student--counting a million fruit fly eggs, which took 3,000 hours over the course of a year--to some of his key scientific discoveries. We see how some of his earliest experiments helped demonstrate that "the force of natural selection" was key to understanding the aging process--a major breakthrough. Rose describes how he created the well-known Methuselah Flies, fruit flies that live far longer than average. Equally important, Rose surveys the entire field, offering colorful portraits of many leading scientists and shedding light on research findings from around the world. We learn that rodents given fifteen to forty percent fewer calories live about that much longer, and that volunteers in Biosphere II, who lived on reduced caloric intake for two years, all had improved vital signs. Perhaps most interesting, we discover that aging hits a plateau and stops. Popular accounts of Rose's work have appeared in The New Yorker, Time magazine, and Scientific American, but The Long Tomorrow is the first full account of this exciting new science written for the general reader. "Among his peers, Rose is considered a brilliantly innovative scientist, who has almost single-handedly brought the evolutionary theory of aging from an abstract notion to one of the most exciting topics in science."--Malcolm Gladwell, The New Yorker
Extending the human life-span past 120 years. The "green" revolution. Evolution and human psychology. These subjects make today's newspaper headlines. Yet much of the science underlying these topics stems from a book published nearly 140 years ago--Charles Darwin's On the Origin of Species. Far from an antique idea restricted to the nineteenth century, the theory of evolution is one of the most potent concepts in all of modern science. In Darwin's Spectre, Michael Rose provides the general reader with an introduction to the theory of evolution: its beginning with Darwin, its key concepts, and how it may affect us in the future. First comes a brief biographical sketch of Darwin. Next, Rose gives a primer on the three most important concepts in evolutionary theory--variation, selection, and adaptation. With a firm grasp of these concepts, the reader is ready to look at modern applications of evolutionary theory. Discussing agriculture, Rose shows how even before Darwin farmers and ranchers unknowingly experimented with evolution. Medical research, however, has ignored Darwin's lessons until recently, with potentially grave consequences. Finally, evolution supplies important new vantage points on human nature. If humans weren't created by deities, then our nature may be determined more by evolution than we have understood. Or it may not be. In this question, as in many others, the Darwinian perspective is one of the most important for understanding human affairs in the modern world. Darwin's Spectre explains how evolutionary biology has been used to support both valuable applied research, particularly in agriculture, and truly frightening objectives, such as Nazi eugenics. Darwin's legacy has been a comfort and a scourge. But it has never been irrelevant.
Based on decades of his own research, a pioneering epidemiologist reveals the surprising factors behind who lives longer and why You probably didn't realize that when you graduated from college you increased your lifespan, or that your co-worker who has a master's degree is more likely to live a longer and healthier life. Seemingly small social differences in education, job title, income, even the size of your house or apartment have a profound impact on your health. For years we have focused merely on how advances in technology and genetics can extend our lives and cure disease. But as Sir Michael Marmot argues, we are looking at the issue backwards. Social inequalities are not a footnote to the real causes of ill health in industrialized countries; they are the cause. The psychological experience of inequality, Marmot shows, has a profound effect on our lives. And while this may be alarming, it also suggests a ray of hope. If we can understand these social inequalities, we can also mitigate their effects. In this groundbreaking book, Marmot, an internationally renowned epidemiologist, marshals evidence from around the world and from nearly thirty years of his research to demonstrate that how much control you have over your life and the opportunities you have for full social participation are crucial for health, well-being, and longevity. Just as Bowling Alone changed the way we think about community in America, The Status Syndrome will change the way we think about our society and how we live our lives.
Bloomsbury's eBooks are protected using Digital Rights Management (DRM). As such, it is not possible to copy or print this eBook, nor will it be accessible with an Adobe ID other than your own. "...an institution for those who practise public law...it has the authority that comes from being compiled by an author of singular distinction". (Lord Woolf, from the Foreword to the Fifth Edition) The new edition of this Handbook remains an indispensable source of reference and a guide to the case-law in judicial review. Established as an essential part of the library of any practitioner engaged in public law cases, if offers unrivalled coverage of administrative law, including, but not confined to, the work of the Administrative Court and its procedures. Once again completely revised and up-dated, the seventh edition approximates to a restatement of the law of judicial review, organised around 63 legal principles, each supported by a comprehensive presentation of the sources and an unequalled selection of reported case quotations. It also includes essential procedural rules, forms and guidance issued by the Administrative Court. As in the previous edition, both the Civil Procedure Rules and Human Rights Act 1998 feature prominently as major influences on the shaping of the case-law. Attention is also given to impact of the Supreme Court. Here Michael Fordham casts an experienced eye over the Court's work in the area of judicial review, and assesses the signs from a Court that will be one of the key influences in the development of judicial review in the modern era. The author, a leading member of the English public law bar, and now has been involved in many of the leading judicial review cases in recent years and is the founding editor of the Judicial Review journal.
These notes were first used in an introductory course team taught by the authors at Appalachian State University to advanced undergraduates and beginning graduates. The text was written with four pedagogical goals in mind: offer a variety of topics in one course, get to the main themes and tools as efficiently as possible, show the relationships between the different topics, and include recent results to convince students that mathematics is a living discipline.
Count Me In! provides practical ways of involving young people in the inclusive classroom. At its heart is a recognition of the power of getting students involved and the value this can bring to their education. It includes a host of ways to get children involved, from seeking their opinions on lessons to allowing them to have a say in school life.
AIDS treatments continues to evolve. Now, so does the definitive reference on this complex and challenging subject! "AIDS Therapy, 3rd Edition" not only brings you comprehensive guidance on the latest treatments for HIV/AIDS and the full range of related disorders and syndromes, but also comes with access to updates online—so you can always tap into the most current therapy guidelines. Written by a "who's who" of leading global experts, the new edition of this classic reference is a must for any clinician who manages patients with HIV/AIDS. The most comprehensive coverage available on AIDS treatment equips you to meet any clinical challenge. Contributions from a large cast of noted international authorities put global "best practices" at your fingertips. Advice from some of the most respected experts in the field helps you manage your patients confidently. Available with a companion website allowing you to access the latest treatment guidelines year after year.
Challenging orthodox assumptions concerning British federalism, The British Tradition of Federalism offers a unique revisionist critique of Britain's recent constitutional past. The central themes of Empire, Ireland and Europe provide the empirical focus of this volume. Together, they reveal a fundamental continuity of British federal ideas: a single intellectual tradition which spans the last century. By reinstating a neglected dimension of the larger British political tradition, Burgess shows how the continuing relevance of this federal tradition serves as both the source of and inspiration for a wide range of constitutional reform proposals in the 1990s.
For three decades psychiatrists have turned to Lishman's Organic Psychiatry as the standard neuropsychiatry reference. It stood as the last great single author reference text in medicine, a combination of meticulous, exhaustive research conveyed in a beautifully clear style. Now the mantle has been passed to a group of five distinguished authors and it is to their considerable credit that the attributes which made Organic Psychiatry such a distinctive voice remain. The fourth Edition of Lishman's Organic Psychiatry is a rich blend of detailed clinical inquiry and up to date neuroscience. It should be on every psychiatrist;s book shelf." —Anthony Feinstein, MPhil, PhD., FRCP, Professor, Department of Psychiatry, University of Toronto, Canada Over the past 30 years, thousands of physicians have depended on Lishman's Organic Psychiatry. Its authoritative and reliable clinical guidance was - and still is - beyond compare. The new edition of this classic textbook has now been extensively revised by a team of five authors, yet it follows the tradition of the original single-authored book. It continues to provide a comprehensive review of the cognitive, emotional and behavioural consequences of cerebral disorders and their manifestations in clinical practice. Enabling clinicians to formulate incisive diagnoses and appropriate treatment strategies, Lishman's Organic Psychiatry is an invaluable source of information for practising psychiatrists, neurologists and trainees. This new edition: covers recent theoretical and clinical developments, with expanded sections on neuropsychology and neuroimaging includes a new chapter on sleep disorders whilst the chapters on Alzheimer's disease and related dementias, Epilepsy, Movement disorders and Traumatic brain injury have been extensively revised reflecting the greatly improved understanding of their underlying pathophysiologies showcases the huge advances in brain imaging and important discoveries in the fields of molecular biology and molecular genetics has been enhanced with the inclusion of more tables and illustrations to aid clinical assessment incorporates important diagnostic tools such as magnetic resonance brain images.
For three decades psychiatrists have turned to Lishman's Organic Psychiatry as the standard neuropsychiatry reference. It stood as the last great single author reference text in medicine, a combination of meticulous, exhaustive research conveyed in a beautifully clear style. Now the mantle has been passed to a group of five distinguished authors and it is to their considerable credit that the attributes which made Organic Psychiatry such a distinctive voice remain. The fourth Edition of Lishman's Organic Psychiatry is a rich blend of detailed clinical inquiry and up to date neuroscience. It should be on every psychiatrist;s book shelf." —Anthony Feinstein, MPhil, PhD., FRCP, Professor, Department of Psychiatry, University of Toronto, Canada Over the past 30 years, thousands of physicians have depended on Lishman's Organic Psychiatry. Its authoritative and reliable clinical guidance was - and still is - beyond compare. The new edition of this classic textbook has now been extensively revised by a team of five authors, yet it follows the tradition of the original single-authored book. It continues to provide a comprehensive review of the cognitive, emotional and behavioural consequences of cerebral disorders and their manifestations in clinical practice. Enabling clinicians to formulate incisive diagnoses and appropriate treatment strategies, Lishman's Organic Psychiatry is an invaluable source of information for practising psychiatrists, neurologists and trainees. This new edition: covers recent theoretical and clinical developments, with expanded sections on neuropsychology and neuroimaging includes a new chapter on sleep disorders whilst the chapters on Alzheimer's disease and related dementias, Epilepsy, Movement disorders and Traumatic brain injury have been extensively revised reflecting the greatly improved understanding of their underlying pathophysiologies showcases the huge advances in brain imaging and important discoveries in the fields of molecular biology and molecular genetics has been enhanced with the inclusion of more tables and illustrations to aid clinical assessment incorporates important diagnostic tools such as magnetic resonance brain images.
With your heavy case load, you can't afford to waste time searching for answers. Cardiology, 3rd Edition, by Drs. Crawford, DiMarco, and Paulus, offers you just the practical, problem-based guidance you need to quickly overcome any clinical challenge. 8 color-coded sections cover the 8 major clinical syndromes of cardiovascular disease—each section a virtual "mini textbook" on its topic! 40 new chapters keep you up to date with the latest advances in the field, while more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs capture clinical manifestations as they present in practice. It’s current, actionable information that you can put to work immediately for your patients! Offers a problem-based approach that integrates basic science, diagnostic investigations, and therapeutic management in one place for each cardiovascular disease so you can quickly find all of the actionable knowledge you need without flipping from one section to another. Features introductory bulleted highlights in each chapter that present the most pertinent information at a glance. Presents abundant algorithms to expedite clinical decision making. Includes more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs that capture clinical manifestations as they present in practice, and promote readability and retention. Includes 40 new chapters including Inherited Arrhythmia Syndromes, Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy in CHD, Management of the Cyanotic Patient with CHD, Special Problems for the Cardiology Consultant Dealing with Bariatric/Gastric Bypass — and many more — that equip you with all of the latest knowledge. Presents "Special Problem" sections—many new to this edition—that provide practical advice on problems that can be difficult to treat.
The essential multidisciplinary spine reference on optimizing complex bony and soft tissue reconstruction Lessons learned from soft tissue reconstruction, wound healing, and infection prevention in plastic surgery and bony arthrodesis strategies and spinal alignment in orthopaedic surgery and neurosurgery have merged to create a new field of surgery. Spinoplastic Reconstruction, edited by Alexander E. Ropper, Sebastian J. Winocour, Michael A. Bohl, and Edward M. Reece provides in-depth discussion of multidisciplinary techniques and complication management in complex bony and soft tissue reconstruction, with the goal of improved outcomes for spine surgery patients. This textbook encompasses the nomenclature, indications, evidence-based techniques, outcomes, and alternatives that laid the groundwork for spinoplastic surgery. Organized into nine sections and 42 chapters, the book begins by delineating the historical and future relevance of multidisciplinary surgery and advent of spinoplastic surgery to ease the growing global disease burden of spine disease. The second section discusses applied anatomy, biomechanics, and bony spinal stability. Sections three to nine provide detailed discussion and pearls on bone healing, bone adjuncts, perioperative management, surgical spine exposures, vascularized autologous bone grafts and flaps, soft tissue spinal reconstruction, and complication management. Key Features Contributions from an impressive group of multidisciplinary spinoplastic surgery founders and innovators exemplifies the ethos of this emerging field Traditional and novel approaches for managing common challenges in spine surgery, including pseudoarthrosis and wound infection High-quality operative photos, illustrations, and 12 videos provide visual understanding of spinal anatomy and techniques This unique resource provides spine surgeons with a better understanding of the tenets of soft tissue reconstruction and plastic surgeons with a clearer understanding of the challenges faced in complex spine surgery, thereby improving collaborative patient management.
These stories of vampire legends and gruesome nineteenth-century practices is “a major contribution to the study of New England folk beliefs” (The Boston Globe). For nineteenth-century New Englanders, “vampires” lurked behind tuberculosis. To try to rid their houses and communities from the scourge of the wasting disease, families sometimes relied on folk practices, including exhuming and consuming the bodies of the deceased. Folklorist Michael E. Bell spent twenty years pursuing stories of the vampire in New England. While writers like H.P. Lovecraft, Henry David Thoreau, and Amy Lowell drew on portions of these stories in their writings, Bell brings the actual practices to light for the first time. He shows that the belief in vampires was widespread, and, for some families, lasted well into the twentieth century. With humor, insight, and sympathy, he uncovers story upon story of dying men, women, and children who believed they were food for the dead. “A marvelous book.” —Providence Journal Includes an updated preface covering newly discovered cases.
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