Michael R. Hamblin's Books

Stimuli-Responsive Polymers

Nano-Dimension

By: Navid Rabiee,Mohammad Rabiee,Mojtaba Bagherzadeh,Michael R Hamblin

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Stimuli-Responsive Polymers

Nano-Dimension

By: Navid Rabiee,Mohammad Rabiee,Mojtaba Bagherzadeh,Michael R Hamblin

This book provides a general introduction to nanogels, and designs of various stimuli-sensitive nanogels that are able to control drug release in response to specific stimuli. Nanogels are three-dimensional nanosized networks that formed by physically or chemically crosslinking polymers. They have highly interesting properties such as biocompatibility, high stability, particle size adjustment, drug loading capability and modification of the surface for active targeting. They can respond to stimuli which results in the controlled release of drug and targeting of the site.

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Morgan & Claypool Publishers

Published Date

ISBN 10

1643276387

ISBN 13

9781643276380

Nanoscopic Electrofocusing for Bio-Nanoelectronic Devices

By: Shanmugamurthy Lakshmanan,Michael R Hamblin

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Nanoscopic Electrofocusing for Bio-Nanoelectronic Devices

By: Shanmugamurthy Lakshmanan,Michael R Hamblin

The ability to arrange precisely designed patterns of nanoparticles into a desired spatial configuration is the key to creating novel nanoscale devices that take advantage of the unique properties of nanomaterials. While two-dimensional arrays of nanoparticles have been demonstrated successfully by various techniques, a controlled way of building ordered arrays of three-dimensional (3D) nanoparticle structures remains challenging. This book describes a new technique called the 'nanoscopic lens' which is able to produce a variety of 3D nano-structures in a controlled manner. This ebook describes the nanoscopic lens technique and how it can serve as the foundation for device development that is not limited to a variety of optical, magnetic and electronic devices, but can also create a wide range of bio-nanoelectronic devices.

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Morgan & Claypool Publishers

Published Date

ISBN 10

1627056904

ISBN 13

9781627056908

Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery

By: Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin

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Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery

By: Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin

The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.

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114

Publisher

Morgan & Claypool Publishers

Published Date

ISBN 10

1681740109

ISBN 13

9781681740102

Skin Photoaging

By: Rui Yin,Qiquan Chen,Michael R. Hamblin

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Skin Photoaging

By: Rui Yin,Qiquan Chen,Michael R. Hamblin

This book focuses on skin photoaging, the premature aging of skin due to environmental effects such as exposure to UV (UVA, UVB) radiation from the sun. Slowing the aging process and rejuvenation have been one of the major goals of medicine and are in high

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Morgan & Claypool Publishers

Published Date

ISBN 10

1627056947

ISBN 13

9781627056946

Antimocrobial Photodynamic Inactivation and Antitumor Photodynamic Therapy with Fullerenes

By: Lucas F de Freitas,Michael R Hamblin

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Antimocrobial Photodynamic Inactivation and Antitumor Photodynamic Therapy with Fullerenes

By: Lucas F de Freitas,Michael R Hamblin

This book provides detailed and current information on using fullerenes (bucky-balls) in photodynamic therapy (PDT), one of the most actively studied applications of photonic science in healthcare. This will serve as a useful source for researchers working in photomedicine and nanomedicine, especially those who are investigating PDT for cancer treatment and infectious disease treatment. The book runs the gamut from an introduction to the history and chemistry of fullerenes and some basic photochemistry, to the application of fullerenes as photosensitizers for cancer and antimicrobial inactivation.

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Morgan & Claypool Publishers

Published Date

ISBN 10

1681742470

ISBN 13

9781681742472

Exosomes and MicroRNAs in Biomedical Science

By: Hamed Mirzaei,Neda Rahimian,Hamid Reza Mirzaei,Javid Sadri Nahand,Michael R. Hamblin

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Exosomes and MicroRNAs in Biomedical Science

By: Hamed Mirzaei,Neda Rahimian,Hamid Reza Mirzaei,Javid Sadri Nahand,Michael R. Hamblin

MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.

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Page Count

175

Publisher

Morgan & Claypool Publishers

Published Date

ISBN 10

1636393489

ISBN 13

9781636393483

Photomedicine and Stem Cells

The Janus Face of Photodynamic Therapy (PDT) to Kill Cancer Stem Cells, and Photobiomodulation (PBM) to Stimulate Normal Stem Cells

By: Heidi Abrahamse,Michael R Hamblin

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Photomedicine and Stem Cells

The Janus Face of Photodynamic Therapy (PDT) to Kill Cancer Stem Cells, and Photobiomodulation (PBM) to Stimulate Normal Stem Cells

By: Heidi Abrahamse,Michael R Hamblin

Janus, the ancient Roman god depicted with two faces is an appropriate metaphor for light therapy. In the right photodynamic therapy conditions, light is able to kill nearly anything that is living such as cancers, microorganisms, parasites, and more. On the opposite face, light of the correct wavelength and proper dose (photobiomodulation) can heal, regenerate, protect, revitalize and restore any kind of dead, damaged, stressed, dying, degenerating cells, tissue, or organ system. This book discusses both sides of Janus' face in regards to light therapy.

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109

Publisher

Morgan & Claypool Publishers

Published Date

ISBN 10

1681743221

ISBN 13

9781681743226

Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery

By: Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin

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Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery

By: Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin

The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo. This can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to internal stimuli that are intrinsic to the target site. These stimuli are specific to the cell type, tissue or organ type, or to the disease state (cancer, infection, inflammation etc). pH-responsive nanostructures can be used for cargo release in acidic endosomal compartments, in the lower pH of tumors, and for specific oral delivery either to the stomach or intestine. Nanocarriers can be designed to be substrates of a wide-range of enzymes that are over-expressed at disease sites. Oxidation and reduction reactions can be taken advantage of in smart nanocarriers by judicious molecular design. Likewise, nanocarriers can be designed to respond to a range of specific biomolecules that may occur at the target site. In this volume we also cover dual and multi-responsive systems that combine stimuli that could be either internal or external.

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Morgan & Claypool Publishers

Published Date

ISBN 10

1681742586

ISBN 13

9781681742588

Advances in Nanomaterials for Drug Delivery

Polymeric, Nanocarbon, and Bio-inspired

By: Mahdi Karimi,Maryam Rad Mansouri,Navid Rabiee,Michael R Hamblin

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Advances in Nanomaterials for Drug Delivery

Polymeric, Nanocarbon, and Bio-inspired

By: Mahdi Karimi,Maryam Rad Mansouri,Navid Rabiee,Michael R Hamblin

Nanomedicine is a developing field, which includes different disciplines such as material science, chemistry, engineering and medicine devoted to the design, synthesis and construction of high-tech nanostructures. The ability of these structures to have their chemical and physical properties tuned by structural modification, has allowed their use in drug delivery systems, gene therapy delivery, and various types of theranostic approaches. Colloidal noble metal nanoparticles and other nanostructures have many therapeutic and diagnostic applications. The concept of drug targeting as a magic bullet has led to much research in chemical modification to design and optimize the binding to targeted receptors. It is important to understand the precise relationship between the drug and the carrier and its ability to target specific tissues, and pathogens to make an efficient drug delivery system. This book covers advances based on different drug delivery systems: polymeric and hyper branched nanomaterials, carbon-based nanomaterials, nature-inspired nanomaterials, and pathogen-based carriers.

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Morgan & Claypool Publishers

Published Date

ISBN 10

1681742896

ISBN 13

9781681742892

Advances in Photodynamic Therapy

Basic, Translational, and Clinical

By: Michael R. Hamblin

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Advances in Photodynamic Therapy

Basic, Translational, and Clinical

By: Michael R. Hamblin

With today's focus on targeted and minimally invasive therapies, photodynamic therapy (PDT) is now being studied and used to combat many disease states and to investigate critical biological questions. This groundbreaking resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT - photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches. Moreover, it gives you an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases.

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601

Publisher

Artech House

Published Date

ISBN 10

1596932783

ISBN 13

9781596932784

Photodynamic Therapy Mediated by Fullerenes and their Derivatives

By: Michael R. Hamblin

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Photodynamic Therapy Mediated by Fullerenes and their Derivatives

By: Michael R. Hamblin

The fullerene molecule with its unique structure of 60 carbon atoms arranged in a soccer ball structure is a molecule of great potential for a variety of applications and has drawn attention of lots of physicists, chemists and engineers. Recently, these nanostructures have also been studied for their biological activities with a view towards using them for biomedical applications. One of the possible therapies for which fullerenes may have a real medical application is the light based therapy called photodynamic therapy (PDT), which is a non-surgical, minimally invasive approach that has been used in the treatment of solid tumors and many non-malignant diseases.

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Momentum Press

Published Date

ISBN 10

1606504169

ISBN 13

9781606504161

Carbon Nanotubes in Drug and Gene Delivery

By: Mahdi Karimi,Amir Ghasemi,Soroush Mirkiani,Masoud Mousavi Basri,Michael Hamblin

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Carbon Nanotubes in Drug and Gene Delivery

By: Mahdi Karimi,Amir Ghasemi,Soroush Mirkiani,Masoud Mousavi Basri,Michael Hamblin

Recent important discoveries and developments in nanotechnology have had a remarkable and ever-increasing impact on many industries, especially materials science, pharmaceuticals, and biotechnology. Nanocarriers have been investigated for a wide variety of different medical applications. Some examples of these nanocarriers include polymersomes, liposomes, micelles and carbon-based nanomaterials. Within this book, the authors describe different features of carbon nanotubes (CNTs), survey the properties of both the multi-walled and single-walled varieties, and cover their applications in drug and gene delivery. In addition, the book explains the structure and properties of CNTs prepared by different method, and discussed their isolation and purification. The future of CNTs in the field of biomedical science will depend on minimizing their adverse effects by careful study of their structure and properties.

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Morgan & Claypool Publishers

Published Date

ISBN 10

1681742616

ISBN 13

9781681742618

Skin Photoaging

By: Rui Yin,Qiquan Chen,Michael R. Hamblin

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Skin Photoaging

By: Rui Yin,Qiquan Chen,Michael R. Hamblin

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Morgan & Claypool Publishers

Published Date

ISBN 10

1627054553

ISBN 13

9781627054553

Imaging in Photodynamic Therapy

By: Michael R. Hamblin,Ying-Ying Huang

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Imaging in Photodynamic Therapy

By: Michael R. Hamblin,Ying-Ying Huang

This book covers the broad field of cellular, molecular, preclinical and clinical imaging associated or combined with photodynamic therapy (PDT). It reflects how the large strides made by PDT in clinical use have resulted in increased studies with imaging elements to optimize treatment. The first sections address basic background, followed by ce

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