This new multi-authored book reviews the current understanding of the role of thrombin in venous and arterial thrombosis and its inhibition in the clinical setting. Heparin, the most widely used antithrombotic, does not effectively regulate thrombin or its formation. Accumulating evidence suggests that other antithrombins are effective in some of the situations where heparin is not. Discussions include the current knowledge on antithrombotic prophylaxis and therapy, from the perspective of the role in thrombin in venous and arterial vascular disease, the limitations of the current anticoagulant therapies, and potential and limitations of newer antithrombins currently being tested in several experimental and clinical settings. Thrombin helps the clinician to better rationalize the use of specific antithrombins in the prevention and management of thrombotic disease and provides the basic scientist with a better understanding of the goals the clinician attempts to achieve with antithrombotic therapy.
Our lives are about to be changed by new technologies that operate on a scale too small to be seen by even the most powerful optical microscopes. Devices measured in nanometers-billionths of a meter-have set off a nanotechnology revolution. In Travels to the Nanoworld, Michael Gross takes us deep into this miniature universe and describes natural processes and new technologies that will make modern machines look like relics from the Stone Age. Starting with the model of the living cell, whose vital processes are directed and carried out by structures with dimensions on the nanometer scale, Gross shows how biochemists are beginning to understand the mechanisms of the "nanotechnology of nature." Soon science will have the knowledge and technology to generate artificial systems that will perform similar tasks, and through them will find new treatments for disease, substitutes for toxic waste, and alternatives to carbon fuel.
This book provides a college-level overview of chemical processing of metals in water-based solutions, in the field that is known as hydrometallurgy"--
Opera and the Novel: The Case of Henry James offers the first full-length study of the theory and practice of the adaptation of fiction into opera: the transference of a work from one medium to another – metaphrasis – is its point of departure. Starting with a survey of the current thinking regarding the nexus between words and music with specific reference to operatic adaptation of existing literary works, it traces the four-hundred-year history of opera, demonstrating that the novel has become increasingly attractive to librettists and composers as an operatic source. As the resources of modern music theatre have increased in sophistication, so too have the possibilities for an expanded engagement with complex fictional works. The intricate relationship between fictional and musical narrative is examined: the proposition that the orchestra assumes much of the function of the narrator in fiction is explored. The second section is a detailed examination of eight operatic works based on Henry James’s fiction. It is opera’s unique capability to present the intense emotional and psychological situations central to James’s fiction as well as the ability to engage with his synthesis of melodrama and psychological ambiguity which makes James’s work peculiarly amenable to operatic adaptation. Composers who have used James as a source include Douglas Moore, Benjamin Britten, Thomas Pasatieri, Donald Hollier, Thea Musgrave, Philip Hagemann and Dominick Argento. The operas discussed represent a contemporary critical and often self-conscious engagement with the art form itself as well as illustrating current adaptive strategies, and suggest ways in which new operatic paths may be forged. This volume is of relevance to students and scholars of English literature and opera as well as readers who take an interest in intermedial research and the question of adaptation in general.
Magnetic Resonance Neuroimaging is a comprehensive volume that focuses on the newest fields of MRI from functional and metabolic mapping to the latest applications of neuro-interventional techniques. Each chapter offers critical discussions regarding available methods and the most recent advances in neuroimaging, including such topics as the use of diffusion and perfusion MRI in the early detection of stroke, the revolutionary advent of high-speed MRI for non-invasively mapping cortical responses to task activation paradigms, and the principles and applications of contrast agents. The chapters also discuss how these new advances are applied to problems in patients ranging in age from the newborn to the elderly, as well as disease states ranging from metabolic encephalopathy to cardiovascular disorders and stroke. Magnetic Resonance Neuroimaging will be a valuable text/reference for residents, research fellows, and clinicians in radiology, neuroradiology, and magnetic resonance imaging.
This book provides a practical guide to molecular dynamics and Monte Carlo simulation techniques used in the modelling of simple and complex liquids. Computer simulation is an essential tool in studying the chemistry and physics of condensed matter, complementing and reinforcing both experiment and theory. Simulations provide detailed information about structure and dynamics, essential to understand the many fluid systems that play a key role in our daily lives: polymers, gels, colloidal suspensions, liquid crystals, biological membranes, and glasses. The second edition of this pioneering book aims to explain how simulation programs work, how to use them, and how to interpret the results, with examples of the latest research in this rapidly evolving field. Accompanying programs in Fortran and Python provide practical, hands-on, illustrations of the ideas in the text.
Massage is such a great pleasure, for both the giver and the receiver and massage using crystals can be a truly profound experience. This book offers an easy way to perform a crystal massage. It also features a Joya Massage Roller, a wooden implement that holds a crystal ball and allows it to spin freely and glide with ease over the skin.
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