Due to increasing traffic flows the extension of transport infrastructure with rail roads and high speed lines is an ongoing process worldwide. Ballastless track systems with concrete slabs are used more and more. Following the first trials in the 1970s and more than four decades of R&D work on ballastless track, the level of development is such that it can be confirmed that ballastless track is suitable for use as an alternative to ballasted track. This book makes a contribution to the state of the art of ballastless track by describing the basics for designing the ballastless track. Important advice is provided regarding the construction of ballastless track on earthworks and in tunnels. There is also a description of the technical history of the development of ballastless track on bridges and the ensuing findings for bridge design. The state of the art of ballastless track for switches, important information on details concerning drainage, transitions, accessibility for road vehicles and experience gleaned from maintenance round off the work. Selected chapters from the German concrete yearbook are now being published in the new English "Beton-Kalender Series" for the benefit of an international audience. Since it was founded in 1906, the Ernst & Sohn "Beton-Kalender" has been supporting developments in reinforced and prestressed concrete. The aim was to publish a yearbook to reflect progress in "ferro-concrete" structures until - as the book's first editor, Fritz von Emperger (1862-1942), expressed it - the "tempestuous development" in this form of construction came to an end. However, the "Beton-Kalender" quickly became the chosen work of reference for civil and structural engineers, and apart from the years 1945-1950 has been published annually ever since.
The fall of Saigon in April 1975 resulted in the largest and most ambitious refugee resettlement effort in Canada’s history. Running on Empty presents the challenges and successes of this bold refugee resettlement program. It traces the actions of a few dozen men and women who travelled to seventy remote refugee camps, worked long days in humid conditions, subsisted on dried noodles and green tea, and sometimes slept on their worktables while rats scurried around them – all in order to resettle thousands of people displaced by war and oppression. After initially accepting 7,000 refugees from camps in Guam, Hong Kong, and military bases in the US in 1975, Canada passed the 1976 Immigration Act to establish new refugee procedures and introduce private refugee sponsorship. In July of 1979, the federal government under Prime Minister Joe Clark announced that Canada would accept an unprecedented 50,000 refugees – later increased to 60,000 – more than half of whom would be sponsored by ordinary Canadians. Running on Empty presents gripping first-hand accounts of the government officials tasked with selecting refugees from eight different countries, receiving and matching them with sponsors, and helping churches, civic organizations, and groups of neighbours to receive and integrate the newcomers in cities, towns, and rural communities across Canada. Timely and inspiring, Running on Empty offers essential lessons for governments, organizations, and individuals trying to come to grips with refugee crises in the twenty-first century.
As Bible believing Christians a question should be asked. Does the Bible confirm the existence of paranormal realities as they pertain to UFOs, ghosts, ancient outer-space travel, teleportation, time travel, shadow governments, and more? The answer to that question is yes it does. However what are the Bible's teachings regarding these subjects? Are they, the same as what mainstream media, and new age teachers are telling us or could it be that the Bible gives a different, and largely untold explanation to what they are. In this book called The Paranormal Phenomena you will read, and discover various Bible passages from the King James Authorized English Bible itself as it reveals many realities of the supernatural, and the paranormal events of this world.
The food analyst plays an important role in modern society. Stricter control over additives in food and concern about the effects of contamination of food by industrial and agricultural chemicals are among the developments which are leading to an increasing emphasis on detailed and accurate analysis of food. However. analysis of food is required for many reasons, including detection of toxic components, monitoring legislation, detecting adulteration, formulation of controlled diets, controlling formulation during product development and detecting changes in food during storage and processing. Foods comprise a complex mixture of components and food analysis requires efficient methods of separation with high sensitivity or specificity of detection. Although many food components are involatile or thermally labile and therefore not suitable for analysis by gas chromatography, other components are volatile and this technique is the preferred analytical method. Developments in methods of derivati zation, injector design and column technology have also extended the applicability of gas chromatography to the analysis of relatively involatile compounds.
Violence has always played a part in the religious imagination, from symbols and myths to legendary battles, from colossal wars to the theater of terrorism. The Oxford Handbook of Religion and Violence surveys intersections between religion and violence throughout history and around the world. The forty original essays in this volume include overviews of major religious traditions, showing how violence is justified within the literary and theological foundations of the tradition, how it is used symbolically and in ritual practice, and how social acts of violence and warfare have been justified by religious ideas. The essays also examine patterns and themes relating to religious violence, such as sacrifice and martyrdom, which are explored in cross-disciplinary or regional analyses; and offer major analytic approaches, from literary to social scientific studies. The contributors to this volume--innovative thinkers who are forging new directions in theory and analysis related to religion and violence--provide novel insights into this important field of studies. By mapping out the whole field of religion and violence, The Oxford Handbook of Religion and Violence will prove an authoritative source for students and scholars for years to come.
“A highly readable and well-documented account of the use and abuse of religion for violent political ends . . . This is a book well worth reading” (Timothy J. Demy, ThD, PhD, coauthor of In the Name of God). Most Americans could not fathom how Islamic terrorists could bring down the World Trade Center or an army psychiatrist could turn on his own soldiers, taking their lives in the name of his religion. How could an ex-army veteran blow up a federal building, or a Jewish doctor gun down Muslims at worship? None of these incidents fit our conceptions of the benevolence of religion. More importantly, is there something inherent within religions that justifies the taking of human lives? In Few Call It War, Dr. Robert Hicks explores these questions and takes the blinders off illuminating the roots of religious violence, what religious terrorists have in common, and how they differ. As Hicks points out, all major religions have used violence and terrorist methodologies at some points in their histories. Few Call It War reveals how the teachings of religious founders and the sacred writings attributed to them provide rich soil from which contemporary religious clerics and ideologues gain converts. If one is interested in gaining an answer to the question, “Of all the religions in the world, which are most prone to using violence?” Few Call It War provides a well-reasoned answer that is well worth the read. “A masterpiece in the study of religiously motivated terrorism. He has been fair in his critique of all religions, including movements within Judaism and even Christianity.” —Robert L. Brennemann, PhD, professor, Intercultural Studies, North Central University
In 'Kind Hearts and Coronets' (1949), Louis Mazzini (Dennis Price) schemes and murders his way to a dukedom. This title looks into the turbulent personalities that formed the complex style of this film to unravel the fusion of cynicism, contempt, sparkling wit and philosophical curiosity.
The only contemporary history of the birth of Silicon Valley—from the reporter who had a ringside seat to it all Over the past five decades, the tech industry has grown into one of the most important sectors of the global economy, and Silicon Valley—replete with sprawling office parks, sky-high rents, and countless self-made millionaires—is home to many of its key players. But the origins of Silicon Valley and the tech sector are much humbler. At a time when tech companies’ influence continues to grow, The Big Score chronicles how they began. One of the first reporters on the tech industry beat at the San Jose Mercury-News, Michael S. Malone recounts the feverish efforts of young technologists and entrepreneurs to build something that would change the world—and score them a big payday. Starting with the birth of Hewlett-Packard in the 1930s, Malone illustrates how decades of technological innovation laid the foundation for the meteoric rise of the Valley in the 1970s. Drawing on exclusive, unvarnished interviews, Malone punctuates this history with incisive profiles of tech’s early luminaries—including Nobelist William Shockley and Apple’s Steve Jobs—when they were struggling entrepreneurs working 18-hour days in their garages. And he plunges us into the darker side of the Valley, where espionage, drugs, hellish working conditions, and shocking betrayals shaped the paths for winners and losers in a booming industry. A decades-long story with individual sacrifice, ingenuity, and big money at its core, The Big Score recounts the history of today's most dynamic sector through its upstart beginnings.
Discover the Millennia Long Secret that has Eluded some of the Greatest Minds of the World. Revealing the intertwining myriad of Synchronicities, from Genesis to Revelation to our most Current Events. See how Mystery 17, first revealed by Michael in 2010, has accurately predicted the Most Current 2020 Vision peace deal in Israel, From the: Rise of Trump and his Connection to ‘Q’ (17th letter) To the Time Predicted of the Beginning of Tribulation, Daniel’s Final Week (7 x 17 2) To the TRUE Revelation of who are ‘Babylon the Great’ and the ‘Beast with the 7 Heads and 10 Horns’ (7 + 10 = 17) To the unraveling of The MYSERY Triangle in Rev. 17:5. and the Final Count Down to 2027 Has the Final Week of Daniel truely already begun? Michael simply tells it straight, where you be the judge. From A.I. take over to Germ Warfare and the Globalist Depopulation Plan of Agenda 2030, Is there any Hope? ‘Well the Answer is Yes and the solution is CLEAR, If you want to make a difference, the Answer is Here.’
Every step in the business bankruptcy litigation process is covered in Aspen Publishers' Bankruptcy Litigation Manual, from the drafting of the first pleadings through the appellate process. In fact, by making the Bankruptcy Litigation Manual a part of your working library, you not only get detailed coverage of virtually all the topics and issues you must consider in any bankruptcy case, you also get field-tested answers to questions you confront every day, such as: How to stay continuing litigation against a corporate debtor's non-debtor officers? What are the limits on suing a bankruptcy trustee? Is the Deprizio Doctrine still alive? Does an individual debtor have an absolute right to convert a case from Chapter 7 to Chapter 13? What prohibitions exist on cross-collateralization in financing disputes? Are option contracts "executory" for bankruptcy purposes? When, and under what circumstances, may a bankruptcy court enjoin an administrative proceeding against a Chapter 11 debtor? What are the current standards for administrative priority claims? When must a creditor assert its setoff rights? When can a remand order issued by a district court be reviewed by a court of appeals? What are the limits on challenging pre-bankruptcy real property mortgage foreclosures as fraudulent transfers? Can an unsecured lender recover contract-based legal fees incurred in post- bankruptcy litigation on issues of bankruptcy law? Is there a uniform federal limitation on perfecting security interests that primes a longer applicable state law period, thus subjecting lenders to a preference attack? Do prior bankruptcy court orders bar a plaintiff's later state court suit and warrant removal of the action in federal court? Michael L. Cook, a partner at Schulte Roth & Zabel LLP in New York and former long-time Adjunct Professor at New York University School of Law, has gathered together some of the country's top bankruptcy litigators to contribute to Bankruptcy Litigation Manual.
There is a strange phenomenon that has been occurring on our planet throughout history. Yes, I'm talking about UFO's. I know what you're thinking. "We've heard all there is to hear regarding the UFO phenomenon." But have you really? You may be surprised to learn what you don't know. Today, there has been a paradigm shift to the belief in cosmic evolution. Is there life out there? If so, how will that change the world? Will we see the return of the Nephilim? What is the evolution connection? This is not just another book on UFO's. It answers a very critical question. Why are they here? What is their intent? After this read, you will gain a clear understanding from behind the scenes of the UFO phenomenon and the Alien Agenda.
Understanding how people learn and fail to learn second and foreign languages is increasingly recognised as a critical social and psycholinguistic issue. Second languages are vitally important to diverse groups of people, ranging from refugees to college students facing foreign language requirements. This book provides a synthesis of empirical findings on second and foreign language learning by children and adults, emphasising the design and execution of appropriate research.
This book is for the reader who takes interest in an age-old issue that remains contemporary with every succeeding generation. When, how, and why we are here are questions that have caused countless generations of thinkers and laymen alike to intuitively seek at the very least the semblance of an answer to questions that have become more of an outlook than a science, and in turn spring up among the problems of modern life as opposed to allowing for a resolution to that which was intended to clarify instead of further complicate. Free from the shackles and bias imposed by the various schools of religious, scientific and philosophical thought, the examinations offered herein are rooted in systematic analyses of the scientific, philosophical, ethical, social and finally the religious; which in turn allows for the explanation and justification of concepts that enable the reader to adopt a perspective relevant to the distinctions of absolute truth and relativistic assumptions. Our age is accurately referred to as the age of advancement and technology and for good reason. The rapid pace of progression over the last century in the life sciences has contributed to a broadened understanding of knowledge itself and its relation to the psychological and sociological aspects of our existence. As a result of the significant expansion of the sciences, the desire for an understanding of "self" and simply of "why" has in many ways been diluted, thus negating the never ending questions that once tugged at man's conscious in the middle of the night for thousands of years. Today's amazing achievements have laid the foundation for a whole series of newer problems and questions that threaten mankind as never before. The medical and biological sciences have enabled us to have a life expectancy beyond that of prior generations, however coupled with that are the problems of population explosion, which in the not too distant future will give rise to serious concerns. We have the ability to harness the power of the atom, yet along with it comes the ability to destroy all that we hold sacred. Taking into consideration the advanced age we live in, how does one account for the remarkable complexity extant throughout the known universe? Is one to assume that our consciousness coupled with our overwhelming sense of purpose can be attributed solely to "random chance" alone? The law of causation deals with the need for a preceding event leading to the outcome, and despite the fact that this scientific age has left its handprint on every facet of life today, it has failed to satisfy the innate question of simply, .............................................. why?
A Tree in Our Soul discusses how the Tree of the Knowledge of Good and Evil caused mankind to make the moral judgments of right and wrong. Michael Tsaphah's new book will explain why we suffer on this earth, because of this tree called morality. Also discussed are the word “righteous” and the difference between the carnal nature and the spiritual laws. About the Author Michael Tsaphah is a birth native of Reno, Nevada, raised by Raymond Edward and Mildred Jones. He is a veteran of the USMC, and now he's a teacher of the gospel. He has embraced the hand he has been dealt with by having clinical depression. Michael thanks God for Carol Cluff, for giving him life, and his adoptive parents, for pushing him to grab his life by the horns and ride it to the end.
Every step in the business bankruptcy litigation process is covered in Aspen Publishersand’ Bankruptcy Litigation Manual, from the drafting of the first pleadings through the appellate process. In fact, by making the Bankruptcy Litigation Manual a part of your working library, you not only get detailed coverage of virtually all the topics and issues you must consider in any bankruptcy case, you also get field-tested answers to questions you confront every day, such as: How to stay continuing litigation against a corporate debtorand’s non-debtor officers? What are the limits on suing a bankruptcy trustee? Is the Deprizio Doctrine still alive? Does an individual debtor have an absolute right to convert a case from Chapter 7 to Chapter 13? What prohibitions exist on cross-collateralization in financing disputes? Are option contracts and“executoryand” for bankruptcy purposes? When, and under what circumstances, may a bankruptcy court enjoin an administrative proceeding against a Chapter 11 debtor? What are the current standards for administrative priority claims? When must a creditor assert its setoff rights? When can a remand order issued by a district court be reviewed by a court of appeals? What are the limits on challenging pre-bankruptcy real property mortgage foreclosures as fraudulent transfers? Can an unsecured lender recover contract-based legal fees incurred in post- bankruptcy litigation on issues of bankruptcy law? Is there a uniform federal limitation on perfecting security interests that primes a longer applicable state law period, thus subjecting lenders to a preference attack? Do prior bankruptcy court orders bar a plaintiffand’s later state court suit and warrant removal of the action in federal court? Michael L. Cook, a partner at Schulte Roth and& Zabel LLP in New York and former long-time Adjunct Professor at New York University School of Law, has gathered together some of the countryand’s top bankruptcy litigators to contribute to Bankruptcy Litigation Manual. Contributing Authors: Jay Alix, Southfield, MI Neal Batson, Alston and& Bird, LLP, Atlanta, GA Kenneth K. Bezozo, Haynes and Boone, New York, NY Susan Block-Lieb, Fordham University School of Law, Newark, NJ Peter W. Clapp, Valle Makoff, LLP, San Francisco, CA Dennis J. Connolly, Alston and& Bird, LLP, Atlanta, GA David N. Crapo, Gibbons P.C., Newark, NJ Karen A. Giannelli, Gibbons P.C., Newark, NJ David M. Hillman, Schulte Roth and& Zabel, LLP, New York, NY Alfred S. Lurey, Kilpatrick and& Stockton, Atlanta, GA Gerald Munitz, Butler Rubin, Salterelli and& Boyd, LLP, Chicago, IL Robert L. Ordin, Retired Bankruptcy Court Judge Stephen M. Pezanosky, Haynes and Boone, LLP, Partner and Chair of Bankruptcy Section, Fort Worth, TX Robin E. Phelan, Haynes and Boone, LLP Dallas, TX Daniel H. Squire, Wilmer Cutler Pickering Hale and Dorr, LLP, Washington, DC Michael L. Temin, Fox Rothschild, LLP, Philadelphia, PA Sheldon S. Toll, Law Office ofSheldon S. Toll, Southfield, MI Jason H. Watson, Alston and& Bird, LLP, Atlanta, GA Kit Weitnauer, Alston and& Bird, LLP, Atlanta, GA Written by Mr. Cook and nineteen other experts, Bankruptcy Litigation Manual provides authoritative, up-to-date information on virtually every aspect of the bankruptcy litigation process, from discovery through appeal.
Michael J. Lindsay wrote this fictional story of a deep state murder that is utterly intertwined with demonic forces and end-time prophecies for the benefit of people who are just wondering what is going on today. This saga comes straight from the abyss and current events. The story line is a continuation of Mike's previous novel, The Nephilim's Revenge, in which Mike's hero uncovered the involvement of the country's elite with Nephilim, fallen angels, and other dark characters in a scheme to subordinate all mankind. At the center of this scheme is a top secret government project to create several genetic lines of supersoldiers through a method known as transhumanism. The main character, detective John Michael McIntyre, attempts to bring all of those responsible for the murder to justice, but the leader of the group escapes after a shoot-out in the Arizona desert. McIntyre's pursuit of this former FBI agent takes him into bizarre territory. The title of this book, Rise of the Nephilim, Pergamos Ascending, reflects the increasing success of these nefarious characters in creating their supersoldiers and world, and evading discovery or capture. This worldwide confederacy is soon to establish its New World Order, which many citizens do not even recognize as rapidly materializing in our day. Detective McIntyre discovers that these demonic goals all parallel what happened in Genesis 6:1-7, and now their nefarious plan is apparent. Readers will be surprised to find that by the end of this complex tale of deception, they will have a real working knowledge of latter-day Bible prophecy that will enable them clearly to see world events that unquestionably signal our entry into the end-time.
Every step in the business bankruptcy litigation process is covered inAspen Publishers' Bankruptcy Litigation Manual, from thedrafting of the first pleadings through the appellate process. In fact, bymaking the Bankruptcy Litigation Manual a part of your workinglibrary, you not only get detailed coverage of virtually all the topics andissues you must consider in any bankruptcy case, you also getfield-tested answers to questions you confront every day, such as:How to stay continuing litigation against a corporate debtor's non-debtorofficers?What are the limits on suing a bankruptcy trustee?Is the Deprizio Doctrine still alive?Does an individual debtor have an absolute right to convert a case fromChapter 7 to Chapter 13?What prohibitions exist on cross-collateralization in financing disputes?Are option contracts "executory" for bankruptcy purposes?When, and under what circumstances, may a bankruptcy court enjoin anadministrative proceeding against a Chapter 11 debtor?What are the current standards for administrative priority claims?When must a creditor assert its setoff rights?When can a remand order issued by a district court be reviewed by a court ofappeals?What are the limits on challenging pre- bankruptcy real propertymortgage foreclosures as fraudulent transfers?Can an unsecured lender recover contract-based legal fees incurred in post-bankruptcy litigation on issues of bankruptcy law ?Is there a uniform federal limitation on perfecting security interests thatprimes a longer applicable state law period, thus subjecting lenders to apreference attack?Do prior bankruptcy court orders bar a plaintiff's later state courtsuit and warrant removal of the action in federal court?Michael L. Cook, a partner at Schulte Roth & Zabel LLP in New York andformer long-time Adjunct Professor at New York University School of Law, hasgathered together some of the country's top bankruptcy litigators tocontribute to Bankruptcy Litigation Manual.Contributing Authors:Jay Alix, Southfield, MINeal Batson, Alston & Bird, LLP, Atlanta, GAKenneth K. Bezozo, Haynes and Boone, New York, NYSusan Block-Lieb, Fordham University School of Law, Newark, NJPeter W. Clapp, Valle Makoff, LLP, San Francisco, CADennis J. Connolly, Alston & Bird, LLP, Atlanta, GADavid N. Crapo, Gibbons P.C., Newark, NJKaren A. Giannelli, Gibbons P.C., Newark, NJDavid M. Hillman, Schulte Roth & Zabel, LLP, New York, NYAlfred S. Lurey, Kilpatrick & Stockton, Atlanta, GAGerald Munitz, Butler Rubin, Salterelli & Boyd, LLP, Chicago, ILRobert L. Ordin, Retired Bankruptcy Court JudgeStephen M. Pezanosky, Haynes and Boone, LLP, Partner and Chair of BankruptcySection, Fort Worth, TXRobin E. Phelan, Haynes and Boone, LLP Dallas, TXDaniel H. Squire, Wilmer Cutler Pickering Hale and Dorr, LLP, Washington, DCMichael L. Temin, Fox Rothschild, LLP, Philadelphia, PASheldon S. Toll, Law Office ofSheldon S. Toll, Southfield, MIJason H. Watson, Alston & Bird, LLP, Atlanta, GAKit Weitnauer, Alston & Bird, LLP, Atlanta, GAWritten by Mr. Cook and nineteen other experts, Bankruptcy LitigationManual provides authoritative, up-to-date information on virtuallyevery aspect of the bankruptcy litigation process, from discovery throughappeal.
God desires men to love their wives using Agape love. The book explains God’s wisdom about why men should love their wives using Agape and how Agape could bring a husband and wife closer together. The book defines and explains Agape love, the responsibilities of a husband, and the dynamics of a marital relationship using scripture as its basis. The book is written in a format that explains scripture in layman’s terms followed immediately by the actual scripture, so the reader can continue to read without pausing in order to look up scripture in a Bible or the internet.
Instrumentation for Trace Organic Monitoring provides comprehensive coverage of instrumental analysis techniques for trace organic analytes in environmental analysis. Sampling/sample preparation is discussed, in addition to mass spectrometry techniques, including GC-MS, HRMS, LCMS, APIMS, and MS-MS. This important book also covers new chromatography techniques, supercritical fluid, solid-phase extraction, and ion mobility spectrometry, which is a new ultra-sensitive technique. Difficult problems, such as dioxin/furan analysis, organometallic speciation, atmospheric organic vapors, water analysis, and flyash toxicity testing are addressed.
Drs. John C. Perkins and Michael E. Winters have assembled an expert team of authors on the topic of Sepsis in the Emergency Department. Article topics include: Defining and Diagnosing Sepsis; Appropriate Antibiotic Therapy; Severe Sepsis Resuscitation in Resource Limited Settings; Source Control in Severe Sepsis; Considerations in Special Populations with Severe Sepsis; Pediatric Severe Sepsis Resuscitation; The New Usual Care; Prehospital Sepsis Care; Endpoints of Sepsis Resuscitation; Pitfalls in the Diagnosis, Treatment, and Disposition of Severe Sepsis; Biomarkers in Sepsis; Vasopressors and Inotropes in Sepsis; and Sepsis Quality Measures and Performance Improvement.
Michael Lindsay wrote this murder mystery coming directly from his forty-plus years of forensic experience as a police officer, crime scene specialist, investigator, and academy crime scene instructor. More than being just a technically correct police story, this saga intertwines Mike's passions for the Wild West and the cowboy life; his awe of the few remaining wilderness areas; his interest in the many legends of the Superstition Mountains of Arizona; and his extensive studies of end-time Bible prophecy, occult manifestations, and UFOs. One would think that these diverse subjects will not be part of a real-world story, but many surprising revelations are exposed in this implicatory but accurate account. In fact, this deep whodunit mystery is actually solved by looking closely at the epic conflict of good versus evil through uncovering several ancient end-time prophecies.Readers will be surprised to find that by the end of this deceit-filled tale of treachery, they will have a real hands-on understanding of the end-time prophecy that will enable them to read and comprehend many prophetic Bible passages that pastors today refuse to teach and that they, quite honestly, do not really understand.This mystery story, coupled with Mike's first book on prophecy, The Town Crier: Two Months to Prophetic Literacy (A Guide to Saving America-One Prophecy at A Time), will bring readers to a level of prophetic understanding far beyond what most priests and pastors possess today.
For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.
Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neuron, synapse, circuit, or entire network, and dysregulation at some or all of these levels may contribute to neuropsychiatric disorders, intellectual disability, and epilepsy. Greater mechanistic understanding of homeostatic plasticity will provide key insights into the etiology of these disorders, which may result from network instability and synaptic dysfunction. Over the past 15 years, the molecular mechanisms of this form of plasticity have been intensely studied in various model organisms, including invertebrates and vertebrates. Though once thought to have a predominantly postsynaptic basis, emerging evidence suggests that homeostatic mechanisms act on both sides of the synapse through mechanisms such as retrograde signaling, to orchestrate compensatory adaptations that maintain stable network function. These trans-synaptic signaling systems ultimately alter neurotransmitter release probability by a variety of mechanisms including changes in vesicle pool size and calcium influx. These adaptations are not expected to occur homogenously at all terminals of a pre-synaptic neuron, as they might synapse with neurons in non-overlapping circuits. However, the factors that govern the homeostatic control of synapse-specific plasticity are only beginning to be understood. In addition to our limited molecular understanding of pre-synaptic homeostatic plasticity, very little is known about its prevalence in vivo or its physiological and disease relevance. In this research topic, we aim to fill the aforementioned void by covering a broad range of topics that include: - Identification of signaling pathways and mechanisms that operate globally or locally to induce specific pre-synaptic adaptations - The nature of pre-synaptic ion channels relevant to this form of plasticity and their synapse-specific modulation and trafficking - Development and utilization of new tools or methods to study homeostatic plasticity in axons and pre-synaptic terminals - Novel mechanisms of homeostatic adaptations in pre-synaptic neurons - Postsynaptic sensors of activity and retrograde synaptic signaling systems - A comprehensive analysis of the kinds of pre-synaptic adaptations in diverse neural circuits and cell types - Identification of physiological or developmental conditions that promote pre-synaptic homeostatic adaptations - How activity-dependent (Hebbian) and homeostatic synaptic changes are integrated to both permit sufficient flexibility and maintain stable activity - Relevance of pre-synaptic homeostatic plasticity to the etiology of neuropsychiatric disorders - Computational modeling of pre-synaptic homeostatic plasticity and network stability.
Kommentierte Bibliografie. Sie gibt Wissenschaftlern, Studierenden und Journalisten zuverlässig Auskunft über rund 6000 internationale Veröffentlichungen zum Thema Film und Medien. Die vorgestellten Rubriken reichen von Nachschlagewerk über Filmgeschichte bis hin zu Fernsehen, Video, Multimedia.
A factual resource to everything one needs to know about E.T. searching. From UFO sightings throughout history to scientific explanation of alien abductions to intergalactic radio signals, this guide delves into every area of this fascinating subject.
Everything you could possibly ever need -- from word processing and spreadsheet software to database and graphics applications, Web publishing tools, and even a personal organizer -- is packed into this top-notch, integrated suite of computer programs. With the powerful array of Lotus programs at your fingertips, you won't be lacking anything else to turn your computer into a full-service system...except, of course, a copy of Lotus SmartSuite Millennium Edition For Dummies, your all-in-one guide to just about any Lotus computing task you can imagine. Lotus SmartSuite Millennium Edition For Dummies helps you manage your day-to-day workload at home or at the office with step-by-step coaching, clear and concise explanations, and fast and friendly tips and techniques for making the power of Lotus SmartSuite work for you. Create professional-looking letters, memos, and reports; crunch numbers to your heart's content; manage and massage huge chunks of data; create high-quality graphics; organize your personal and professional life; and publish it all on the World Wide Web with the wide range of programs that make Lotus SmartSuite a must-have for all your computing needs.
Covering Lotus 1-2-3, Word Pro, Approach, Freelance Graphics, and Organizer scheduler for Windows 95, this book includes a great overview of each application, giving users the basics in easy-to-understand language. It introduces users to common interface of applications including Smartlcons and Status Bars.
Due to increasing traffic flows the extension of transport infrastructure with rail roads and high speed lines is an ongoing process worldwide. Ballastless track systems with concrete slabs are used more and more. Following the first trials in the 1970s and more than four decades of R&D work on ballastless track, the level of development is such that it can be confirmed that ballastless track is suitable for use as an alternative to ballasted track. This book makes a contribution to the state of the art of ballastless track by describing the basics for designing the ballastless track. Important advice is provided regarding the construction of ballastless track on earthworks and in tunnels. There is also a description of the technical history of the development of ballastless track on bridges and the ensuing findings for bridge design. The state of the art of ballastless track for switches, important information on details concerning drainage, transitions, accessibility for road vehicles and experience gleaned from maintenance round off the work. Selected chapters from the German concrete yearbook are now being published in the new English "Beton-Kalender Series" for the benefit of an international audience. Since it was founded in 1906, the Ernst & Sohn "Beton-Kalender" has been supporting developments in reinforced and prestressed concrete. The aim was to publish a yearbook to reflect progress in "ferro-concrete" structures until - as the book's first editor, Fritz von Emperger (1862-1942), expressed it - the "tempestuous development" in this form of construction came to an end. However, the "Beton-Kalender" quickly became the chosen work of reference for civil and structural engineers, and apart from the years 1945-1950 has been published annually ever since.
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