Michael McLafferty's Books

Intermediate Organic Chemistry

By: Michael Leonard

Write a review Read reviews Take a Quiz Solve Book Puzzle

Intermediate Organic Chemistry

By: Michael Leonard

The mission of Intermediate Organic Chemistry is to bridge the gap between introductory Organic Chemistry coursework and advanced/graduate-level coursework but to do so in a way that extends the student-centered approach of most modern introductory Organic Chemistry textbooks. This text makes extensive use of detailed explanations and color coding to facilitate the learning process. This text's style is one that is shared by many instructors of Organic Chemistry: mechanistically driven and detailed. Extensive use of color coding helps students to learn mechanism and cogently predict reaction products. The electrons that are mechanistically involved in each transformation are color coded. The mechanistic arrows originating from those electrons are colored identically, as are the bonds and/or lone pairs that result from the electron flow. This approach, along with detailed verbal explanations, conveys the narrative of the mechanism.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

430

Publisher

Lulu.com

Published Date

ISBN 10

1304217566

ISBN 13

9781304217561

Organic Chemistry

An Acid—Base Approach

By: Michael B. Smith

Write a review Read reviews Take a Quiz Solve Book Puzzle

Organic Chemistry

An Acid—Base Approach

By: Michael B. Smith

Based on the premise that many, if not most, reactions in organic chemistry can be explained by variations of fundamental acid-base concepts, Organic Chemistry: An Acid–Base Approach provides a framework for understanding the subject that goes beyond mere memorization. The individual steps in many important mechanisms rely on acid–base reactions, and the ability to see these relationships makes understanding organic chemistry easier. Using several techniques to develop a relational understanding, this textbook helps students fully grasp the essential concepts at the root of organic chemistry. Providing a practical learning experience with numerous opportunities for self-testing, the book contains: Checklists of what students need to know before they begin to study a topic Checklists of concepts to be fully understood before moving to the next subject area Homework problems directly tied to each concept at the end of each chapter Embedded problems with answers throughout the material Experimental details and mechanisms for key reactions The reactions and mechanisms contained in the book describe the most fundamental concepts that are used in industry, biological chemistry and biochemistry, molecular biology, and pharmacy. The concepts presented constitute the fundamental basis of life processes, making them critical to the study of medicine. Reflecting this emphasis, most chapters end with a brief section that describes biological applications for each concept. This text provides students with the skills to proceed to the next level of study, offering a fundamental understanding of acids and bases applied to organic transformations and organic molecules.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

1594

Publisher

CRC Press

Published Date

ISBN 10

1420079212

ISBN 13

9781420079210

March's Advanced Organic Chemistry

Reactions, Mechanisms, and Structure

By: Michael B. Smith

Write a review Read reviews Take a Quiz Solve Book Puzzle

March's Advanced Organic Chemistry

Reactions, Mechanisms, and Structure

By: Michael B. Smith

The completely revised and updated, definitive resource for students and professionals in organic chemistry The revised and updated 8th edition of March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions The opening chapters of March's Advanced Organic Chemistry, 8th Edition deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms. This edition: Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017 Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction The 8th edition of March's Advanced Organic Chemistry proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields. Winner of the Textbook & Acadmic Authors Association 2021 McGuffey Longevity Award.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

2146

Publisher

John Wiley & Sons

Published Date

ISBN 10

1119371805

ISBN 13

9781119371809

The PMO Theory of Organic Chemistry

By: Michael Dewar

Write a review Read reviews Take a Quiz Solve Book Puzzle

The PMO Theory of Organic Chemistry

By: Michael Dewar

This textbook introduces the perturbation molecular orbital (PMO) th,eory of organic chemistry. Organic chemistry encompasses the largest body of factual information of any of the major divisions of science. The sheer bulk of the subject matter makes many demands on any theory that attempts to systematize it. Time has shown that the PMO method meets these demands admirably. The PMO method can provide practicing chemists with both a pictorial description of bonding and qualitative theoretical results that are well founded in more sophisticated treatments. The only requirements for use of the theory are high school algebra and a pencil and paper. The treatment described in this book is by no means new. Indeed, it was developed as a complete theory of organic chemistry more than twenty years ago. Although it was demonstrably superior to resonance theory and no more complicated to use, it escaped notice for two very simple reasons. First, the original papers describing it were very condensed, perhaps even obscure, and contained few if any examples. Second, for various reasons, no general account appeared in book form until 1969,* and this was still relatively inaccessible, being in the form of a monograph where molecular orbital (MO) theory was treated mainly at a much more sophisticated level. The generality of the PMO method is illustrated by the fact that all the new developments over the last two decades can be accommodated in it.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

584

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461344042

ISBN 13

9781461344049

Geographic Information Science and Systems

By: Paul A. Longley,Michael F. Goodchild,David J. Maguire,David W. Rhind

Write a review Read reviews Take a Quiz Solve Book Puzzle

Geographic Information Science and Systems

By: Paul A. Longley,Michael F. Goodchild,David J. Maguire,David W. Rhind

Effective use of today’s vast geographic information (GI) resources requires more than just powerful technology for problem solving. It requires science to help us understand the way the world works, and to help us devise effective procedures for making decisions. Three previous editions have established this text as a defining multidisciplinary treatment of the scientific principles that underpin the use of geographic information technologies for problem solving. This extensively revised and updated edition provides a guide to the enduring scientific principles and information systems that support effective use of today’s GI. It also provides a primer on essential methods for analysis of GI, and the ways in which effective management of GI informs policy and action.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

500

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118676955

ISBN 13

9781118676950

Health and Medical Geography

By: Michael Emch,Elisabeth Dowling Root,Margaret Carrel

Write a review Read reviews Take a Quiz Solve Book Puzzle

Health and Medical Geography

By: Michael Emch,Elisabeth Dowling Root,Margaret Carrel

Why are rainfall, carcinogens, and primary care physicians distributed unevenly over space? The fourth edition of the leading text in the field has been updated and reorganized to cover the latest developments in disease ecology and health promotion across the globe. The book accessibly introduces the core questions and perspectives of health and medical geography and presents cutting-edge techniques of mapping and spatial analysis. It explores the intersecting genetic, ecological, behavioral, cultural, and socioeconomic processes that underlie patterns of health and disease in particular places, including how new diseases and epidemics emerge. Geographic dimensions of health care access and service provision are addressed. More than 100 figures include 16 color plates; most are available as PowerPoint slides at the companion website. New to This Edition: *Chapters on the political ecology of health; emerging infectious diseases and landscape genetics; food, diet, and nutrition; and urban health. *Coverage of Middle East respiratory syndrome, Ebola, and Zika; impacts on health of global climate change; contaminated water crises in economically developed countries, including in Flint, Michigan; China's rapid industrial growth; and other timely topics. *Updated throughout with current data and concepts plus advances in GIS. Pedagogical Features: *End-of-chapter review questions and suggestions for further reading. *Section Introductions that describe each chapter. *"Quick Reviews"--within-chapter recaps of key concepts. *Bold-faced key terms and an end-of-book glossary.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

553

Publisher

Guilford Publications

Published Date

ISBN 10

1462528961

ISBN 13

9781462528967

The Singing Irish

A History of the Notre Dame Glee Club

By: Michael Alan Anderson

Write a review Read reviews Take a Quiz Solve Book Puzzle

The Singing Irish

A History of the Notre Dame Glee Club

By: Michael Alan Anderson

In The Singing Irish, Michael Alan Anderson brings to life the rich history and traditions of the Notre Dame Glee Club. Replete with nearly three hundred images, the stunning large-format book examines the early history of the ensemble before 1915, its robust membership, rehearsal and concert customs, and the contributions of its conductors through the decades. Anderson interviewed dozens of Glee Club alumni going back to the early 1940s to narrate the vibrant story of the group, while assembling a wealth of documents that detail the activities undertaken—and impressions made—by this extraordinary musical ensemble. The group’s famous appearances on the Ed Sullivan Show in the early 1950s marked the height of the Glee Club’s visibility; however, the ensemble continues to sell out concerts on national and international tours, having traveled to nearly every state in the United States and numerous countries in Europe, Asia, and Central America. Through its eclectic repertoire and polished singing, the Glee Club has achieved a lofty status among collegiate choral ensembles in the United States, beloved by students, members of the Notre Dame family, and friends and supporters of the university around the world. Combining the meaningful culture of Notre Dame with the highest standards of artistic excellence, The Singing Irish makes a wonderful keepsake for fans and alumni of the Notre Dame Glee Club as it enters its centennial year.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

908

Publisher

University of Notre Dame Pess

Published Date

ISBN 10

0268074852

ISBN 13

9780268074852

Organic Synthesis

By: Michael Smith

Write a review Read reviews Take a Quiz Solve Book Puzzle

Organic Synthesis

By: Michael Smith

Organic Synthesis 5e provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature.? There have been advancements in organic reactions, particularly organometallic reactions, and there is a need to show how these advancements have influenced current organic synthesis. The goal is to revise and update the examples of reaction examples taken from the synthesis literature from about 2017-2023. The reactions illustrate those that are used most often in modern organic synthesis, but recent examples will show their current relevance.? Where new approaches and new reactions have been developed for organic synthesis, examples will be added as new material. - Provides new content, reaction examples, and study problems from recent research? - Features improved organization, new art, and new chapter content on process chemistry and green organic chemistry - Includes revised homework for each chapter, with new examples and questions?

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

2403

Publisher

Elsevier

Published Date

ISBN 10

0443158681

ISBN 13

9780443158681

Medical Geography, Third Edition

By: Melinda S. Meade,Michael Emch

Write a review Read reviews Take a Quiz Solve Book Puzzle

Medical Geography, Third Edition

By: Melinda S. Meade,Michael Emch

The leading text in the field, this comprehensive book reviews geographic approaches to studying disease and public health issues across the globe. It presents cutting-edge techniques of spatial and social analysis and explores their relevance for understanding cultural and political ecology, disease systems, and health promotion. Essential topics include how new diseases emerge and epidemics develop in particular places; the intersecting influences on health of biological processes, culture, environment, and behavior; and the changing landscape of health care planning and service delivery. The text is richly illustrated with tables, figures, and maps, including 16 color plates.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

529

Publisher

Guilford Press

Published Date

ISBN 10

1606236911

ISBN 13

9781606236918

Athletic and Orthopedic Injury Assessment

Case Responses and Interpretations

By: David C. C Berry,Michael G. Miller,Leisha M. Berry

Write a review Read reviews Take a Quiz Solve Book Puzzle

Athletic and Orthopedic Injury Assessment

Case Responses and Interpretations

By: David C. C Berry,Michael G. Miller,Leisha M. Berry

Athletic and Orthopedic Injury Assessment: Case Responses and Interpretations is a companion book that provides responses and interpretations to the case studies in Athletic and Orthopedic Injury Assessment: A Case Study Approach. Research, evidence-based practices, and professional experience form the basis of these responses and interpretations. The suggested answers for case questions include information such as identification of differential and clinical diagnoses, explanations of diagnostic tests, relevant anatomical information, and more. We hope you find this book helpful in responding to the case questions, whether you are an instructor leading class discussions and analyzing student work, a preprofessional preparing to interpret the case scenarios on the BOC national certification examination, or a student seeking to compare the suggested answers with your own analyses.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

406

Publisher

Routledge

Published Date

ISBN 10

1351818635

ISBN 13

9781351818636

Physician Communication with Patients

Research Findings and Challenges

By: Jon Christianson,Louise H. Warrick,Michael Finch,Wayne B. Jonas

Write a review Read reviews Take a Quiz Solve Book Puzzle

Physician Communication with Patients

Research Findings and Challenges

By: Jon Christianson,Louise H. Warrick,Michael Finch,Wayne B. Jonas

We all have a good idea of how we want things to go when we visit a physician. We expect to be able to explain why we are there, and we hope the physician will listen and possibly ask questions that help us clarify our thoughts. Most of us hope that the physician will provide some expression of empathy, offer a clear, nontechnical assessment of our problem, and describe "next steps" in a way that is easy to understand. Ideally, we would like to be asked about our ability to follow treatment recommendations. Some experts say that these expectations are not only reasonable but even necessary if patients are to get the care they need. Yet there is a growing body of research that suggests the reality of physician communication with patients often falls short of this ideal in many respects. A careful analysis of the findings of this research can provide guidance to physician educators, health care administrators, and health policy makers interested in understanding the role that improved physician communication can play in improving quality of care and patient outcomes. Physician Communication with Patients summarizes findings from the academic literature pertaining to various aspects of this question, discussing those findings in the context of current pressures for change in the organization and delivery of medical services.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

364

Publisher

University of Michigan Press

Published Date

ISBN 10

0472028367

ISBN 13

9780472028368

Metabolome Analysis

An Introduction

By: Silas G. Villas-Boas,Jens Nielsen,Jorn Smedsgaard,Michael A. E. Hansen,Ute Roessner-Tunali

Write a review Read reviews Take a Quiz Solve Book Puzzle

Metabolome Analysis

An Introduction

By: Silas G. Villas-Boas,Jens Nielsen,Jorn Smedsgaard,Michael A. E. Hansen,Ute Roessner-Tunali

Providing information on the main approaches for the analysis of metabolites, this textbook: Covers basic methodologies in sample preparation and separation techniques, as well as the most recent techniques of mass spectrometry. Differentiates between primary and secondary metabolites. Includes four chapters discussing successful metabolome studies of different organisms. Highlights the analytical challenges of studying metabolites. Illustrates applications of metabolome analysis through the use of case studies.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

339

Publisher

John Wiley & Sons

Published Date

ISBN 10

047010550X

ISBN 13

9780470105504

Sequence — Evolution — Function

Computational Approaches in Comparative Genomics

By: Eugene V. Koonin,Michael Galperin

Write a review Read reviews Take a Quiz Solve Book Puzzle

Sequence — Evolution — Function

Computational Approaches in Comparative Genomics

By: Eugene V. Koonin,Michael Galperin

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

482

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1475737831

ISBN 13

9781475737837

Principles and Applications of Gas Chromatography in Food Analysis

By: Michael H. Gordon

Write a review Read reviews Take a Quiz Solve Book Puzzle

Principles and Applications of Gas Chromatography in Food Analysis

By: Michael H. Gordon

The food analyst plays an important role in modern society. Stricter control over additives in food and concern about the effects of contamination of food by industrial and agricultural chemicals are among the developments which are leading to an increasing emphasis on detailed and accurate analysis of food. However. analysis of food is required for many reasons, including detection of toxic components, monitoring legislation, detecting adulteration, formulation of controlled diets, controlling formulation during product development and detecting changes in food during storage and processing. Foods comprise a complex mixture of components and food analysis requires efficient methods of separation with high sensitivity or specificity of detection. Although many food components are involatile or thermally labile and therefore not suitable for analysis by gas chromatography, other components are volatile and this technique is the preferred analytical method. Developments in methods of derivati zation, injector design and column technology have also extended the applicability of gas chromatography to the analysis of relatively involatile compounds.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

371

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461306817

ISBN 13

9781461306818

Instrumentation for Trace Organic Monitoring

By: Raymond E. Clement,Herbert H. Hill, Jr.,K. W. Michael Siu

Write a review Read reviews Take a Quiz Solve Book Puzzle

Instrumentation for Trace Organic Monitoring

By: Raymond E. Clement,Herbert H. Hill, Jr.,K. W. Michael Siu

Instrumentation for Trace Organic Monitoring provides comprehensive coverage of instrumental analysis techniques for trace organic analytes in environmental analysis. Sampling/sample preparation is discussed, in addition to mass spectrometry techniques, including GC-MS, HRMS, LCMS, APIMS, and MS-MS. This important book also covers new chromatography techniques, supercritical fluid, solid-phase extraction, and ion mobility spectrometry, which is a new ultra-sensitive technique. Difficult problems, such as dioxin/furan analysis, organometallic speciation, atmospheric organic vapors, water analysis, and flyash toxicity testing are addressed.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

336

Publisher

CRC Press

Published Date

ISBN 10

0873712137

ISBN 13

9780873712132

Laser Experiments for Chemistry and Physics

By: Robert N. Compton,Michael A. Duncan

Write a review Read reviews Take a Quiz Solve Book Puzzle

Laser Experiments for Chemistry and Physics

By: Robert N. Compton,Michael A. Duncan

This book provides a collection of experiments to introduce lasers into the undergraduate curricula in Chemistry and Physics. A variety of experiments are included with different levels of complexity. All have background information, experimental details and the theoretical background necessary to interpret the results.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

415

Publisher

Oxford University Press

Published Date

ISBN 10

0198742983

ISBN 13

9780198742982

Lewis's Child and Adolescent Psychiatry

A Comprehensive Textbook

By: Andrés Martin,Fred R. Volkmar,Michael H. Bloch

Write a review Read reviews Take a Quiz Solve Book Puzzle

Lewis's Child and Adolescent Psychiatry

A Comprehensive Textbook

By: Andrés Martin,Fred R. Volkmar,Michael H. Bloch

For 25 years, Lewis's Child and Adolescent Psychiatry has been the cornerstone of every child and adolescent psychiatrist’s library. Now, three colleagues of Dr. Lewis at the world-renowned Yale Child Study Center, have substantially updated and revised this foundational textbook for its long-awaited fifth edition, the first in ten years. Encyclopedic in scope, it continues to serve as a broad reference, deftly encompassing and integrating scientific principles, research methodologies, and everyday clinical care.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

2821

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1496367685

ISBN 13

9781496367686

One Nation Divisible

What America Was and What It Is Becoming

By: Michael B. Katz,Mark J. Stern

Write a review Read reviews Take a Quiz Solve Book Puzzle

One Nation Divisible

What America Was and What It Is Becoming

By: Michael B. Katz,Mark J. Stern

American society today is hardly recognizable from what it was a century ago. Integrated schools, an information economy, and independently successful women are just a few of the remarkable changes that have occurred over just a few generations. Still, the country today is influenced by many of the same factors that revolutionized life in the late nineteenth century—immigration, globalization, technology, and shifting social norms—and is plagued by many of the same problems—economic, social, and racial inequality. One Nation Divisible, a sweeping history of twentieth-century American life by Michael B. Katz and Mark J. Stern, weaves together information from the latest census with a century's worth of data to show how trends in American life have changed while inequality and diversity have endured. One Nation Divisible examines all aspects of work, family, and social life to paint a broad picture of the American experience over the long arc of the twentieth century. Katz and Stern track the transformations of the U.S. workforce, from the farm to the factory to the office tower. Technological advances at the beginning and end of the twentieth century altered the demand for work, causing large population movements between regions. These labor market shifts fed both the explosive growth of cities at the dawn of the industrial age and the sprawling suburbanization of today. One Nation Divisible also discusses how the norms of growing up and growing old have shifted. Whereas the typical life course once involved early marriage and living with large, extended families, Americans today commonly take years before marrying or settling on a career path, and often live in non-traditional households. Katz and Stern examine the growing influence of government on trends in American life, showing how new laws have contributed to more diverse neighborhoods and schools, and increased opportunities for minorities, women, and the elderly. One Nation Divisible also explores the abiding economic paradox in American life: while many individuals are able to climb the financial ladder, inequality of income and wealth remains pervasive throughout society. The last hundred years have been marked by incredible transformations in American society. Great advances in civil rights have been tempered significantly by rising economic inequality. One Nation Divisible provides a compelling new analysis of the issues that continue to divide this country and the powerful role of government in both mitigating and exacerbating them. A Volume in the Russell Sage Foundation Census Series

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

369

Publisher

Russell Sage Foundation

Published Date

ISBN 10

1610443314

ISBN 13

9781610443319

Name Reactions and Reagents in Organic Synthesis

By: Bradford P. Mundy,Michael G. Ellerd,Frank G. Favaloro, Jr.

Write a review Read reviews Take a Quiz Solve Book Puzzle

Name Reactions and Reagents in Organic Synthesis

By: Bradford P. Mundy,Michael G. Ellerd,Frank G. Favaloro, Jr.

This Second Edition is the premier name resource in the field. It provides a handy resource for navigating the web of named reactions and reagents. Reactions and reagents are listed alphabetically, followed by relevant mechanisms, experimental data (including yields where available), and references to the primary literature. The text also includes three indices based on reagents and reactions, starting materials, and desired products. Organic chemistry professors, graduate students, and undergraduates, as well as chemists working in industrial, government, and other laboratories, will all find this book to be an invaluable reference.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

900

Publisher

John Wiley & Sons

Published Date

ISBN 10

0471739863

ISBN 13

9780471739869

Application of Selected Reaction Monitoring to Highly Multiplexed Targeted Quantitative Proteomics

A Replacement for Western Blot Analysis

By: Michael Kinter,Caroline S. Kinter

Write a review Read reviews Take a Quiz Solve Book Puzzle

Application of Selected Reaction Monitoring to Highly Multiplexed Targeted Quantitative Proteomics

A Replacement for Western Blot Analysis

By: Michael Kinter,Caroline S. Kinter

A key experiment in biomedical research is monitoring the expression of different proteins in order to detect changes that occur in biological systems under different experimental conditions. The method that is most widely used is the Western blot analysis. While Western blot is a workhorse in laboratories studying protein expression and has several advantages, it also has a number of significant limitations. In particular, the method is semi-quantitative with limited dynamic range. Western blot focuses on a single protein per sample with only a small number of representative samples analyzed in an experiment. New quantitative tools have been needed for some time to at least supplement, & possibly replace, the Western blot. Mass spectrometric methods have begun to compete with Western blot for routine quantitative analyses of proteins. One of these methods is based on the tandem mass spectrometry technique of selected reaction monitoring (SRM), which is also called multiple reaction monitoring (MRM). Selected reaction monitoring is actually an older tandem mass spectrometry technique, first described in the late 70s, that is widely utilized in the quantitative analysis of small molecules like drugs & metabolites. The use of selected reaction monitoring for the quantitative analysis of proteins has a number of advantages. Most importantly, it is fundamentally quantitative with a wide dynamic range. The output of the analysis is a numerical result that can range over several orders of magnitude. Other advantages include sufficient specificity & sensitivity to detect low abundance proteins in complex mixtures. Finally, selected reaction monitoring can be multiplexed to allow the quantitative analysis of relatively large numbers of proteins in a single sample in a single experiment. This Brief will explain both the theoretical & experimental details of the selected reaction monitoring experiment as it is applied to proteins.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461486661

ISBN 13

9781461486664

Fire and Brimstone

The North Butte Mining Disaster of 1917

By: Michael Punke

Write a review Read reviews Take a Quiz Solve Book Puzzle

Fire and Brimstone

The North Butte Mining Disaster of 1917

By: Michael Punke

The author of the #1 New York Times bestseller, The Revenant -- basis for the award-winning motion picture starring Leonardo DiCaprio -- tells the remarkable story of the worst hard-rock mining disaster in American history. A half-hour before midnight on June 8, 1917, a fire broke out in the North Butte Mining Company's Granite Mountain shaft. Sparked more than two thousand feet below ground, the fire spewed flames, smoke, and poisonous gas through a labyrinth of underground tunnels. Within an hour, more than four hundred men would be locked in a battle to survive. Within three days, one hundred and sixty-four of them would be dead. Fire and Brimstone recounts the remarkable stories of both the men below ground and their families above, focusing on two groups of miners who made the incredible decision to entomb themselves to escape the gas. While the disaster is compelling in its own right, Fire and Brimstone also tells a far broader story striking in its contemporary relevance. Butte, Montana, on the eve of the North Butte disaster, was a volatile jumble of antiwar protest, an abusive corporate master, seething labor unrest, divisive ethnic tension, and radicalism both left and right. It was a powder keg lacking only a spark, and the mine fire would ignite strikes, murder, ethnic and political witch hunts, occupation by federal troops, and ultimately a battle over presidential power.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

307

Publisher

Hachette Books

Published Date

ISBN 10

1401305717

ISBN 13

9781401305710

Journal of International Doctoral Research (JIDR) Volume 4, Number 1, December 2015

By: Gillian Warner-Søderholm,Pat Joynt,Petter Gottschalk,Claudette Knight,Clare Stone,Katarina M. Pajchel,Michael Benson,Tor Grenness

Write a review Read reviews Take a Quiz Solve Book Puzzle

Journal of International Doctoral Research (JIDR) Volume 4, Number 1, December 2015

By: Gillian Warner-Søderholm,Pat Joynt,Petter Gottschalk,Claudette Knight,Clare Stone,Katarina M. Pajchel,Michael Benson,Tor Grenness

This forth volume of the JIDR is devoted to a wide range of research themes, which are all linked to the concept of diversity; both implicitly and explicitly. In addition, this volume showcases research related to the doctorate journey. As the mission statement and title of our journal suggests, our goal is to promote excellence in publications with a focus on both doctorate studies and also on research disseminated from specific doctorate studies. In next year's journal, empirical data will be presented which investigates variables which impact the 'safe navigation of the doctoral voyage'. Elements such as choice of research methodology, professional background, family issues, career path, gender and choice of supervisor all impact the success rate of PhD candidate. Two of our articles this year therefore showcase the doctoral research journey.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

100

Publisher

Lulu.com

Published Date

ISBN 10

1329714369

ISBN 13

9781329714366

Understanding Geographical and Environmental Education

By: Michael C. Williams

Write a review Read reviews Take a Quiz Solve Book Puzzle

Understanding Geographical and Environmental Education

By: Michael C. Williams

These papers aim to provide a substantial review of the literature pertaining to a comprehensive range of traditional and contemporary research paradigms and research methods. The book is designed as a reference work for novice researchers in the fields of geographical and environmental education.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

319

Publisher

A&C Black

Published Date

ISBN 10

1847140904

ISBN 13

9781847140906

Families in Rehabilitation Counseling

A Community-Based Rehabilitation Approach

By: Michael J. Millington, PhD, CRC

Write a review Read reviews Take a Quiz Solve Book Puzzle

Families in Rehabilitation Counseling

A Community-Based Rehabilitation Approach

By: Michael J. Millington, PhD, CRC

Presents an innovative family-based approach to rehabilitation counseling that can be put to use immediately! While the family has traditionally been a secondary consideration in rehabilitation, this graduate text presents an innovative approach to rehabilitation counseling that focuses on the family as the center of a person-centered model, rather than as an adjunct to individual counseling. It advocates counseling in the context of community, requiring the recognition of social transaction as the primary focus of all interventions. The book provides the tools and knowledge base to effectively work with the family and within the community, delivering a new inclusive model of care and establishing best practices in research, practice, training, and management. The text examines the rationale for embracing family values in rehabilitation counseling and provides a framework that redefines the relationship between counselor and client in the context of family and community. It describes the community-based rehabilitation model in detail according to the International Classification of Function (ICF) and presents a series of illustrative disability profiles—distilled from systematic reviews of the literature—reflecting this framework. In each case, the impact upon family participation is illustrated and optimal service and support resources are identified. The role and function of the rehabilitation counselor provide the integrative conclusion to each chapter. The book also describes grassroots initiatives, the role of family in community-based rehabilitation in developing countries, family policy across rehabilitation systems, and best practices in research, training, and management. Additionally, the text comes with access to an Instructor‘s Manual that includes case study discussion questions, classroom activities, and multiple-choice questions. Key Features: • Describes an innovative family-/community-focused approach to rehabilitation counseling, framed in ICF taxonomy • Presents a pragmatic model that can be put to use immediately • Describes an array of family experiences across disability contexts, providing an opportunity to critique current practice through the lens of community-based constructs • Provides plentiful case studies based on family narratives • Broadens the scope of practice with service initiatives from around the world • Includes an Instructor‘s Manual with case study discussion questions, classroom activities, and multiple-choice questions

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

328

Publisher

Springer Publishing Company

Published Date

ISBN 10

0826198767

ISBN 13

9780826198761

Expedition and Wilderness Medicine

By: Gregory H. Bledsoe,Michael J. Manyak,David A. Townes

Write a review Read reviews Take a Quiz Solve Book Puzzle

Expedition and Wilderness Medicine

By: Gregory H. Bledsoe,Michael J. Manyak,David A. Townes

With an increase in visits to remote and dangerous locations around the world, the number of serious and fatal injuries and illnesses associated with these expeditions has markedly increased. Medical personnel working in or near such locations are not always explicitly trained in the management of unique environmental injuries, such as high-altitude sickness, the bends, lightning strikes, frostbite, acute dehydration, venomous stings and bites, and tropical diseases. Many health care professionals seek training in the specialty of wilderness medicine to cope with the health risks faced when far removed from professional care resources, and the American College of Emergency Medicine has recently mandated that a minimum level of proficiency needs to be exhibited by all ER physicians in this discipline. This book covers everything a prospective field physician or medical consultant needs to prepare for when beginning an expedition and explains how to treat a variety of conditions in a concise, clinically oriented format.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

750

Publisher

Cambridge University Press

Published Date

ISBN 10

1139643851

ISBN 13

9781139643856

Protein Sequencing and Identification Using Tandem Mass Spectrometry

By: Michael Kinter,Nicholas E. Sherman

Write a review Read reviews Take a Quiz Solve Book Puzzle

Protein Sequencing and Identification Using Tandem Mass Spectrometry

By: Michael Kinter,Nicholas E. Sherman

How to design, execute, and interpret experiments for protein sequencing using mass spectrometry The rapid expansion of searchable protein and DNA databases in recent years has triggered an explosive growth in the application of mass spectrometry to protein sequencing. This timely and authoritative book provides professionals and scientists in biotechnology research with complete coverage of procedures for analyzing protein sequences by mass spectrometry, including step-by-step guidelines for sample preparation, analysis, and data interpretation. Michael Kinter and Nicholas Sherman present their own high-quality, laboratory-tested protocols for the analysis of a wide variety of samples, demonstrating how to carry out specific experiments and obtain fast, reliable results with a 99% success rate. Readers will get sufficient experimental detail to apply in their own laboratories, learn about the proper selection and operation of instruments, and gain essential insight into the fundamental principles of mass spectrometry and protein sequencing. Coverage includes: * Peptide fragmentation and interpretation of product ion spectra * Basic polyacrylamide gel electrophoresis * Preparation of protein digests for sequencing experiments * Mass spectrometric analysis using capillary liquid chromatography * Techniques for protein identification by database searches * Characterization of modified peptides using tandem mass spectrometry And much more

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

321

Publisher

John Wiley & Sons

Published Date

ISBN 10

0471231886

ISBN 13

9780471231882

Abrams' Angiography

Interventional Radiology

By: Jeffrey Geschwind,Michael Dake

Write a review Read reviews Take a Quiz Solve Book Puzzle

Abrams' Angiography

Interventional Radiology

By: Jeffrey Geschwind,Michael Dake

The Interventional Radiology volume of the landmark reference Abrams' Angiography has now been expanded and thoroughly revised to reflect dynamic advances in interventional radiology. More than 60 contributors representing a "Who's Who" of the specialty provide comprehensive, step-by-step coverage of all contemporary vascular and nonvascular interventional procedures. Major sections discuss today's equipment and describe interventions for specific disorders of each organ system, as well as for trauma, pediatric diseases, abscess drainage, and miscellaneous disorders. More than 1,100 illustrations complement the text. This edition incorporates an extensive new section on interventional oncologic procedures. The section covers all organ-specific cancers for which interventional therapies are used. Other sections include artervenous malformations, liver diseases, arterial occlusive disease, aneurysms, traumatic arterial injuries, hemorrhage, and venous diseases. It also has full color.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

2360

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1469852373

ISBN 13

9781469852379

Biochemistry

An Organic Chemistry Approach

By: Michael B. Smith

Write a review Read reviews Take a Quiz Solve Book Puzzle

Biochemistry

An Organic Chemistry Approach

By: Michael B. Smith

“There is a continuing demand for up to date organic & bio-organic chemistry undergraduate textbooks. This well planned text builds upon a successful existing work and adds content relevant to biomolecules and biological activity”. -Professor Philip Page, Emeritus Professor, School of Chemistry University of East Anglia, UK “Introduces the key concepts of organic chemistry in a succinct and clear way”. -Andre Cobb, KCL, UK Reactions in biochemistry can be explained by an understanding of fundamental organic chemistry principles and reactions. This paradigm is extended to biochemical principles and to myriad biomolecules. Biochemistry: An Organic Chemistry Approach provides a framework for understanding various topics of biochemistry, including the chemical behavior of biomolecules, enzyme activity, and more. It goes beyond mere memorization. Using several techniques to develop a relational understanding, including homework, this text helps students fully grasp and better correlate the essential organic chemistry concepts with those concepts at the root of biochemistry. The goal is to better understand the fundamental principles of biochemistry. Features: Presents a review chapter of fundamental organic chemistry principles and reactions. Presents and explains the fundamental principles of biochemistry using principles and common reactions of organic chemistry. Discusses enzymes, proteins, fatty acids, lipids, vitamins, hormones, nucleic acids and other biomolecules by comparing and contrasting them with the organic chemistry reactions that constitute the foundation of these classes of biomolecules. Discusses the organic synthesis and reactions of amino acids, carbohydrates, nucleic acids and other biomolecules.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

432

Publisher

CRC Press

Published Date

ISBN 10

1351258060

ISBN 13

9781351258067

Bitterness

Perception, Chemistry and Food Processing

By: Michel Aliani,Michael N. A. Eskin

Write a review Read reviews Take a Quiz Solve Book Puzzle

Bitterness

Perception, Chemistry and Food Processing

By: Michel Aliani,Michael N. A. Eskin

The increasing demand for healthy foods has resulted in the food industry developing functional foods with health-promoting and/or disease preventing properties. However, many of these products bring new challenges. While drugs are taken for their efficacy, functional foods need to have tastes that are acceptable to consumers. Bitterness associated with the functional foods is one of the major challenges encountered by food industry today and will remain so in years to come. This important book offers a thorough understanding of bitterness, the food ingredients that cause it and its accurate measurement. The authors provide a thorough review of bitterness that includes an understanding of the genetics of bitterness perception and the molecular basis for individual differences in bitterness perception. This is followed by a detailed review of the chemical structure of bitter compounds in foods where bitterness may be considered to be a positive or negative attribute. To better understand bitterness in foods, separation and analytical techniques used to identify and characterize bitter compounds are also covered. Food processing can itself generate compounds that are bitter, such as the Maillard reaction and lipid oxidation related products. Since bitterness is considered a negative attribute in many foods, the methods being used to remove and/mask it are also thoroughly discussed.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

260

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118590295

ISBN 13

9781118590294

Molecular Modeling in Heavy Hydrocarbon Conversions

By: Michael T. Klein,Gang Hou,Ralph Bertolacini,Linda J. Broadbelt,Ankush Kumar

Write a review Read reviews Take a Quiz Solve Book Puzzle

Molecular Modeling in Heavy Hydrocarbon Conversions

By: Michael T. Klein,Gang Hou,Ralph Bertolacini,Linda J. Broadbelt,Ankush Kumar

In the past two decades, new modeling efforts have gradually incorporated more molecular and structural detail in response to environmental and technical interests. Molecular Modeling in Heavy Hydrocarbon Conversions introduces a systematic molecule-based modeling approach with a system of chemical engineering software tools that can automate the e

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

263

Publisher

CRC Press

Published Date

ISBN 10

1420030612

ISBN 13

9781420030617

Thermodynamics of Organic Compounds in the Gas State

By: Michael Frenkel,G J Kabo,K N Marsh,G N Roganov,R C Wilhoit

Write a review Read reviews Take a Quiz Solve Book Puzzle

Thermodynamics of Organic Compounds in the Gas State

By: Michael Frenkel,G J Kabo,K N Marsh,G N Roganov,R C Wilhoit

Volume II of two, from the Thermodymaics Research Centre, this includes Thermodynamic Functions of the Substances in the Ideal Gas State; and Empirical Functions for Thermodynamical Properties of Ideal Gases.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

1052

Publisher

CRC Press

Published Date

ISBN 10

188340004X

ISBN 13

9781883400040

Environmental Health and the U.S. Federal System

Sustainably Managing Health Hazards

By: Michael R Greenberg,Dona Schneider

Write a review Read reviews Take a Quiz Solve Book Puzzle

Environmental Health and the U.S. Federal System

Sustainably Managing Health Hazards

By: Michael R Greenberg,Dona Schneider

This book explains how the U.S. federal system manages environmental health issues, with a unique focus on risk management and human health outcomes. Building on a generic approach for understanding human health risk, this book shows how federalism has evolved in response to environmental health problems, political and ideological variations in Washington D.C, as well as in-state and local governments. It examines laws, rules and regulations, showing how they stretch or fail to adapt to environmental health challenges. Emphasis is placed on human health and safety risk and how decisions have been influenced by environmental health information. The authors review different forms of federalism, and analyse how it has had to adapt to ever evolving environmental health hazards, such as global climate change, nanomaterials, nuclear waste, fresh air and water, as well as examining the impact of robotics and artificial intelligence on worker environmental health. They demonstrate the process for assessing hazard information and the process for federalism risk management, and subsequently arguing that human health and safety should receive greater attention. This book will be essential reading for students and scholars working on environmental health and environmental policy, particularly from a public health, and risk management viewpoint, in addition to practitioners and policymakers involved in environmental management and public policy.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

307

Publisher

Routledge

Published Date

ISBN 10

042955530X

ISBN 13

9780429555305

Cholera, Chloroform, and the Science of Medicine

A Life of John Snow

By: Peter Vinten-Johansen,Howard Brody,Nigel Paneth,Stephen Rachman,Michael Rip,David Zuck

Write a review Read reviews Take a Quiz Solve Book Puzzle

Cholera, Chloroform, and the Science of Medicine

A Life of John Snow

By: Peter Vinten-Johansen,Howard Brody,Nigel Paneth,Stephen Rachman,Michael Rip,David Zuck

The product of six years of collaborative research, this fine biography offers new interpretations of a pioneering figure in anesthesiology, epidemiology, medical cartography, and public health. It modifies the conventional rags to riches portrait of John Snow by synthesizing fresh information about his early life from archival research and recent studies. It explores the intellectual roots of his commitments to vegetarianism, temperance, and pure drinking water, first developed when he was a medical apprentice and assistant in the north of England. The authors argue that all of Snow's later contributions are traceable to the medical paradigm he imbibed as a medical student in London and put into practice early in his career as a clinician: that medicine as a science required the incorporation of recent developments in its collateral sciences--chiefly anatomy, chemistry, and physiology--in order to understand the causes of disease. Snow's theoretical breakthroughs in anesthesia were extensions of his experimental research in respiratory physiology and the properties of inhaled gases. Shortly thereafter, his understanding of gas laws led him to reject miasmatic explanations for the spread of cholera, and to develop an alternative theory in consonance with what was then known about chemistry and the physiology of digestion. Using all of Snow's writings, the authors follow him when working in his home laboratory, visiting patients throughout London, attending medical society meetings, and conducting studies during the cholera epidemics of 1849 and 1854. The result is a book that demythologizes some overly heroic views of Snow by providing a fairer measure of his actual contributions. It will have an impact not only on the understanding of the man but also on the history of epidemiology and medical science.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

456

Publisher

Oxford University Press

Published Date

ISBN 10

019028563X

ISBN 13

9780190285630

The Antimicrobial Drugs

By: Eric Michael Scholar,William B. Pratt

Write a review Read reviews Take a Quiz Solve Book Puzzle

The Antimicrobial Drugs

By: Eric Michael Scholar,William B. Pratt

For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

632

Published Date

ISBN 10

0195125282

ISBN 13

9780195125283

Levin and O'Neal's the Diabetic Foot

By: Marvin E. Levin,John H. Bowker,Michael A. Pfeifer

Write a review Read reviews Take a Quiz Solve Book Puzzle

Levin and O'Neal's the Diabetic Foot

By: Marvin E. Levin,John H. Bowker,Michael A. Pfeifer

Fully updated, now in full color, this latest edition of Levin and O'Neal's The Diabetic Foot provides diagnostic and management information for the challenging problems faced by patients with diabetic foot problems. The book has a team care focus and offers tips and pearls in every chapter.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

648

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323041450

ISBN 13

9780323041454

Vascular and Interventional Radiology: The Requisites

By: John A. Kaufman,Michael J. Lee

Write a review Read reviews Take a Quiz Solve Book Puzzle

Vascular and Interventional Radiology: The Requisites

By: John A. Kaufman,Michael J. Lee

Get the essential tools you need to make an accurate diagnosis with Vascular and Interventional Radiology: The Requisites! This bestselling volume delivers the conceptual, factual, and interpretive information you need for effective clinical practice in vascular and interventional radiology, as well certification and recertification review. Master core knowledge the easy and affordable way with clear, concise text enhanced by at-a-glance illustrations, boxes, and tables ? all completely rewritten to bring you up to date with today?s state of the art in vascular and interventional radiology. "... a volume that should retain its utility for several years to come, both as a primer for radiology trainees and fellows at the start of their IR training and as a reference for more experienced interventionalists." Reviewed by Dr Simon Padley and Dr Narayanan Thulasidasan on behalf of RAD Magazine, April 2015 Understand the basics with a comprehensive yet manageable review of the principles and practice of vascular and interventional radiology. Whether you're a resident preparing for exams or a practitioner needing a quick-consult source of information, Vascular and Interventional Radiology is your guide to the field. Master the latest techniques for liver-directed cancer interventions; arterial and venous interventions including stroke therapy; thoracic duct embolization; peripheral arterial interventions; venous interventions for thrombosis and reflux; percutaneous ablation procedures; and much more. Prepare for the written board exam and for clinical practice with critical information on interventional techniques and procedures. Clearly visualize the findings you're likely to see in practice and on exams with vibrant full-color images and new vascular chapter images. Access the complete, fully searchable text and downloadable images online with Expert Consult.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

625

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323045847

ISBN 13

9780323045841

Book's by Michael McLafferty

Username

Password

Password again

Birthday

Email