Quantitative NMR (qNMR) has been around for a long time, but also has great potential to solve future problems in any quantitative analysis. As a primary method, it differs fundamentally from chromatographic methods: it is better described as a quantum mechanical balance. Successful implementation of qNMR requires certain attention to detail. 'qNMR - the handbook' is intended to be a guide for analysts to help understand the fundamental principles of NMR and the significant points relating to its implementation for quantitation. Regulatory considerations of qNMR adoption are explained. NMR fundamentals are explained to provide understanding. Together with many useful examples, the book is a compelling addition to the laboratory's reference library, providing all the tools that any practitioner should know to successfully implement qNMR. The authors are qNMR pioneers and come from a variety of backgrounds including business, government, and academia.
Dublin 1940. An IRA attack leaves two guards dead on the streets of Dublin. Two days later, a battle between warring gangs erupts at a race meeting, and on Ireland's east coast the cremated bodies of a wealthy family of five are found in their shuttered, burned-out villa. Dispatched from Special Branch to investigate, Detective Inspector Stefan Gillespie soon finds himself caught in a web of Irish, British and German Intelligence - all playing against each other, all watching each other, and all plagued by rogue operators they can't quite control, as the certainty grows that Hitler is about to invade England. And then, Stephen is sent to Berlin on a sensitive mission. His journey home becomes a dangerous pursuit in which no one can be trusted and the information he carries puts his life on the line.
The last research frontier in high frequency electronics now lies in the so-called THz (or submillimeter-wave) regime between the traditional microwave and infrared domains. Significant scientific and technical challenges within the terahertz (THz) frequency regime have recently motivated an array of new research activities. During the last few years, major research programs have emerged that are focused on advancing the state of the art in THz frequency electronic technology and on investigating novel applications of THz frequency sensing. This book serves as a detailed reference for the new THz frequency technological advances that are emerging across a wide spectrum of sensing and technology areas.
Tap into the gold standard on central nervous system infections: Infections of the Central Nervous System, 4e is now fully revised and updated to accommodate the wealth of new CNS information discovered over the past decade. More than 90 leading experts contribute chapters, providing comprehensive, up-to-date information. With a broad scope and thorough detail, the text addresses pathogenesis, clinical manifestations, diagnosis, and therapy of various CNS infections and related conditions. Features: Every chapter has been extensively revised and updated, nearly half with new author teams NEW chapter on acute encephalitis NEW clinical information on treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease NEW color design and color images Numerous diagrams, figures, tables, illustrations and photographs demonstrate the content Evidence-based references
This history of the discipline of public law in Germany covers three dramatic decades of the Twentieth century. It opens with the First World War, analyses the highly creative years of the Weimar Republic, and recounts the decline of German public law that began in 1933 and extended to the downfall of the Third Reich.
Health professionals are recognizing the major role that nutraceuticals play in health enhancement. As a result, there is a dramatic increase in research aimed at identifying new functional foods and nutraceuticals. There is not, however, a single source that presents this research in a thorough and accessible manner. Comprehensive and complete, th
Michael Stolberg offers the first comprehensive presentation of medical training and day-to-day medical practice during the Renaissance. Drawing on previously unknown manuscript sources, he describes the prevailing notions of illness in the era, diagnostic and therapeutic procedures, the doctor–patient relationship, and home and lay medicine.
Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.
Network Security, Firewalls, and VPNs, third Edition provides a unique, in-depth look at the major business challenges and threats that are introduced when an organization’s network is connected to the public Internet.
This groundbreaking two-volume handbook provides a comprehensive collection of evidence-based analyses of the causes, treatment, and prevention of eating disorders. A two-volume handbook featuring contributions from an international group of experts, and edited by two of the leading authorities on eating disorders and body image research Presents comprehensive coverage of eating disorders, including their history, etiological factors, diagnosis, assessment, prevention, and treatment Tackles controversies and previously unanswered questions in the field Includes coverage of DSM-5 and suggestions for further research at the end of each chapter 2 Volumes
The Queen’s Gambit is easily the most talked-about chess opening since the immensely popular Netflix TV series of the same name became a hit. The screen adventures of Beth Harmon have inspired thousands to start playing the Royal Game but didn’t offer any information on this highly popular chess opening. This book fills that gap. German Grandmaster Michael Prusikin presents a solid but dynamic opening repertoire for Black against the Queen’s Gambit. He wants you to understand rather than memorize what is important. His primary focus is on explaining the relevant pawn structures and the middlegame ideas behind the lines he recommends. Prusikin deals with every single variation of the Queen’s Gambit in a way that is highly accessible for club players but at the same time surprisingly effective and concise: the Catalan, Tartakower, Carlsbad, London, Colle, Veresov, and all the others. As a bonus, the FIDE Senior Trainer also provides responses to openings such as the Bird, Réti, and Nimzo-Larsen. It may seem unlikely, and yet it is true: in less than 200 pages, Countering the Queen’s Gambit has Black covered for really every first move except 1.e4! To test your newly acquired insights in the tactical motifs and strategic ideas of the Queen’s Gambit, you are invited to solve 36 exercises in carefully selected key positions from actual games.
This book departs from the assumption that Artificial Intelligence (AI) systems will provide a maximum advantage by replacing human cognitive processing. Instead, this book subscribes to the assumption that AI systems will provide a maximal advantage when the system is specifically designed to augment human intelligence. It provides methods for designing effective systems that include one or more humans and one or more AI entities and uses the approach that assumes automation does not replace human activity but fundamentally changes the structure of human work when AI is added to existing systems. Integrating Artificial and Human Intelligence through Agent Oriented Systems Design discusses the potential impact of AI on human work and life and explores why teamwork is necessary today for complex work environments. The book explains the processes and methods humans employ to effectively team with one another and presents the elements of artificial agents that permit them to function as team members in joint human and artificial teams. It discusses design goals and illustrates how the methods that have been used to model the complex interactions among human and artificial agents can be expanded to enable the design of interaction between them to make possible the attainment of the shared goals. Model-Based Systems Engineering (MBSE) tools that provide logical designs of human–agent teams, the AI within these teams, training to be deployed for human and artificial agent team members, and the interfaces between human and artificial agent team members are all covered. MBSE files containing profiles and examples for building MBSE models used in the design approach are featured on the author’s website (https://lodesterresci.com/hat). This book is an ideal read for students, professors, engineers, and project managers associated with designing and developing AI systems or systems that seek to incorporate AI.
A practical and accessible introduction to the bootstrap method——newly revised and updated Over the past decade, the application of bootstrap methods to new areas of study has expanded, resulting in theoretical and applied advances across various fields. Bootstrap Methods, Second Edition is a highly approachable guide to the multidisciplinary, real-world uses of bootstrapping and is ideal for readers who have a professional interest in its methods, but are without an advanced background in mathematics. Updated to reflect current techniques and the most up-to-date work on the topic, the Second Edition features: The addition of a second, extended bibliography devoted solely to publications from 1999–2007, which is a valuable collection of references on the latest research in the field A discussion of the new areas of applicability for bootstrap methods, including use in the pharmaceutical industry for estimating individual and population bioequivalence in clinical trials A revised chapter on when and why bootstrap fails and remedies for overcoming these drawbacks Added coverage on regression, censored data applications, P-value adjustment, ratio estimators, and missing data New examples and illustrations as well as extensive historical notes at the end of each chapter With a strong focus on application, detailed explanations of methodology, and complete coverage of modern developments in the field, Bootstrap Methods, Second Edition is an indispensable reference for applied statisticians, engineers, scientists, clinicians, and other practitioners who regularly use statistical methods in research. It is also suitable as a supplementary text for courses in statistics and resampling methods at the upper-undergraduate and graduate levels.
Michael Hrobak studied hybrid integrated front end modules for high frequency measurement equipment and especially for synthetic automatic test systems. Recent developments of innovative, critical millimeter-wave components like frequency multipliers, directional couplers, filters, triple balanced mixers and power detectors are illustrated by the author separately and in combination.
This foundational coursebook offers an accessible and up-to-date introduction to all relevant areas of Teaching English. Definitions and practical examples guide the understanding and reflection of basic and advanced concepts of foreign language learning. The fully revised second edition responds to new developments in language education: (1) Recent policies from the Kultusministerkonferenz and updates of the Common European Framework of Reference for Languages with its Companion Volume (2020) pay more attention to language awareness, mediation, and media literacy. (2) New empirical research explores the aims, methods, and impact of professional teacher education, Task-Based Language Teaching, and Content-and-Language-Integrated Learning. (3) The dramatic need for online teaching has met with refined concepts of multimodal media competence and cutting-edge tools for the digital classroom. This essential introduction and the PowerPoint presentations online facilitate multimodal teaching and learning.
Kommentierte Bibliografie. Sie gibt Wissenschaftlern, Studierenden und Journalisten zuverlässig Auskunft über rund 6000 internationale Veröffentlichungen zum Thema Film und Medien. Die vorgestellten Rubriken reichen von Nachschlagewerk über Filmgeschichte bis hin zu Fernsehen, Video, Multimedia.
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