New Mexico's Española Valley is situated in the northern part of the state between the fabled Sangre de Cristo and Jemez Mountains. Many of the Valley’s communities have roots in the Spanish and Mexican periods of colonization, while the Native American Pueblos of Ohkay Owingeh and Santa Clara are far older. The Valley's residents include a large Native American population, an influential "Anglo" or "non-Hispanic white" minority, and a growing Mexican immigrant community. In spite of the varied populace, native New Mexican Latinos, or Nuevomexicanos, remain the majority and retain control of area politics. In this experimental ethnography, Michael Trujillo presents a vision of Española that addresses its denigration by neighbors--and some of its residents--because it represents the antithesis of the positive narrative of New Mexico. Contradicting the popular notion of New Mexico as the "Land of Enchantment," a fusion of race, landscape, architecture, and food into a romanticized commodity, Trujillo probes beneath the surface to reveal the causes of social dysfunction brought about by colonization and te transition from a pastoral to an urban economy.
An Atlas and Survey of Latin American History provides a comprehensive, accessible introduction to both the human and physical geography of Latin America and the social, cultural, political and economic events that have defined its history. Featuring 77 maps and accompanying text, the book provides topical overviews of the key developments and movements in Latin American history, ranging from the earliest human settlement to the present day. The fully updated second edition includes a new chapter on Latin America in the 21st century, featuring maps and essays on topics ranging from sports and telenovelas to the growth of the Latin American middle class and the rise and ebb of left-leaning political movements. Highly readable and beautifully designed, An Atlas and Survey of Latin American History 2e remains an engaging resource for students and others interested in Latin American history, politics, and culture.
Volume Two of an award-winning professor's introduction to essential concepts of calculus and mathematical modeling for students in the biosciences This is the second of a two-part series exploring essential concepts of calculus in the context of biological systems. Building on the essential ideas and theories of basic calculus taught in Mathematical Models in the Biosciences I, this book focuses on epidemiological models, mathematical foundations of virus and antiviral dynamics, ion channel models and cardiac arrhythmias, vector calculus and applications, and evolutionary models of disease. It also develops differential equations and stochastic models of many biomedical processes, as well as virus dynamics, the Clancy-Rudy model to determine the genetic basis of cardiac arrhythmias, and a sketch of some systems biology. Based on the author's calculus class at Yale, the book makes concepts of calculus less abstract and more relatable for science majors and premedical students.
Symbolic regression (SR) is one of the most powerful machine learning techniques that produces transparent models, searching the space of mathematical expressions for a model that represents the relationship between the predictors and the dependent variable without the need of taking assumptions about the model structure. Currently, the most prevalent learning algorithms for SR are based on genetic programming (GP), an evolutionary algorithm inspired from the well-known principles of natural selection. This book is an in-depth guide to GP for SR, discussing its advanced techniques, as well as examples of applications in science and engineering. The basic idea of GP is to evolve a population of solution candidates in an iterative, generational manner, by repeated application of selection, crossover, mutation, and replacement, thus allowing the model structure, coefficients, and input variables to be searched simultaneously. Given that explainability and interpretability are key elements for integrating humans into the loop of learning in AI, increasing the capacity for data scientists to understand internal algorithmic processes and their resultant models has beneficial implications for the learning process as a whole. This book represents a practical guide for industry professionals and students across a range of disciplines, particularly data science, engineering, and applied mathematics. Focused on state-of-the-art SR methods and providing ready-to-use recipes, this book is especially appealing to those working with empirical or semi-analytical models in science and engineering.
Foreword by James F. Dunnigan. From Alexander the Great to Adolf Hitler and Joan of Arc to George S. Patton, The Miltiary 100 vividly details the lives of the world's most famous - and infamous - military leaders. Now in paperback, this provocative compendium ranks the heroes and villains, liberators and conquerors, those who invented the tools of combat, and those who developed the art of war. Sure to generate controversy, this edition provides invaluable insight into those who have shaped history. Illustrated with 100 photos, prints and drawings.
A study of the powerful impact that sugar had on U.S.-Dominican relations as the primary vehicle of reciprocal manipulation from 1958 to 1962, Sugar and Power examines the development of the sugar industry in the Dominican Republic. Hall uncovers new evidence that supports the belief that U.S.-Latin American relations during this period were frequently a two-way street, with the United States reacting to Latin American initiatives just as frequently as Latin Americans responded to American initiatives. Both Eisenhower and Kennedy used sugar quota legislation as a foreign policy tool. At the same time, the Trujillo regime played upon Washington's fear of communism in response to the Cuban revolution to obtain an expanded sugar quota. Drawing heavily on U.S. and Dominican government documents, this study argues that the U.S. initiated economic sanctions against Trujillo to gain hemispheric support against Castro's Cuban revolution. Kennedy expanded those sanctions in an attempt to push the Dominican Republic along the path toward democracy. Although Juan Bosch's election at the end of 1962 and the allotment of a generous sugar quota indicated the apparent success of U.S. foreign policy toward the Dominican Republic, the overthrow of Bosch in 1963 indicated that the path toward democracy was longer than American policy makers had anticipated. This case study in the role of economic coercion in U.S.-Latin American relations during the Cold War tries to present a balanced account of both sides of the story.
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
Protecting the natural environment and promoting sustainability have become important objectives, but achieving such goals presents myriad challenges for even the most committed environmentalist. American Environmentalism: Philosophy, History, and Public Policy examines whether competing interests can be reconciled while developing consistent, coherent, effective public policy to regulate uses and protection of the natural environment without destroying the national economy. It then reviews a range of possible solutions. The book delves into key normative concepts that undergird American perspectives on nature by providing an overview of philosophical concepts found in the western intellectual tradition, the presuppositions inherent in neoclassical economics, and anthropocentric (human-centered) and biocentric (earth-centered) positions on sustainability. It traces the evolution of attitudes about nature from the time of the Ancient Greeks through Europeans in the Middle Ages and the Renaissance, the Enlightenment and the American Founders, the nineteenth and twentieth centuries, and up to the present. Building on this foundation, the author examines the political landscape as non-governmental organizations (NGOs), industry leaders, and government officials struggle to balance industrial development with environmental concerns. Outrageous claims, silly misrepresentations, bogus arguments, absurd contentions, and overblown prophesies of impending calamities are bandied about by many parties on all sides of the debate—industry spokespeople, elected representatives, unelected regulators, concerned citizens, and environmental NGOs alike. In lieu of descending into this morass, the author circumvents the silliness to explore the crucial issues through a more focused, disciplined approach. Rather than engage in acrimonious debate over minutiae, as so often occurs in the context of "green" claims, he recasts the issue in a way that provides a cohesive look at all sides. This effort may be quixotic, but how else to cut the Gordian knot?
First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke. Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Make efficient and accurate diagnoses with the aid of abundant full-color CT images and pathology slides. Stay up to date on hot topics such as mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more.
This thoroughly revised and updated second edition of Operations Management in Healthcare: Strategy and Practice describes how healthcare organizations can cultivate a competitive lead by developing superior operations using a strategic perspective. In clearly demonstrating the "how-tos" of effectively managing a healthcare organization, this new edition also addresses the "why" of providing quality and value-based care. Comprehensive and practice-oriented, chapters illustrate how to excel in the four competitive priorities - quality, cost, delivery, and flexibility - in order to build a cumulative model of healthcare operations in which all concepts and tools fit together. This textbook encourages a hands-on approach and integrates mind maps to connect concepts, icons for quick reference, dashboards for measurement and tracking of progress, and newly updated end-of-chapter problems and assignments to reinforce creative and critical thinking. Written with the diverse learning needs in mind for programs in health administration, public health, business administration, public administration, and nursing, the textbook equips students with essential high-level problem-solving and process improvement skills. The book reveals concepts and tools through a series of short vignettes of a fictitious healthcare organization as it embarks on its journey to becoming a highly reliable organization. This second edition also includes a strong emphasis on the patient's perspective as well as expanded and added coverage of Lean Six Sigma, value-based payment models, vertical integration, mergers and acquisitions, artificial intelligence, population health, and more to reflect evolving innovations in the healthcare environment across the United States. Complete with a full and updated suite of Instructor Resources, including Instructor’s Manual, PowerPoints, and test bank in addition to data sets, tutorial videos, and Excel templates for students. Key Features: Demonstrates the "how-tos" of effectively managing a healthcare organization Sharpens problem-solving and process improvement skills through use of an extensive toolkit developed throughout the text Prepares students for Lean Six Sigma certification with expanded coverage of concepts, tools, and analytics Highlights new trends in healthcare management with coverage of value-based payments, mergers and acquisitions, population health, telehealth, and more Intertwines concepts with vivid vignettes to describe human dynamics, organizational challenges, and applications of tools Employs boxed features and YouTube videos to address frequently asked questions and real-world instances of operations in practice
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