The Real Case for Driverless Mobility: Putting Driverless Vehicles to Use for Those Who Really Need a Ride explores solutions for providing mobility for the unserved/underserved, including those who cannot drive themselves, afford transport alternatives, or who live in areas where neither public nor private transport is offered. The book synthesizes the career-long activities of the authors and the Princeton SmartDrivingCars Summits and assesses whether cars without drivers can deliver an affordable and more effective alternative to mass transit and taxis. A high percentage of the residents in many U.S. cities are poor, and the jobs that remain are often not easily reached by public transit systems which struggle to deliver a minimum level of service with their limited budgets. The SDC Summits were initiated in 2017 by Alain Kornhauser to attempt to address this problem. This book presents the problem and the proposed solution in a form that can be used by a wide audience and help build a constituency, both for the proof of concept and for an eventual implementation in many cities and towns in North America and other parts of the world. Professionals, investors, researchers and students alike will find this book a valuable exploration of how driverless technology can be applied to personal transport that can be used by a large sub-group of the population who are not currently served by automobile transport and are poorly served by public transport solutions. Takes a perspective from the demand side focused on the have-nots and on assessing and designing the technology to start there and grow Looks at how to start small, achieve success, and evolve to scale, with an emphasis on affordability Discusses automated vehicles from a multidisciplinary perspective with each chapter touching on a unique issue related to AVs
The Real Case for Driverless Mobility: Putting Driverless Vehicles to Use for Those Who Really Need a Ride explores solutions for providing mobility for the unserved/underserved, including those who cannot drive themselves, afford transport alternatives, or who live in areas where neither public nor private transport is offered. The book synthesizes the career-long activities of the authors and the Princeton SmartDrivingCars Summits and assesses whether cars without drivers can deliver an affordable and more effective alternative to mass transit and taxis. A high percentage of the residents in many U.S. cities are poor, and the jobs that remain are often not easily reached by public transit systems which struggle to deliver a minimum level of service with their limited budgets. The SDC Summits were initiated in 2017 by Alain Kornhauser to attempt to address this problem. This book presents the problem and the proposed solution in a form that can be used by a wide audience and help build a constituency, both for the proof of concept and for an eventual implementation in many cities and towns in North America and other parts of the world. Professionals, investors, researchers and students alike will find this book a valuable exploration of how driverless technology can be applied to personal transport that can be used by a large sub-group of the population who are not currently served by automobile transport and are poorly served by public transport solutions. Takes a perspective from the demand side focused on the have-nots and on assessing and designing the technology to start there and grow Looks at how to start small, achieve success, and evolve to scale, with an emphasis on affordability Discusses automated vehicles from a multidisciplinary perspective with each chapter touching on a unique issue related to AVs
Molecular studies reveal highly ordered geographic patterns in plant and animal distributions. The tropics illustrate these patterns of community immobilism leading to allopatric differentiation, as well as other patterns of mobilism, range expansion, and overlap of taxa. Integrating Earth history and biogeography, Molecular Panbiogeography of the Tropics is an alternative view of distributional history in which groups are older than suggested by fossils and fossil-calibrated molecular clocks. The author discusses possible causes for the endemism of high-level taxa in tropical America and Madagascar, and overlapping clades in South America, Africa, and Asia. The book concludes with a critique of adaptation by selection, founded on biogeography and recent work in genetics.
MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.
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