This book is an investigation into processes associated with evolutionary divergence and diversification, focussing on the role played by the exchange of genes between divergent lineages.
Michael L. Arnold offers an exploration of the evolutionary process of natural hybridisation, and presents data from various sources that support the paradigm of natural hybridisation as an important evolutionary process.
Even before the publication of Darwin's Origin of Species, the perception of evolutionary change has been a tree-like pattern of diversification - with divergent branches spreading further and further from the trunk. In the only illustration of Darwin's treatise, branches large and small never reconnect. However, it is now evident that this view does not adequately encompass the richness of evolutionary pattern and process. Instead, the evolution of species from microbes to mammals builds like a web that crosses and re-crosses through genetic exchange, even as it grows outward from a point of origin. Some of the avenues for genetic exchange, for example introgression through sexual recombination versus lateral gene transfer mediated by transposable elements, are based on definably different molecular mechanisms. However, even such widely different genetic processes may result in similar effects on adaptations (either new or transferred), genome evolution, population genetics, and the evolutionary/ecological trajectory of organisms. For example, the evolution of novel adaptations (resulting from lateral gene transfer) leading to the flea-borne, deadly, causative agent of plague from a rarely-fatal, orally-transmitted, bacterial species is quite similar to the adaptations accrued from natural hybridization between annual sunflower species resulting in the formation of several new species. Thus, more and more data indicate that evolution has resulted in lineages consisting of mosaics of genes derived from different ancestors. It is therefore becoming increasingly clear that the tree is an inadequate metaphor of evolutionary change. In this book, Arnold promotes the 'web-of-life' metaphor as a more appropriate representation of evolutionary change in all lifeforms. This research level text is suitable for senior undergraduate and graduate level students taking related courses in departments of genetics, ecology and evolution. It will also be of relevance and use to professional evolutionary biologists and systematists seeking a comprehensive and authoritative overview of this rapidly expanding field.
This work considers a small random perturbation of alpha-stable jump type nonlinear reaction-diffusion equations with Dirichlet boundary conditions over an interval. It has two stable points whose domains of attraction meet in a separating manifold with several saddle points. Extending a method developed by Imkeller and Pavlyukevich it proves that in contrast to a Gaussian perturbation, the expected exit and transition times between the domains of attraction depend polynomially on the noise intensity in the small intensity limit. Moreover the solution exhibits metastable behavior: there is a polynomial time scale along which the solution dynamics correspond asymptotically to the dynamic behavior of a finite-state Markov chain switching between the stable states.
This book describes the important role that the transfer of genes between organisms has played during the origin and evolution of humans, and the evolution of organisms on which the human species depends for shelter, sustenance and companionship.
For 25 years, Lewis's Child and Adolescent Psychiatry has been the cornerstone of every child and adolescent psychiatrist’s library. Now, three colleagues of Dr. Lewis at the world-renowned Yale Child Study Center, have substantially updated and revised this foundational textbook for its long-awaited fifth edition, the first in ten years. Encyclopedic in scope, it continues to serve as a broad reference, deftly encompassing and integrating scientific principles, research methodologies, and everyday clinical care.
A Doody's Core Title for 2023! The #1 Textbook in Pharmacotherapy providing optimal patient outcomes using evidence-based medication therapies—updated with the latest advances and guidelines For more than 30 years, DiPiro’s Pharmacotherapy has been the essential textbook for learning how to properly select, administer, and monitor drugs―everything needed to provide safe, effective drug therapy across all therapeutic categories. This new edition has been fully updated with the latest evidence-based information and recommendations. With content from 300 expert contributors, this valuable resource offers detailed descriptions of common and uncommon disease states, including treatment by pharmacologic and non-pharmacologic means. Each disease chapter opens with a Patient Care Process, helping readers understand the collaborative care model in which pharmacists work and communicate with other healthcare providers for effective coordinated care. Here's why DiPiro's Pharmacotherapy: A Pathophysiologic Approach is the perfect learning tool for students, pharmacists, and other healthcare providers: All chapters provide the most current, reliable, and relevant information available Key concepts are included at the beginning of each chapter Clinical Presentation boxes concisely outline disease signs and symptoms New: Beyond the Book feature points readers to multimedia resources to deepen their understanding of the material Diagnostic flow diagrams, treatment algorithms, dosing guideline recommendations, and monitoring approaches clearly distinguish treatment pathways New: Drug monitoring tables have been added Patient care process boxes help readers know how to communicate with other health care providers New: Additional FREE E-Chapters are available on AccessPharmacy New: Over 2000 Review Questions to help prepare students!
J. Howard Wert's Lost History of the 209Th Regiment, Pennsylvania Volunteer Infantry, 1864-1865, Including the Defense of Bermuda Hundred, the Battle of Fort Stedman and the Storming of Petersburg with Additional Documents
J. Howard Wert's Lost History of the 209Th Regiment, Pennsylvania Volunteer Infantry, 1864-1865, Including the Defense of Bermuda Hundred, the Battle of Fort Stedman and the Storming of Petersburg with Additional Documents
Glorious Recollections: J. Howard Wert's Lost History of the 209th Regiment, Pennsylvania Volunteer Infantry, 1864-1865, including the Battles of Bermuda Hundred, Fort Stedman, and Petersburg is a Civil War regimental history originally written in 1894. It was not published at the time and has now been edited and supplemented for today's readers. Wert's text is both a detailed history and a devoted memoir. It describes his regiment's actions in the closing months of the war, particularly its participation in the battles of Bermuda Hundred, Fort Stedman, and Petersburg, and, after the war, its marching in the Grand Review. On the same pages, Wert also shows Civil War memory and veteran pride taking shape. The editors have supplemented Wert's manuscript with introductory and interpretive essays, personal documents from the soldiers, reminiscences from unit reunions, a biographical sketch of its commander, a collective portrait of one of its companies, and the rosters of the entire regiment. The publication of this regimental history, previously unknown, adds to our understanding of Pennsylvania soldiers serving late in the war. Many of them had prior service while others were enlisting for the first time, such as Wert himself. This history also deepens our understanding of J. Howard Wert, one of Pennsylvania's most productive historians, novelists, poets and educators in the late 19th century. His account of a notorious Harrisburg neighborhood, the "Old Eighth Ward," has been republished recently; his "lost world" science fiction novel, Alecto and Ebony, is being prepared for publication; his Civil War poetry has been well-known for over a century; his collection of Battle of Gettysburg artifacts is world famous; and with this book his accomplishment as a military historian comes to light.
Every step in the business bankruptcy litigation process is covered in Aspen Publishersand’ Bankruptcy Litigation Manual, from the drafting of the first pleadings through the appellate process. In fact, by making the Bankruptcy Litigation Manual a part of your working library, you not only get detailed coverage of virtually all the topics and issues you must consider in any bankruptcy case, you also get field-tested answers to questions you confront every day, such as: How to stay continuing litigation against a corporate debtorand’s non-debtor officers? What are the limits on suing a bankruptcy trustee? Is the Deprizio Doctrine still alive? Does an individual debtor have an absolute right to convert a case from Chapter 7 to Chapter 13? What prohibitions exist on cross-collateralization in financing disputes? Are option contracts and“executoryand” for bankruptcy purposes? When, and under what circumstances, may a bankruptcy court enjoin an administrative proceeding against a Chapter 11 debtor? What are the current standards for administrative priority claims? When must a creditor assert its setoff rights? When can a remand order issued by a district court be reviewed by a court of appeals? What are the limits on challenging pre-bankruptcy real property mortgage foreclosures as fraudulent transfers? Can an unsecured lender recover contract-based legal fees incurred in post- bankruptcy litigation on issues of bankruptcy law? Is there a uniform federal limitation on perfecting security interests that primes a longer applicable state law period, thus subjecting lenders to a preference attack? Do prior bankruptcy court orders bar a plaintiffand’s later state court suit and warrant removal of the action in federal court? Michael L. Cook, a partner at Schulte Roth and& Zabel LLP in New York and former long-time Adjunct Professor at New York University School of Law, has gathered together some of the countryand’s top bankruptcy litigators to contribute to Bankruptcy Litigation Manual. Contributing Authors: Jay Alix, Southfield, MI Neal Batson, Alston and& Bird, LLP, Atlanta, GA Kenneth K. Bezozo, Haynes and Boone, New York, NY Susan Block-Lieb, Fordham University School of Law, Newark, NJ Peter W. Clapp, Valle Makoff, LLP, San Francisco, CA Dennis J. Connolly, Alston and& Bird, LLP, Atlanta, GA David N. Crapo, Gibbons P.C., Newark, NJ Karen A. Giannelli, Gibbons P.C., Newark, NJ David M. Hillman, Schulte Roth and& Zabel, LLP, New York, NY Alfred S. Lurey, Kilpatrick and& Stockton, Atlanta, GA Gerald Munitz, Butler Rubin, Salterelli and& Boyd, LLP, Chicago, IL Robert L. Ordin, Retired Bankruptcy Court Judge Stephen M. Pezanosky, Haynes and Boone, LLP, Partner and Chair of Bankruptcy Section, Fort Worth, TX Robin E. Phelan, Haynes and Boone, LLP Dallas, TX Daniel H. Squire, Wilmer Cutler Pickering Hale and Dorr, LLP, Washington, DC Michael L. Temin, Fox Rothschild, LLP, Philadelphia, PA Sheldon S. Toll, Law Office ofSheldon S. Toll, Southfield, MI Jason H. Watson, Alston and& Bird, LLP, Atlanta, GA Kit Weitnauer, Alston and& Bird, LLP, Atlanta, GA Written by Mr. Cook and nineteen other experts, Bankruptcy Litigation Manual provides authoritative, up-to-date information on virtually every aspect of the bankruptcy litigation process, from discovery through appeal.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. 25+ additional chapters available online! The classic guide to driving optimal patient outcomes using evidence-based medication therapies—updated with the latest advances and guidelines Presented in full color, Pharmacotherapy: A Pathophysiologic Approach, 11th Edition helps you deliver the highest-quality patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. It takes you beyond drug indications and dosages, showing how to properly select, administer, and monitor drugs—everything you need to provide safe, effective drug therapy across all therapeutic categories. With all-new monitoring tables and authoritative content from 300 expert contributors, this new edition has been fully updated to reflect the latest evidence-based information and recommendations. You’ll find Key Concepts at the beginning of each chapter, Clinical Presentation tables that summarize disease signs and symptoms, and Clinical Controversies boxes that examine the complicated issues faced by students and clinicians in providing drug therapy. Why Pharmacotherapy: A Pathophysiologic Approach is perfect for students, pharmacists, and other healthcare providers: • All chapters provide the most current, reliable, and relevant information available. • Key concepts kick off every chapter. • Clinical Presentation Tables summarize disease signs and symptoms. • The majority of sections include personalized pharmacotherapy content. • Clinical Controversies Boxes clarify the most complex drug therapy issues you’ll face. • Diagnostic flow diagrams, treatment algorithms, dosing recommendations, and monitoring approaches have been updated in full color to distinguish treatment pathways. • Most disease-oriented chapters are enhanced by updated evidence-based treatment guidelines, which often include ratings of the level of evidence to support key therapeutic approaches. • Instructors who adopt this text are eligible for a PowerPoint presentation of all images and answers to Self-Assessment Questions! The most trusted guide of its kind for decades, Pharmacotherapy: A Pathophysiologic Approach is the go-to text for students and practitioners seeking clear, objective coverage of core pathophysiologic and therapeutic elements.
TRB's National Cooperative Highway Research Program (NCHRP) Report 803: Pedestrian and Bicycle Transportation Along Existing Roads--ActiveTrans Priority Tool Guidebook presents a tool and guidance that may be used to help prioritize improvements to pedestrian and bicycle facilities, either separately or together as part of a "complete streets" evaluation approach. The guidebook is supplemented by a CD that contains a programmed spreadsheet to facilitate implementation of the ActiveTrans methodology, as well as a final report that documents the research approach, findings, and conclusions." -- Publisher's description.
The most comprehensive text available on the use of evidence-based medication therapies for optimal patient outcomes – updated with the latest breakthroughs and guidelines A Doody's Core Title for 2019! Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories. Presented in full-color, the Tenth Edition is enriched by more than 300 expert contributors, and every chapter has been updated to reflect the latest in evidence-based information and recommendations. This sweeping updates include tables, charts, algorithms, and practice guidelines. This edition is also enhanced by a timely all-new chapter on Travel Health. Here’s why this is the perfect learning tool for students, patient-focused pharmacists, and other health care providers: • All chapters have been updated to provide the most current, reliable, and relevant information possible • Key Concepts at the beginning of each chapter • Clinical Presentation Tables summarize disease signs and symptoms • Clinical Controversies Boxes examine the complicated issues faced by students and clinicians in providing drug therapy • Color coded diagnostic flow diagram, treatment algorithms, dosing recommendations, and monitoring approaches clearly distinguish treatment pathways • Most disease-oriented chapters include updated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches Edition after trusted edition, Pharmacotherapy: A Pathophysiologic Approach has been unmatched in its ability to clearly and impartially impart core pathophysiological and therapeutic elements that students and practitioners must be familiar with.
This is a comprehensive survey of the technical and design aspects of play production, including scene design and construction, lighting, sound, costume, and makeup. Health and safety precautions for the backstage crew appear throughout in boxes labeled " Safety Tips, " and " Design Inspiration" boxes show how professional designers create the desired look.
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