124 articles provide ready reference to details about the most popular and most dangerous substances, both legal and illegal, that affect students and the general public today.
The Addicted Brain" explains clearly and vividly what has been learned about how and why some people become addicted and abuse drugs or other substances, the relatively long-term changes these substances can make in the brain, and the progress being made on treatments.
An author who uses bionic implants to help him hear explains exactly how the brain reacts to common communication tools and discusses the risks, implications, and amazing possibilities that the future holds.
by E.K. ZSIGMOND, M.D. Department of Anesthesiology University of Illinois Chicago U.S.A. It is, indeed, a distinct honor and privilege to be invited by the authors to write a preface to this monumental monograph, Regional Opioid Analgesia. Regional Opioid Analgesia is a colossal undertaking by Drs. De Castro, Meynadier and Zenz shortly after the introduction of this revolutionary approach to pain relief which opened a new epoch in analgesiology. This is, indeed, the first authentic and comprehensive textbook encompassing the current knowl edge on this novel approach to pain relief. We are indebted to the authors for introducing the new opioids to regional analgesia with the scientists, who de veloped the potent short and ultrashort acting opioids with high therapeutic indices, which many researchers dreamt about but never before materialized. The side effect liabilities of these new opioids are minute as compared to morphine and meperidine. Regional Opioid Analgesia could not have been more authentically written than by Drs. De Castro,Zenz and Meynadier,who have conducted daily clinical investigations on all known opioids for regional analgesia as well as for neurolept analgesia. Therein lies the great value of this monograph: it is the most authentic work on this topic.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction are detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Psychostimulants, Volume 2 in the series, explores the molecular and cellular systems in the brain responsible for psychostimulant addiction, including both direct/indirect sympathomimetics and nonsympathomimetics. This volume introduces the readers to the history of psychostimulant use. The authors clearly differentiate the neurobiological effects into three distinct stages of the addiction cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Highlights recent advances in psychostimulant addiction - Includes neurocircuitry, cellular and molecular neurobiological mechanisms of psychostimulant addiction - Defines the abuse and addiction potentials of both direct and indirect sympathomimetics and nonsympathomimetics
The Addicted Brain" explains clearly and vividly what has been learned about how and why some people become addicted and abuse drugs or other substances, the relatively long-term changes these substances can make in the brain, and the progress being made on treatments.
3 remarkable books reveal the latest scientific discoveries about addiction, antibiotic-resistant disease, bacteria — and you These three remarkable books take you to the cutting edge of health science, revealing today’s most powerful scientific discoveries about addiction, antibiotic-resistant disease, and bacteria. In The Addicted Brain, leading neuroscientist Michael Kuhar, Ph.D. explains how and why addiction destroys lives, and presents the latest advances in treatment and prevention. Using breathtaking brain imagery and other research, Kuhar reveals the powerful, long-term brain changes that drugs can cause, explaining why it can be so difficult for addicts to escape them. He describes why some people are unusually susceptible to addiction; illuminates striking neural similarities between drugs and pleasures ranging from alcohol and gambling to sex and caffeine; and outlines the 12 characteristics most often associated with successful treatment. Next, in Antibiotic Resistance: Understanding and Responding to an Emerging Crisis, Karl S. Drlica and David S. Perlin presents a thorough and authoritative overview of the growing resistance of pathogenic bacteria to antibiotics, and what this means to our ability to control and treat infectious diseases. The authors answer crucial questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? Are there better ways to discover new antibiotics? How can we strengthen our defenses against resistance, minimize public health risks and extend the effectiveness of the antibiotics we have? Finally, in Allies and Enemies, Anne Maczulak tells the story of the amazing, intimate partnership between humans and bacteria. Offering a powerful new perspective on Earth’s oldest creatures, Maczulak explains how bacteria work, how they evolve, their surprising contributions and uses, the roles they’ve played in human history – and why you can't survive without them. From pioneering scientists and researchers including Michael Kuhar, Karl S. Drlica, David S. Perlin, and Anne Maczulak
Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You’ll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors—such as heavy metals and pesticides—and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. Provides a complete listing of neurotoxic agents—from manufactured to environmental—so you get comprehensive, clinical coverage. Covers how toxins manifest themselves according to age and co-morbidity so that you can address the needs of all your patients. Offers broad and in-depth coverage of toxins from all over the world through contributions by leading authorities and up-and-coming clinical neurotoxicologists. Features discussion of controversial and unusual topics such as Gulf War Syndrome, Parkinson’s Disease, motor neuron disease, as well as other issues that are still in question.
Historically, the major emphasis on the study of purinergic systems has been predominantly in the areas of physiology and gross pharmacology. The last decade has seen an exponential in crease in the number of publications related to the role of both adenosine and A TP in mammalian tissue function, a level of interest that has evolved from a more molecular focus on the identity of adenosine and A TP receptor subtypes and the search for selective ligands and development of radioligand binding assays by Fred Bruns and colleagues (especially that for A receptors) that played z a highly significant role in advancing research in the area. In the 60 years since adenosine was first shown to be a potent hypotensive agent, a considerable investment has been made by several pharmaceutical companies-including Abbott, Byk Gulden, Takeda, Warner-LambertlParke Davis, Boehringer Mann heim, Boehringer Ingelheim, Nelson/Whitby Research and CffiA Geigy-as well as John Daly's laboratory at the National Institutes of Health, to design new adenosine receptor ligands, and both agon ists and antagonists with the aim of developing new therapeutic entiities. Numerous research tools have derived from these efforts including: 2-chloroadenosine, R-PIA (~-phenylisopropyladeno sine; NECA (5' N-ethylcarboxamidoadenosine); CV1808; CI936; PD 125,944; ~-benzyladenosine; PACPX; CPX; CPT; XAC; CGS 15943 and CGS 21680. Yet in the realm of therapeutics it was only in 1989 that adenosine itself was approved for human use in the treatment of supraventricular arrythmias.
How does the brain regulate sexual behavior, or control our body weight? How do we cope with stress? Addressing these questions and many more besides, this thoroughly revised new edition reflects the significant advances that have been made in the study of neuroendocrinology over the last twenty years. The text examines the importance of the hypothalamus in regulating hormone secretion from the endocrine glands, describing novel sites of hormone release including bone, heart, skeletal muscle and liver. The role of steroid hormone, neurotransmitter and peptide receptors, and the molecular responses of target tissues, is integrated into the discussion of the neuroendocrine brain, especially through changes in gene expression. Particular attention is attached to neuropeptides, including their profound influence on behavior. Complete with new full-color figures throughout, along with review and essay questions for each chapter, this is an ideal resource for undergraduate and graduate students of neuroscience, psychology, biology and physiology.
The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black's H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.
This book is written as both a text and a reference book. It contains numerous images from the biological sciences and clinical practice, tables, graphs, and fig ures, as well as exercises that are worked out to aid the reader in understanding principles or solving problems. In some cases, derivations are placed in appen dices so as not to break up the flow of the subject matter in the text. The book is intended for a broad audience interested in molecular imaging with positron emission tomography (PET). It is expected that the readers will range from undergraduate, graduate, and medical students to residents, physi cians, and scientists with backgrounds from various physical, biological, and medical specialty areas. Each chapter presents material in a straightforward man ner that is well illustrated and explained. Because of the diverse audience for the book, certain chapters or sections of chapters will be of more interest than oth ers to certain segments of the readership. Chapter 1 introduces the fundamental physics upon which PET imaging sys tems is based and discusses in detail the technologies and methods used to pro duce PET images. The chapter starts out by reviewing the physics of positron emission and annihilation and explains how positron range and photon non colinearity in coincidence detection place certain limits on spatial resolution.
First published in 1999, this volume examines the history of psychiatry and pathogenic parenting models over the past two centuries and contains the results of a study carried out by the author on the experiences of the parents of patients with Schizophrenia drawn from a sample of parents of patients in a forensic and a community setting. Michael Ferriter draws out the themes of the rival claims of organic and non-organic explanations of disorder, therapeutic optimism and therapeutic pessimism and rivalry between the medical professions and the non-medical for supremacy in the treatment of the mentally disordered. Ferriter further explores the issues of blame and guilt, the quality of interaction between mental health professionals and parents and the relevance of attribution theory as an explanation of why parents might still experience self-blame, even when they have nothing to blame themselves for.
In a conversational, easy-to-read style, Avoiding Common Errors in the Emergency Department, 2nd Edition, discusses 365 errors commonly made in the practice of emergency medicine and gives practical, easy-to-remember tips for avoiding these pitfalls. Chapters are brief, approachable, and evidence-based, suitable for reading immediately before the start of a rotation, used for quick reference on call, or read daily over the course of one year for personal assessment and review.
A collection of cutting-edge reviews of many of the key recent medical and legal advances in forensic science. These critical surveys concentrate on common pathological entities likely to be encountered in daily forensic routine, as well as on specific pathological conditions rarely seen in the autopsy room. Complementing rather than replacing the classic textbooks in forensic pathology, the authors explore new avenues for analyzing the pathology of burned bodies, traumatic brain injury, death by drug abuse, sudden cardiac death, sudden infant death and neonaticide, and fatalities resulting from kicking and trampling. Other areas of interest include accidental autoerotic deaths, hypothermia fatalities, injuries from resuscitation procedures, the interpretation of alcohol levels in different specimens, and the potential forensic differential diagnoses and interpretation of iliopsoas muscle hemorrhage in the light of autopsy.
Various brain areas of mammals can phyletically be traced back to homologous structures in amphibians. The amphibian brain may thus be regarded as a kind of "microcosm" of the highly complex primate brain, as far as certain homologous structures, sensory functions, and assigned ballistic (pre-planned and pre-pro grammed) motor and behavioral processes are concerned. A variety of fundamental operations that underlie perception, cognition, sensorimotor transformation and its modulation appear to proceed in primate's brain in a way understandable in terms of basic principles which can be investigated more easily by experiments in amphibians. We have learned that progress in the quantitative description and evaluation of these principles can be obtained with guidance from theory. Modeling - supported by simulation - is a process of transforming abstract theory derived from data into testable structures. Where empirical data are lacking or are difficult to obtain because of structural constraints, the modeler makes assumptions and approximations that, by themselves, are a source of hypotheses. If a neural model is then tied to empirical data, it can be used to predict results and hence again to become subject to experimental tests whose resulting data in tum will lead to further improvements of the model. By means of our present models of visuomotor coordination and its modulation by state-dependent inputs, we are just beginning to simulate and analyze how external information is represented within different brain structures and how these structures use these operations to control adaptive behavior.
Concise, portable, and user-friendly, The Washington ManualTM Infectious Diseases Subspecialty Consult, Third Edition, provides essential information needed to evaluate patients on a subspecialty consult service. This edition offers state-of-the-art content on the diagnosis, investigation, and treatment of a wide variety of infectious diseases, including coverage of new and emerging pathogens, rapid molecular diagnostics for infectious diseases, and new therapeutic and preventive strategies. Ideal for trainees and practicing physicians who need quick access to current scientific and clinical information in this rapidly changing area, the manual is also useful as a first-line resource for internists and other primary care providers.
This second part of a 2-part issue of Infectious Disease Clinics, edited by Michael S. Saag, MD and Henry Masur, MD, is devoted to HIV/AIDS. This issue will address the prevention of HIV/AIDS with topics such as: Mother to Child Transmission; Treatment as Prevention; Barrier and Microbicides; Prevention of HIV/AIDS: Pre-exposure Prophylaxis; Post-Exposure Prophylaxis; HIV Vaccine, and a final article addressing the cure of HIV/AIDS.
A definitive guide to the depth and breadth of the ecological sciences, revised and updated The revised and updated fifth edition of Ecology: From Individuals to Ecosystems – now in full colour – offers students and practitioners a review of the ecological sciences. The previous editions of this book earned the authors the prestigious ‘Exceptional Life-time Achievement Award’ of the British Ecological Society – the aim for the fifth edition is not only to maintain standards but indeed to enhance its coverage of Ecology. In the first edition, 34 years ago, it seemed acceptable for ecologists to hold a comfortable, objective, not to say aloof position, from which the ecological communities around us were simply material for which we sought a scientific understanding. Now, we must accept the immediacy of the many environmental problems that threaten us and the responsibility of ecologists to play their full part in addressing these problems. This fifth edition addresses this challenge, with several chapters devoted entirely to applied topics, and examples of how ecological principles have been applied to problems facing us highlighted throughout the remaining nineteen chapters. Nonetheless, the authors remain wedded to the belief that environmental action can only ever be as sound as the ecological principles on which it is based. Hence, while trying harder than ever to help improve preparedness for addressing the environmental problems of the years ahead, the book remains, in its essence, an exposition of the science of ecology. This new edition incorporates the results from more than a thousand recent studies into a fully up-to-date text. Written for students of ecology, researchers and practitioners, the fifth edition of Ecology: From Individuals to Ecosystems is anessential reference to all aspects of ecology and addresses environmental problems of the future.
A collection of the total range of scholarly and popular writing on English as spoken from Maryland to Texas and from Kentucky to Florida The only book-length bibliography on the speech of the American South, this volume focuses on the pronunciation, vocabulary, grammar, naming practices, word play, and other aspects of language that have interested researchers and writers for two centuries. Compiled here are the works of linguists, historians, anthropologists, sociologists, and educators, as well as popular commentators. With over 3,800 entries, this invaluable resource is a testament to the significance of Southern speech, long recognized as a distinguishing feature of the South, and the abiding interest of Southerners in their speech as a mark of their identity. The entries encompass Southern dialects in all their distinctive varieties—from Appalachian to African American, and sea islander to urbanite.
First published in 1997, Primate Cognition was a groundbreaking and highly successful book that set the agenda for a new field of study. Borrowing theoretical constructs and paradigms from human cognitive science and developmental psychology, the book reviewed all of the empirical research existing at that time concerning both physical cognition (space and objects, tools and causality, features and categories, and quantities) as well as social cognition (social knowledge and interaction, social strategies and communication, social learning and culture, and theory of mind). Since that time research on primate cognition has burgeoned, and this all-new second edition mainly focuses on research conducted after 1997. It is divided into two volumes, the current volume on Primate Social Cognition and a forthcoming volume on Primate Physical Cognition. Existing areas of research are updated with the latest findings, and there are several areas of research that for all practical purposes did not exist at the time of the first edition, for example, on prosocial behavior, behavior in social dilemmas, and metacognition. There is also a chapter on theories of primate social cognition and an account of how the human primate fits into the overall evolutionary picture. This second edition of Primate Cognition provides an up-to-date survey of the field.
Engineering Materials 2, Fourth Edition, is one of the leading self-contained texts for more advanced students of materials science and mechanical engineering. It provides a concise introduction to the microstructures and processing of materials, and shows how these are related to the properties required in engineering design. Each chapter is designed to provide the content of one 50-minute lecture. This updated version includes new case studies, more worked examples; links to Google Earth, websites, and video clips; and a companion site with access to instructors' resources: solution manual, image bank of figures from the book, and a section of interactive materials science tutorials. Other changes include an increased emphasis on the relationship between structure, processing, and properties, and the integration of the popular tutorial on phase diagrams into the main text. The book is perfect as a stand-alone text for an advanced course in engineering materials or a second text with its companion Engineering Materials 1: An Introduction to Properties, Applications, and Design, Fourth Edition in a two-semester course or sequence. - Many new or revised applications-based case studies and examples - Treatment of phase diagrams integrated within the main text - Increased emphasis on the relationship between structure, processing and properties, in both conventional and innovative materials - Frequent worked examples – to consolidate, develop, and challenge - Many new photographs and links to Google Earth, websites, and video clips
In addition to filling a need within the field of parental behavior, this book contributes importantly to the growing area of emotional and motivational neuroscience. A major part of neuroscience research at the whole organism level has been focused on cognitive neuroscience, with an emphasis on the neurobiology of learning and memory, but there has been a recent upsurge in research which is attempting to define the neural basis of basic motivational and emotional systems which regulate such behaviors as food intake, aggression, reproduction, reward-seeking behaviors, and anxiety-related behaviors. In this book the emphasis is on the research findings obtained from rodents, sheep and primates. The authors' goal, of course, was to provide a foundation that may help us understand the neurobiology of human parental behavior. Indeed, the last chapter attempts to integrate the non-human research data with some human data in order to make some inroads toward an understanding of postpartum depression, child abuse, and child neglect. Clearly, motivational and emotional neuroscience has close ties to psychiatry, and this connection will be very evident in the final chapter. By understanding the neurobiology of parental behavior we are also delving into neurobiological factors which may have an impact on core human characteristics involved in sociality, social attachment, nurturing behavior, and love. In this very violent world, it is hard to conceive of a group of characteristics that are more worthy of study.
This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entired field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost im anyone person to stay informed on this subject by reading the possible for At the same time it is becoming increasingly apparent that primary literature. these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony-stimulating factors," was quite artifactual; they are in fact the basis of a common language for intercellular communication. As a set they affect es sentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research.
In this practical text, the author covers the fundamentals of biological electron microscopy - including fixation, instrumentation, and darkroom work - to provide an excellent introduction to the subject for the advanced undergraduate or graduate student.
Using an easy-to-read style, Avoiding Common Errors in the Emergency Department, Third Edition, discusses 365 topics in which errors are frequently committed in the practice of emergency medicine. The authors give practical, easy-to-remember key points for avoiding these pitfalls. Chapters are brief, evidence-based, and easy-to-read immediately before the start of a shift, used for quick reference during a shift, or read daily over the course of one year for personal growth and review. Drs. Michael E. Winters, Dale P. Woolridge, Evie Marcolini, Mimi Lu, and Sarah B. Dubbs have fully revised this edition offering a fresh perspective in this rapidly changing field.
New York State’s Finger Lakes region attracts over 25 million visitors every year, making it the state’s second-largest tourist destination behind New York City. Besides its beautiful lakes, stunning foliage, and welcoming people, the Finger Lakes has long been known as one of the country’s – let alone world’s – greatest winemaking regions. And, beyond Rieslings and Chardonnays, IPAs, ciders, gins, and whiskeys have risen the ranks in central New York. The Finger Lakes Drinking Guide is a comprehensive guidebook to every major winery, brewery, cidery, and distillery in New York State’s Finger Lakes region. At the heart of this book are true pioneers – friends and neighbors, many of whom author Michael Turback has come to know during his nearly three decades as a restaurateur in Ithaca, NY. The book features almost 200 establishments, including detailed maps and photos, lively profiles on purveyors, addresses and contract information for each location, focusing on each producer's specialties, with personal interviews that highlight the identity and personality of each winery, brewery, cidery, and distillery within. Whether you are a local or a visitor to the FLX region – or a reader with a reverence for artisanal wines, beers, ciders, and spirits – this guide will enlighten and entertain even the most seasoned drinker.
Core Readings in Psychiatry, Second Edition, stands as an essential text for the academic. The contributors are distinguished experts who have a firm grasp of the relevant and classical citations in specific areas of psychiatry. In the intervening 8 years since the first edition, the profession's knowledge base has changed immensely. Included in this second edition are numerous citations and new topics such as AIDS, neuropsychiatry, models of psychoanalytic thought, child development, and medical economics. The book will open bibliographic doors for the academician as well as for the provider, manager, and consumer of psychiatric services and knowledge. It is designed to be an introduction and guide to the entire psychiatric literature.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Highlights recent advances in opioid addiction - Includes Neurocircuitry, Cellular and Molecular neurobiological mechanisms of opioid addiction - Defines opioid abuse and addiction potential, including biological tolerance
Unlike typical American texts, this book provides an international approach to introductory psychology, providing comprehensive and lively coverage of current research from a global perspective, including the UK, Germany, Scandinavia, Holland, Australia and Canada, as well as the USA.
THE UPDATED, AUTHORITATIVE GUIDE TO SPORTS FIELD MANAGEMENT THAT INCLUDES THE LATEST DEVELOPMENTS IN, AND ON, THE FIELD The updated Third Edition of Sports Fields: Design, Construction, and Maintenance is a comprehensive reference for professionals who are responsible for the design, construction, renovation, and maintenance of athletic facilities. This book contains illustrative examples of specific design elements of the most popular sports facilities. This Third Edition contains new chapters on safety, public relations, and professionalism for future sports field managers, as well as fresh drawings and photos that highlight innovative field layout, grading, irrigation, and drainage. All-new case studies review best practices and techniques for sports fields ranging from youth and high school fields to fields that are designed for professional athletes. This text is also an ideal resource for anyone studying for Sports Field Manager Certification (offered by STMA). Features new case studies that include design and management best practices for all levels and types of sports facilities Offers new chapters on safety, public relations, and professionalism for future sports field managers Includes new illustrations and photos of innovative field layout, grading, irrigation, and drainage Contains the most recent information on sand-based field systems and synthetic turf Presents discussions of a range of fields including baseball, softball, football, soccer, lacrosse, field hockey, tennis, and track and field Sports Fields: Design, Construction, and Maintenance, Third Edition is a blueprint for field managers, designers, and builders for successful sports field projects.
This is the only book entirely devoted to the sensory circumventricular organs. It reviews research into their detailed anatomy, neurochemistry, neural connections, and functions, and provides the reader with many illustrations previously unpublished.
This is a thorough updating of a classic text that has been published in three editions since Pratt's Chemotherapy of Infection (OUP, 1973). Its treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infectionshas been greatly expanded, and this edition includes two completely new chapters on the fluoroquinolones and the drugs used to treat AIDS. the frugs used to treat AIDS.
Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide. * outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemical target being sought after in the drug discovery process; and, * provides excellent demonstrations of how to use powerful pharmacological and statistical tools to optimize high-throughput screening assays. Written by two internationally known and well-regarded experts, this book is an essential reference for research and development scientists working in the pharmaceutical and biotechnology industries. It will also be useful for postgraduates studying pharmacology and applied statistics.
In a clear and engaging style, he explains what to do and how to do it, giving the rationale for each step and synthesizing neuropsychiatric principles with practical guidelines for diagnosis and management of adult patients."--BOOK JACKET.
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