This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research.Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNSassesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters examines the multidrug resistance protein P-glycoprotein as a natural transporter analyzes current drug designs to known requirements for transport looks at drug delivery systems for the brain and much more!Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.
Fresh Expressions of Church": Neue Glaubensgemeinschaften sprießen plötzlich an den ungewöhnlichsten Orten aus dem Boden – in Cafés, Fitnesscentern, Pubs und unter Leuten, die ein gemeinsames Interesse verbindet wie Fahrräder reparieren, filzen oder kochen. Und Christen lernen auf ganz neue Art, ihren Glauben im Alltag zu leben. Michael Moynagh erklärt, was eine Fresh X ist, wie sie funktioniert und warum es sie geben sollte. Er erläutert die Schritte, die man gehen muss, um eine Fresh-X zu gründen, ohne einen Fahrplan vorzugeben. Wer Michael Moynaghs neues Buch zur Hand nimmt, bekommt keine theoretische Abhandlung, aber eine theologisch kluge Hinführung zur Praxis, durchsetzt mit einer Fülle von ermutigenden und berührenden Erfahrungen und Geschichten. Oft heißt es dabei "how to", aber ebenso oft "It is the Spirit's Agenda". Und das alles mit der gewohnt soliden Qualität des britischen Vordenkers für Fresh Expressions." Prof. Dr. Michael Herbst, Universität Greifswald Michael Moynagh versteht es in seinem Praxisbuch sowohl theologisch-tiefgreifend, als auch praxisnah-inspirierend zu schreiben. Wer dabei ist, neue Gemeindeformen im deutschsprachigen Kontext zu realisieren, wird durch die zahlreichen "Pioneer-Stories" zusätzlich herausgefordert und unterstützt. Eine hervorragende Arbeitshilfe." Markus Weimer, Church Convention
Giving full coverage of drug delivery systems and drugs being developed, this is an ideal text for students and professionals for the developments in modern drugs and is extremely useful as a foundation guide for further research.
With the words: "Now I have the feeling that there is a leaden weight over everything," Bodo Ramelow described the social mood in Germany on September 1, 2013, a few weeks before the federal election. At this time, Ramelow was still the parliamentary group leader of the Left Party (Die Linke) in the Thuringian State Parliament. With his "feeling," Ramelow, born on February 16, 1956 in Osterholz-Scharmbeck, Lower Saxony, was not alone. The society itself seemed on the verge of being crushed by a leaden burden, not just the mood within it. In those days, the final recourse of German politics had narrowed to the dogma of inevitability, and the ruling elite, in a grotesque manner, asserted a claim to political infallibility. In various coalitions, they had subjected the actions of the state to the paradigm of neoliberalism and called for market-radical globalization. They had reduced the role of the state to ensuring the functioning of the market. They treated its social responsibility towards the individual, society, and nature as a historical footnote. This paved the way for the concentration of wealth in fewer and fewer hands. Many people had begun to oppose the dictate of supposed inevitability. The disillusioned turned away from the governing parties. Not a few ended up in right-wing extremist groups. Against this background, the interviewer conducted the following conversation with Bodo Ramelow. In the lead-up to the 2013 federal election, it was intended to shed light on the extent to which the party Die Linke had a concept for how to win over those disillusioned by the politics of the governing parties for a democratic and emancipatory society. A few months after the interview, Bodo Ramelow became the first Minister President of the party Die Linke in a German state. The outcome of the 2013 federal election arithmetically would have permitted a red-red-green coalition government. – But things turned out differently.
The thoroughly updated Second Edition of Health Promotion in Multicultural Populations grounds readers in the understanding that health promotion programs in multicultural settings require an in-depth knowledge of the cultural group being targeted. Numerous advances and improvements in theory and practice in health promotion and disease prevention (HPDP) are presented. Editors Michael V Kline and Robert M Huff have expanded the book to include increased attention directed to students and instructors while also continuing to provide a handbook for practitioners in the field. This book combines the necessary pedagogical features of a textbook with the scholarship found in a traditional handbook. Several new chapters have been added early in the text to provide stronger foundations for understanding the five sections that follow. The book considers five specific multicultural groups: Hispanic/Latino, African American, American Indian and Alaska Native, Asian American, and Pacific Islander populations. The first chapter in each of the five population group sections presents an overview devoted to understanding this special population from a variety of perspectives. The second chapter of each section explains how to assess, plan, implement, and evaluate health promotion programs for each of the specific groups. The third chapter in each section highlights a case study to emphasize points made in the overview and planning chapters. The fourth chapter in each section provides "Tips" for working with the cultural groups described in that section. New to the Second Edition Devotes a chapter to traditional health beliefs and traditions that can help the practitioner better understand how these beliefs and traditions can impact on Western biomedical practices Contains a new chapter that evaluates health disparities across the U.S. Presents a new chapter that examines ethical dilemmas and considerations in a multicultural context Offers updated citations and content throughout Gives selected Web sites of interest Intended Audience This book is ideal for practitioners and students in the fields of health promotion and education, public health, nursing, medicine, psychology, sociology, social work, physical therapy, radiology technology and other allied professions.
Brooks' Theorem (1941) is one of the most famous and fundamental theorems in graph theory -- it is mentioned/treated in all general monographs on graph theory. It has sparked research in several directions. This book presents a comprehensive overview of this development and see it in context. It describes results, both early and recent, and explains relations: the various proofs, the many extensions and similar results for other graph parameters. It serves as a valuable reference to a wealth of information, now scattered in journals, proceedings and dissertations. The reader gets easy access to this wealth of information in comprehensive form, including best known proofs of the results described. Each chapter ends in a note section with historical remarks, comments and further results. The book is also suitable for graduate courses in graph theory and includes exercises. The book is intended for readers wanting to dig deeper into graph coloring theory than what is possible in the existing book literature. There is a comprehensive list of references to original sources.
The New York loft jazz scene of the 1970s was a pivotal period for uncompromising, artist-produced work. Faced with a flagging jazz economy, a group of young avant-garde improvisers chose to eschew the commercial sphere and develop alternative venues in the abandoned factories and warehouses of Lower Manhattan. Loft Jazz provides the first book-length study of this period, tracing its history amid a series of overlapping discourses surrounding collectivism, urban renewal, experimentalist aesthetics, underground archives, and the radical politics of self-determination.
The Strange Genius of Ignatius Donnelly sheds light on the inimitable life of a neglected figure in US political and literary history. The father of American Populism, lieutenant governor of Minnesota, People's Party candidate for vice president, popularizer of the Shakespeare authorship controversy, proponent of the Atlantis theory, and author of bestselling speculative fictions, Ignatius Donnelly (1831–1901) positively defies categorization. Called a crank and a pseudoscientist by some and a genius by others, Donnelly broke all the rules. When skeptics said he was too green for politics, he got elected Minnesota's youngest-ever lieutenant governor. When they said a politician who prized his Irish heritage could never ascend to national office in a state dominated by conservative Scandinavians, he proved his critics wrong again. As Zachary Michael Jack' shows, in the latter half of Donnelly's remarkable life, he generated more fame and infamy than he had as a combative congressman. In an uncanny reversal of the usual midcareer doldrums, Donnelly turned political defeat into an opportunity for personal and professional reinvention, remaking himself as a visionary author and a champion of people-first third-party politics. The man known by enemies and friends alike as the Sage of Nininger pushed through poverty and ignominious defeat to introduce the masses to surprising theories about ancient civilizations, world-ending comets, and cryptograms purported to reveal the true authorship of Shakespeare's plays. At root, The Strange Genius of Ignatius Donnelly reveals the story of a man unafraid to speak truth to power, consequences be damned.
This title was first published in 2001. Addressing a range of key theoretical and practical issues, this volume is the latest in an important series proceeding from the Annual Conference on the Promotion of Mental Health. It will be essential reading for policy makers, researchers and practitioners in the field.
Marketing Public Health: Strategies to Promote Social Change was designed to help public health practitioners understand basic marketing principles and strategically apply these principles in planning, implementing, and evaluating public health initiatives. The first edition has been widely used by public health practitioners at all levels of government and in the private sector as a tool to help run more effective campaigns to change individual behavior, improve social and economic conditions, advance social policies, and compete successfully for public attention and resources. This thorougly revised, second edition includes new case studies, written by respected and well-known guest contributors from the front lines and will help illustrate the principles and strategies in a way that makes it immediately apparent to readers how the material can be used in modern, real-life public health campaigns. Current themes in the social marketing world, such as the concept of branding, have also been incorporated into the book in both its narrative and its case studies and examples.
Social Marketing is the utilisation of marketing principles and methods to encourage individual and organisational behaviour change for the public good. Traditionally the domain of government it is increasingly also utilised by non-government and non-profit organisations and other institutions of civil society as a non-regulatory means to achieve policy and public good goals. At a time when concerns over tourism's contribution to undesirable environmental, economic and social change is greater than ever, social marketing strategies are important for encouraging more appropriate and desirable behaviours by tourists and the tourism industry. Tourism and Social Marketing is the first book to comprehensively detail the relevance of social marketing principles and practice to tourism, destination management and marketing. By considering this relationship and application of social marketing approaches to key issues facing contemporary tourism development, such as the environment, this book provides significant insights into how the behaviours of visitors and businesses may be changed so as to develop more sustainable forms of tourism and improve the quality of life of destination communities. It further provides a powerful impetus to the development of tourism related forms of sustainable consumption and the promotion of ethical tourism and marketing. This innovative book is comprehensive in scope by considering a variety of relevant fields relevant to tourism and social marketing practice including, health, non - profit organisations, governance, the politics of marketing and consumption, consumer advocacy and environmental and sustainable marketing. It integrates selected international cases studies to help tourism students engage with the broader debates in social marketing, governance and the politics of behaviour change and shows the relationship of theory to practice. Written by a leading authority in the field, topical and integrative, this book will be valuable reading for students, scholars and researchers in tourism.
Praise for the First Edition: "This is an excellent book, but the best parts are the stories of the disabled, which give readers insights into their struggles and triumphs." Score: 94, 4 Stars–-Doody's Medical Reviews What are the differences between individuals with disabilities who flourish as opposed to those who never really adjust after a trauma? How do those born with a disability differ from individuals who acquire one later in life? Fully updated and revised, this second edition of a unique rehabilitation counseling text reflects growing disparities among "haves and have-nots" as they bear on the psychosocial aspects of disability. New content focuses on returning veterans afflicted with physical and mental health problems, persons with disabilities living in poverty, and the need for increased family and community-based engagement. The book provides updated information about assisted suicide, genetic testing, new legislation, and much more. Using a minority model perspective, the text provides students and practitioners of rehabilitation and mental health counseling with vivid insight into the experience of living with a disability. It features first-person narratives from people living with a variety of disabling conditions, which are integrated with sociological and societal perspectives toward disability, and strategies for counseling such individuals. The text encompasses an historical perspective, psychological and sociological research, cultural variants regarding disability, myths and misconceptions, the attitudes of special interest and occupational groups, the use positive psychology, and adjustments to disability by the individual and family. A wealth of counseling guidelines and useful strategies are geared to individuals with specific disabilities. Designed for a 15-week semester, the book also includes thought-provoking discussion questions and exercises, an Instructor’s Manual and PowerPoints. New to the Second Edition: Reflects the growing disparities between “haves and have-nots” as they impact people with disabilities Includes new content on veterans with physical and mental disabilities Describes the experience of impoverished individuals with disabilities Examines the need for increase family and community-based engagement Discusses strengths and weaknesses of the Americans with Disabilities Act Covers assisted suicide, genetic testing, and recent legislationExpanded coverage of sexual identity Provides an Instructor Manual and PowerPoints Key Features: Provides 16 personal narratives demonstrating the "normalcy" of individuals with different types of disabling conditions Includes stories of people living with blindness, hearing impairments, spinal chord injuries, muscular dystrophy, mental illness, and other disabilities Delivers counseling strategies geared toward specific disabilities, with "do’s" and "don'ts" Discusses ongoing treatment issues and ethical dilemmas for rehabilitation counselors
Inclusive education has grown as an international movement to not only support students with disabilities but also promote equitable access, participation, and success for all students. This book will transform the capacity of teachers and specialists working with students and families to effectively support an inclusive approach to education for students on the autism spectrum. This book addresses the urgent need to identify inclusive educational environments and strategies for students on the autism spectrum so that they have the best chance of social, behavioural, and academic success at school. Teachers who include students on the autism spectrum in primary and secondary classrooms require greater knowledge of how they can best support the learning, social, and behavioural needs of their students. Without such knowledge, the consequences can include unsatisfactory learning experiences for all students, and interrupted schooling for the student on the autism spectrum through reduced attendance and retention, lower academic performance, exclusion, disengagement, and pressure on parents to make alternative arrangements for their child’s education. Inclusive education is socially, emotionally, and academically beneficial for all students and positively impacts on respectful attitudes to difference. This book presents innovative, evidence-based practices that will build the capacity of teachers and specialists implementing an inclusive and contextually relevant approach to education that will support students on the autism spectrum and meet the diverse needs of all students in their classrooms.
Negative Emissions Technologies for Climate Change Mitigation provides a comprehensive introduction to the full range of technologies that are being researched, developed and deployed in order to transition from our current energy system, dominated by fossil fuels, to a negative-carbon emissions system. After an introduction to the challenge of climate change, the technical fundamentals of natural and engineered carbon dioxide removal and storage processes and technologies are described. Each NET is then discussed in detail, including the key elements of the technology, enablers and constraints, governance issues, and global potential and cost estimates. This book offers a complete overview of the field, thus enabling the community to gain a full appreciation of NETs without the need to seek out and refer to a multitude of sources. Covers the full spectrum of technologies to underpin the transition to a negative emissions energy system, from technical fundamentals to the current state of deployment and R&D Critically evaluates each technology, highlighting advantages, limitations, and the potential for large scale environmental applications Combines natural science and environmental science perspectives with the practical use of state-of-the-art technologies for sustainability
A Companion to Survey Research provides a critical overview and guide to survey methods. Rather than a set of formulas, survey design is understood as a craft where the translation of research questions into a questionnaire, sample design and data collection strategy is based on understanding how respondents answer questions and their willingness to complete a survey. Following an account of the invention of survey research in the 1930s, a synthesis of research on question design is followed by a practical guide to designing a questionnaire. Chapters on sampling, which deal with the statistical basis of survey sampling and practical design issues, are followed by extensive discussions of survey pretesting and data collection. The book concludes with a discussion of the extent and implications of falling response rates. This book is written for researchers, analysts and policy makers who want to understand the survey data they use, for researchers and students who want to conduct a survey, and for anyone who wants to understand contemporary survey research.
Behavioral sciences research -- Health behavior and theory -- Determinants of behavior -- Behavioral epidemiologic research -- Frequency measures in epidemiology -- Sources and uses of available population-based behavior data -- Data collection, misclassification and missing data -- Statistical application to behavior data -- Epidemiological input for selecting behavioral intervention targets
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction are detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Psychostimulants, Volume 2 in the series, explores the molecular and cellular systems in the brain responsible for psychostimulant addiction, including both direct/indirect sympathomimetics and nonsympathomimetics. This volume introduces the readers to the history of psychostimulant use. The authors clearly differentiate the neurobiological effects into three distinct stages of the addiction cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Highlights recent advances in psychostimulant addiction Includes neurocircuitry, cellular and molecular neurobiological mechanisms of psychostimulant addiction Defines the abuse and addiction potentials of both direct and indirect sympathomimetics and nonsympathomimetics
Public opinion polling is in crisis. People aren't responding to polls and misses in critical elections have undermined the field's credibility. Polling at a Crossroads points a way forward by presenting an intuitive new paradigm that confronts the full spectrum of challenges facing modern polling.
Are advances in technology working for us or against us? When our phones become our keys to access everything, will our lives be more convenient or more at the mercy of whoever can hack into our devices? Will self-driving cars help us maximize our time and get to our destination safely, or will they erode the autonomy and freedom we feel when we drive ourselves? What happens if the government, in the name of public health, gains access to the data in our handy fitness trackers and uses it to reward or limit us? In Neuromined, data sovereignty advocate Robert Edward Grant and prolific technology author Michael Ashley team up to explore significant questions such as these. Each chapter imagines a near-future surveillance dystopia through a riveting fictional tale and provides a companion analysis connecting the story to our present reality. Entertaining and provoking, this book shows readers how the technology that has promised a lifetime of convenience has also constrained a public’s individual options and agency. But all hope is not lost. Neuromined, at its core, demonstrates how technology, when viewed through a different ethos and used by a conscientious public, can instead provide greater autonomy and greater access to liberation.
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