This book combines the two major functions of fatty acids in skin biol ogy. Fatty acids play an important role in the barrier function of ski n and represent a major source of proinflammatory mediators such as pr ostaglandins, leukotrienes and other lipids in inflammatory skin disor ders (e.g. proinflammatory eicosanoids which play a role in psoriasis and a topic dermatitis). The pharmacological inhibition of eicosanoid biosynthesis is also reviewed.
In 1967, the North Vietnamese launched a series of offensives in the Central Highlands along the border with South Vietnam--a strategic move intended to draw U.S. and South Vietnamese forces away from major cities before the Tet Offensive. A series of bloody engagements known as "the border battles" followed, with the principle action taking place at Dak To. Drawing on the writings of key figures, veterans' memoirs and the author's records from two tours in Vietnam, this book merges official history with the recollections of those who were there, revealing previously unpublished details of these decisive battles.
Significantly revised and updated, the new edition of this highly regarded reference on the shoulder continues to impress. A multitude of leading international authorities—30% new to this 4th edition—present today’s most comprehensive, in-depth view of the current state of shoulder practice, all in a beautifully illustrated, full-color 2-volume masterwork. They deliver the most up-to-date coverage of shoulder function and dysfunction, along with practical approaches for patient evaluation and balanced discussions of treatment alternatives—open and arthroscopic, surgical and nonsurgical. Greatly expanded and visually enhanced coverage of arthroscopy, as well as many new chapters, provide expert guidance on the latest minimally invasive approaches. New “Critical Points summary boxes highlight key technical tips and pearls, and two DVDs deliver new videos that demonstrate how to perform open and arthroscopic procedures. And now, as an Expert Consult title, this thoroughly updated 4th edition comes with access to the complete fully searchable contents online, as well as videos of arthroscopic procedures from the DVDs—enabling you to consult it rapidly from any computer with an Internet connection. Includes tips and pearls from leaders in the field, as well as their proven and preferred methods. Offers scientifically based coverage of shoulder function and dysfunction to aid in the decision-making process. Provides a balance between open and arthroscopic techniques so you can chose the right procedures for each patient. Includes the entire contents of the book online, fully searchable, as well as procedural videos from the DVDs, for quick, easy anywhere access. Features 30% new expert contributors and new chapters, including Effectiveness Evaluation and the Shoulder, Revision of Rotator Cuff Problems, Management of Complications of Rotator Cuff Surgery, Management of Infected Shoulder Prosthesis, and others, providing you with abundant fresh insights and new approaches. Provides new and expanded material on the management of advanced arthritis and CTA, infected arthroplasty, procedures to manage the stiff shoulder, and much more keeping you on the cusp of the newest techniques. Offers enhanced coverage of shoulder arthroscopy, including basic and advanced techniques and complications, for expert advice on all of the latest minimally invasive approaches. Devotes an entire new chapter to research frontiers to keep you apprised of what’s on the horizon. Incorporates “Critical Points summary boxes that highlight key technical tips and pearls. Uses a new full-color design for optimal visual guidance of arthroscopic views and procedures. Presents new videos on arthroscopic procedures on 2 DVDs to help you master the latest techniques.
This classic text, one of the true anchors of our clinical genetics publishing program, covers over 700 different genetic syndromes involving the head and neck, and it has established itself as the definitive, comprehensive work on the subject. The discussion covers the phenotype spectrum, epidemiology, mode of inheritance, pathogenesis, and clinical profile of each condition, all of which is accompanied by a wealth of illustrations. The authors are recognized leaders in the field, and their vast knowledge and strong clinical judgment will help readers make sense of this complex and burgeoning field. Dr. Gorlin retires as editor in this edition and co-editor Raoul Hennekam takes over. Dr. Hennekam is regarded as one of the top dysmorphologists--and indeed one of the top clinical geneticists--in the world. Judith Allanson is new to the book but is a veteran OUP author and a widely respected geneticist, and Ian Krantz at Penn is a rising star in the field. Dr. Gorlin's name has always been closely associated with the book, and it has now become part of the title. As in all fields of genetics, there has been an explosion in the genetics of dysmorphology syndromes, and the author has undertaken a complete updating of all chapters in light of the discoveries of the Human Genome Project and other ongoing advances, with some chapters requiring complete rewriting. Additional material has been added both in terms of new syndromes and in updating information on existing syndromes. The book will appeal to clinical geneticists, pediatricians, neurologists, head and neck surgeons, otolarynologists, and dentists. The 4th edition, which published in 2001, has sold 2,600 copies.
Introduction to the Chemistry of Food describes the molecular composition of food and the chemistry of its components. It provides students with an understanding of chemical and biochemical reactions that impact food quality and contribute to wellness. This innovative approach enables students in food science, nutrition and culinology to better understand the role of chemistry in food. Specifically, the text provides background in food composition, demonstrates how chemistry impacts quality, and highlights its role in creating novel foods. Each chapter contains a review section with suggested learning activities. Text and supplemental materials can be used in traditional face-to-face, distance, or blended learning formats. - Describes the major and minor components of food - Explains the functional properties contributed by proteins, carbohydrates and lipids in food - Explores the chemical and enzymatic reactions affecting food attributes (color, flavor and nutritional quality) - Describes the gut microbiome and influence of food components on its microbial population - Reviews major food systems and novel sources of food protein
What do unions do and why do they do it? Do they seek to maximise profit for their members, or to obtain better working conditions that benefit society as a whole? Derek H. Aldcroft and Michael J. Oliver here provide one of the first sustained studies of the effects of union activities in terms of economic performance and the impact on the business world. From the rise of the British mass trade union movement in the 1870s to the present day, the book examines the main trends in union development and structure, and the core strategies unions have used to achieve their objectives: the use of strikes, work rules and restrictive practices; workers’ attitudes to innovation; the wage bargaining process. Important assessments are made of the influence of these strategies on investment, innovation, economic growth, and the cost of structure and competitiveness of the UK economy.
The book begins with the basic science behind the medical applications of the knowledge: cardiovascular biology, pathways, and their relationship to cancer treatment and principles of chemotherapy and immunotherapy. The second section consists of an overview and classification of anti-cancer drugs and a look at their cardiotoxicity. The third section looks at cardiac imaging in the cancer patient, including cardiac ultrasound, Doppler imaging, nuclear imaging, magnetic resonance imaging, and computed tomography in the cancer patient. In section four, management of cardiac disease in the cancer patient is discussed, including cardiac rhythm disturbances and heart failure. Cardiac emergencies and interventions are described as is preoperative assessment of the cancer patient for non- cardiovascular surgery. The final section includes a range of topics such as the pericardium, cardiovascular effects of endocrine treatments, primary cardiac tumors and malignancies of the myocardium and pericardium. Cardiac monitoring during clinical trials and pulmonary concerns are also addressed, as are psychosocial, social, economic, and legal issues of the cancer patient with heart disease.
Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.
For over 50 years covering 10 previous editions, Schiff's Diseases of the Liver has provided hepatologists with an outstanding evidence-based clinical reference work covering all aspects of liver disease, and is without doubt one of the world’s leading hepatology textbooks. Now fully revised and updated, it will serve as your first-stop reference for today’s demanding clinical situations. With a strong clinical focus, Schiff’s Diseases of the Liver covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs, before moving on to sections that address specific diseases and clinical syndromes. Its enormous appeal has been due to the clarity of text, combined with the sheer thoroughness of its breadth of content. Key features include: An attractive full color design throughout Informative section overviews for each section Concise key concepts box in every chapter Treatment guidelines and management algorithms for every disease A full liver transplant section This 11th edition sees all existing chapters fully revised and refreshed with the very latest in clinical information from the world’s leading hepatologists. Also new to this edition is a companion website containing a variety of important extra materials, including: Approximately 100 multiple choice questions of the standard used in ABIM board exams in gastroenterology, to allow the user to self-assess their clinical knowledge All 450+ figures from the book in a high-quality, fully transportable and downloadable electronic format High-quality video clips of a variety of surgical procedures, all fully linked to the text 35 case studies featuring real-life clinical scenarios. Schiff’s Diseases of the Liver remains the key textbook for all gastroenterologists and hepatologists, in training or fully qualified, managing patients with liver disease.
Fully updated with completely updated content, exciting new authors, and commentary by national and international experts in the field, Rockwood and Matsen’s The Shoulder, 5th Edition continues its tradition of excellence as the cornerstone reference for effective management of shoulder disorders. This masterwork provides how-to guidance on the full range of both tried-and-true and recent surgical techniques, including both current arthroscopic methods and the latest approaches in arthroplasty. An outstanding editorial team headed by Drs. Charles A. Rockwood, Jr. and Frederick A. Matsen III ensures that you have the tools you need to achieve optimal patient outcomes for any shoulder challenge you encounter. Throughout the book the authors focus on the value of the procedures to patients, showing ways that expense and risk can be minimized. Combines the ‘how to’ for ‘tried and true’ shoulder procedures along with the latest arthroscopic methods for managing shoulder disorders. Focuses on the most challenging open procedures, including those often overlooked in training programs, yet thoroughly reviews the rationale for using minimally invasive arthroscopic techniques whenever possible. Offers scientifically based coverage of shoulder function and dysfunction to aid in the decision-making process. Features new commentaries from international authorities – including dissenting and alternative viewpoints -- and final comments by our editorial experts. Covers new approaches, including reverse total shoulder, the latest rotator cuff repair methods, and the "ream and run" procedure, as well as emerging imaging methods.
Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley's Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource.
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
This timely book provides a critical review of the growth of alternative food networks and their struggle to defend their ethical and aesthetic values against the standardising pressures of the corporate mainstream with their "placeless and nameless" global supply networks. It explores how these alternative movements are "making a difference" and their possible role as fears of global climate change and food insecurity continue to intensify.
Rutter’s Child and Adolescent Psychiatry has become an established and accepted textbook of child psychiatry. Now completely revised and updated, the fifth edition provides a coherent appraisal of the current state of the field to help trainee and practising clinicians in their daily work. It is distinctive in being both interdisciplinary and international, in its integration of science and clinical practice, and in its practical discussion of how researchers and practitioners need to think about conflicting or uncertain findings. This new edition now offers an entirely new section on conceptual approaches, and several new chapters, including: neurochemistry and basic pharmacology brain imaging health economics psychopathology in refugees and asylum seekers bipolar disorder attachment disorders statistical methods for clinicians This leading textbook provides an accurate and comprehensive account of current knowledge, through the integration of empirical findings with clinical experience and practice, and is essential reading for professionals working in the field of child and adolescent mental health, and clinicians working in general practice and community pediatric settings.
From June 28, 1933 to June 27, 1934, every day for a year, Dorman B. E. Kent wrote an article for the Montpelier Evening Argus about the people, places and events of late 19th and early 20th century Montpelier and many surrounding towns. In these articles he mentions thousands of people by name and writes a compelling history of Montpelier not so much through the eyes of the community leaders and high society types that often dominate such histories, but through anecdotes of those both great and small and in doing so he gives a good account that should be of interest to all of those who can trace their roots back to the smallest state capitol in the country.
Fourteen brucellosis experts from seven countries discuss the history, epidemiology, microbiology, immunology, diagnosis, treatment, and control of brucellosis in animals and man. Edited by members of the World Health Organization's Expert Committee on Brucellosis, this text is the first comprehensive treatment of the disease since The Nature of Brucellosis by Wesley W. Spink in 1956. Topics reviewed with current references include infection caused by newer species of Brucella, such as B. canis, newer diagnostic techniques, such as radioimmunoassay and ELISA, and newer treatments, such as rifampin and the quinolones. The pathogenesis and pathophysiology of brucellosis is reviewed in depth, correlating the disease in animals with the illness in humans. This volume is extremely useful for clinicians, researchers, and students in medicine, veterinary science, microbiology, immunology, epidemiology, public health, and international health.
This novel title explores the central and peripheral nervous system in health and disease. By first establishing a fundamental basic science knowledge about the cellular elements of the nervous system, the reader is then presented with clinical cases in a pathophysiologic manner, as exemplified in unifying Guillain Barre and Multiple Sclerosis in one chapter on Demyelinating Disease. The reader is encouraged to adopt a systematic approach of sorting out neurologic problems he or she may face in clinical practice by identifying time and space factors based on the age of a patient. High quality illustrations for each case are included in the book along with novel three-dimensional reconstructions of MR, PET, and CT data whenever possible. Developed largely for medical students as an introduction to the clinical neurosciences, for neurology residents, and for others doing graduate level neuroscience study, Neurology - A Modern, Pathophysiologic Approach to the Diagnosis and Treatment of Neurologic Disease will also be of significant interest to the established neurologist as a comprehensive, up-to-date reference.
The new edition of this established core textbook continues to give an insightful, authoritative and accessible overview of competing theoretical positions on the sociological study of childhood. The book explores the ways these theories inform key themes, including education, work, identity and agency. The study of childhood has taken on an increasingly global focus in recent years, honing in on how issues of rights, protection and development shape the lives of children and those around them at political, social and institutional levels across the world. As a result, this book guides students through the theories and research on childhood in both local and global contexts. Author Michael Wyness clearly illustrates how a study of childhood can inform sociological thinking on social crises, changes and problems such as globalisation, criminality and disruption of the social order. Written for students exploring childhood from a sociological perspective, this is the essential introduction to the topic. New to this Edition: - A broadened global focus throughout every chapter, including more on the developing world. - A revised chapter on researching children and childhood. - An updated critical appraisal of children's rights, as well as new data on child protection and schooling. - The introduction of new key readings and 'Academic Insights' boxes that explore research on important topics in more detail.
Could there be any new and promising approach to the question of the historicity of Jesus' resurrection? Yes, answers Michael Licona. And he convincingly points us to a significant deficiency in approaching this question: our historiographical orientation and practice. He then carefully and effectively applies his principles and methods to the question of Jesus' resurrection.
The fighting on the first day at Gettysburg on July 1, 1863, was unexpected, heavy, confusing, and in many ways, decisive. Much of it consisted of short and often separate simultaneous engagements or “firefights,” a term soldiers often use to describe close, vicious, and bloody combat. Several books have studied this important inaugural day of Gettysburg, but none have done so from the perspective of the rank and file of both armies. John Michael Priest’s “Strong Men of the Regiment Sobbed Like Children”: John Reynolds’ I Corps at Gettysburg on July 1, 1863 rectifies this oversight in splendid style. When dawn broke on July 1, no one on either side could have conceived what was about to take place. Anticipating a fight and with a keen appreciation for terrain, Brig. Gen. John Buford deployed his Union cavalry in a giant arc north and west of Gettysburg to slow down any Confederate advance until Maj. Gen. John Reynolds could bring up his infantry. By the time the foot soldiers of the I Corps arrived, A. P. Hill’s heavy Confederate formations had pushed back the troopers from the west. Richard Ewell’s troops would soon arrive from the north, threatening the town and its key road network. Reynolds, who would die early in the fighting, poured his troops in as they arrived. The road system and undulating ground broke up command control, and the various ridges, tall ground cover, and powder smoke made target recognition difficult. Brigades and regiments often engaged on their own initiatives without the direction of a division or corps commander. The men of both armies fought with determination born of desperation, valor, and fear. By the time the fighting ended, the I Corps was in shambles and in pell-mell retreat for Cemetery Hill. Its bold stand, together with the XI Corps north of town, bought precious hours for the rest of the Army of the Potomac to arrive and occupy good defensive ground. Priest, who Edwin Bearss hailed as “the Ernie Pyle of the Civil War,” spent a decade researching this study and walking the ground to immerse readers into the uncertain world of the rank-and-file experience. He consulted more than 300 primary sources, including letters, diaries, memoirs, newspaper accounts, recollections, casualty lists, and drill manuals to present the battle from the ground up. Nineteen detailed regimental-level maps illustrate the ebb and flow of the battle. The result is a fast-paced narrative sure to please the most demanding students of the Civil War. The footnotes alone are worth the price of admission. Readers will close the book with a full understanding of why a veteran New Yorker spoke for the survivors of both armies when he wrote, “Strong men of the regiment sobbed like children.”
Problems and Materials in Federal Income Taxation is respected for its distinctive explanation of the intricacies of the federal income tax code. Its realistic, problem-solving approach helps clarify material in an often frustrating course. Organized according to the taxing formula (i.e., the different tax rates), the text leads students to a clear understanding of each level of taxation. Numerous problems reinforce fundamental concepts. The Eighth Edition features substantially revised and updated material on medical expenses, including recent case law on the deductibility of cosmetic surgery expenses as well as the impact of the Affordable Care Act on exclusions from gross income and medical expense deductions. Updated, revised, and significantly longer, the discussion of constitutional and historical issues relating to the taxing power shows their impact on the modern debate over its scope. The current debate over fundamental tax reform and deficit reduction is included in an updated and revised final chapter. Hallmark features: Clear explanation of the intricacies of the federal income tax code Realistic problem-solving approach to a potentially frustrating course Organized according to the taxing formula (different tax rates) o students develop a clear understanding of each level of taxation fundamental concepts through numerous problems Thoroughly updated, the revised Eight Edition presents: Substantially revised and updated sections related to medical expenses o recent case law on the deductibility of cosmetic surgery expenses o impact of the Affordable Care Act on exclusions from gross income and medical expense deductions Updated, revised, and substantially longer discussion of constitutional and historical issues relating to the taxing power o shows impact on modern debate over the scope of taxing power New material on current debate over fundamental tax reform and deficit reduction o shows ways to structure and teach problems in 3-credit and 4-credit courses
Direct and Allosteric Control of Glutamate Receptors describes in detail recent research that has demonstrated that glutamate receptors are subject to numerous modulatory controls. Significant new insights into the physiology and pathophysiology of the nervous system have been obtained by these discoveries. The sites on the receptor proteins where modulation occurs have provided a platform of opportunities for medicinal chemists to design new therapeutic modalities. These new drugs will be of major significance in treating diseases (such as stroke, Alzheimer's, epilepsy, Parkinson's, Huntington's, neurotrauma, schizophrenia, pain, and anxiety) associated with abnormal excitatory amino acid neurotransmission and function.
Instant New York Times Bestseller Uncover the evidence-based science to slowing the effects of aging, from the New York Times bestselling author of the How Not to Die series When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don’t need Big Pharma to keep us feeling young—we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies’ cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent “zombie” cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of “blue zone” regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity.
Functional Testing in Human Performance offers clinicians the first-ever compilation of information on clinical and data-based functional testing for sport, exercise, and occupational settings. This unique text serves as a primary resource for accurate assessment of individuals' functional abilities in order to develop program prescriptions to enhance their performance. Functional Testing in Human Performance is a comprehensive learning tool for novices and an essential reference for advanced clinicians. The text defines the role of function in physical performance and how it can be appropriately tested. Especially helpful for novices, the text explains testing criteria, testing terms relevant to research, and selecting the most appropriate test and testing sequence. Common testing mistakes are also presented as well as pitfalls to avoid when testing. The text also includes case studies that illustrate a variety of situations--including testing for a client recovering from a lower-extremity injury, discussing preseason testing for a large group of athletes, and presenting the study of a client in an occupational setting. These cases include detailed statistical analysis and normative data, offering clinicians the opportunity to consider the application of functional testing and implementation strategies adaptable to their specific practice setting. After laying a foundation, the text progresses to detailed testing procedures for discrete physical parameters and specific regions of the body. Tests are organized from least to most complex, and each test is presented in a step-by-step manner outlining the purpose of the test, equipment needed, testing procedure and recommendations for performing the test, interpretation of results, and the data to suggest normative values, reliability, and validity for each test. This formatting facilitates quick reference to testing information for on-the-spot use, whether in the clinic, athletic training room, gym, or job site. Throughout the text, the functional tests are accompanied by photos for visual clarity. To enhance understanding, a companion DVD features live-action demonstrations of 40 of the most advanced tests. Icons on those test pages indicate they are modeled on the DVD. In addition, the DVD may be loaded onto a computer to offer convenient print-on-demand access to reproducible forms for recording data from selected tests. Functional Testing in Human Performance offers a unique and comprehensive reference for assessment of physical activities in sport, recreation, work, and daily living. By presenting the theory and detailing the practice, this text assists clinicians in understanding and incorporating functional testing to identify their patients' or clients' limitations and enhance their performance, rehabilitation, and daily functioning.
Zakim and Boyer's Hepatology-the defining work in hepatology-presents comprehensive coverage of both basic science and clinically relevant developments so you can provide the best possible patient care. Drs. Thomas Boyer, Michael Manns, and Arun Sanyal have reorganized and updated the contents of this trusted global reference to reflect today's more clinical approach to hepatology. They bring you up to date on hot topics including HIV Co-Infection Drug Toxicity, Hepatocellular Carcinoma (HCC), and much more. This new streamlined edition is now a single volume with access to the fully searchable contents and an image bank online at www.expertconsult.com making it easier to find the treatment information you need. Effectively treat all liver diseases currently seen in clinical practice with authoritative guidance from leading international authorities. Reinforce your foundation in basic science with the concise Pathophysiology of Therapeutic Targets section. See clear presentations of liver disease through hundreds of detailed, color illustrations. Explore topics further with up-to-date references that direct you to the significant literature. Access the complete, fully searchable contents of the book online at www.expertconsult.com, along with a downloadable image bank and complete list of references. Stay current on new developments in the field through five new chapters on Pathogenesis Liver Injury in HBV, HCV; HCC; Imaging and Non-Invasive DX Liver Disease CT, US, Fibroscan, MRI; HIV Co-Infection Drug Toxicity; and HBC, HCV in Non-Liver Transplant Patients, plus comprehensive updates throughout. Apply best practices with reorganized and updated content that reflects today's need for a more clinical approach to hepatology. Reference key information more easily thanks to streamlined content that now fits into one volume.
Operative Techniques: Sports Medicine Surgery offers you all the how-to step-by-step guidance from experts Bruce Reider, Michael Terry, and Matthew Provencher that you need to perform the latest techniques in this specialty. Large full-color intraoperative photos, accompanied by detailed illustrations and a dedicated website demonstrate procedures, both arthroscopic and open. This concise, accessible multimedia resource shows you what you need to know and how to do it all—from ACL reconstruction and labral tear repair to loose body removal and treatment of turf toe. The result is a detailed, easy-to-use reference that no sports medicine surgeon should be without. This is a title in the Operative Techniques series. Please visit www.operativetechniques.com for more information. Includes full-text web access so you can search the text online, view surgical videos that let you see the experts perform the techniques and perfect your own, zoom in on illustrations and use reference links for further research on the procedures. Discusses pearls and pitfalls with an emphasis on optimizing outcomes to improve the quality of your technique and learn the expert’s approach to getting the best results. Outlines positioning, exposures, instrumentation, and implants to give you a step-by-step guide for every procedure. Provides discussions of post-operative care and expected outcomes, including potential complications and brief notes on controversies and supporting evidence to give you important details about patient-focused surgery. Highlights key anatomies with color photos and illustrations as well as diagrams that present cases as they appear in real life to help you see every detail with clarity.
Now in a revised and updated fifth edition, this gold-standard text and K–8 practitioner resource provides a roadmap for comprehensive literacy instruction informed by the science of reading. Rather than advocating one best approach, the book shows how to balance skills- and meaning-focused instruction to support all students' success. Chapters describe specific ways to build word recognition, fluency, vocabulary, and comprehension, especially for learners who are struggling. The book explains the conceptual underpinnings of recommended strategies and techniques and shows how exemplary teachers actually put them into practice. New to This Edition *Updated throughout with new coauthor Tim Pressley; incorporates the latest research about reading development and difficulties. *Chapter on instruction for emergent bilingual learners (EBs), plus an appendix on selecting texts for EBs. *Expanded discussions of dyslexia and the role of executive function in reading. *Application tables that translate key concepts into recommended classroom strategies.
Environmental Marketing: Strategies, Practice, Theory, and Research is a timely resource for the 1990s. It examines a broad range of issues that affect environmental behavior while providing materials and guidance to marketing decisionmakers. It will guide your organization toward a decidedly “green” marketing movement, toward marketing concepts and tools that not only serve your organization's objectives but preserve and protect the environment as well. Environmental Marketing clearly defines the potential roles of organizations, consumers, and governments and examines how these groups impact environmental factors through the marketing process. The book helps you understand alternative perspectives to green marketing issues and, in turn, enables you to make clearer, more conscious decisions toward improving your environmental marketing performance. This resourceful text begins by defining the concept of environmental or “green” marketing and how the idea of a healthy planet and successful marketing strategies can co-exist. It discusses the consumer's behavior toward environmental products and how marketers can effectively educate them, the guidelines involved in doing so, and the consequences of failing to do so. The marketer's position on environmental changes in industry is examined along with alternatives for striking a balance between marketing objectives and environmental concerns. Finally, the book discusses the global response to environmental marketing and where multi-national organizations belong within this balance. Environmental Marketing is a book for all managers involved in decisions impacting the environment. It is also of great interest to public policymakers and academics who wish for quick insight into environmental marketing issues.
Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.
In the context of substantial changes in health service policy and public health policy in England and Wales over the last two decades, Health Policy, Power and Politics fills an important gap by providing an up-to-date and accessible account and sociological analysis of recent trends in health policies.
Integrating theory with practice, this core textbook provides a structured and sequential introduction to motor learning and motor control. Part 1 begins by introducing what motor learning is and how movement is controlled, before exploring how a learning environment may be manipulated to assist in the learning and performance of movement skills. Part 2 explores motor control from neural, behavioural and dynamic systems perspectives. Part 3 provides an overview of considerations in applying motor learning and skill acquisition principles to physical education, exercise and sports science. Chapters are illustrated with flowcharts and diagrams to aid students' understanding, and include activities and end-of-chapter review questions to consolidate knowledge. Motor Learning and Skill Acquisition is essential reading for all Physical Education, Exercise and Sports Science and Sports Coaching students. New to this Edition: - New and updated chapters on skill acquisition approaches, talent identification and development, and performance analysis and feedback as well as separate chapters on practice design and task modification, and practice organisation and planning - Contains additional content on decision-making, tactical and strategic skills, traditional and constraints-led skill acquisition approaches, practice design, and skill-drill and game-based practice for skill acquisition - Supported by a bank of online lecturer resources, including PowerPoints, MCQs and lab activities
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