This book offers a thorough technical elaboration and philosophical defense of an objectivist informational interpretation of quantum mechanics according to which its novel content is located in its kinematical framework, that is, in how the theory describes systems independently of the specifics of their dynamics. It will be of interest to researchers and students in the philosophy of physics and in theoretical physics with an interest in the foundations of quantum mechanics. Additionally, parts of the book may be used as the basis for courses introducing non-physics majors to quantum mechanics, or for self-study by those outside of the university with an interest in quantum mechanics. With a Foreword by Jeffrey Bub. -- “Understanding Quantum Raffles is a wonderful book for both the specialists and those with curious minds. The elegance and the simplicity with which the 'three Mikes' explain some of the deepest aspects of quantum mechanics on the basis of probabilities and correlations are dazzling and delightful. The same elegance and simplicity also make the book ideal for any engaged reader who ever wondered what is so special about quantum mechanics. In our age of new quantum technologies, this is something anyone should read.” (Guido Bacciagaluppi, author of Quantum Theory at the Crossroads) “This book makes a sustained argument for an informational interpretation of quantum theory, blending an elegant mathematical characterisation of quantum correlations with incisive historical and philosophical analysis. A must-read for those interested in quantum foundations, and also a fertile source of teaching inspiration for quantum theory.” (Leah Henderson, Department of Theoretical Philosophy, University of Groningen) “This is one of the most fascinating and accessible presentations of the informational approach to quantum mechanics. What has so far been mostly restricted to the theoretical physics community is here masterfully explained for a broader audience even without a physics background. Scholars, students, and laypeople alike will appreciate the clear, vivid, and yet deep discussion of what raffle tickets and correlation elliptopes can tell us about the physics and philosophy of the quantum world.” (Markus Müller, Institute for Quantum Optics and Quantum Information, Vienna)
This book describes the exciting discovery of every isotope observed on earth to date, which currently numbers some 3000. The discoveries are arranged in chapters according to the observation techniques or production methods. Each chapter contains tables listing the first authors of the first publication as well as details about the production and detection methods used. At the end, a comprehensive table lists all isotopes sorted by elements. The book is based on individual paragraphs for each isotope, which were published over the last few years as separate articles in the journal “Atomic Data and Nuclear Data Tables”. The work re-evaluates all prior assignments judging them with a uniform set of criteria. In addition, the author includes over 100 new isotopes which have been discovered since the articles published. This book is a source of information for researchers as well as enthusiastic laymen alike. From the prepublication review: “The explanations focus on the essentials, which makes the various chapters pleasingly compact. The phrasing is well understandable also for non-experts. This makes the book easy to read, even thrilling. I have to confess that parts of the manuscript I was even reading as an evening lecture in the bed, so exciting was the history of isotope discoveries.” Sigurd Hofmann, Helmholtz Professor at GSI Darmstadt, Germany, and a leading expert in superheavy nuclei
A practical and accessible introduction to the bootstrap method——newly revised and updated Over the past decade, the application of bootstrap methods to new areas of study has expanded, resulting in theoretical and applied advances across various fields. Bootstrap Methods, Second Edition is a highly approachable guide to the multidisciplinary, real-world uses of bootstrapping and is ideal for readers who have a professional interest in its methods, but are without an advanced background in mathematics. Updated to reflect current techniques and the most up-to-date work on the topic, the Second Edition features: The addition of a second, extended bibliography devoted solely to publications from 1999–2007, which is a valuable collection of references on the latest research in the field A discussion of the new areas of applicability for bootstrap methods, including use in the pharmaceutical industry for estimating individual and population bioequivalence in clinical trials A revised chapter on when and why bootstrap fails and remedies for overcoming these drawbacks Added coverage on regression, censored data applications, P-value adjustment, ratio estimators, and missing data New examples and illustrations as well as extensive historical notes at the end of each chapter With a strong focus on application, detailed explanations of methodology, and complete coverage of modern developments in the field, Bootstrap Methods, Second Edition is an indispensable reference for applied statisticians, engineers, scientists, clinicians, and other practitioners who regularly use statistical methods in research. It is also suitable as a supplementary text for courses in statistics and resampling methods at the upper-undergraduate and graduate levels.
The Solidarity movement of the early 1980s not only triggered a transformation in Polish society, it forced a fundamental reconsideration of the nature of socialism throughout the Soviet Union and Eastern Europe. Seen as one of the most important social movements of the century, this pathbreaking study analyses Solidarity's significance in Soviet societies.
In November 1944, the U.S. Navy fleet lay at anchor deep in the Pacific Ocean, when the oiler USS Mississinewa exploded. Japan’s secret weapon, the Kaiten—a manned suicide submarine—had succeeded in its first mission. The Kaiten was so secret that even Japanese naval commanders didn’t know of its existence. And the Americans kept it secret as well. Embarrassed by the attack, the U.S. Navy refused to salvage the sunken Mighty Miss. Not until 2001, when a diving team located the wreck, would survivors learn what really happened. In Kaiten, Michael Mair and Joy Waldron tell the full story, from newly revealed secrets of the Kaiten development and training schools to gripping firsthand accounts of U.S. Navy survivors in the wake of the attack, as well as the harrowing recovery efforts that came later. INCLUDES PHOTOGRAPHS
The interaction of database and AI technologies is crucial to such applications as data mining, active databases, and knowledge-based expert systems. This volume collects the primary readings on the interactions, actual and potential, between these two fields. The editors have chosen articles to balance significant early research and the best and most comprehensive articles from the 1980s. An in-depth introduction discusses basic research motivations, giving a survey of the history, concepts, and terminology of the interaction. Major themes, approaches and results, open issues and future directions are all discussed, including the results of a major survey conducted by the editors of current work in industry and research labs. Thirteen sections follow, each with a short introduction. Topics examined include semantic data models with emphasis on conceptual modeling techniques for databases and information systems and the integration of data model concepts in high-level data languages, definition and maintenance of integrity constraints in databases and knowledge bases, natural language front ends, object-oriented database management systems, implementation issues such as concurrency control and error recovery, and representation of time and knowledge incompleteness from the viewpoints of databases, logic programming, and AI.
A comprehensive introduction to bootstrap methods in the R programming environment Bootstrap methods provide a powerful approach to statistical data analysis, as they have more general applications than standard parametric methods. An Introduction to Bootstrap Methods with Applications to R explores the practicality of this approach and successfully utilizes R to illustrate applications for the bootstrap and other resampling methods. This book provides a modern introduction to bootstrap methods for readers who do not have an extensive background in advanced mathematics. Emphasis throughout is on the use of bootstrap methods as an exploratory tool, including its value in variable selection and other modeling environments. The authors begin with a description of bootstrap methods and its relationship to other resampling methods, along with an overview of the wide variety of applications of the approach. Subsequent chapters offer coverage of improved confidence set estimation, estimation of error rates in discriminant analysis, and applications to a wide variety of hypothesis testing and estimation problems, including pharmaceutical, genomics, and economics. To inform readers on the limitations of the method, the book also exhibits counterexamples to the consistency of bootstrap methods. An introduction to R programming provides the needed preparation to work with the numerous exercises and applications presented throughout the book. A related website houses the book's R subroutines, and an extensive listing of references provides resources for further study. Discussing the topic at a remarkably practical and accessible level, An Introduction to Bootstrap Methods with Applications to R is an excellent book for introductory courses on bootstrap and resampling methods at the upper-undergraduate and graduate levels. It also serves as an insightful reference for practitioners working with data in engineering, medicine, and the social sciences who would like to acquire a basic understanding of bootstrap methods.
Light therapy' is established worldwide as the treatment of choice for seasonal affective disorder. It is also successfuly used in nonseasonal depression, as well as for many other psychiatric and neurologic illnesses, and in sleep medicine. Wake therapy is the fastest antidepressant known. Imaging studies show that both methods share neurobiological substrates with antidepressants, but act much faster. 'Chronotherapeutics' the combination of light and wake therapy achieves rapid results and, by reducing residual symptoms, also minimises relapse. Written by three prominent clinical and research experts in biological rhythms, this manual aims to broaden knowledge and practical application of these non-pharmacologic interventions for bipolar and unipolar disorders. Clinical understanding is deepened by an explanation of the circadian timing system and sleep regulatory mechanisms which underlie the novel treatment strategy. The step-by-step guide and description of the interventions in centers throughout the world provides clear hands-on instructions, supported by a solid body of clinical research. The first edition of 'Chronotherapeutics for Affective Disorders' has kindled a network of psychiatrists and psychologists who are actively introducing these treatments for their inpatients and outpatients. This manual is also essential reading for primary care physicians, sleep medicine specialists and health care administrators.
From citrus trees to spring breakers, Transforming the Irvine Ranch tells the story of Orange County’s metamorphosis from 93,000 acres of farmland into an iconic Southern California landscape of beaches and modernist architecture. Drawing on decades of archival research and their own years at the famed Irvine Company, the authors bring a collection of colorful characters responsible for the transformation to life, including: Ray Watson, whose nearly century-long life took him from an Oakland boarding house to the Irvine and Walt Disney Company boardrooms Joan Irvine Smith, a much-married heiress who waged war against the US government and the Irvine Foundation's reactionary board and won William Pereira, the visionary architect whose work became synonymous with the LA cityscape. Spanning the history of modern California from its Gold Rush past to the late 1970s, Transforming the Irvine Ranch chronicles a storied family’s largely successful attempts to remake the vast Irvine Ranch in its own image.
Greeks arrived in America with the expectation that freedom would permit their families to thrive and be successful. With hard work, belief in the Orthodox faith, and commitment to education, Greeks ascended in Chicago, and America, to positions of responsibility and success. Today Greek Americans are among the wealthiest and most successful of immigrant groups. Greeks recognized a historical imperative that they meet the challenges and aspirations of a classical Hellenic heritage. Greeks in Chicago celebrates the rich history of the Greek community through copious pictorial documentation.
Raif was tough. He was the toughest guy on the block and the undisputed leader of the Sixth Street Kerugma Gang. He had a rough upbringing, and well, home was little more than a place to crash for a while before going back into the streets to commit more mayhem. He was well-known to the cops having stolen several cars and newly branching out to become a sidewalk pharmacist. As he was chased by the police, he finds himself trapped in a blind alley. In a panic, he challenges God to save him. Much to his confusion, his challenge is answered. This book is filled with many other stories that may answer some of your challenges and perhaps surprise you as you read!
This book explores the fabrication of soft material and biomimetic MEMS sensors, presents a review of MEMS/NEMS energy harvesters and self-powered sensors, and focuses on the recent efforts in developing flexible and wearable piezoelectric nanogenerators. It also includes a critical analysis of various energy harvesting principles, such as electromagnetic, piezoelectric, electrostatic, triboelectric, and magnetostrictive. This multidisciplinary book is appropriate for students and professionals in the fields of material science, mechanical engineering, electrical engineering, and bioengineering.
Protecting the natural environment and promoting sustainability have become important objectives, but achieving such goals presents myriad challenges for even the most committed environmentalist. American Environmentalism: Philosophy, History, and Public Policy examines whether competing interests can be reconciled while developing consistent, coherent, effective public policy to regulate uses and protection of the natural environment without destroying the national economy. It then reviews a range of possible solutions. The book delves into key normative concepts that undergird American perspectives on nature by providing an overview of philosophical concepts found in the western intellectual tradition, the presuppositions inherent in neoclassical economics, and anthropocentric (human-centered) and biocentric (earth-centered) positions on sustainability. It traces the evolution of attitudes about nature from the time of the Ancient Greeks through Europeans in the Middle Ages and the Renaissance, the Enlightenment and the American Founders, the nineteenth and twentieth centuries, and up to the present. Building on this foundation, the author examines the political landscape as non-governmental organizations (NGOs), industry leaders, and government officials struggle to balance industrial development with environmental concerns. Outrageous claims, silly misrepresentations, bogus arguments, absurd contentions, and overblown prophesies of impending calamities are bandied about by many parties on all sides of the debate—industry spokespeople, elected representatives, unelected regulators, concerned citizens, and environmental NGOs alike. In lieu of descending into this morass, the author circumvents the silliness to explore the crucial issues through a more focused, disciplined approach. Rather than engage in acrimonious debate over minutiae, as so often occurs in the context of "green" claims, he recasts the issue in a way that provides a cohesive look at all sides. This effort may be quixotic, but how else to cut the Gordian knot?
Even the creator of Sherlock Holmes, Sir Arthur Conan Doyle, would rave about the Baker Street mystery series! A Baker Street Wedding is another winner, and not to be missed. "Any [Sherlock] Holmes fan would enjoy Michael Robertson's fresh new take on the Holmes stories...fast-paced and thoroughly entertaining." —CNN, Must Read Books on The Baker Street Translation "Agatha Christie fans will revel in Robertson’s fifth novel...a classic fair play whodunit leavened with humor." —Publishers Weekly (starred review) on The Baker Street Jurors The wedding of Reggie Heath and the celebrated actress Laura Rankin was reported in all the tabloids—which is to say, it was a disaster. Now, in a remote village on the British coast, locked in by sea cliffs on one side and moors on the other, the newlywed’s plane—piloted by Laura—has landed. Reggie doesn’t understand why Laura has picked this god-forsaken hamlet for their honeymoon. What is she keeping from him? The answers are in Laura’s past, but she’s not saying, and Reggie is out of his depth. He must have help—or his worst fears and more will be realized.
One of the most valuable roles a manager can perform in today's rapidly changing environment is to mentor and inspire the people around them to learn. By nurturing talent, motivating individual development, and encouraging excellence, a manager's mentoring can enhance individual performance and the organization's prospects for success. Mentoring is not an easy skill to develop, and many managers, who may excel at leading or coaching, may be disasters as mentors when it comes to creating a bond and bringing out untapped qualities in others. The Manager as Mentor goes beyond traditional approaches to explore the newest techniques in mentoring and collaboration. Featuring personal development tools, worksheets, and references, The Manager as Mentor will enable managers to bring out the best in themselves, the people they guide, and their organizations. Mentoring is an age-old practice, tracing its roots in ancient Greek folklore to Odysseus' friend, Mentor, whom the Homeric hero entrusted as guide to his son's development. Today, with the ascendance of the knowledge age and the transformation of the workplace into an environment of continual learning, mentoring has emerged as one of the most important and valuable roles a manager can perform. By serving as a role model, providing feedback, nurturing talent, inspiring individual development, and facilitating excellence, a manager's mentoring strengthens relationships within the organization, and ultimately contributes to such critical factors as improved job performance, low turnover, and greater profitability. Mentoring is not an easy skill to attain, however, and many managers who may excel at leading teams or coordinating projects may be disasters as mentors. The Manager as Mentor explores emerging trends and approaches to help managers master the skills of effective mentoring—and enhance themselves, their proteges, and their organizations in the process. Drawing from extensive research, dozens of examples, and their own practical application in training managers around the world, the authors argue that exceptional mentoring skills can be developed. They guide the reader toward understanding the key roles that mentors play and the activities and techniques they can employ for maximum impact. Diagnostic exercises will help readers assess their strengths, weaknesses, and opportunities for development, and create a step-by-step action plan for achieving goals—either individually or in groups. The authors also offer an extensive listing of resources for more in-depth information on various aspects of mentoring, such as problem solving, active listening, and employee advocacy. Ultimately, The Manager as Mentor offers the tools by which managers can promote learning, empowerment, and insight to create vibrant organizational cultures.
The premier single-volume reference in the field of anesthesia, Clinical Anesthesia is now in its Sixth Edition, with thoroughly updated coverage, a new full-color design, and a revamped art program featuring 880 full-color illustrations. More than 80 leading experts cover every aspect of contemporary perioperative medicine in one comprehensive, clinically focused, clear, concise, and accessible volume. Two new editors, Michael Cahalan, MD and M. Christine Stock, MD, join Drs. Barash, Cullen, and Stoelting for this edition. A companion Website will offer the fully searchable text, plus access to enhanced podcasts that can be viewed on your desktop or downloaded to most Apple and BlackBerry devices. This is the tablet version which does not include access to the supplemental content mentioned in the text.
50th Anniversary Edition of the groundbreaking case-based pharmacotherapy text, now a convenient two-volume set. Celebrating 50 years of excellence, Applied Therapeutics, 12th Edition, features contributions from more than 200 experienced clinicians. This acclaimed case-based approach promotes mastery and application of the fundamentals of drug therapeutics, guiding users from General Principles to specific disease coverage with accompanying problem-solving techniques that help users devise effective evidence-based drug treatment plans. Now in full color, the 12th Edition has been thoroughly updated throughout to reflect the ever-changing spectrum of drug knowledge and therapeutic approaches. New chapters ensure contemporary relevance and up-to-date IPE case studies train users to think like clinicians and confidently prepare for practice.
The riveting true story of the rise and fall of Murder, Inc. and the executioner-turned-informant whose mysterious death became a turning point in Mob history. In the fall of 1941, a momentous trial was underway that threatened to end the careers and lives of New York’s most brutal mob kingpins. The lead witness, Abe Reles, had been a trusted executioner for Murder, Inc., the enforcement arm of a coast-to-coast mob network known as the Commission. But the man responsible for coolly silencing hundreds of informants was about to become the most talkative snitch of all. In exchange for police protection, Reles was prepared to rat out his murderous friends, from Albert Anastasia to Bugsy Siegel—but before he could testify, his shattered body was discovered on a rooftop outside his heavily-guarded hotel room. Was it a botched escape, or punishment for betraying the loyalty of the country’s most powerful mobsters? Michael Cannell's A Brotherhood Betrayed traces the history of Murder, Inc. through Reles’ rise from street punk to murder chieftain to stool pigeon, ending with his fateful death on a Coney Island rooftop. It resurrects a time when crime became organized crime: a world of money and power, depravity and corruption, street corner ambushes and elaborately choreographed hits by wise-cracking foot soldiers with names like Buggsy Goldstein and Tick Tock Tannenbaum. For a brief moment before World War II erupted, America fixated on the delicate balance of trust and betrayal on the Brooklyn streets. This is the story of the one man who tipped the balance.
Home to the New York Yankees, the Bronx Zoo, and the Grand Concourse, the Bronx was at one time a haven for upwardly mobile second-generation immigrants eager to leave the crowded tenements of Manhattan in pursuit of the American dream. Once hailed as a "wonder borough" of beautiful homes, parks, and universities, the Bronx became -- during the 1960s and 1970s -- a national symbol of urban deterioration. Thriving neighborhoods that had long been home to generations of families dissolved under waves of arson, crime, and housing abandonment, turning blocks of apartment buildings into gutted, graffiti-covered shells and empty, trash-filled lots. In this revealing history of the Bronx, Evelyn Gonzalez describes how the once-infamous New York City borough underwent one of the most successful and inspiring community revivals in American history. From its earliest beginnings as a loose cluster of commuter villages to its current status as a densely populated home for New York's growing and increasingly more diverse African American and Hispanic populations, this book shows how the Bronx interacted with and was affected by the rest of New York City as it grew from a small colony on the tip of Manhattan into a sprawling metropolis. This is the story of the clattering of elevated subways and the cacophony of crowded neighborhoods, the heady optimism of industrial progress and the despair of economic recession, and the vibrancy of ethnic cultures and the resilience of local grassroots coalitions crucial to the borough's rejuvenation. In recounting the varied and extreme transformations this remarkable community has undergone, Evelyn Gonzalez argues that it was not racial discrimination, rampant crime, postwar liberalism, or big government that was to blame for the urban crisis that assailed the Bronx during the late 1960s. Rather, the decline was inextricably connected to the same kinds of social initiatives, economic transactions, political decisions, and simple human choices that had once been central to the development and vitality of the borough. Although the history of the Bronx is unquestionably a success story, crime, poverty, and substandard housing still afflict the community today. Yet the process of building and rebuilding carries on, and the revitalization of neighborhoods and a resurgence of economic growth continue to offer hope for the future.
A majority of evolutionary biologists believe that we now can envision our biological predecessors--not the first, but nearly the first, living beings on Earth. This book is about these vanished forebears. The era between the first rudimentary life on Earth and the appearance of more complex beings is called the RNA world. It is RNA (ribonucleic acid) long believed to be a mere biologic copier and messenger, that offers a glimpse into our ancient predecessors. To describe early RNA creatures, here called "ribocytes" or RNA cells, the author uses basics of molecular biology. He reviews our current understanding of the tree of life, examines the structure of RNA itself, explains the operation of the genetic code, and more. Courting controversy among those who question the role of ribocytes -- citing the chemical fragility of RNA and the uncertainty about the origin of an RNA synthetic apparatus -- he offers a vision of early life on Earth.
Between 1936 and 1939, almost 1,700 Canadians defied their government and volunteered to fight in the Spanish Civil War. They left behind punishing lives in Canadian relief camps, mines, and urban flophouses to confront fascism in a country few knew much about. Michael Petrou has drawn on recently declassified archival material, interviewed surviving Canadian veterans, and visited the battlefields of Spain to write the definitive account of Canadians in the Spanish Civil War. Renegades is an intimate and unflinching story of idealism and courage, duplicity and defeat.
Clinical Anesthesia, Seventh Edition covers the full spectrum of clinical options, providing insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This classic book is unmatched for its clarity and depth of coverage. *This version does not support the video and update content that is included with the print edition. Key Features: • Formatted to comply with Kindle specifications for easy reading • Comprehensive and heavily illustrated • Full color throughout • Key Points begin each chapter and are labeled throughout the chapter where they are discussed at length • Key References are highlighted • Written and edited by acknowledged leaders in the field • New chapter on Anesthesia for Laparoscopic and Robotic Surgery Whether you’re brushing up on the basics, or preparing for a complicated case, the digital version will let you take the content wherever you go.
Breastfeeding is a comprehensive reference that provides basic science information as well as practical applications. Dr. Ruth Lawrence-a pioneer in the field of human lactation-covers the uses of certain drugs in lactating women, infectious diseases related to lactation, the latest Australian research on anatomy and physiology, and much more.in print and online. Provide thoughtful guidance to the breastfeeding mother according to her circumstances, problems, and lifestyle from integrated coverage of evidence-based data and practical experience. Make appropriate drug recommendations, including approved medications, over-the-counter medications, and herbal remedies. Access the fully searchable text online at www.expertconsult.com. Treat conditions associated with breastfeeding-such as sore nipples, burning pain, or hives-using extensive evidence-based information. Apply the latest understanding of anatomy and physiology through coverage of recent Australian CT and MR studies of the breast and its function. Stay current on new research on infectious diseases germane to lactation and new antibiotics, antivirals, and immunizations available for use during lactation. Effectively manage the use of medications during lactation thanks to an updated discussion of this difficult subject. The latest research on breastfeeding and evidence-based solutions for treating associated medical problems from the authority in the field, Dr. Ruth Lawrence
The essential reference book to have for preparing and watching the 2006 tournament in Germany this Summer. Everything is here, from the historical perspective to line-up for each match. The book has the statistics, the groupings, team and player profiles, the venues and the trivia. A historical perspective since 1930 is given with extensive game and round commentary. One chapter recalls the most memorable games in each tournament. Another chapter is devoted to the best and brightest players. The qualifying rounds of the international soccer competition are summarised, highlighting the pivotal games for each of the 32 qualifying nations. the twelve German venues for the tournament are described, assessing the pros and cons of each site. The centrepiece of the book is an entry for each qualifying team describing the country, previous appearances and history, qualifying games, key players, player pool, probable line-up and a short discussion of how the team will fare in this competition. Many interesting features, anecdotes, and trivia on the participating teams are sprinkled throughout the text.
The third edition of this book provides comprehensive coverage of pediatric medical adherence, including such important topics as the extent of nonadherence and medical consequences, predictors of adherence, theories about adherence and clinical applications, and assessment strategies for adherence and health outcomes. In addition, chapters describe strategies for improving adherence, review research studies on improving adherence, and address ways to improve research on adherence for children and adolescents with chronic diseases. The new edition also examines the developmental aspects of adherence assessment and intervention as well as cultural, ethical, and legal issues in adherence research and practice. Key areas of coverage include: Consequences of nonadherence and correlates of adherence. Developmental aspects related to assessing and improving pediatric medical adherence. Assessing pediatric disease and health status. Cultural, ethical, and legal issues related to pediatric medical adherence. Adherence to Pediatric Medical Regimens, Third Edition, is an essential reference for researchers, professors, and graduate students as well as clinicians, therapists, and other practitioners in developmental, clinical child and school psychology, child and adolescent psychiatry, pediatrics and pediatric psychology, social work, public health, health psychology, and all interrelated fields.
It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.
Written by respected experts in the field, Biomaterials in Orthopedics discusses bioabsorbable biomaterials for bone repair, nondegradable materials in orthopaedics and delivery systems. Topics in this text include biocompatibility and the biomaterial/tissue interface; self-reinforced bioabsorbable devices and guided regeneration; bone substitutes,
Clinical Anesthesia, Seventh Edition covers the full spectrum of clinical options, providing insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This classic book is unmatched for its clarity and depth of coverage. *This version does not support the video and update content that is included with the print edition. Key Features: • Formatted to comply with Kindle specifications for easy reading • Comprehensive and heavily illustrated • Full color throughout • Key Points begin each chapter and are labeled throughout the chapter where they are discussed at length • Key References are highlighted • Written and edited by acknowledged leaders in the field • New chapter on Anesthesia for Laparoscopic and Robotic Surgery Whether you’re brushing up on the basics, or preparing for a complicated case, the digital version will let you take the content wherever you go.
For over fifty years, McDonald's Blood Flow in Arteries has remained the definitive reference work in the field of arterial hemodynamics, including arterial structure and function with special emphasis on pulsatile flow and pressure. Prestigious, authoritative and comprehensive, the sixth edition has been totally updated and revised with several ne
A classic for all lovers of the Mediterranean, this newly revised and updated edition helps readers discover the individual charm of each of the more than 40 Italian Islands. 30 maps and drawings.
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