Emerging as the dark side of Romanticism, horror is one of literature’s oldest genres. Its history is so diverse it’s sometimes difficult to define. Are moody stories about ghosts and vampires related to gory tales of beasts and zombies? And what about the more realistic terrors of murderous rogues and diabolical doctors? The emotion of fear unifies the 14 stories in First Came Fear: New Tales of Horror. But fear is legion in its varieties. The authors skillfully navigate terror of all types. M.P. Diederich’s “Dressage for Beginners” and Christopher Calix’s “The Wedding Gift” are fine examples of the ghoulish humor tradition while J.P. Whitmer’s “Loved to Death” will frighten you in a stunningly visceral way. Oliver Ledesma’s “Atabey” and Samantha Pilecki’s “Roser and the Guide to the Inexplicable” impart fear through non-traditional storytelling and Sarah K. Stephens’ “The Factory” shows how effectively, and chillingly, horror can tackle social issues. All the stories are accompanied by Luke Spooner’s dramatic art, which combines Gothic macabre with echoes of classic horror illustration. The entire collection will have you gripping the edge of your seat or biting your fingernails, yet leave you longing for more!
The Guide to the Presidency is an extensive study of the most important office of the U.S. political system. Its two volumes describe the history, workings and people involved in this office from Washington to Clinton. The thirty-seven chapters of the Guide, arranged into seven distinct subject areas (ranging from the origins of the office to the powers of the presidency to selection and removal) cover every aspect of the presidency. Initially dealing with the constitutional evolution of the presidency and its development, the book goes on to expand on the history of the office, how the presidency operates alongside the numerous departments and agents of the federal bureaucracy, and how the selection procedure works in ordinary and special cicumstances. Of special interest to the reader will be the illustrated biographies of every president from Washington to the present day, and the detailed overview of the vice-presidents and first ladies of each particular office. Also included are two special appendices, one of which gathers together important addresses and speeches from the Declaration of Independence to Clinton's Inaugural Address, and another which provides results from elections and polls and statistics from each office.
First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke. Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Make efficient and accurate diagnoses with the aid of abundant full-color CT images and pathology slides. Stay up to date on hot topics such as mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more.
“An orthopedic surgeon’s down-to-earth, fast-paced, and frequently funny memoir of his residency [told] with a born storyteller’s skill.” —Kirkus Reviews Michael Collins’ account of his four-year surgical residency at the famed Mayo Clinic traces his rise from an eager but clueless first-year resident navigating chaos and feelings of inadequacy to accomplished Chief Resident in his final year. With unparalleled humor, he recounts the disparity between people’s perceptions of a doctor’s glamorous life and the real thing: a succession of rundown cars towed to the junk yard, long weekends moonlighting at rural hospitals, a family that grows larger every year, and a laughable income. Collins’ good nature helps him over some of the rough spots—but cannot spare him the harsh realities and heart-wrenching decisions of a doctor’s life. A teenager’s leg is mangled by a tractor: risk the boy’s life to save his leg, or amputate immediately? A woman diagnosed with bone cancer injures her hip: should he recommend a painful operation even though she has only months to live? Unflinching and deeply engaging, Hot Lights, Cold Steel captures the author’s struggles to reconcile his idealism and desire to heal with the recognition of his own limitations and imperfections. “Collins’ life as a surgical resident is heartbreaking one minute and triumphant the next. You’ll laugh and cry and cheer.” —Augusten Burroughs, New York Times–bestselling author of Dry “At once darkly humorous and truly compassionate. Not since House of God has there been such a ferociously funny look at the world of hospital medicine.” —Michael Palmer, New York Times–bestselling author of The Last Surgeon “I adore this book.” —Tess Gerritsen, New York Times–bestselling author of the Rizzoli & Isles novels
Dark Times: A Lockdown and a Call to Arms is a historical political thriller that explores an American revolution that broke out during a once in a hundred years pandemic that killed more than four hundred thousand Americans. As a trained historian, he explains the dynamic involved in the complicated event which has everybody on pins and needles. He articulates the frustration and fear people experience during this pandemic. He explores the sick ideology of Antifa and the Black Lives Matter movement that is attempting to destroy the American way of life. These are Communist groups who reject the middle-class way of life. They want to do away with the nuclear family and reject hard work and initiative. He also looks at the actions Tea Party groups took to fight back against the pandemic lockdown and ridiculous mask mandate for everyone. They believed only the older and immune comprised people needed masks. As you read through this account, you will be able to feel the pain and joy the characters experience as the story unfolds. The author tells a hopeful story about America and the American people's future. He shows the ups and downs of families' lives during this very troubling period of our history. You will have a hard time putting this book down as he quickly goes from one family story to the next one. We highly recommend this tale as we are moving through the revolution we are presently experiencing.
The Mormon tradition's emphasis on prophetic authority makes the Church of Jesus Christ of Latter-day Saints unique within America's religious culture. The religion that Joseph Smith created established a kingdom of God in a land distrustful of monarchy while positioning Smith as Christ's voice on earth, with the power to form cities, establish economies, and arrange governments. Michael Hubbard MacKay traces the Church of Jesus Christ of Latter-day Saints' claim to religious authority and sets it within the context of its times. Delving into the evolution of the concept of prophetic authority, MacKay shows how the Church emerged as a hierarchical democracy with power diffused among leaders Smith chose. At the same time, Smith's settled place atop the hierarchy granted him an authority that spared early Mormonism the internal conflict that doomed other religious movements. Though Smith faced challenges from other leaders, the nascent Church repeatedly turned to him to decide civic plans and define the order of both the cosmos and the priesthood.
Emergency managers and officials have seen a tremendous increase in the planning responsibilities placed on their shoulders over the last decade. Crisis Management and Emergency Planning: Preparing for Today's Challenges supplies time-tested insights to help communities and organizations become better prepared to cope with natural and manmade disas
The application of digital information and communication technologies (ICTs) to reform governmental structures and public service is widely and perhaps naively viewed as the 21st century "savior", the enlightened way to reinvigorate democracy, reduce costs, and improve the quality of public services. This book examines the transition from e-government to digital governance in light of the financial exigencies and political controversies facing many governments. The chapters concentrate on strategies for public sector organizational transformation and policies for improved and measurable government performance in the current contentious political environment. This fully updated second edition of Digital Governance provides strategies for public officials to apply advanced technologies, manage remote workforces, measure performance, and improve service delivery in current crisis-driven administrative and political environments. The full implementation of advanced digital governance requires fundamental changes in the relationship between citizens and their governments, using ICTs as catalysts for political as well as administrative communication. This entails attitudinal and behavioral changes, secure networks, and less dependence on formal bureaucratic structures (covered in Part I of this book); transformation of administrative, educational, and security systems to manage public services in a more citizen-centric way (covered in Part II); the integration of advanced digital technologies with remote broadband wireless internet services (Part III); and the creation of new forms of global interactive citizenship and self-governance (covered in Part IV). Author Michael E. Milakovich offers recommendations for further improvement and civic actions to stimulate important instruments of governance and public administration. This book is required reading for political science, public administration, and public policy courses, as well as federal, state, and local government officials.
Current knowledge of the epidemiology, clinical expression, pathophysiology and available medical and surgical therapy for ocular surface diseases, providing an invaluable text for ocular surface specialists, general ophthalmologists, optometrists and residents.
Creatine and Creatine Phosphate: Scientific and Clinical Perspectives is an up-to-date summary of both the scientific and medical aspects of creatine and creatine phosphate metabolism and therapy.It covers in detail the basic biochemistry, bioenergetics and biophysics of these agents with particular emphasis on their role on the cardiovascular and muscle systems. Modern in vivo myocardial and skeletal muscle measurements are outlined, and the importance of the molecules in cardiovascular medicine, sport science and cardiac surgery are highlighted.This book is designed for those interested in the basic scientific background to creatine and creatine phosphate, and also for physicians treating or studying heart and vascular disease. The book will also be vital for sports scientists who wish to acquire a comprehensive knowledge of the molecule which is currently being promoted for performance and exercise programmes.
The doctor duo that brought you to the low-carb lifestyle shows you how to regain in midlife the figure of sleek, flat-bellied youth. Why is it that even though we might maintain our high school weight, few of us maintain our high school belt size? In your twenties and thirties, the layers of fat on top of your abs were the problem. But once you reach middle-age, the enemy shifts. The 6-Week Cure for the Middle-Aged Middle is the first book to deal specifically with the issues we face in the next stage of life, providing a plan for eliminating the unhealthy fat that accumulates around the organs–visceral fat–that is the true cause of the middle-aged bulge. The good news is that with the right diet, visceral fat can be quickly reduced and eliminated, enhancing both your looks and your health. Even after twenty years researching and refining the science of weight loss and management, bestselling authors Drs. Michael and Mary Dan Eades fell victim to the middle-aged middle themselves. Although otherwise fit and healthy, both lost the flat belly that signals youth. In The 6-Week Cure for the Middle-Aged Middle, they share the simple dietary program they created to shed the weight. Discover: • How eating saturated fat can actively trim your middle • Why the “eat less, exercise more” prescription fails–and what to do about it • Why “inner” and “outer” tube fat measurements are important to your health • How to fight the fat stored inside your liver that leads to hard-to-lose middle-body flab
With your heavy case load, you can't afford to waste time searching for answers. Cardiology, 3rd Edition, by Drs. Crawford, DiMarco, and Paulus, offers you just the practical, problem-based guidance you need to quickly overcome any clinical challenge. 8 color-coded sections cover the 8 major clinical syndromes of cardiovascular disease—each section a virtual "mini textbook" on its topic! 40 new chapters keep you up to date with the latest advances in the field, while more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs capture clinical manifestations as they present in practice. It’s current, actionable information that you can put to work immediately for your patients! Offers a problem-based approach that integrates basic science, diagnostic investigations, and therapeutic management in one place for each cardiovascular disease so you can quickly find all of the actionable knowledge you need without flipping from one section to another. Features introductory bulleted highlights in each chapter that present the most pertinent information at a glance. Presents abundant algorithms to expedite clinical decision making. Includes more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs that capture clinical manifestations as they present in practice, and promote readability and retention. Includes 40 new chapters including Inherited Arrhythmia Syndromes, Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy in CHD, Management of the Cyanotic Patient with CHD, Special Problems for the Cardiology Consultant Dealing with Bariatric/Gastric Bypass — and many more — that equip you with all of the latest knowledge. Presents "Special Problem" sections—many new to this edition—that provide practical advice on problems that can be difficult to treat.
A poignant look at empathetic encounters between staunch ideological rivals, all centered around our common need for food. While America's new reality appears to be a deeply divided body politic, many are wondering how we can or should move forward from here. Can political or social divisiveness be healed? Is empathy among people with very little ideological common ground possible? In A Decent Meal, Michael Carolan finds answers to these fundamental questions in a series of unexpected places: around our dinner tables, along the aisles of our supermarkets, and in the fields growing our fruits and vegetables. What is more common, after all, than the simple fact that we all need to eat? This book is the result of Carolan's career-long efforts to create simulations in which food could be used to build empathy, among even the staunchest of rivals. Though most people assume that presenting facts will sway the way the public behaves, time and again this assumption is proven wrong as we all selectively accept the facts that support our beliefs. Drawing on the data he has collected, Carolan argues that we must, instead, find places and practices where incivility—or worse, hate—is suspended and leverage those opportunities into tools for building social cohesion. Each chapter follows the individuals who participated in a given experiment, ranging from strawberry-picking, attempting to subsist on SNAP benefits, or attending a dinner of wild game. By engaging with participants before, during, and after, Carolan is able to document their remarkable shifts in attitude and opinion. Though this book is framed around food, it is really about the spaces opened up by our need for food, in our communities, in our homes, and, ultimately, in our minds.
Principles of Emergency Management and Emergency Operations Centers (EOC) provides a clear and up-to-date understanding of how an EOC should operate within the guidance of various federal and national programs. It discusses the processes and systems that must be considered in emergency planning and preparedness efforts. The culmination of more than
Wellsboro, the county seat of Tioga County, owes much of its vitality to dense forests, abundant wildlife, and mountainous terrain. Named by the National Park Service as a Natural Landmark in 1968, nearby Pine Creek Gorge was introduced by George Washington Sears, better known as "Nessmuk," in 1860 and later publicized as "the Grand Canyon of Pennsylvania." A weeklong Laurel Festival, organized in 1938, celebrates the canyon, the state flower, and Wellsboro. The Laurel Parade and the Laurel Queen coronation conclude the festivities each year. Wellsboro also owes its long-term prosperity to agriculture, logging, mining, and industry, all of which have contributed to the town's economic survival and growth. Corning Glass Works, a shining example of industrial innovation, made Wellsboro "the Christmas Bulb Capital of the World." Described as quaint, Wellsboro is often compared to a New England village. In addition to a row of antique gaslights lining the boulevard, the Penn-Wells Hotel, the Arcadia Theatre, and Dunham's Department Store, all of which date to the early 1900s, add to Main Street's charm, while the Green features a fountain statue of "Wynken, Blynken, and Nod.
Behavioral sciences research -- Health behavior and theory -- Determinants of behavior -- Behavioral epidemiologic research -- Frequency measures in epidemiology -- Sources and uses of available population-based behavior data -- Data collection, misclassification and missing data -- Statistical application to behavior data -- Epidemiological input for selecting behavioral intervention targets
Brain Beat: A Scientific and Evolutionary Perspective of Brain Health examines the origins of the pillars of brain health, expounding the current scientific basis for recommending physical exercise, cognitive exercises, sleep hygiene, socialization and brain-foods. However in addition to the "how" question, the more important "why" question is addressed from a neuro-archeological and evolutionary standpoint. The clinical and laboratory brain sciences are replete with ever increasing numbers of p
First published in 1989, written with contributions from experts who have critically evaluated the state of the art and the prospects of isolated adults cardiac myocytes in cardiological research, this two-volume publication summarizes the current knowledge of this technology. The methodology, structure, and metabolism of cardiomyocytes are presented, along with metabolism and cation homeostasis and energy metabolism and hypoxic injury. Additionally, cell isolation and culture and the structure and biochemistry of the sarcolemma is explained. Electrophysiology and contractile function with ionic currents and membrane channels is discussed. Also, the electro-physiological effects of transmitters and hormones are presented, with excitation-contraction coupling and the use of cardiomyocytes in drug design and research explained.
Cancer survivors are returning to the workplace in higher numbers than ever before. This is a positive outcome of the “war on cancer”, however, many of these cancer survivors face the possibility of illness- or treatment-related complications; employer discrimination or harassment; and other serious concerns. Cancer Survivorship and Work reviews many of the issues relevant to cancer survivors in the workplace from the survivors’, employers’, and global perspectives. This interdisciplinary and international volume brings together experts in fields as varied as epidemiology, economics, rehabilitation, psychology, human factors and ergonomics; law, and public policy to create a unique, up-to-date reference of what is currently known and what needs to be considered in the future. With this knowledge, challenges faced by this growing population can be better addressed by health care providers, employers, survivors and their families.
The largest seaweed, giant kelp (Macrocystis) is the fastest growing and most prolific of all plants found on earth. Growing from the seafloor and extending along the ocean surface in lush canopies, giant kelp provides an extensive vertical habitat in a largely two-dimensional seascape. It is the foundation for one of the most species-rich, productive, and widely distributed ecological communities in the world. Schiel and FosterÕs scholarly review and synthesisÊtake the reader from DarwinÕs early observations to contemporary research, providing a historical perspective for the modern understanding of giant kelp evolution, biogeography, biology, and physiology. The authors furnish a comprehensive discussion of kelp species and forest ecology worldwide, with considerations of human uses and abuses, management and conservation, and the current and likely future impacts of global change. This volume promises to be the definitive treatise and reference on giant kelp and its forests for many years, and it will appeal to marine scientists and others who want a better appreciation and understanding of these wondrous forests of the sea.
This first-of-its-kind book offers clinicians a unique and comprehensive system of cognitive and behavioral testing that is tiered and context-appropriate for the diagnosis of mental status. Because the challenge nowadays with neurologic syndrome presentations is no longer merely lesion localization, but the degree, extent and nature of a cognitive and/or behavioral impairment, this work proposes a more targeted system of mentation evaluation -- one that incorporates behavioral, neurological, neuropsychiatric, and neuropsychological components. Developed by synthesizing outcomes data from a range of stroke registries, this novel work offers a stepwise, hierarchical approach to mentation evaluation largely determined by level of consciousness and degree of cooperation. Organized across 14 chapters, the book begins with an introduction to the challenges of cognitive and behavioral assessment, as well as a discussion of various clinical presentations ranging from mild behavioral impairment to cognitive reserve and its implications. Subsequent chapters then address various approaches to mental status evaluation and explore how these tests affect brain physiology. The work closes with a unique discussion of the various lay populations that may benefit from cognitive and behavioral evaluation. Authored by a renowned expert in the field, Clinical Mentation Evaluation: A Connectomal Approach to Rapid and Comprehensive Assessment is an invaluable reference that seeks to revitalize neurological and psychiatric disease measurement within the clinical setting. The work will be of interest to all clinicians in training and clinical practice who regularly, or even periodically, conduct mental status examination.
Big Intel recounts the dramatic story of the rise and Cold War heroics of the CIA and the American intelligence apparatus followed by its unfortunate slide into Marxist-influenced Deep State dysfunction as BIG INTEL became BAD INTEL. How the Left Subverted the CIA and FBI Once upon a time, the FBI and the CIA fought America’s enemies at home and abroad. Now they are tools of a growing police state, attacking the left’s political enemies and spying on ordinary American citizens—even parents who push back against radical public schools. How did we get here? In this revealing and thoroughly documented book, a former CIA operative traces the origins of Big Intel to a loose network of Marxist academic agitators known as the Frankfurt School. Their ideology appealed to the Ivy League elites populating the CIA, but the subversion of the FBI took longer, impeded for a time by the bureau’s staunchly anti-Communist director, J. Edgar Hoover. Eventually both institutions succumbed, and today Big Intel is controlled by the cultural Marxists. Chronicling the parasitic infiltration of the CIA and FBI, Big Intel shows how normal intelligence functions have given way to political correctness and never-ending “pride” propaganda, trap- ping agents in the “diversity, equity, and inclusion” house of mirrors. Most chilling of all is the emergence of the leftist security state. Big Intel has become Bad Intel. There are hard times ahead, but if Americans remember what freedom once was, we can still defang Big Intel and return our intelligence services to the service of democracy.
From Pandemic to Insurrection: Voting in the 2020 US Presidential Election describes voting in the 2020 election, from the presidential nomination to new voting laws post-election. Election officials and voters navigated the challenging pandemic to hold the highest turnout election since 1900. President Donald Trump’s refusal to acknowledge the pandemic’s severity coupled with frequent vote fraud accusations affected how states provided safe voting, how voters cast ballots, how lawyers fought legal battles, and ultimately led to an unsuccessful insurrection.
Psychology Around Us, Fourth Canadian Edition offers students a wealth of tools and content in a structured learning environment that is designed to draw students in and hold their interest in the subject. Psychology Around Us is available with WileyPLUS, giving instructors the freedom and flexibility to tailor curated content and easily customize their course with their own material. It provides today's digital students with a wide array of media content — videos, interactive graphics, animations, adaptive practice — integrated at the learning objective level to provide students with a clear and engaging path through the material. Psychology Around Us is filled with interesting research and abundant opportunities to apply concepts in a real-life context. Students will become energized by the material as they realize that Psychology is "all around us.
While viruses—the world’s most abundant biological entities—are not technically alive, they invade, replicate, and evolve within living cells. Michael Cordingley goes beyond our familiarity with infections to show how viruses spur evolutionary change in their hosts and shape global ecosystems, from ocean photosynthesis to drug-resistant bacteria.
The law governing family relationships has changed dramatically in the course of the 20th century and this book - drawing extensively on both published and archival material and on legal as well as other sources - gives an account of the processes and problems of reform.
The definitive text in its field, McGlamry's Comprehensive Textbook of Foot and Ankle Surgery, is the ideal reference for the podiatric or orthopedic surgeon, resident, or student preparing for certification exams. From perioperative management to postoperative complications and considerations, this must-have resource prepares you for a full range of podiatric surgeries and procedures ranging from routine trauma of the foot and leg to compound deformities, enabling you to face any challenge with confidence. This is the tablet version of McGlamry's Comprehensive Textbook of Foot and Ankle Surgery which does not include access to the supplemental content mentioned in the text.
Michael Dear and Jennifer Wolch examine the emergence of urban ghettos of the socially dependent--an unforeseen "solution" to the problem of developing community-based care for a variety of service-dependent groups, including the mentally and physically disabled, ex-offenders, and addicts. Based on detailed case studies drawn from several cities in Canada and the United States, Landscapes of Despair is a comprehensive analysis of these ghettos. Originally published in 1987. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
In the 1850s, early Euro-American settlers established two remote outposts on the slopes of the eastern Sierra Nevada, both important way stations on the central emigrant trail. The Carson Valley settlement was located on the western edge of the Utah Territory, while the Honey Lake Valley hamlet, 120 miles north, fell within California’s boundaries but was separated from the rest of the state by the formidable mountain range. Although these were some of the first white communities established in the region, both areas had long been inhabited by Indigenous Americans. Carson Valley had been part of Washoe Indian territory, and Honey Lake Valley was a section of Northern Paiute land. Michael Makley explores the complexities of this turbulent era, when the pioneers’ actions set the stage for both valleys to become part of national incorporation. With deft writing and meticulously researched portrayals of the individuals involved, including the Washoe and Northern Paiute peoples, Imposing Order Without Law focuses on the haphazard evolution of “frontier justice” in these remote outposts. White settlers often brought with them their own ideas of civil order. Makley’s work contextualizes the extralegal acts undertaken by the settlers to enforce edicts in their attempt to establish American communities. Makley’s book reveals the use and impact of group violence, both within the settlements and within the Indigenous peoples’ world, where it transformed their lives.
The last research frontier in high frequency electronics lies in the so-called terahertz (or submillimeter wave) regime, between the traditional microwave and the infrared domains. Significant scientific and technical challenges within the terahertz (THz) frequency regime have recently motivated an array of new research activities. During the last few years, major research programs have emerged that are focused on advancing the state of the art in THz frequency electronic technology and on investigating novel applications of THz frequency sensing. This book provides a detailed review of the new THz frequency technological developments that are emerging across a wide spectrum of sensing and technology areas.Volume II presents cutting edge results in two primary areas: (1) research that is attempting to establish THz-frequency sensing as a new characterization tool for chemical, biological and semiconductor materials, and (2) theoretical and experimental efforts to define new device concepts within the ?THz gap?.
The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black's H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.
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