A terrorist attack leaves millions inflicted with a horrific disease. This scar on humanity has left desperate politicians no alternative than to rest their hopes on bizarre theories and hypotheses regarding an unknown cure. The ensuing lust for answers and power by the corrupt New World Order leads to betrayal, assassinations, concentration camps, and the potential destruction of the United States. In this ultimate battle between good and evil, who will win the race against time?
A critical examination of Canadian regulatory governance and politics over the past fifty years, Rules and Unruliness builds on the theory and practice of rule-making to show why government "unruliness" - the inability to form rules and implement structures for compliance - is endemic and increasing. Analyzing regulatory politics and governance in Canada from the beginning of Pierre Trudeau's era to Stephen Harper's government, the authors present a compelling argument that current regulation of the economy, business, and markets are no longer adequate to protect Canadians. They examine rules embedded in public spending programs and rules regarding political parties and parliamentary government. They also look at regulatory capitalism to elucidate how Canada and most other advanced economies can be characterized by co-governance and co-regulation between governments, corporations, and business interest groups. Bringing together literature on public policy, regulation, and democracy, Rules and Unruliness is the first major study to show how and why increasing unruliness affects not only the regulation of economic affairs, but also the social welfare state, law and order, parliamentary democracy, and the changing face of global capitalism.
High-throughputomics' projects such as genome sequencing, structural genomics and proteomics mean that there is no shortage of information on proteins. But the more information we have, the harder it is to make sense of it, to know where to start, and to identify the important results. This book is a clear, up to date and authoritative account of
Introduction to Addiction, Volume One in the series, introduces the reader to the study of neurobiology of addiction by clearly defining addiction and its neuroadaptational views. This volume includes thorough descriptions of the various animal models applicable to the study of addiction, including Animal Models of the Binge-Intoxication Stage of the Addiction Cycle and Animal Models of Vulnerability to Addiction. The book's authors also include a section on numerous neurobiological theories that aid in the understanding of addiction, including dopamine, prefrontal cortex and relapse. Provides neurobiological theories on how addiction works Explains addiction cycle stages of binge, withdrawal and anticipation Reviews the role of dopamine and the frontal cortex in addiction Discusses the neurocircuitry of reward and stress Includes animal models and neuroadaptational views on addiction
In the wake of Shelby County v. Holder and the January 6 Capitol insurrection, changes to election laws, policies, and especially access to voting have become a key political battleground. A central point of contention is whether new restrictive voting laws intentionally discriminate against Black and Hispanic subpopulations in the United States. Conversely, do policies that expand voting access favor Democrats and increase the possibility of election fraud? In The Cost of Voting in the American States, Michael J. Pomante II, Scot Schraufnagel, and Quan Li test these questions. The authors look specifically for systematic outcomes produced by distinctive election policies in the American states. First, they establish a competent measure of voting restrictions to begin this unraveling. The authors create a Cost of Voting Index (COVI) for the fifty states, which uses a statistical procedure to extract an underlying dimension and to determine significance from state laws based on how restrictive the polices are. The authors call the underlying dimension extracted the “cost of voting.” With this measure in place, they evaluate which states have a higher cost of voting, how this cost impacts who votes, and whether there is a correlation between the cost of voting and minority populations. Using Racial Threat Theory arguments, the authors demonstrate that states with larger or growing Black and Hispanic populations have more restricted voting, and that these restrictive voting laws disproportionately demobilize these populations in predictable ways. States with a higher cost of voting also show lower minority electoral success as well as a larger gap in Black and female representation, and the authors reveal that decreasing the cost of voting does not lead to fraud or favor one party over another. The Cost of Voting in the American States makes a case for a new preclearance formula, and the COVI provides a viable approach for future election law.
Here is a basic introduction to Lattice Boltzmann models that emphasizes intuition and simplistic conceptualization of processes, while avoiding the complex mathematics that underlies LB models. The model is viewed from a particle perspective where collisions, streaming, and particle-particle/particle-surface interactions constitute the entire conceptual framework. Beginners and those whose interest is in model application over detailed mathematics will find this a powerful 'quick start' guide. Example simulations, exercises, and computer codes are included.
How do governments govern today and how well do they do it? How do governments choose the tools or instruments they will use to get things done? In today's world, how could these decisions be improved from the standpoint of efficiency, effectiveness, legitimacy and accountability? "Designing Government" brings together leading experts to examine the "instrument choice" perspective on government and public policy over the past two decades. The authors examine such issues as accountability, effectiveness, sustainability, legitimacy, and the impact of globalization. The debate is enriched by contributors from several countries who provide a comparative context and, most importantly, help chart a course for the future. Moving beyond the traditional regulatory sphere and its preoccupations with deregulation and efficiency, the authors trace the complex relationships between instrument choices and governance. "Designing Government" encourages the reader to consider factors in the design of complex mixes, such as issues of redundancy, context, the rule of law and accountability. These latter factors are especially central in today's world to the design and implementation of effective instrument choices by governments and, ultimately, to good governance. The authors conclude, in fact, that seeing instrument choice itself as part and parcel of designing government and achieving good governance is both the promise and the challenge for instrument-based perspectives in the years ahead. Contributors include Hans Bressers (University of Twente), Neil Gunningham (Australian National University), John Hoornbeck (University of Pittsburgh), Margaret Hill (Infrastructure Canada), Michael Howlett (Simon Fraser University), Bridget Hutter (London School of Economics and Political Science), Pierre Issalys (Université Laval), Réjean Landry (Laval University), Roderick A. Macdonald (McGill University), Larry O'Toole (University of Georgia), B. Guy Peters (University of Pittsburgh), Michael J. Prince (University of Victoria), Sean Rehaag (University of Toronto), Arthur B. Ringeling (Erasmus University), Stephen J. Toope (McGill University), Michael J. Trebilcock (University of Toronto), Frédéric Varone (Université Catholique de Louvain, Belgium), and Kernaghan Webb (Carleton University).
Marketplace complexity and dynamics create an environment that increases the uncertainty of innovation activities. In this context systematic management of innovation and product management are increasingly important for company success. This book presents the fundamentals of innovation and product management and introduces the reader to a holistic process model with particular focus on innovation and uncertainty. This integrated consideration of innovation management and product innovation within an interdisciplinary approach represents a unique characteristic of this book. The book is designed to address the needs of managers who want a practical but well-researched guide to innovation and product management. Graduate and advanced undergraduate students would also find the chapters in this book particularly useful.
Revised, updated, and enhanced from cover to cover, the Sixth Edition of Greenfield’s Surgery: Scientific Principles and Practice remains the gold standard text in the field of surgery. It reflects surgery’s rapid changes, new technologies, and innovative techniques, integrating new scientific knowledge with evolving changes in surgical care. Updates to this edition include new editors and contributors, and a greatly enhanced visual presentation. Balancing scientific advances with clinical practice, Greenfield’s Surgery is an invaluable resource for today’s residents and practicing surgeons.
Current knowledge of the epidemiology, clinical expression, pathophysiology and available medical and surgical therapy for ocular surface diseases, providing an invaluable text for ocular surface specialists, general ophthalmologists, optometrists and residents.
1. Introduction 2. What is Proportionality? 3. Proportionality: A Multiplicity of Meanings 4. Proportionality in the Just War Tradition 5. Proportionality in International Humanitarian Law 6. Proportionality in Human Rights Law and Morality 7. The Uniqueness of Jus in Bello Proportionality 8. Countermeasures and Counterinsurgency 9. Human Shields and Risk 10. Targeted Killings and Proportionality in Law: Two Models 11. The Nature of War and the Idea of "Cyberwar" 12. Thresholds of Jus in Bello Proportionality Bibliography Index.
A comprehensive introduction to the role of epidemiology in veterinary medicine This fully revised and expanded edition of Veterinary Epidemiology introduces readers to the field of veterinary epidemiology. The new edition also adds new chapters on the design of observational studies, validity in epidemiological studies, systematic reviews, and statistical modelling, to deliver more advanced material. This updated edition begins by offering an historical perspective on the development of veterinary medicine. It then addresses the full scope of epidemiology, with chapters covering causality, disease occurrence, determinants, disease patterns, disease ecology, and much more. Veterinary Epidemiology, Fourth Edition: ● Features updates of all chapters to provide a current resource on the subject of veterinary epidemiology ● Presents new chapters essential to the continued advancement of the field ● Includes examples from companion animal, livestock, and avian medicine, as well as aquatic animal diseases ● Focuses on the principles and concepts of epidemiology, surveillance, and diagnostic-test validation and performance ● Includes access to a companion website providing multiple choice questions Veterinary Epidemiology is an invaluable reference for veterinary general practitioners, government veterinarians, agricultural economists, and members of other disciplines interested in animal disease. It is also essential reading for epidemiology students at both the undergraduate and postgraduate levels.
Biotechnology has become one of the most important issues in public policy and governance, altering the boundaries between the public and the private, the economic and the social, and further complicating the divide between what is scientifically possible and ethically preferred. Given the importance of biotechnology in shaping relations between the state, science, the economy, and the citizenry, a book that explores the Canadian biotechnology regime and its place in our democracy is timelier than ever. Three Bio-Realms provides the first integrated examination of the thirty-year story of the democratic governance of biotechnology in Canada. G. Bruce Doern and Michael J. Prince, two recognized specialists in governance innovation and social policy, look at particular ‘network-based’ factors that seek to promote and to regulate biotechnology inside the state as well as at broader levels. Unmatched by any other book in its historical scope and range, Three Bio-Realms is sure to be read for years to come.
The Canada Pension Plan disability benefit is a monthly payment available to disabled citizens who have contributed to the CPP and are unable to work regularly at any job. Covering the program’s origins, early implementation, liberalization of benefits, and more recent restraint and reorientation of this program, Struggling for Social Citizenship is the first detailed examination of the single largest public contributory disability plan in the country. Focusing on broad policy trends and program developments and highlighting the role of cabinet ministers, members of Parliament, public servants, policy advisors, and other political actors, Michael Prince examines the pension reform agendas and records of the Pearson, Trudeau, Mulroney, Chrétien, Martin, and Harper prime ministerial eras. Shedding light on the immediate world of applicants and clients of the CPP disability benefit, this study reviews academic literature and government documents, features interviews with officials, and provides an analysis of administrative data regarding trends in expenditures, caseloads, decisions, and appeals related to CPP disability benefits. Struggling for Social Citizenship looks into the ways in which disability has been defined in programs and distinguished from ability in given periods, how these distinctions have operated, been administered, contested and regulated, as well as how, through income programs, disability is a social construct and administrative category. Weaving together literature on social policy, political science, and disability studies, Struggling for Social Citizenship produces an innovative evaluation of Canadian citizenship and social rights.
From the physician behind the wildly popular NutritionFacts website, How Not to Die reveals the groundbreaking scientific evidence behind the only diet that can prevent and reverse many of the causes of disease-related death. The vast majority of premature deaths can be prevented through simple changes in diet and lifestyle. In How Not to Die, Dr. Michael Greger, the internationally-renowned nutrition expert, physician, and founder of NutritionFacts.org, examines the fifteen top causes of premature death in America-heart disease, various cancers, diabetes, Parkinson's, high blood pressure, and more-and explains how nutritional and lifestyle interventions can sometimes trump prescription pills and other pharmaceutical and surgical approaches, freeing us to live healthier lives. The simple truth is that most doctors are good at treating acute illnesses but bad at preventing chronic disease. The fifteen leading causes of death claim the lives of 1.6 million Americans annually. This doesn't have to be the case. By following Dr. Greger's advice, all of it backed up by strong scientific evidence, you will learn which foods to eat and which lifestyle changes to make to live longer. History of prostate cancer in your family? Put down that glass of milk and add flaxseed to your diet whenever you can. Have high blood pressure? Hibiscus tea can work better than a leading hypertensive drug-and without the side effects. Fighting off liver disease? Drinking coffee can reduce liver inflammation. Battling breast cancer? Consuming soy is associated with prolonged survival. Worried about heart disease (the number 1 killer in the United States)? Switch to a whole-food, plant-based diet, which has been repeatedly shown not just to prevent the disease but often stop it in its tracks. In addition to showing what to eat to help treat the top fifteen causes of death, How Not to Die includes Dr. Greger's Daily Dozen -a checklist of the twelve foods we should consume every day.Full of practical, actionable advice and surprising, cutting edge nutritional science, these doctor's orders are just what we need to live longer, healthier lives.
This issue of Clinics in Chest Medicine, edited by Dr. Michael Niederman, focuses on Pneumonia, with topics including: Inflammation and Pneumonia; The Lung Microbiome's Role in Pneumonia; Biomarkers for the Management of Pneumonia; Influenza and Viral Pneumonia; Guidelines to Manage Community-Acquired Pneumonia (CAP); Vaccines to Prevent CAP; Adjunctive Therapies for CAP; Healthcare Associated Pneumonia; Rapid Diagnostic Methods for Pneumonia; Airway Devices in VAP Pathogenesis and Prevention; Management of VAP; Distinguishing Ventilator-Associated Tracheobronchitis from VAP; Practical Approaches to VAP Prevention; Optimizing Antibiotic Administration for Pneumonia; New Antibiotics for Pneumonia; and Personalized Approach to Pneumonia Management.
Networks provide a very useful way to describe a wide range of different data types in biology, physics and elsewhere. Apart from providing a convenient tool to visualize highly dependent data, networks allow stringent mathematical and statistical analysis. In recent years, much progress has been achieved to interpret various types of biological network data such as transcriptomic, metabolomic and protein interaction data as well as epidemiological data. Of particular interest is to understand the organization, complexity and dynamics of biological networks and how these are influenced by network evolution and functionality. This book reviews and explores statistical, mathematical and evolutionary theory and tools in the understanding of biological networks. The book is divided into comprehensive and self-contained chapters, each of which focuses on an important biological network type, explains concepts and theory and illustrates how these can be used to obtain insight into biologically relevant processes and questions. There are chapters covering metabolic, transcriptomic, protein interaction and epidemiological networks as well as chapters that deal with theoretical and conceptual material. The authors, who contribute to the book, are active, highly regarded and well-known in the network community.
This reference manual is designed to enable more geophysicists to appreciate static corrections, especially their limitations, their relationship with near-surface geology, and their impact on the quality of final interpreted sections. The book is addressed to those involved in data acquisition (datum static corrections), data processing (datum static and residual static corrections), and interpretation (the impact that unresolved static corrections, especially the long-wavelength or low-spatial-frequency component, have on the interpretation of the final section). Simple explanations of the underlying principles are included in an attempt to remove some of the mystique of static corrections. The principles involved are illustrated with simple models; these are supplemented with many data examples. This book details differences in approaches that must be considered among 2D, 3D, and crooked-line recordings as well as between P-wave and S-wave surveys. Static corrections are shown to be a simplified yet practical approach to modeling the effects of the near surface where a more correct wavefield or raypath-modeled method may not be efficiently undertaken. Chapters cover near-surface topography and geology; computation of datum static corrections; uphole surveys; refraction surveys; static corrections-limitations and effect on seismic data processes; residual static corrections; and interpretation aspects. An extensive index and a large list of references are included.
Here’s all the guidance you need to overcome the most difficult musculoskeletal problems using orthoses and assistive devices! With new coverage of postpolio syndrome, cranial orthoses, and now incorporating the perspectives of renowned physiatrists, this is a one-stop rehabilitation resource. Tips and Pearls in every chapter and a new 2-color format make accessing information a snap. Includes Chapters on biomechanics of spine, upper limb and hand and lower limb to help you understand the factors that determine the orthoses available for these joints. Incorporates chapters on the Orthotic Prescription, Strength and Materials, and the Normal and Pathologic Gait help you understand your role in the rehabilitative process. Contains information about the specific science behind the construction of orthoses—perfect for the Certified Prosthetist/Orthotist and the interested physician. Carries the authority and approval of AAOS, the preeminent orthopaedic professional society. Uses a new 2-color format to make the book easier to use and information easier to retain. Includes Tips and Pearls boxes in every chapter so you can quickly access expert guidance. Contains new chapters on: Orthoses for Persons with Postpolio Paralysis; Orthoses for Persons with Postpolio Syndromes; and Cranial Orthoses. Incorporates evidence-based recommendations into the chapters on spinal, upper- and lower-limb orthoses to help you select the most proven approach for your patients.
Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.
Research on vitamin C and its effects on cancer is growing in popularity around the world as positive research continues to accumulate building a stronger case for its effectiveness. This concise SpringerBrief on Vitamin C and Cancer presents the latest findings on how vitamin C induces apoptosis. A high concentration of vitamin C allows for ascorbate to generate hydrogen peroxide in tissue that can selectively kill cancer cells. Research has confirmed that high-dose vitamin C is cytotoxic to a wide variety of cancer cell lines, and that it also boosts the anti-cancer activity of several common chemotherapy drugs. Vitamin C also does more than just kill cancer cells. It boosts immunity by stimulating collagen formation to help the body wall off the tumor. It inhibits hyaluronidase, an enzyme that tumors use to metastasize and invade other organs throughout the body. This concise and up-to-date Brief is geared towards cancer researchers and scientists, as well as physicians interested in the basic science and the translational potential of vitamin C in cancer therapeutics.
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