The remarkable excavation of a previously unidentified city in Israel from the time of King David, shedding new light on the link between the bible and history King David is a pivotal figure in the Bible, which tells his life story in detail and gives stirring accounts of his deeds, including the slaying of the Philistine giant Goliath and the founding of his capital in Jerusalem. But no certain archaeological finds from the period of his reign or of the kingdom he ruled over have ever been uncovered—until now. In this groundbreaking account, the excavators of Khirbet Qeiyafa in the Valley of Elah, where the Bible says David fought Goliath, reveal how seven years of exhaustive investigation have uncovered a city dating to the time of David— the late eleventh and early tenth century BCE—surrounded by massive fortifications with impressive gates and a clear urban plan, as well as an abundance of finds that tell us much about the inhabitants. Discussing the link between the Bible, archaeology, and history In the Footsteps of King David explains the significance of these discoveries and how they shed new light on David’s kingdom. The topic is at the center of a controversy that has raged for decades, but these findings successfully challenge scholars disputing the historicity of the Bible and the chronology of the events recounted in it.
Over the years, a large and growing literature on the economics of climate change has developed. Within this volume the contributors have included a wide range of journal essays that consider the impact of climate change on specific sectors; goods and services; the costs and benefits of greenhouse gas (GHG) mitigation; and policy design for mitigation, including both domestic instruments and issues related to international agreements.
Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.
Having gone through 30 years of development, the new edition of this highly-regarded classic is the most trusted companion for understanding and promoting the potential for social work with disabled people. It offers readers a clear introduction to the core issues of disability alongside discussion and assessment of the social worker's role. Written by an experienced and highly respected team of authors, the book reflects: - The latest updates, developments and policy changes - The broad range of areas needing to be understood for informed practice - Recent changes to the focus of social work education and practice - The Social Model of Disability, encouraging debate about its role in social work - Developments for independent living - The heightened importance of safeguarding issues, giving attention to the topical issue of disabilist hate crime Accessible to a broad readership and respected by disabled people themselves, this text is the foundation for effective practice.
The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes--and indeed because of them--our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come.
This timely book examines how fascist ideology has taken hold among certain segments of American society and how this can be addressed in curriculum and instruction. Vavrus presents middle, secondary, and college educators and their students with a conceptual framework for enacting a critical multicultural pedagogy by analyzing discriminatory discourse and recommending civic anti-fascist steps people can take right now. For teacher education programs and policymakers, anti-fascist civic assessment rubrics are provided. To help clarify contemporary debates over what can be taught in public schools, an advance organizer highlights contested and misunderstood terminology. Featuring historical and contemporary patterns of fascist politics, this accessible text is organized in four parts: (1) "Good Trouble," (2) Unpacking Ideological Orientations, (3) Indicators of Colonial Proto-Fascism and U.S. Fascist Politics, and (4) An Anti-Fascist "Reading the World." Readers will come away with a deeper knowledge base that marshalls a century of anti-fascist actions in response to contemporary acts of racism, anti-Semitism, Islamophobia, gender and sexuality discrimination, bias against Latinx and migrant populations, and other actions that undermine our democracy and harm marginalized students and their families and communities. Book Features: A groundbreaking framework for incorporating anti-fascist pedagogical concepts into multicultural education Descriptions of common characteristics of historical fascism, far-right extremism, and anti-fascism. Anti-fascist assessment rubrics for teacher educators. Guidance to assist classroom teachers in contextualizing current anti-democracy events. Recommended and annotated anti-fascist background readings informed by critical, theoretical, and intersectional perspectives.
The Geometry and Topology of Coxeter Groups is a comprehensive and authoritative treatment of Coxeter groups from the viewpoint of geometric group theory. Groups generated by reflections are ubiquitous in mathematics, and there are classical examples of reflection groups in spherical, Euclidean, and hyperbolic geometry. Any Coxeter group can be realized as a group generated by reflection on a certain contractible cell complex, and this complex is the principal subject of this book. The book explains a theorem of Moussong that demonstrates that a polyhedral metric on this cell complex is nonpositively curved, meaning that Coxeter groups are "CAT(0) groups." The book describes the reflection group trick, one of the most potent sources of examples of aspherical manifolds. And the book discusses many important topics in geometric group theory and topology, including Hopf's theory of ends; contractible manifolds and homology spheres; the Poincaré Conjecture; and Gromov's theory of CAT(0) spaces and groups. Finally, the book examines connections between Coxeter groups and some of topology's most famous open problems concerning aspherical manifolds, such as the Euler Characteristic Conjecture and the Borel and Singer conjectures.
Now published by Academic Press and revised from the author's previous Five Kingdoms Third edition, this extraordinary, all inclusive catalogue of the world's living organisms describes the diversity of the major groups, or phyla, of nature's most inclusive taxa. Developed after consultation with specialists, this modern classification scheme is consistent both with the fossil record and with recent molecular, morphological and metabolic data. Generously illustrated, now in full color, Kingdoms and Domains is remarkably easy to read. It accesses the full range of life forms that still inhabit our planet and logically and explicitly classifies them according to their evolutionary relationships. Definitive characteristics of each phylum are professionally described in ways that, unlike most scientific literature, profoundly respect the needs of educators, students and nature lovers. This work is meant to be of interest to all evolutionists as well as to conservationists, ecologists, genomicists, geographers, microbiologists, museum curators, oceanographers, paleontologists and especially nature lovers whether artists, gardeners or environmental activists.Kingdoms and Domains is a unique and indispensable reference for anyone intrigued by a planetary phenomenon: the spectacular diversity of life, both microscopic and macroscopic, as we know it only on Earth today. - New Foreword by Edward O. Wilson - The latest concepts of molecular systematics, symbiogenesis, and the evolutionary importance of microbes - Newly expanded chapter openings that define each kingdom and place its members in context in geological time and ecological space - Definitions of terms in the glossary and throughout the book - Ecostrips, illustrations that place organisms in their most likely environments such as deep sea vents, tropical forests, deserts or hot sulfur springs - A new table that compares features of the most inclusive taxa - Application of a logical, authoritative, inclusive and coherent overall classification scheme based on evolutionary principles
How can classroom teachers effectively differentiate learning and teaching programs to provide for the needs of every student in their class? This best-selling text begins by asking "Why include all students?" in regular classrooms and then shows how this can be done. It outlines the philosophy of inclusive education and focuses on the use of individualised planning and effective teaching practices to maximise learning outcomes within positive and productive environments. Vignettes and narratives provide real-life examples that help put the theory in context. This fifth edition includes broader coverage of issues to do with diversity and individual differences, particularly cultural and multicultural inclusion, linguistic diversity and giftedness. There is more throughout on the universal design for learning framework and on partnerships with families, while new pedagogical features encourage readers to reflect. Throughout, it emphasises a practical, research-based approach to teaching that can be applied to support students with a range of differences and additional needs.
Significantly revised and updated, the new edition of this highly regarded reference on the shoulder continues to impress. A multitude of leading international authorities—30% new to this 4th edition—present today’s most comprehensive, in-depth view of the current state of shoulder practice, all in a beautifully illustrated, full-color 2-volume masterwork. They deliver the most up-to-date coverage of shoulder function and dysfunction, along with practical approaches for patient evaluation and balanced discussions of treatment alternatives—open and arthroscopic, surgical and nonsurgical. Greatly expanded and visually enhanced coverage of arthroscopy, as well as many new chapters, provide expert guidance on the latest minimally invasive approaches. New “Critical Points summary boxes highlight key technical tips and pearls, and two DVDs deliver new videos that demonstrate how to perform open and arthroscopic procedures. And now, as an Expert Consult title, this thoroughly updated 4th edition comes with access to the complete fully searchable contents online, as well as videos of arthroscopic procedures from the DVDs—enabling you to consult it rapidly from any computer with an Internet connection. Includes tips and pearls from leaders in the field, as well as their proven and preferred methods. Offers scientifically based coverage of shoulder function and dysfunction to aid in the decision-making process. Provides a balance between open and arthroscopic techniques so you can chose the right procedures for each patient. Includes the entire contents of the book online, fully searchable, as well as procedural videos from the DVDs, for quick, easy anywhere access. Features 30% new expert contributors and new chapters, including Effectiveness Evaluation and the Shoulder, Revision of Rotator Cuff Problems, Management of Complications of Rotator Cuff Surgery, Management of Infected Shoulder Prosthesis, and others, providing you with abundant fresh insights and new approaches. Provides new and expanded material on the management of advanced arthritis and CTA, infected arthroplasty, procedures to manage the stiff shoulder, and much more keeping you on the cusp of the newest techniques. Offers enhanced coverage of shoulder arthroscopy, including basic and advanced techniques and complications, for expert advice on all of the latest minimally invasive approaches. Devotes an entire new chapter to research frontiers to keep you apprised of what’s on the horizon. Incorporates “Critical Points summary boxes that highlight key technical tips and pearls. Uses a new full-color design for optimal visual guidance of arthroscopic views and procedures. Presents new videos on arthroscopic procedures on 2 DVDs to help you master the latest techniques.
This volume presents the proceedings of the Tel Aviv International Topology Conference held during the Special Topology Program at Tel Aviv University. The book is dedicated to Professor Mel Rothenberg on the occasion of his 65th birthday. His contributions to topology are well known-from the early work on triangulations to numerous papers on transformation groups and on geometric and analytic aspects of torsion theory. Current research related to those contributions are reported in this book. Coverage is included on the following topics: vanishing theorems for the Dirac operator, the theory of Reidemeister torsion (including infinite dimensional flat bundles), Nobikov-Shubin invariants of manifolds, topology of group actions, Lusternik-Schnirelman theory for closed 1-forms, finite type invariants of links and 3-manifolds, equivariant cobordisms, equivariant orientations and Thom isomorphisms, and more.
We re-examine the extent to which personal taxes on dividends are capitalized into the equity prices of domestic firms, using data from around the time of the 1997 U.K. dividend tax reform, which removed a significant tax credit for an important group of investors: U.K. pension funds. The tax-adjusted CAPM suggests that the impact should depend on an average of dividend tax rates across all investors, and that U.K. pension funds should reduce their holdings of the previously tax-favored asset: U.K. equities. Given that U.K. pension funds are small relative to the total size of the world capital market, a small open economy-type argument implies that the main effect of the reform would be to reduce U.K. pension funds' ownership of U.K. equities, with little impact on their price. We present evidence which is consistent with these hypotheses. We discuss why previous research (Bell and Jenkinson, 2002) reached a different conclusion.
One of the greatest mathematicians in the world, Michael Atiyah has earned numerous honors, including a Fields Medal, the mathematical equivalent of the Nobel Prize. While the focus of his work has been in the areas of algebraic geometry and topology, he has also participated in research with theoretical physicists. For the first time, these volumes bring together Atiyah's collected papers--both monographs and collaborative works-- including those dealing with mathematical education and current topics of research such as K-theory and gauge theory. The volumes are organized thematically. They will be of great interest to research mathematicians, theoretical physicists, and graduate students in these areas.
Fully revised and updated, the second edition of this authoritative guide is a comprehensive, scholarly and systematic review of modern English. In one volume the book presents a description of both the linguistic structure of present-day English and its geographical, social, gender, and ethnic variations. Covering new developments such as the impact of email on language and corpus-based grammars, this accessible text has been extensively rewritten and brings the survey of modern English right up to date. It also offers new examples and suggestions for further reading.
What is happiness? Why are some people happier than others? This new edition of The Psychology of Happiness provides a comprehensive and up-to-date account of research into the nature of happiness. Major research developments have occurred since publication of the first edition in 1987 – here they are brought together for the first time, often with surprising conclusions. Drawing on research from the disciplines of sociology, physiology and economics as well as psychology, Michael Argyle explores the nature of positive and negative emotions, and the psychological and cognitive processes involved in their generation. Accessible and wide-ranging coverage is provided on key issues such as: the measurements and study of happiness, mental and physical health; the effect of friendship, marriage and other relationships on positive moods; happiness, mental and physical health; the effects of work, employment and leisure; and the effects of money, class and education. The importance of individual personality traits such as optimism, purpose in life, internal control and having the right kind of goals is also analysed. New to this edition is additional material on national differences, the role of humour, and the effect of religion. Are some countries happier than others? This is just one of the controversial issues addressed by the author along the way. Finally the book discusses the practical application of research in this area, such as how happiness can be enhanced, and the effects of happiness on health, altruism and sociability. This definitive and thought-provoking work will be compulsive reading for students, researchers and the interested general reader
Professor Atiyah is one of the greatest living mathematicians and is renowned in the mathematical world. He is a recipient of the Fields Medal, the mathematical equivalent of the Nobel Prize, and is still actively involved in the mathematics community. His huge number of published papers, focusing on the areas of algebraic geometry and topology, have here been collected into seven volumes, with the first five volumes divided thematically and the sixth and seventh arranged by date. This seventh volume in Michael Atiyah's Collected Works contains a selection of his publications between 2002 and 2013, including his work on skyrmions; K-theory and cohomology; geometric models of matter; curvature, cones and characteristic numbers; and reflections on the work of Riemann, Einstein and Bott.
This book takes a lofty vision of "recovery" and of "a life in the community" for every adult with a serious mental illness promised by the U.S. President's 2003 New Freedom Commission on Mental Health and shows the reader what is entailed in making this vision a reality. Beginning with the historical context of the recovery movement and its recent emergence on the center stage of mental health policy around the world, the authors then clarify various definitions of mental health recovery and address the most common misconceptions of recovery held by skeptical practitioners and worried families. With this framework in place, the authors suggest fundamental principles for recovery-oriented care, a set of concrete practice guidelines developed in and for the field, a recovery guide model of practice as an alternative to clinical case management, and tools to self-assess the recovery orientation of practices and practitioners. In doing so, this volume represents the first book to go beyond the rhetoric of recovery to its implementation in everyday practice. Much of this work was developed with the State of Connecticut's Department of Mental Health and Addiction Services, helping the state to win a #1 ranking in the recent NAMI report card on state mental health authorities. Since initial development of these principles, guidelines, and tools in Connecticut, the authors have become increasingly involved in refining and tailoring this approach for other systems of care around the globe as more and more governments, ministry leaders, system managers, practitioners, and people with serious mental illnesses and their families embrace the need to transform mental health services to promote recovery and community inclusion. If you've wondered what all of the recent to-do has been about with the notion of "recovery" in mental health, this book explains it. In addition, it gives you an insider's view of the challenges and strategies involved in transforming to recovery and a road map to follow on the first few steps down this exciting, promising, and perhaps long overdue path.
A vital, timely text on the viruses that cause pandemics and how to face them, by the New York Times bestselling author of How Not to Die. As the world grapples with the devastating impact of COVID-19, Dr Michael Greger reveals not only what we can do to protect ourselves and our loved ones during a pandemic, but also what human society must rectify to reduce the likelihood of even worse catastrophes in the future. From tuberculosis to bird flu and HIV to coronavirus, these infectious diseases share a common origin story: human interaction with animals. Otherwise known as zoonotic diseases for their passage from animals to humans, these pathogens – both pre-existing ones and those newly identified – emerge and re-emerge throughout history, sparking epidemics and pandemics that have resulted in millions of deaths around the world. How did these diseases come about? And what – if anything – can we do to stop them and their fatal march into our countries, our homes, and our bodies? In How to Survive a Pandemic, Dr Michael Greger, physician and internationally-recognized expert on public health issues, delves into the origins of some of the deadliest pathogens the world has ever seen. Tracing their evolution from the past until today, Dr Greger spotlights emerging flu and coronaviruses as he examines where these pathogens originated, as well as the underlying conditions and significant human role that have exacerbated their lethal influence to large, and even global, levels.
A vital, timely text on the viruses that cause pandemics and how to face them, by the New York Times bestselling author of How Not to Die. From tuberculosis to bird flu and HIV to coronavirus, these infectious diseases share a common origin story: human interaction with animals. Otherwise known as zoonotic diseases for their passage from animals to humans, these pathogens—both pre-existing ones and those newly identified—emerge and re-emerge throughout history, sparking epidemics and pandemics that have resulted in millions of deaths around the world. How did these diseases come about? And what—if anything—can we do to stop them and their fatal march into our countries, our homes, and our bodies? In How to Survive a Pandemic, Dr. Michael Greger, physician and internationally-recognized expert on public health issues, delves into the origins of some of the deadliest pathogens the world has ever seen. Tracing their evolution from the past until today, Dr. Greger spotlights emerging flu and coronaviruses as he examines where these pathogens originated, as well as the underlying conditions and significant human role that have exacerbated their lethal influence to large, and even global, levels. As the world grapples with the devastating impact of the novel coronavirus 2019, Dr. Greger reveals not only what we can do to protect ourselves and our loved ones during a pandemic, but also what human society must rectify to reduce the likelihood of even worse catastrophes in the future.
More than 50 years ago, President Kennedy gave an address to Congress that launched the community mental health movement in the U.S. This movement involved a vast and complex effort to replace the wholesale institutionalization of people with serious mental illnesses with community mental health centers, public education on mental illness, and prevention efforts. The mission and main thrust of this new movement, however, were quite simple: we would provide effective mental health treatment to people in their home communities and provide the conditions for them to have 'a life in the community.' Starting in the 1990s with Jim, a person who was homeless and initially refused help from outreach workers, Citizenship & Mental Health tells a 20-year story of practice, theory, and research to support the full participation of persons with mental illnesses who, in many cases, have also been homeless, have criminal charges in their past, and are poor. As the first of its kind, this book addresses the concept of citizenship as an applied theory for fulfilling the promise of the community mental health center movement. Citizenship is defined as a strong connection to the 5 R's of rights, responsibilities, roles, resources, and relationships that society offers to its members, and a sense of belonging that comes from others' recognition of one's valued membership in society. The citizenship model supports the strengths, hopes, and aspirations of people with mental illnesses to become neighbors, community members, and citizens.
Some of the world's leading research scientists in the field have contributed to this new book on malaria vaccine development. The book examines various strategies being pursued against the different stages of the parasite (the sporozoite, asexual erythrocytic stages, and sexual stages). It describes vaccines that combat the parasite directly, vaccines aimed at preventing disease, vaccines based on attenuated parasites, and vaccines based on small, carefully defined synthetic peptides. The book provides a compendium of current approaches, lists of preferred antigens, and the results of vaccine trials to date. Molecular immunology involved with both the natural immune response to parasites and with the constraints on inducing immunity are emphasized throughout the book. Views on how vaccines may be tested and then integrated into malaria control programs are also discussed. Molecular Immunological Considerations in Malaria Vaccine Development will be useful for researchers and students in immunology, parasitology, biotechnology, vaccine design, and tropical and public health.
Researchers examine the existing state of knowledge regarding surprises (effects that are not natural extensions of existing trends) and nonlinearities (responses disproportionate to changes in stimuli that may threaten adaptive capacities) in natural and socioeconomic systems confronted with human-induced climatic change.
This comprehensive, authoritative text presents the scientific foundations and clinical practice of neural blockade in both regional anesthesia and the management of pain. The descriptions and illustrations of pain mechanisms are considered classic examples. The Fourth Edition has been refined for clarity and flows logically from principles and pharmacology, to techniques for each anatomic region, to applications. This edition has two new co-editors and several new chapters on topics including neurologic complications, neural blockade for surgery, treatment of pain in older people, and complications in pain medicine. A companion Website will offer the fully searchable text and an image bank.
The latest edition of this in-depth look at athletic injuries of the shoulder has been updated to feature 16 new chapters, additional illustrations and algorithms, an added focus on arthroscopic treatments, and pearls that highlight key information. Additional contributing authors give you a fresh spin on new and old topics from rehabilitation exercises to special coverage of female athletes, pediatrics, and golfers. This book offers coverage of arthroscopy, total joint replacement, instability, football, tennis, swimming, and gymnastic injuries, rotator cuff injuries, and much, much more! The large range of topics covered in this text ensures that it's a great resource for orthopaedists, physical therapists, athletic trainers, and primary care physicians. Presents a multidisciplinary approach to the care of the shoulder, combining contributions from the leaders in the field of orthopedic surgery, physical therapy, and athletic training. Demonstrates which exercises your patients should perform in order to decrease their chance of injury or increase strength following an injury through illustrated exercises for rehabilitation and injury prevention. Illustrates how the shoulder is affected during activity of certain sports with a variety of tables and graphs. Covers a large range of topics including all shoulder injuries to be sufficiently comprehensive for both orthopaedists and physical therapists/athletic trainers. Features 16 new chapters, including Internal Impingement, Bankarts: Open vs. Arthroscopy, Adhesive Capsulitis of the Shoulder, Cervicogenic Shoulder Pain, Proprioception: Testing and Treatment, and more. Details current surgical and rehabilitation information for all aspects of shoulder pathology to keep you up-to-date. Organizes topics into different sections on anatomy, biomechanics, surgery, and rehabilitation for ease of reference.
A practical overview of OMA specifications and how they enable mobile multimedia services & much more ...! The Open Mobile Alliance (OMA) is an industry forum, which develops open specifications to help in the creation of applications and services to be deployed over converged networks. The alliance is the leading industry forum for generating market-driven specifications for interoperable mobile service enablers that facilitate global user adoptions of mobile multimedia services. Members include traditional wireless industry segments, such as mobile operators mobile operators (e.g. AT&T, China Mobile, Orange, Sprint Nextel, T-Mobile, Telefonica, Vodafone), equipment and mobile systems manufacturers (e.g. Alcatel-Lucent, Ericsson, Motorola, Nokia, Philips, Samsung, Siemens, Sony-Ericsson), and Information Technology vendors (e.g. BEA Systems, IBM, Microsoft, Oracle Corporation, Sun Microsystems and NEC). Since its formation in 2002, the OMA has made significant progress in areas such as push-to-talk over cellular, device management, presence and group management, and messaging. The Open Mobile Alliance: Provides a comprehensive overview of the service enablers published by the OMA, tying together all the different piece parts developed by the individual working groups Offers a thorough introduction to the OMA Service Environments (OSE) and the specification process for enabling technologies. Discusses enablers for services such as gaming, IMS, Parlay, mobile broadcast and web services. Contains contributions from all stakeholders in the mobile application value chain. The Open Mobile Alliance Alliance is an invaluable resource for OMA members, product managers, network architects and planners, standards managers, standards engineers and IT professionals. Advanced Students and lecturers on mobile application development and standardization courses will also find this book of interest."The success of OMA is due to its individual members' contributions, and this book is testament to their hard work. The individual members' efforts and the authors of this book are to be congratulated on their magnificent achievements." Mark Cataldo, Senior Advisor, Orange SA, OMA Technical Plenary Chairman
Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.
Instant New York Times Bestseller Uncover the evidence-based science to slowing the effects of aging, from the New York Times bestselling author of the How Not to Die series When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don’t need Big Pharma to keep us feeling young—we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies’ cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent “zombie” cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of “blue zone” regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity.
Written by respected experts in the field, Biomaterials in Orthopedics discusses bioabsorbable biomaterials for bone repair, nondegradable materials in orthopaedics and delivery systems. Topics in this text include biocompatibility and the biomaterial/tissue interface; self-reinforced bioabsorbable devices and guided regeneration; bone substitutes,
Advances in Pediatrics reviews the most current practices in pediatrics. A distinguished editorial board, headed by Dr.Michael Kappy, identifies key areas of major progress and controversy and invites expert pediatricians to contribute original articles devoted to these topics. These insightful overviews bring concepts to a clinical level and explore their everyday impact on patient care. Topics such as fetal diagnosis and surgical intervention, updates in pharmacology, and fatty liver disease are represented, highlighting the most current and relevant information in the field.
This valuable resource prepares graduate-level students in social work and other helping professions to provide integrated behavioral health services in community-based health and mental healthcare settings. Responding to the increasing prevalence of behavioral health issues in the general U.S. population and the resulting additional responsibilities for social workers and health professionals, this textbook describes the latest evidence-based practices and interventions for common behavioral health disorders as well as issues related to suicide, violence, substance use, and trauma. Detailed case studies help illustrate the effects of a range of interventions, inviting readers to consider how best to implement behavioral health assessment and treatment practices that are evidence-based, trauma-informed, and recovery-oriented. In addition to outlining integrated behavioral health service models and assessment tools, chapters address specific topics such as: Public health approaches to addressing interpersonal violence Intersections of social, behavioral, and physical health Achieving recovery and well-being from behavioral health disorders Motivating clients to achieve and maintain recovery from addiction Stage-based treatments for substance use disorders Cognitive behavioral approaches to treating anxiety and depressive disorders Evidence-based approaches to treating the effects of trauma and PTSD Integrated Behavioral Health Practice equips graduate students and health professionals alike to provide sensitive and informed interprofessional care for patients and families while consistently engaging in practices that emphasize recovery and well-being.
Covering preventive, non-invasive, and natural treatments, Textbook of Natural Medicine, 4th Edition offers more than just alternative medicine. It promotes an integrated practice that can utilize natural medicine, traditional Western medicine, or a combination of both in a comprehensive, scientific treatment plan. Based on a combination of philosophy and clinical studies, Textbook of Natural Medicine helps you provide health care that identifies and controls the underlying causes of disease, is supportive of the body's own healing processes, and is considerate of each patient's unique biochemistry. Internationally known authors Joseph Pizzorno and Michael Murray include detailed pharmacologic information on herbs and supplements, plus evidence-based coverage of diseases and conditions to help you make accurate diagnoses and provide effective therapy. Comprehensive, unique coverage makes this book the gold standard in natural medicine. A scientific presentation includes the science behind concepts and treatments, and discusses Western medical treatments and how they can work with natural medicine in a comprehensive treatment plan; if natural medicine is not effective, this book recommends the Western treatment. Coverage of pharmacology of natural medicines includes the uses and potential dangers of nearly 80 herbal medicines, special nutrients, and other natural agents, addressing topics such as general information, chemical composition, history, pharmacology, clinical applications dosage, and toxicology. In-depth, evidence-based coverage of 73 diseases and conditions includes key diagnostic criteria, pathophysiology of diseases, and therapeutic rationales. Coverage of potential interactions between drugs, herbs, and supplements ensures the safest possible use for each of 79 herbs and supplements. Diagnostic procedures include practical, easy-to-follow descriptions of evidence-based techniques plus discussions of clinical application of diet analysis, food allergy testing, immune function assessment, fatty acid profiling, hair mineral analysis, and other diagnostic approaches. Common therapeutic modalities are described and reviewed, including botanical medicine, nutritional therapy, therapeutic fasting, exercise therapy, hydrotherapy, counseling, acupuncture, homeopathy, and soft tissue manipulation. Coverage of syndromes and therapies helps in understanding the underlying causes of diseases by discussing topics such as food reactions, functional toxicology, sports nutrition, stress management, and breathing pattern disorders. Coverage of the philosophy of natural medicine includes its history and background, with discussions of toxicity, detoxification, and scientific documentation of the healing actions of nature and natural substances. Internationally known authors Joseph Pizzorno and Michael Murray and more than 90 expert contributors provide material that is up to date, accurate, and informed. More than 10,000 research literature citations show that the content is based on science rather than opinions or anecdotes. 13 useful appendices offer quick lookup of frequently used charts, handouts, and information. New chapters are included on hot topics such as female infertility, medicinal mushrooms, natural products and quality control, pregnancy health and primary prevention, and Vitamin K; new appendices include a supplier certification questionnaire and cervical escharotics treatment. Thorough updates ensure that you use only the most current research and provide the most effective treatment of patients. Tabs in Specific Health Problems section separate more than 70 alphabetized diseases/conditions. One convenient volume replaces the cumbersome two-volume set for easy, convenient reference. Electronic access is available via Pageburst, making it easy to search topics, drugs, herbs and supplements, and diseases and conditions. Sold separately.
Covering preventive, non-invasive, and natural treatments, Textbook of Natural Medicine, 4th Edition offers more than just alternative medicine. It promotes an integrated practice that can utilize natural medicine, traditional Western medicine, or a combination of both in a comprehensive, scientific treatment plan. Based on a combination of philosophy and clinical studies, Textbook of Natural Medicine helps you provide health care that identifies and controls the underlying causes of disease, is supportive of the body's own healing processes, and is considerate of each patient's unique biochemistry. Internationally known authors Joseph Pizzorno and Michael Murray include detailed pharmacologic information on herbs and supplements, plus evidence-based coverage of diseases and conditions to help you make accurate diagnoses and provide effective therapy. - Comprehensive, unique coverage makes this book the gold standard in natural medicine. - A scientific presentation includes the science behind concepts and treatments, and discusses Western medical treatments and how they can work with natural medicine in a comprehensive treatment plan; if natural medicine is not effective, this book recommends the Western treatment. - Coverage of pharmacology of natural medicines includes the uses and potential dangers of nearly 80 herbal medicines, special nutrients, and other natural agents, addressing topics such as general information, chemical composition, history, pharmacology, clinical applications dosage, and toxicology. - In-depth, evidence-based coverage of 73 diseases and conditions includes key diagnostic criteria, pathophysiology of diseases, and therapeutic rationales. - Coverage of potential interactions between drugs, herbs, and supplements ensures the safest possible use for each of 79 herbs and supplements. - Diagnostic procedures include practical, easy-to-follow descriptions of evidence-based techniques plus discussions of clinical application of diet analysis, food allergy testing, immune function assessment, fatty acid profiling, hair mineral analysis, and other diagnostic approaches. - Common therapeutic modalities are described and reviewed, including botanical medicine, nutritional therapy, therapeutic fasting, exercise therapy, hydrotherapy, counseling, acupuncture, homeopathy, and soft tissue manipulation. - Coverage of syndromes and therapies helps in understanding the underlying causes of diseases by discussing topics such as food reactions, functional toxicology, sports nutrition, stress management, and breathing pattern disorders. - Coverage of the philosophy of natural medicine includes its history and background, with discussions of toxicity, detoxification, and scientific documentation of the healing actions of nature and natural substances. - Internationally known authors Joseph Pizzorno and Michael Murray and more than 90 expert contributors provide material that is up to date, accurate, and informed. - More than 10,000 research literature citations show that the content is based on science rather than opinions or anecdotes. - 13 useful appendices offer quick lookup of frequently used charts, handouts, and information.
Use this atlas-style guide to master implant procedures and techniques! Written by leading expert Michael S. Block, DMD, Color Atlas of Dental Implant Surgery, 3rd Edition provides clear, full-color clinical photos and practical instructions covering a wide range of implant challenges. It takes you through treatment planning, presurgical guidelines, detailed surgical techniques, and postoperative follow-up. This edition adds more case studies and coverage of computed tomography. With this book, you'll be able to address any implant-related situation and achieve optimal results! This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. - Clear step-by-step procedures include indications, contraindications, and treatment results for each procedure. - Over 1,400 full-color photographs and drawings depict important concepts and techniques, and show treatment from beginning to end. - Indications and contraindications for each procedure provide details of why a procedure is performed. - A discussion of the result of prosthodontic treatment is provided for each case, explaining how implant placement factors into successful therapy. - Chapters are organized by oral anatomy and surgical technique, with each chapter presenting a different area of the mouth or a specific surgical technique. - The Mandible section covers various approaches to augmentation of the atrophic mandible, including a case that utilizes distraction osteogenesis. - Detailed cases of posterior mandible surgery demonstrate onlay bone harvesting and grafting the deficient ridge. - The Maxilla section features sinus grafting, hard and soft tissue procedures, and the relatively new zygomaticus implant procedure. - References are provided at the end of every chapter for additional reading and research.
A recipient of the PROSE 2017 Honorable Mention in Chemistry & Physics, Radioactivity: Introduction and History, From the Quantum to Quarks, Second Edition provides a greatly expanded overview of radioactivity from natural and artificial sources on earth, radiation of cosmic origins, and an introduction to the atom and its nucleus. The book also includes historical accounts of the lives, works, and major achievements of many famous pioneers and Nobel Laureates from 1895 to the present. These leaders in the field have contributed to our knowledge of the science of the atom, its nucleus, nuclear decay, and subatomic particles that are part of our current knowledge of the structure of matter, including the role of quarks, leptons, and the bosons (force carriers). Users will find a completely revised and greatly expanded text that includes all new material that further describes the significant historical events on the topic dating from the 1950s to the present. - Provides a detailed account of nuclear radiation – its origin and properties, the atom, its nucleus, and subatomic particles including quarks, leptons, and force carriers (bosons) - Includes fascinating biographies of the pioneers in the field, including captivating anecdotes and insights - Presents meticulous accounts of experiments and calculations used by pioneers to confirm their findings
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