This thesis describes novel approaches and implementation of high-resolution microscopy in the extreme ultraviolet light regime. Using coherent ultrafast laser-generated short wavelength radiation for illuminating samples allows imaging beyond the resolution of visible-light microscopes. Michael Zürch gives a comprehensive overview of the fundamentals and techniques involved, starting from the laser-based frequency conversion scheme and its technical implementation as well as general considerations of diffraction-based imaging at nanoscopic spatial resolution. Experiments on digital in-line holography and coherent diffraction imaging of artificial and biologic specimens are demonstrated and discussed in this book. In the field of biologic imaging, a novel award-winning cell classification scheme and its first experimental application for identifying breast cancer cells are introduced. Finally, this book presents a newly developed technique of generating structured illumination by means of so-called optical vortex beams in the extreme ultraviolet regime and proposes its general usability for super-resolution imaging.
The Geometry and Topology of Coxeter Groups is a comprehensive and authoritative treatment of Coxeter groups from the viewpoint of geometric group theory. Groups generated by reflections are ubiquitous in mathematics, and there are classical examples of reflection groups in spherical, Euclidean, and hyperbolic geometry. Any Coxeter group can be realized as a group generated by reflection on a certain contractible cell complex, and this complex is the principal subject of this book. The book explains a theorem of Moussong that demonstrates that a polyhedral metric on this cell complex is nonpositively curved, meaning that Coxeter groups are "CAT(0) groups." The book describes the reflection group trick, one of the most potent sources of examples of aspherical manifolds. And the book discusses many important topics in geometric group theory and topology, including Hopf's theory of ends; contractible manifolds and homology spheres; the Poincaré Conjecture; and Gromov's theory of CAT(0) spaces and groups. Finally, the book examines connections between Coxeter groups and some of topology's most famous open problems concerning aspherical manifolds, such as the Euler Characteristic Conjecture and the Borel and Singer conjectures.
Religion was integral to the conduct of war in the ancient world and the Greeks were certainly no exception. No campaign was undertaken, no battle risked, without first making sacrifice to propitiate the appropriate gods (such as Ares, god of War) or consulting oracles and omens to divine their plans. Yet the link between war and religion is an area that has been regularly overlooked by modern scholars examining the conflicts of these times. This volume addresses that omission by drawing together the work of experts from across the globe. The chapters have been carefully structured by the editors so that this wide array of scholarship combines to give a coherent, comprehensive study of the role of religion in the wars of the Archaic and Classical Greek world. Aspects considered in depth will include: Greek writers on religion and war; declarations of war; fate and predestination, the sphagia and pre-battle sacrifices; omens, oracles and portents, trophies and dedications to cult centers; militarized deities; sacred truces and festivals; oaths and vows; religion & Greek military medicine.
Integrating theory with practice, this core textbook provides a structured and sequential introduction to motor learning and motor control. Part 1 begins by introducing what motor learning is and how movement is controlled, before exploring how a learning environment may be manipulated to assist in the learning and performance of movement skills. Part 2 explores motor control from neural, behavioural and dynamic systems perspectives. Part 3 provides an overview of considerations in applying motor learning and skill acquisition principles to physical education, exercise and sports science. Chapters are illustrated with flowcharts and diagrams to aid students' understanding, and include activities and end-of-chapter review questions to consolidate knowledge. Motor Learning and Skill Acquisition is essential reading for all Physical Education, Exercise and Sports Science and Sports Coaching students. New to this Edition: - New and updated chapters on skill acquisition approaches, talent identification and development, and performance analysis and feedback as well as separate chapters on practice design and task modification, and practice organisation and planning - Contains additional content on decision-making, tactical and strategic skills, traditional and constraints-led skill acquisition approaches, practice design, and skill-drill and game-based practice for skill acquisition - Supported by a bank of online lecturer resources, including PowerPoints, MCQs and lab activities
Michael J. Klarman, author of From Jim Crow to Civil Rights, which won the prestigious Bancroft Prize in American History, is one of the leading authorities on the history of civil rights law in the United States. In Unfinished Business, he illuminates the course of racial equality in America, revealing that we have made less progress than we like to think. Indeed, African Americans have had to fight for everything they have achieved. Klarman highlights a variety of social and political factors that have influenced the path of racial progress--wars, migrations, urbanization, shifting political coalitions--and he looks in particular at the contributions of law and of court decisions to American equality. The author argues that court decisions tend to reflect the racial mores of the times, which is why the Supreme Court has not been a heroic defender of the rights of racial minorities. And even when the Court has promoted progressive racial change, its decisions have often been unenforced, in part because severely oppressed groups rarely have the resources necessary to force the issue. Klarman also sheds light on the North/South dynamic and how it has influenced racial progress, arguing that as southerners have become more anxious about outside challenges to their system of white supremacy, they have acted in ways that eventually undermined that system. For example, as southern slave owners demanded greater guarantees for slavery from the federal government, they alienated northerners, who came to fear a slave power conspiracy that would interfere with their liberties. Unfinished Business offers an invaluable, succinct account of racial equality and civil rights throughout American history.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
This updated and revised second edition of “Alcohol and Tobacco” reflects the new ICD 11 and DSM V classifications and provides comprehensive descriptions of new therapeutic approaches, outlining the different interactions between personality, environment and the effects of the respective substance. In addition to new data on prevention-based therapies, especially for smoking addiction, the book also presents essential psychological and sociological strategies, and medication-based therapies. Particular attention is given to new medications and new compounds for e-cigarettes, while a broad overview of the American and European epidemiology of alcohol and nicotine addictions rounds out the coverage. Given the breadth and depth of its coverage, the book will appeal to a wide readership, from professionals to researchers and students.
A good sport scientist and coach must understand both the underlying mechanisms and the practical application of training principles. Strength and Conditioning in Sports: From Science to Practice is unique in that it covers both of these areas in a comprehensive manner. This textbook "connects" the mechanism with practical application. Selecting the appropriate training process is paramount to success in competitive sport. A major component of this textbook is the detailed explanations of developing that process from creating an annual plan, selection of the appropriate periodization model and how to program that model. In application, connecting physiology to performance can be enhanced by using appropriate athlete monitoring techniques. Although there can be overlap, monitoring can be divided into two components: fatigue management and program efficacy. One of the features of this text is the in-depth description of how the monitoring process should take place and how monitoring data can be used in program application. This exciting new text provides a comprehensive overview of the application of science to sport and will be key reading for undergraduate and postgraduate students of strength and conditioning, athletic training, exercise physiology, human performance, personal training, and other related disciplines of sport science and kinesiology.
Part of the highly regarded Master Techniques in Orthopaedic Surgery series, Fractures, Fourth Edition, is a concise, lavishly illustrated reference covering the most advanced, successful surgical techniques for fractures of the upper extremity, lower extremity, pelvis, and acetabulum—all in step-by-step detail. This fully revised edition presents the preferred techniques of surgical masters, illustrated with full-color, sequential, surgeon’s-eye view intraoperative photographs, as well as superb drawings by noted medical illustrators. New and rewritten chapters keep you fully up to date with recent changes in the field.
Written by leading orthopaedists and rehabilitation specialists, the second edition of Hoppenfeld’s Rehabilitation and Treatment of Fractures presents sequential treatment and rehabilitation plans for fractures of the upper extremity, lower extremity, and spine. The book demonstrates how to treat each fracture--from both an orthopaedic and a rehabilitation standpoint--at each stage of healing. Introductory chapters review the fundamentals of fracture management--bone healing, treatment modalities, biomechanics, assistive devices and adaptive equipment, gait, splints and braces, therapeutic exercise and range of motion, and determining when a fracture is healed. Subsequent chapters focus on management of individual fractures. Each chapter on an individual fracture is organized by weekly post fracture time zones, from the day of injury through twelve weeks. For each time zone, the text discusses bone healing, physical examination, dangers, x-rays, weight bearing, range of motion, strength, functional activities, and gait/ambulation.
Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.
The autobiography of one of America's most important gastroenterologists. Michael Lepore [1910-2000] was a pioneer in the field of gastroenterology. He was a member of one of the first graduating classes of the University of Rochester Medical School, and went on to a distinguished career at Columbia University, New York University, and St. Vincent's Hospital and Medical Center of New York. This autobiography tells of his experiences as an Italian-American who overcame prejudices to become the personal physician to such notablesas Greta Garbo and President Herbert Hoover. His story is witty and cleverly written, and details the way the medical profession changed from the Great Depression to the late 1990s. Michael Lepore was an alumnus of Duke University Medical School and the University of Rochester School of Medicine, and was the Director, Gastroenterology Section, Departments of Medicine and Surgery Emeritus, St. Vincent's Hospital and Medical Center of New York.
The civil rights revolutions of the 1950s and 1960s transformed the literature on Reconstruction in America by emphasizing the social history of emancipation and the hopefulness that reunification would bring equality. Much of this revisionist work served to counter and correct the racist and pro-Confederate accounts of Reconstruction written in the early twentieth century. While there have been modern scholarly revisions of individual states, most are decades old, and Michael W. Fitzgerald’s Reconstruction in Alabama is the first comprehensive reinterpretation of that state’s history in over a century. Fitzgerald’s work not only revises the existing troubling histories of the era, it also offers a compelling and innovative new look at the process of rebuilding Alabama following the war. Attending to an array of issues largely ignored until now, Fitzgerald’s history begins by analyzing the differences over slavery, secession, and war that divided Alabama’s whites, mostly along the lines of region and class. He examines the economic and political implications of defeat, focusing particularly on how freed slaves and their former masters mediated the postwar landscape. For a time, he suggests, whites and freedpeople coexisted mostly peaceably in some parts of the state under the Reconstruction government, as a recovering cotton economy bathed the plantation belt in profit. Later, when charting the rise and fall of the Republican Party, Fitzgerald shows that Alabama's new Republican government implemented an ambitious program of railroad subsidy, characterized by substantial corruption that eventually bankrupted the state and helped end Republican rule. He shows, however, that the state’s freedpeople and their preferred leaders were not the major players in this arena: they had other issues that mattered to them far more, like public education, civil rights, voting rights, and resisting the Klan’s terrorist violence. After Reconstruction ended, Fitzgerald suggests that white collective memory of the era fixated on black voting, big government, high taxes, and corruption, all of which buttressed the Jim Crow order in the state. This misguided understanding of the past encouraged Alabama's intransigence during the later civil rights era. Despite the power of faulty interpretations that united segregationists, Fitzgerald demonstrates that it was class and regional divisions over economic policy, as much as racial tension, that shaped the complex reality of Reconstruction in Alabama.
The monograph series Oxford Studies in Medieval Literature and Culture showcases the plurilingual and multicultural quality of medieval literature and actively seeks to promote research that not only focuses on the array of subjects medievalists now pursue—in literature, theology, and philosophy, in social, political, jurisprudential, and intellectual history, the history of art, and the history of science—but also that combines these subjects productively. It offers innovative studies on topics that may include, but are not limited to, manuscript and book history; languages and literatures of the global Middle Ages; race and the post-colonial; the digital humanities, media and performance; music; medicine; the history of affect and the emotions; the literature and practices of devotion; the theory and history of gender and sexuality, ecocriticism and the environment; theories of aesthetics; medievalism. The Middle English Book addresses a series of questions about the copying and circulation of literature in late medieval England: How do we make sense of the variety of manuscripts surviving from this period? Who copied and disseminated these diverse manuscripts? Who read the literary texts that they transmit? And what was the relationship between those copying literature and those reading it? To answer these questions, this book examines 202 literary manuscripts from the period 1350 to 1500. First, this study suggests that most surviving manuscripts fall into four categories, depending on the proximity and relationship of that manuscript's scribes and readers. But beyond proposing these new categories, this book also looks at the history of writing practices, and demonstrates the ubiquity of bureaucracies within late medieval England. As a result, The Middle English Book argues that literary production was a decentered affair, one that took place within these numerous, modest, yet complex, bureaucracies. But this book also argues that, because literary production arose in such scattered bureaucracies, manuscripts were local products, produced within the cultural and economic milieu of their users. Manuscripts thus form a fundamentally different sort of cultural artefact than the printed books with which we are familiar—a form of centralized, urbanized, and commercialized textual production that was just over the historical horizon in late medieval England.
A monumental investigation of the Supreme Court's rulings on race, From Jim Crow To Civil Rights spells out in compelling detail the political and social context within which the Supreme Court Justices operate and the consequences of their decisions for American race relations. In a highly provocative interpretation of the decision's connection to the civil rights movement, Klarman argues that Brown was more important for mobilizing southern white opposition to racial change than for encouraging direct-action protest. Brown unquestioningly had a significant impact--it brought race issues to public attention and it mobilized supporters of the ruling. It also, however, energized the opposition. In this authoritative account of constitutional law concerning race, Michael Klarman details, in the richest and most thorough discussion to date, how and whether Supreme Court decisions do, in fact, matter.
In 1864, General Sterling Price with an army of 12,000 ragtag Confederates invaded Missouri in an effort to wrest it from the United States Army's Department of Missouri. Price hoped his campaign would sway the 1864 presidential election, convincing war-weary Northern voters to cast their ballots for a peace candidate rather than Abraham Lincoln. It was the South's last invasion of Northern territory. But it was simply too late in the war for the South to achieve such an outcome, and Price grossly mismanaged the campaign, guaranteeing the defeat of his force and of the Confederate States. This book chronicles the Confederacy's desperate, final, ill-fated attempt to win a decisive victory.
Nationally syndicated radio host and columnist Michael Brown provides a handbook for a biblically-based moral and cultural renaissance, revealing that the key to recapturing America’s greatness consists in returning to our spiritual and moral roots. America is at a tipping point, and never has this been more apparent than right now. We are in danger of losing our spiritual and moral heritage, making many believe that we have fallen beyond the point of recovery. This book is here to say, that, yes, we have fallen. In fact, fallen much further than we realize, but that our country’s best days are ahead—with the help of a radical, moral, and cultural revolution, beginning with the church. This book is a manual for the revolution. On all fronts, Americans are talking about the need for revolution, arguing from the left and the right that “the status quo must go!” This book comes at just the right time, as people are wondering what in the world has happened to our country—from the homes to the college campuses, from the inner cities to the White House, from our national debt to the material found on our computers and TV screens. In clear, compelling prose, Brown covers topics ranging from the sexualization of pop culture to the dumbing down of our schools to the undermining of family structures to a pervasive culture of entitlement, while pointing consistently to the Bible’s solution to these issues. A radical call for reformation written with sobriety and hope, Saving a Sick America provides the inspiration and guidance necessary for a moral and cultural revolution.
This book focuses on the belief-desire-intention (BDI) model of rational agents, which recognizes the primacy of beliefs, desires, and intentions in rational action. One goal of modern computer science is to engineer computer programs that can act as autonomous, rational agents; software that can independently make good decisions about what actions to perform on our behalf and execute those actions. Applications range from small programs that intelligently search the Web buying and selling goods via electronic commerce, to autonomous space probes. This book focuses on the belief-desire-intention (BDI) model of rational agents, which recognizes the primacy of beliefs, desires, and intentions in rational action. The BDI model has three distinct strengths: an underlying philosophy based on practical reasoning in humans, a software architecture that is implementable in real systems, and a family of logics that support a formal theory of rational agency.The book introduces a BDI logic called LORA (Logic of Rational Agents). In addition to the BDI component, LORA contains a temporal component, which allows one to represent the dynamics of how agents and their environments change over time, and an action component, which allows one to represent the actions that agents perform and the effects of the actions. The book shows how LORA can be used to capture many components of a theory of rational agency, including such notions as communication and cooperation.
Case Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, followed by clinical presentation, diagnosis and treatment. Five core sets of questions are posed in each case. What is the nature of the infectious agent, how does it gain access to the body, what cells are infected, and how does the organism spread? What are the host defense mechanisms against the agent and how is the disease caused? What are the typical manifestations of the infection and the complications that can occur? How is the infection diagnosed and what is the differential diagnosis? How is the infection managed, and what preventative measures can be taken to avoid infection? This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms, fully integrating microbiology and immunology throughout.
Case Studies in Infectious Disease: Coxiella burnetti presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.
Offering a unique and original perspective on Bourdieu, language-based ethnographies,and reflexivity, this volume provides a nuanced, in-depth discussion of the complex relationship between these interconnected topics and their impact in real-world contexts. Part I opens the book with an overview of the historical background and development of language-based ethnographic research and Bourdieu’s work in this space. Part II presents a series of case studies that highlight a Bourdieusian perspective and demonstrate how reflexivity impacts language-based ethnography. In each study, Bourdieu’s conceptual framework of reflexively-informed objectivity examines the ways in which the studies themselves were constructed and understood. Building on Parts I and II, the concluding set of chapters in Part III unpacks the messiness of the theory and practice of language-based ethnography, and provides insights into what reflexivity means for Bourdieu and in practical contexts. Arguing for a greater reflexive understanding in research practice, this volume sets an agenda for future literacy and language research.
The closed orbits of three-dimensional flows form knots and links. This book develops the tools - template theory and symbolic dynamics - needed for studying knotted orbits. This theory is applied to the problems of understanding local and global bifurcations, as well as the embedding data of orbits in Morse-smale, Smale, and integrable Hamiltonian flows. The necesssary background theory is sketched; however, some familiarity with low-dimensional topology and differential equations is assumed.
Each year, Advances in Pediatrics brings you the best current thinking from the preeminent practitioners in your field. A distinguished editorial board identifies current areas of major progress and controversy and invites specialists to contribute original articles on these topics. These insightful overviews bring concepts to a clinical level and explore their everyday impact on patient care. Among the topics included in this year’s edition are Immunizations, Vitamin D Deficiency, Treatment of Allergic Disease, Interventional Pediatric Cardiology, Sudden Cardiac Death in Young Athletes, and Necrotizing Enterocolitis, to name a few. Each edition has a tradition of honoring those who contributed greatly to pediatrics in the "Foundations of Pediatrics" segment; this edition features Helen Brook Taussig, MD, leader and innovator in pediatric cardiology, as the annual honoree.
A Wall Street Journal Favorite Read of the Year A Guardian Top Science Book of the Year Tool-making or culture, language or religious belief: ever since Darwin, thinkers have struggled to identify what fundamentally differentiates human beings from other animals. In this much-anticipated book, Michael Tomasello weaves his twenty years of comparative studies of humans and great apes into a compelling argument that cooperative social interaction is the key to our cognitive uniqueness. Once our ancestors learned to put their heads together with others to pursue shared goals, humankind was on an evolutionary path all its own. “Michael Tomasello is one of the few psychologists to have conducted intensive research on both human children and chimpanzees, and A Natural History of Human Thinking reflects not only the insights enabled by such cross-species comparisons but also the wisdom of a researcher who appreciates the need for asking questions whose answers generate biological insight. His book helps us to understand the differences, as well as the similarities, between human brains and other brains.” —David P. Barash, Wall Street Journal
In Volume III, as in Volumes I and II, the classic topics of reading are included--from vocabulary and comprehension to reading instruction in the classroom--and, in addition, each contributor was asked to include a brief history that chronicles the legacies within each of the volume's many topics. However, on the whole, Volume III is not about tradition. Rather, it explores the verges of reading research between the time Volume II was published in 1991 and the research conducted after this date. The editors identified two broad themes as representing the myriad of verges that have emerged since Volumes I and II were published: (1) broadening the definition of reading, and (2) broadening the reading research program. The particulars of these new themes and topics are addressed.
This second in the series of three volumes builds upon the basic theory of linear PDE given in volume 1, and pursues more advanced topics. Analytical tools introduced here include pseudodifferential operators, the functional analysis of self-adjoint operators, and Wiener measure. The book also develops basic differential geometrical concepts, centred about curvature. Topics covered include spectral theory of elliptic differential operators, the theory of scattering of waves by obstacles, index theory for Dirac operators, and Brownian motion and diffusion.
The author attempts to show that scientific realism is compatible with the presence of idealization in the sciences. His main contention is that idealized theories can be treated as counterfactuals about how things are in worlds that are similar to but simpler than the actual world.
One of the great achievements of contemporary mathematics is the new understanding of four dimensions. Michael Freedman and Frank Quinn have been the principals in the geometric and topological development of this subject, proving the Poincar and Annulus conjectures respectively. Recognition for this work includes the award of the Fields Medal of the International Congress of Mathematicians to Freedman in 1986. In Topology of 4-Manifolds these authors have collaborated to give a complete and accessible account of the current state of knowledge in this field. The basic material has been considerably simplified from the original publications, and should be accessible to most graduate students. The advanced material goes well beyond the literature; nearly one-third of the book is new. This work is indispensable for any topologist whose work includes four dimensions. It is a valuable reference for geometers and physicists who need an awareness of the topological side of the field. Originally published in 1990. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Historically, the major emphasis on the study of purinergic systems has been predominantly in the areas of physiology and gross pharmacology. The last decade has seen an exponential in crease in the number of publications related to the role of both adenosine and A TP in mammalian tissue function, a level of interest that has evolved from a more molecular focus on the identity of adenosine and A TP receptor subtypes and the search for selective ligands and development of radioligand binding assays by Fred Bruns and colleagues (especially that for A receptors) that played z a highly significant role in advancing research in the area. In the 60 years since adenosine was first shown to be a potent hypotensive agent, a considerable investment has been made by several pharmaceutical companies-including Abbott, Byk Gulden, Takeda, Warner-LambertlParke Davis, Boehringer Mann heim, Boehringer Ingelheim, Nelson/Whitby Research and CffiA Geigy-as well as John Daly's laboratory at the National Institutes of Health, to design new adenosine receptor ligands, and both agon ists and antagonists with the aim of developing new therapeutic entiities. Numerous research tools have derived from these efforts including: 2-chloroadenosine, R-PIA (~-phenylisopropyladeno sine; NECA (5' N-ethylcarboxamidoadenosine); CV1808; CI936; PD 125,944; ~-benzyladenosine; PACPX; CPX; CPT; XAC; CGS 15943 and CGS 21680. Yet in the realm of therapeutics it was only in 1989 that adenosine itself was approved for human use in the treatment of supraventricular arrythmias.
Hyperbolic Manifolds and Discrete Groups is at the crossroads of several branches of mathematics: hyperbolic geometry, discrete groups, 3-dimensional topology, geometric group theory, and complex analysis. The main focus throughout the text is on the "Big Monster," i.e., on Thurston’s hyperbolization theorem, which has not only completely changes the landscape of 3-dimensinal topology and Kleinian group theory but is one of the central results of 3-dimensional topology. The book is fairly self-contained, replete with beautiful illustrations, a rich set of examples of key concepts, numerous exercises, and an extensive bibliography and index. It should serve as an ideal graduate course/seminar text or as a comprehensive reference.
Have agricultural management efforts begun in the desperation of the Dust Bowl brought us to where we need to be tomorrow? Questions about the environmental footprint of farming make this book required reading. Approximately 62% of the total U.S. land area is used for agriculture, and this land also provides critical ecosystem functions. Authors from each region of the continental United States describe the progress of soil and water conservation to date and visualize how agricultural production practices must change in future years to address the newest challenges.
In this groundbreaking book, Michael Tomasello presents a comprehensive usage-based theory of language acquisition. Drawing together a vast body of empirical research in cognitive science, linguistics, and developmental psychology, Tomasello demonstrates that we don’t need a self-contained “language instinct” to explain how children learn language. Their linguistic ability is interwoven with other cognitive abilities. Tomasello argues that the essence of language is its symbolic dimension, which rests on the uniquely human ability to comprehend intention. Grammar emerges as the speakers of a language create linguistic constructions out of recurring sequences of symbols; children pick up these patterns in the buzz of words they hear around them. All theories of language acquisition assume these fundamental skills of intention-reading and pattern-finding. Some formal linguistic theories posit a second set of acquisition processes to connect somehow with an innate universal grammar. But these extra processes, Tomasello argues, are completely unnecessary—important to save a theory but not to explain the phenomenon. For all its empirical weaknesses, Chomskian generative grammar has ruled the linguistic world for forty years. Constructing a Language offers a compellingly argued, psychologically sound new vision for the study of language acquisition.
The book is based on lectures given at the TASI summer school of 2010. It aims to provide advanced graduate students, postdoctorates and senior researchers with a survey of important topics in particle physics and string theory, with special emphasis on applications of methods from string theory and quantum gravity in condensed matter physics and QCD (especially heavy ion physics).
This report describes the differences and similarities between two approaches to health equity and inequalities. These approaches are individually oriented behaviour change and the social or wider determinants of health. The report is based on a review of reviews of the behavioural intervention and wider determinants literatures, and a narrative review of other relevant materials. The report makes the case for the scientific consilience between the differing approaches. This report is part of a suite of publications and tools designed to support Member States and public health practitioners to use behavioural science in their work.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.