This new multi-authored book reviews the current understanding of the role of thrombin in venous and arterial thrombosis and its inhibition in the clinical setting. Heparin, the most widely used antithrombotic, does not effectively regulate thrombin or its formation. Accumulating evidence suggests that other antithrombins are effective in some of the situations where heparin is not. Discussions include the current knowledge on antithrombotic prophylaxis and therapy, from the perspective of the role in thrombin in venous and arterial vascular disease, the limitations of the current anticoagulant therapies, and potential and limitations of newer antithrombins currently being tested in several experimental and clinical settings. Thrombin helps the clinician to better rationalize the use of specific antithrombins in the prevention and management of thrombotic disease and provides the basic scientist with a better understanding of the goals the clinician attempts to achieve with antithrombotic therapy.
A complete and comprehensive collaboration providing insight on future approaches to telephone survey methodology Over the past fifteen years, advances in technology have transformed the field of survey methodology, from how interviews are conducted to the management and analysis of compiled data. Advances in Telephone Survey Methodology is an all—encompassing and authoritative resource that presents a theoretical, methodological, and statistical treatment of current practices while also establishing a discussion on how state—of—the—art developments in telecommunications have and will continue to revolutionize the telephone survey process. Seventy—five prominent international researchers and practitioners from government, academic, and private sectors have collaborated on this pioneering volume to discuss basic survey techniques and introduce the future directions of the telephone survey. Concepts and findings are organized in four parts—sampling and estimation, data collection, operations, and nonresponse—equipping the reader with the needed practical applications to approach issues such as choice of target population, sample design, questionnaire construction, interviewing training, and measurement error. The book also introduces important topics that have been overlooked in previous literature, including: The impact of mobile telephones on telephone surveys and the rising presence of mobile—only households worldwide The design and construction of questionnaires using Computer Assisted Telephone Interviewing (CATI) software The emerging use of wireless communication and Voice over Internet Protocol (VoIP) versus the telephone Methods for measuring and improving interviewer performance and productivity Privacy, confidentiality, and respondent burden as main factors in telephone survey nonresponse Procedures for the adjustment of nonresponse in telephone surveys In—depth reviews of the literature presented along with a full bibliography, assembled from references throughout the world Advances in Telephone Survey Methodology is an indispensable reference for survey researchers and practitioners in almost any discipline involving research methods such as sociology, social psychology, survey methodology, and statistics. This book also serves as an excellent text for courses and seminars on survey methods at the undergraduate and graduate levels.
Examining, in the widest sense, the changes in political philosophy that have occurred in Western capitalist states since the early 1980s, this book focuses on the introduction of neo-liberal principles in the combined area of social and education policy. New Zealand presents a paradigm example of the neo-liberal shift in political philosophy. From constituting the social laboratory of the Western world in the 1930s in terms of social welfare provision, New Zealand has become the neo-liberal experiment of the fully marketised society in the 1990s. Against the theoretical background of educational theory and practice, this book examines neo-liberalism and its critiques as responses to the so-called crisis of the welfare state and argues for a reformulated critical social policy in the postmodern condition. The conclusions about social policy drawn by the authors can be generalized to similar situations in other Western capitalist countries.
A major goal of research in neuroeconomics is to formulate a theory of how we make decisions, grounded in both the psychology and economics of choice behavior and a knowledge of the underlying biology. Consistent decision making requires assigning values to the available options – a process referred to as valuation. Thus, understanding how valuation emerges from the interactions of millions of neurons in different brain systems is a central question for research in neuroeconomics. This chapter reviews work applying different neuroscientific methods, such as functional brain-imaging, single neuron recording, work on lesion patients and transcranial magnetic stimulation, which sheds light on the different brain regions involved in the representation of distinct valuation signals and the contributions of these valuation signals to behavior.
A fresh look at school improvement from the perspective of professional development. There are many things that teachers can do to improve the conditions for learning and teaching in their own schools. This book shows how staff can take the initiative and identify areas in their school in need of attention, and tackle them. It provides case-study accounts of schemes in a number of schools, together with accounts of the action research based development work undertaken by teachers to improve their schools. The studies illuminate issues such as: improving the quality of learning and teaching; developing an effective school council; building partnerships and community schemes; developing economic and industrial understanding.
An Introduction to Political Geography continues to provide a broad-based introduction to contemporary political geography for students following undergraduate degree courses in geography and related subjects. The text explores the full breadth of contemporary political geography, covering not only traditional concerns such as the state, geopolitics, electoral geography and nationalism; but also increasing important areas at the cutting-edge of political geography research including globalization, the geographies of regulation and governance, geographies of policy formulation and delivery, and themes at the intersection of political and cultural geography, including the politics of place consumption, landscapes of power, citizenship, identity politics and geographies of mobilization and resistance. This second edition builds on the strengths of the first. The main changes and enhancements are: four new chapters on: political geographies of globalization, geographies of empire, political geography and the environment and geopolitics and critical geopolitics significant updating and revision of the existing chapters to discuss key developments, drawing on recent academic contributions and political events new case studies, drawing on an increasing number of international and global examples additional boxes for key concepts and an enlarged glossary. As with the first edition, extensive use is made of case study examples, illustrations, explanatory boxes, guides to further reading and a glossary of key terms to present the material in an easily accessible manner. Through employment of these techniques this book introduces students to contributions from a range of social and political theories in the context of empirical case study examples. By providing a basic introduction to such concepts and pointing to pathways into more specialist material, this book serves both as a core text for first- and second- year courses in political geography, and as a resource alongside supplementary textbooks for more specialist third year courses.
Nine years have elapsed since the second edition of this book was published. In this time the principal advances in neuromuscular diseases have been in the application of molecular genetics to understanding the aetiology and pathogenesis of this group of disorders. As a result many previously unrecognised disorders have been charac terised. Some clinical syndromes, such as the limb girdle dystrophies, have become better defined. In many such instances the new genetic information has led to major advances in knowledge of the biology of cell structures, for example, the membrane structural and channel proteins. The clinical syndromes themselves, and their patho logical and electrophysiological characteristics, however, remain as important as ever, since they constitute the clinical problem itself and, indeed, the database from which all other concepts emerge. Knowledge of the pathogenesis, genetics, and molecular biology of neuromuscular disorders is essential both in developing and applying new therapies and preventive measures, and in formulating genetic and prognostic advice. However, this informa tion does not necessarily always define clinically useful syndromes. Myotonia, for example, is an electrophysiological finding in some syndromes in which it is un detectable by clinical examination, although the phenomenon itself was originally defined as a clinical entity. The limb girdle muscular dystrophy syndromes can be defined by severity, distribution of weakness, age of onset, sex distribution and other characteristics and many of these can be better understood by study of the under lying defect in cell structural proteins.
Culture and Health offers an overview of different areas of culture and health, building on foundations of medical anthropology and health behavior theory. It shows how to address the challenges of cross-cultural medicine through interdisciplinary cultural-ecological models and personal and institutional developmental approaches to cross-cultural adaptation and competency. The book addresses the perspectives of clinically applied anthropology, trans-cultural psychiatry and the medical ecology, critical medical anthropology and symbolic paradigms as frameworks for enhanced comprehension of health and the medical encounter. Includes cultural case studies, applied vignettes, and self-assessments.
This book provides a good foundation for understanding influences on children’s health and development. The volume brings together in a single reference source the world’s leading thinkers on children’s health and development. It sets out the basic concepts that underpin the study of child development and response to impairments to development, including attachment, changes in brain structure, and resilience. The book explores the idea of life-course development, explaining how experiences at each stage in a person’s life shapes his or her future. It goes on to example the relative contribution of societal, neighbourhood, school, family and individual influences to child well-being. This includes a look at the way these forces interact, such as when genes shape environments, and vice versa. The book summarises the evidence on the incidence and consequences of impairments to children’s health and development, covering both the majority of typical children and the minority who experience significant problems.
The long, dark history of political violence in the United States Violence has been employed to achieve political objectives throughout history. Taking the life of a perceived enemy is as old as mankind. Antiquity is filled with examples of political murders, such as when Julius Caesar was felled by assassins in 44 BCE. While assassinations and assassination attempts are not unique to the American way of life, denizens of other nations sometimes look upon the US as populated by reckless cowboys owing to a “Wild West” attitude about violence, especially episodes involving guns. In this book, J. Michael Martinez focuses on assassinations and attempts in the American republic. Nine American presidents—Andrew Jackson, Abraham Lincoln, James A. Garfield, William McKinley, Harry S. Truman, John F. Kennedy, Richard Nixon, Gerald Ford, and Ronald Reagan—have been the targets of assassins. President-elect Franklin D. Roosevelt was also a target shortly before he was sworn into office in 1933. Moreover, three presidential candidates—Theodore Roosevelt, Robert F. Kennedy, and George Wallace—were shot by assailants. In addition to presidents and candidates for the presidency, eight governors, seven U.S. senators, nine U.S. House members, eleven mayors, seventeen state legislators, and eleven judges have been victims of political violence. Not all political assassinations involve elected officials. Some of those targeted, such as Joseph Smith, Malcolm X, and Martin Luther King Jr., were public figures who influenced political issues. But their cases are instructive because of their connection to, and influence on, the political process. No other nation with a population of over 50 million people has witnessed as many political assassinations or attempts. These violent episodes trigger a series of important questions. First, why has the United States—a country constructed on a bedrock of the rule of law and firmly committed to due process—been so susceptible to political violence? Martinez addresses these questions as he examines twenty-five instances of violence against elected officials and public figures in American history.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
**Selected for Doody's Core Titles® 2024 in Trauma Surgery** Describing the diagnosis and management of maxillofacial and associated traumatic injuries step by step, Oral and Maxillofacial Trauma, 4th Edition takes you beyond the surgical management of head and neck trauma to cover the general management of traumatic injuries, systemic evaluation of the trauma patient, and special considerations associated with maxillofacial trauma patient care. New to this edition are over 700 full-color illustrations showing details of traumatic injuries and their treatment. Edited by head and neck trauma expert Dr. Raymond J. Fonseca, along with over 80 highly respected contributors, this comprehensive reference provides all of the information you need to offer the best care possible to maxillofacial trauma patients. - One-of-a-kind, comprehensive chapters cover current research literature with topics including advances in maxillofacial trauma surgery, nonpenetrating chest trauma, metabolic response to trauma, maxillofacial prosthetics, and the societal impact of maxillofacial trauma. - Coverage of emerging topics includes firearm injuries, neurologic injuries (the leading cause of death from trauma), wound healing, airway management, shock, and nasal fractures, so you can work confidently with team members from other disciplines such as neurologists, anesthesiologists, and orthopedists. - Over 80 expert contributors represent the specialties of oral and maxillofacial surgery, anesthesiology, and otolaryngology. - UPDATED content reflects current thinking and the latest techniques in the management of traumatic injuries. - NEW full-color illustrations and design highlight clinical areas and show details of injuries and their treatment. - NEW! Streamlined, single-volume format makes information easier to access and the book easier to carry.
Michael Kelly's writing is driven by love of his native Liverpool, which reaches back to his ancestral Ireland. In this collection of short biographies, Michael becomes the friend of his subjects, rather than a mere researcher. He writes of them because he is one of them, an Irish Liverpudlian in the grand old tradition.
Amphibians are one of the world’s most rapidly declining fauna groups. In an era of devastating climate change, habitat destruction and irreplaceable loss of biological diversity, it has never been more important to have effective resources for identifying and managing wildlife. Tapping into the deep knowledge of the best frog experts in south-eastern Australia, Frogs of Victoria not only provides the tools to identify Victorian frogs – including keys, photographs and comparative information on similar species – it also presents detailed information on their biology, habitats, status and threats. Importantly, the authors also detail the urgent actions required to prevent further loss of amphibian diversity in Victoria. Including stunning images from some of Australia’s finest wildlife photographers, Frogs of Victoria is an authoritative resource for ecologists, land managers, conservationists and all who are fascinated by frogs.
Ethical Maturity in the Helping Professions provides a comprehensive overview of the most influential ideas in ethical thinking across the ages. It explores the ethical challenges through an interdisciplinary approach and presents a brand new model for becoming ethically mature professionals in the process.
WINNER of the British Agricultural History Society's 2022 Thirsk Prize WINNER of the 2022 CHOICE Outstanding Academic Title Award An investigation into farming practices throughout a period of seismic change.
This book addresses the challenges of conducting program evaluations in real-world contexts where evaluators and the agencies face budget and time constraints and where critical data is missing. The book is organized around a seven-step model developed by the authors, which has been tested and refined in workshops. Vignettes and case studies—representing evaluations from a variety of geographic regions and sectors—demonstrate adaptive possibilities for small projects with budgets of a few thousand dollars to large-scale, long-term evaluations. The text incorporates quantitative, qualitative, and mixed-method designs and this Second Edition reflects important developments in the field over the last five years.
Breastfeeding is a comprehensive reference that provides basic science information as well as practical applications. Dr. Ruth Lawrence-a pioneer in the field of human lactation-covers the uses of certain drugs in lactating women, infectious diseases related to lactation, the latest Australian research on anatomy and physiology, and much more.in print and online. Provide thoughtful guidance to the breastfeeding mother according to her circumstances, problems, and lifestyle from integrated coverage of evidence-based data and practical experience. Make appropriate drug recommendations, including approved medications, over-the-counter medications, and herbal remedies. Access the fully searchable text online at www.expertconsult.com. Treat conditions associated with breastfeeding-such as sore nipples, burning pain, or hives-using extensive evidence-based information. Apply the latest understanding of anatomy and physiology through coverage of recent Australian CT and MR studies of the breast and its function. Stay current on new research on infectious diseases germane to lactation and new antibiotics, antivirals, and immunizations available for use during lactation. Effectively manage the use of medications during lactation thanks to an updated discussion of this difficult subject. The latest research on breastfeeding and evidence-based solutions for treating associated medical problems from the authority in the field, Dr. Ruth Lawrence
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. - Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. - Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. - Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. - Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. - Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. - Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This book is written as both a text and a reference book. It contains numerous images from the biological sciences and clinical practice, tables, graphs, and fig ures, as well as exercises that are worked out to aid the reader in understanding principles or solving problems. In some cases, derivations are placed in appen dices so as not to break up the flow of the subject matter in the text. The book is intended for a broad audience interested in molecular imaging with positron emission tomography (PET). It is expected that the readers will range from undergraduate, graduate, and medical students to residents, physi cians, and scientists with backgrounds from various physical, biological, and medical specialty areas. Each chapter presents material in a straightforward man ner that is well illustrated and explained. Because of the diverse audience for the book, certain chapters or sections of chapters will be of more interest than oth ers to certain segments of the readership. Chapter 1 introduces the fundamental physics upon which PET imaging sys tems is based and discusses in detail the technologies and methods used to pro duce PET images. The chapter starts out by reviewing the physics of positron emission and annihilation and explains how positron range and photon non colinearity in coincidence detection place certain limits on spatial resolution.
The Fifth Edition of Greenfield's Surgery has been thoroughly revised, updated, and refocused to conform to changes in surgical education and practice. Reflecting the increasingly clinical emphasis of residency programs, this edition features expanded coverage of clinical material and increased use of clinical algorithms. Key Points open each chapter, and icons in the text indicate where Key Points are fully discussed. Many of the black-and-white images from the previous edition have been replaced by full-color images. This edition has new chapters on quality assessment, surgical education, and surgical processes in the hospital. Coverage of surgical subspecialty areas is more sharply focused on topics that are encountered by general surgeons and included in the current general surgery curriculum and ABSITE exam. The vascular section has been further consolidated. A new editor, Diane M. Simeone, MD, PhD, has joined the editorial team. This edition is available either in one hardbound volume or in a four-volume softbound set. The lightweight four-volume option offers easy portability and quick access. Each volume is organized by organ system so you can find the facts you need within seconds. The companion website presents the fully searchable text, an instant-feedback test bank featuring over 800 questions and answers, and a comprehensive image bank. Unique to this new edition's website are 100 "Morbidity and Mortality" case discussions. Each case reviews a specific surgical complication, how the complication was addressed, and reviews the literature on approaches and outcomes.
In this provocative book, Michael Mauboussin offers the structure needed to analyze the relative importance of skill and luck, offering concrete suggestions for making these insights work to your advantage by making better decisions.
Jones discusses obvious symbols such as corporate logos, office sizes and use of titles, as well as focusing on the more subtle aspect of expressive forms of symbolism such as storytelling, institutional jargon and workplace personalisation.
Rutter’s Child and Adolescent Psychiatry has become an established and accepted textbook of child psychiatry. Now completely revised and updated, the fifth edition provides a coherent appraisal of the current state of the field to help trainee and practising clinicians in their daily work. It is distinctive in being both interdisciplinary and international, in its integration of science and clinical practice, and in its practical discussion of how researchers and practitioners need to think about conflicting or uncertain findings. This new edition now offers an entirely new section on conceptual approaches, and several new chapters, including: neurochemistry and basic pharmacology brain imaging health economics psychopathology in refugees and asylum seekers bipolar disorder attachment disorders statistical methods for clinicians This leading textbook provides an accurate and comprehensive account of current knowledge, through the integration of empirical findings with clinical experience and practice, and is essential reading for professionals working in the field of child and adolescent mental health, and clinicians working in general practice and community pediatric settings.
Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.
Pattern Theory: From Representation to Inference provides a comprehensive and accessible overview of the modern challenges in signal, data and pattern analysis in speech recognition, computational linguistics, image analysis and computer vision. Aimed at graduate students in biomedical engineering, mathematics, computer science and electrical engineering with a good background in mathematics and probability, the text includes numerous exercises and an extensive bibliography. Additional resources including extended proofs, selected solutions and examples are available on a companion website. The book commences with a short overview of pattern theory and the basics of statistics and estimation theory. Chapters 3-6 discuss the role of representation of patterns via conditioning structure and Chapters 7 and 8 examine the second central component of pattern theory: groups of geometric transformation applied to the representation of geometric objects. Chapter 9 moves into probabilistic structures in the continuum, studying random processes and random fields indexed over subsets of Rn, and Chapters 10, 11 continue with transformations and patterns indexed over the continuum. Chapters 12-14 extend from the pure representations of shapes to the Bayes estimation of shapes and their parametric representation. Chapters 15 and 16 study the estimation of infinite dimensional shape in the newly emergent field of Computational Anatomy, and finally Chapters 17 and 18 look at inference, exploring random sampling approaches for estimation of model order and parametric representing of shapes.
The fields of molecular evolution, genome evolution, and evolutionary genetics are now well-established. Remarkably, however, although all evolutionary modifications begin at the cellular level, and despite the advances made in cell biology and microbiology over the past few decades, there is as yet no recognised discipline of evolutionary cell biology. The goal of this book is to help establish the foundations for this emerging field. Its principal aims are twofold: firstly, to promote an understanding among evolutionary biologists as to why the cellular details matter if we are to understand the mechanisms of evolution; secondly, to make clear to non-evolutionary biologists - cell biologists in particular - that evolution is not just a matter of natural selection and optimization, but a process whose reach depends on other population genetic features such as mutation, recombination, and random genetic drift. Although there are many excellent books on cell biology, microbiology, and biophysics, almost no attention is given to evolution. Likewise, although there are numerous evolutionary biology books on the market, none of them gives more than passing attention to details at the cellular level. Thus Evolutionary Cell Biology is genuinely novel, offering a broader understanding of evolutionary processes and an appreciation for the many interesting problems that remain to be solved at the cellular and subcellular levels. This advanced textbook is aimed at both cell biologists and evolutionary biologists. It will be accessible to upper-level undergraduates in biology, and certainly to graduate students in all areas of the life sciences. Professionals from a wide range of fields - cell biology, microbiology, evolution, biophysics, biochemistry, and mathematics - will be exposed to entirely new ideas not traditionally covered in their primary fields of expertise.
Since its first edition over 60 years ago, Rockwood and Green’s Fractures in Adults has been the go-to reference for treating a wide range of fractures in adult patients. The landmark, two-volume tenth edition continues this tradition with two new international editors, a refreshed mix of contributors, and revised content throughout, bringing you fully up to date with today’s techniques and technologies for treating fractures in orthopaedics. Drs. Paul Tornetta III, William M. Ricci, Robert F. Ostrum, Michael D. McKee, Benjamin J. Ollivere, and Victor A. de Ridder lead a team of experts who ensure that the most up-to-date information is presented in a comprehensive yet easy to digest manner.
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