This book reexamines current knowledge on the evolution, ecology, and conservation biology of both New World vultures (Cathartidae) and Old World vultures (Accipitridae) and seeks answers to past and present regional extinctions, colorizations, and conservation questions. Extinct species of both families are examined, as is the disputed evidence fo
Organizations invest vast amounts of time and effort implementing the very best processes that their cleverest minds can come up with and then hand implementation over the least predictable of their assets, their people. Because of their imperfections people: make mistakes, fail to meet goals, get distracted, or just don’t follow instructions, all at great cost. But, can we really do much about this? The answer is yes. Read how affective accountability can solidify change, help us meet targets, and reduce people related defective performance, not in some marginal way, but dramatically. Enjoy this easy to understand guide to accountability systems that work.
As XML gains popularity, developers are looking to implement XML technologies in their line-of-business applications This book offers readers real-world insight into XML so that they can build the best possible applications Offers an in-depth look at XML and discusses XML tools, services (RSS, SOAP, REST, WSDL), programming (DOM, SAX, Ajax), and languages (.NET, Java, PHP)
The completely revised and updated, definitive resource for students and professionals in organic chemistry The revised and updated 8th edition of March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions The opening chapters of March's Advanced Organic Chemistry, 8th Edition deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms. This edition: Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017 Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction The 8th edition of March's Advanced Organic Chemistry proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields. Winner of the Textbook & Acadmic Authors Association 2021 McGuffey Longevity Award.
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. - Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. - Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. - Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. - Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. - Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. - Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Need the go-to reference on adult bone and joint injuries? Get the definitive guide on fracture treatment, written by the world’s top orthopaedic surgeons: Rockwood and Green’s Fractures in Adults. This fully updated and expanded 8th edition offers up-to-the-minute research and recommendations from more than 80 leading orthopaedic experts from around the world. An essential resource on fractures for every orthopaedic surgeon or resident.. Features: NEW chapters on: Management of the Geriatric or Elderly Patient; Management of Bone Defects;; Psychological Aspect of Trauma NEW authors from countries including India, China, Columbia, Greece, and Denmark NEW 10 new full length videos added to the video library. All videos feature easy navigation so you can go directly to specific steps in the procedure, or watch the entire procedure from start to finish Pearls and Pitfalls and preventive measures listed for all procedures NEW Time-saving outline template for easy quick-reference “Before the Case” checklists of all necessary equipment for each surgical procedure Preferred Technique section provides algorithms explaining each author’s choice of preferred procedure Full-color operative photos, tables, x-rays, diagrams, and more than 500 line drawings of surgical procedures
Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching. - Winner, 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association - Fully revised and updated throughout, and organized into 19 chapters for a more cogent and versatile presentation of concepts - Includes reaction examples taken from literature research reported between 2010-2015 - Features new full-color art and new chapter content on process chemistry and green organic chemistry - Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Solutions Manual for qualified course instructors
This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.
Nuclear medicine is the bridge between a particular clinical problern and a relevant test using radionuclides. It began as a minor technical tool used in a few branches of medicine, notably endocrinology and nephrology. However, throughout the world it has now become established as a clinical discipline in its own right, with specific training programmes, special skills and a particular approach to patient management. Although the practising nuclear medicine physician must necessarily learn a great deal of basic science and technology, a sound medical training and a clinical approach to the subject remains of fundamental importance. It is for this reason that we have attempted in this book to approach the subject from a clinical standpoint, including where necessary relevant physiological material. There exist many excellent texts which cover the basic science and technology of nuclear medicine. We have, therefore, severely limited our coverage of these aspects of the subject to matters which we felt tobe essential, particularly those which have been less well covered in other texts- for example, the contents of Chapter 20 on Measurement by Royal and McNeill. Similarly, we have limited details of methodology to skeletal summaries of protocol (Appendix 1) and have included at the end of some chapters descriptions of particular techniques where we and the authors felt that it would be helpful.
Designed to meet the needs of clinicians working with adults with congenital heart disease, Diagnosis and Management of Adult Congenital Heart Disease , by Drs. Michael A. Gatzoulis, Gary D. Webb, and Piers E. F. Daubeney, offers essential guidance on the anatomical issues, clinical presentation, diagnosis, and treatment options available to practitioners today. This latest edition features completely updated content, including new information for nurses and nurse practitioners who, now more than ever, are playing an important role in the care of adults with CHD. You'll also access four new chapters, illustrated congenital defects, coverage of long-term outcomes, and much more. - Drs. Gatzoulis, Webb, and Daubeney lead a team of experts ideally positioned to provide state-of-the-art global coverage of this increasingly important topic. - Each disease-oriented chapter is written to a highly structured template and provides key information on incidence, genetics, morphology, presentation, investigation and imaging, and treatment and intervention. - Congenital defects are illustrated with full-color line drawings and by the appropriate imaging modality (for example, EKG, x-ray, echocardiogram, MRI, CT, ). - Provides coverage of long-term outcomes, including the management of pregnant patients and patients undergoing non-cardiac surgery. - Features the addition of four new chapters: A Historic Perspective; Quality of Life in Patients with Pulmonary Hypertension; Psychosocial Issues in ACHD; Supportive and Palliative Care for End-Stage ACHD.
Discrediting 'mystical' or 'psychical' interpretations of out-of-body and near-death experiences, Michael Marsh demonstrates how these phenomena are explicable in terms of brain neurophysiology and its neuropathological disturbances, and discusses the theological and philosophical implications of his hypotheses.
Compendium of Organic Synthetic Methods, Volume 11 continues the motivation of the series, which is to facilitate the search for quality, selected functional group transformations, organized by reacting functional group of starting material and functional group formed, with full references to each reaction.
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
Grammatical Evolution: Evolutionary Automatic Programming in an Arbitrary Language provides the first comprehensive introduction to Grammatical Evolution, a novel approach to Genetic Programming that adopts principles from molecular biology in a simple and useful manner, coupled with the use of grammars to specify legal structures in a search. Grammatical Evolution's rich modularity gives a unique flexibility, making it possible to use alternative search strategies - whether evolutionary, deterministic or some other approach - and to even radically change its behavior by merely changing the grammar supplied. This approach to Genetic Programming represents a powerful new weapon in the Machine Learning toolkit that can be applied to a diverse set of problem domains.
Provides important new content on specific ethical, leadership, and advocacy capabilities that advance the DNP role in nursing practice This core text for the DNP curriculum encompasses all facets of the evolving advanced practice role including diverse professional opportunities and options for career advancement. With ten completely new chapters, the third edition conveys the latest developments in doctoral-level capabilities, including the specific ethical, leadership, and advocacy components that advance these roles. New content addresses health equity, role negotiation, ethical and leadership dilemmas for the clinician, and the preceptor role in relation to doctoral-level advanced practice. Considering the predominance of students seeking the Nurse Practitioner role, the book emphasizes the clinical context for the DNP along with the new AACN Domain of Professionalism. There also are contributions from Nurse Midwives, Nurse Anesthetists, Clinical Nurse Specialists, and DNPs in the Nurse Educator role. The text is distinguished by distinctive Reflective Responses to the authors of all chapters. These may be characterized as a Point-Counterpoint feature—consisting of commentaries by scholars of varying points of view—that stimulates substantive critical dialogue. It examines the role of evidence—both practice-based evidence and evidence-based practice—in the context of clinical problems and policy formation and focuses on how the doctoral advanced prepared nurse can discriminate, translate, and sometimes generate new nursing evidence. The text addresses the need for both forms of evidence and underscores the importance of innovative healthcare intervention models. Included is practical information illustrated with examples geared for both BSN-DNP students and MSN-DNP students. Content on the DNP/PhD double doctorate and the impact of DNP leadership on organizations further examines the relationship between nursing practice, education, and science. New to the Third Edition: Ten new chapters, including coverage of: COVID-19; BSN-DNP Trajectories; Practice-Based Evidence and Evidence-Based Practice; Health Equity; Role Negotiation, Ethical, Leadership, and Advocacy Roles; and 2021 AACN Essentials Expanded roles and content for students of varying experience levels Emphasis on the new AACN Domain of Professionalism throughout Key Features: Focuses on DNP role development with extensive contributions by leading DNP scholars and clinicians Delivers Reflective Responses in a Point-Counterpoint format to stimulate vigorous class discussion Provides critical thinking questions throughout including Reflective Response
Spectral Data for Steroids provides a comprehensive compilation of spectral data for 211 steroids. The compounds are arranged on the basis of their molecular structures:
Written by leading food animal researchers, practitioners, and educators, this comprehensive guide provides quick access to the latest medical and surgical interventions for cattle, sheep, and goats. The concise, quick-reference format and logical body systems organization make it ideal for use in both the clinical setting and the field. You'll easily locate key information on preventing, treating, and managing disease in food animals, as well as expert insights on improving outcomes for individual animals and herd populations. - Authoritative, cutting-edge coverage offers clinically relevant strategies for diagnosing and managing a wide range of diseases and disorders in food animals, with a focus on cattle, sheep, and goats. - Logically organized content is easy-to-follow and provides a practical approach to determining appropriate medical and surgical interventions. - Concise, easy-to-read format helps you find essential information quickly and easily. - Expert editors, consultants, and writers ensure the accuracy, relevance, and timeliness of each topic to keep you on the cutting edge of food animal therapy. - New editors and a new team of section editors bring a fresh perspective and authoritative guidance on caring for food animals. - Completely revised and updated content includes new sections on topics such as: - Genital surgery - Pharmacology and therapeutics - Restraint, anesthesia, and pain management - Cow-calf/small ruminant production medicine - Feedlot production medicine - Coverage of hot topics in the field includes biosecurity in feedlots, therapy in organic livestock medicine, and ethical responsibilities in selecting drugs for use in food animals. - Expanded treatment options incorporate surgical interventions where appropriate, including laparoscopic procedures.
Here’s the text that builds a strong foundation in the science of sports medicine, and teaches you to apply that knowledge to the planning, development, and implementation of therapeutic exercise programs for specific dysfunctions for all joints of the body. You’ll begin with an introduction to the science behind rehabilitation and the application of specific techniques. Then, for each joint, guided decision-making, chapter-specific case studies, lab activities and skill performance help you meet all of the competencies for therapeutic exercise required by the NATA.
Cases in Adult Congenital Heart Disease, by Michael Gatzoulis et al., is a new, one-of-a-kind cardiology reference designed to help you effectively manage challenging congenital conditions in adults through comprehensive visual guidance. Leading experts present 85 cases-ranging from the simple to the complex, supplemented by abundant images-which enable you to diagnose these cases from a real-life, clinical perspective. A companion website at expertconsult.com featuring full text and images and supplemented by a library of dynamic imaging clips allows you to access this unique resource in another convenient way. Features 85 cases encompassing a full range of congenital heart disease problems-from the simple to the complex-that provide a better understanding of these conditions from a real-life, clinical perspective. Presents examples of multiple imaging modalities (including chest radiography, echocardiography, CT, MR, and angiography) clearly depict the clinical manifestations of congenital defects and provide you with the best views available of these conditions. Includes a companion website at expertconsult.com featuring the full text fully searchable online and images and supplemented by a library of dynamic imaging clips allows you to access this unique resource in another convenient way. Offers guidance on the assessment of congenital heart disease during pregnancy equips you with essential knowledge in addressing the needs of this growing patient population.
Urolithiasis: A Comprehensive History provides a historical sojourn into the varied manifestations of kidney stone disease. Utilizing historical sources and integrating classic material with new concepts, this new volume provides depth and details on stone disease not found in modern overviews on the topic. This volume serves as a very useful tool for physicians and researchers dealing with kidney stone disease. Written by a renowned expert in the field, Urolithiasis: A Comprehensive History is an in depth resource that heightens our medical understanding of this ancient disease and is of great value to urologists, nephrologists, endocrinologists interested in stone disease.
The aim of this Compilation has been to provide a comprehensive, non critical source of information concerning organometallic compounds. The scope is limited to the compounds containing at least one carbon-metal bond. The information includes methods of preparation, properties, chemical reactions and applications. The First Edition comprised the literature from 1937 to 1958. The Second Edition is completely revised and extended through 1964. The literature prior to 1937 was thoroughly covered by E. Krause and A. von Grosse in 11 11 Die Chemie der metall-organischen Verbindungen, Verlag von Gebrueder Borntraeger, Berlin, 1937. Our work consists of three volumes. Volume I contains derivatives of the transition metals of Groups III through VIII of the Periodic Table. Volume II contains derivatives of germanium, tin and lead. Volume Ill contains derivatives of arsenic, antimony and bismuth. The Compilation is based on searches through Chemical Abstracts. The collection of references for 1964 was completed before the Subject Indexes to Volumes 60 and 61 of the Abstracts were available; thus some omissions in the coverage of that year are possible. We have attempted to make the coverage of the literature complete in order that the Compilation may have best utility to the chemist, chemical engineer, patent attorney and editor. In the interest of brevity, certain numerical data are omitted, but references to the original literature are given. Yield data are rounded to two significant figures. Wherever possible, tables have been used. The entries in the Bibliography section include references to Chemical Abstracts.
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