The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
Better understand your patients' complete medical profile and provide the best possible care! This one-of-a-kind reference provides a practical look at neurological disease and how it affects, and is affected by, other disease. It helps neurologists manage patients with co-existing medical conditions, and helps internists understand and treat the neurological manifestations of patients' primary diseases. A new emphasis on diagnosis and management—including advances in pharmacology, genetic-based therapies, and new imaging techniques—makes this 4th Edition more clinically valuable than ever! Focused content highlights the vital links between neurology and other medical specialties, promoting a better understanding of all disciplines, as well as enhancing patient care. Comprehensive coverage of advances in pharmacology, such as new antibiotics for infectious diseases, helps you successfully manage a full range of diseases and disorders. An interdisciplinary team of authors provides insight into the neurological aspects of the conditions you see in daily practice. Easy-to-read chapters apply equally well to neurologists and non-neurologists, providing essential knowledge that covers the full spectrum of medical care. Expanded chapters emphasize key diagnostic and therapeutic information, including appropriate testing and treatments for neurological disease. An emphasis on advances in pharmacology and new imaging techniques helps you better manage your patients and understand how new drugs or therapies will affect your patients and practice. New chapters on auditory and vestibular disease, ocular disease, and cutaneous disease provide a well-rounded look at the specialty. Updated illustrations make complex concepts easier to understand and apply.
Providing a robust understanding of what really works for educators and pupils alike, this book shows how inclusive practices function effectively in schools. Rose and Shevlin identify key factors which can influence successful inclusive practice and examine how schools can establish and implement an agenda for change. Using a framework for analysing and understanding how students become effective social learners, this book guides readers through sections on context, observed experiences, and the factors for success they highlight, covering topics such as: The respective attitudes of students, caregivers and teachers Insights from support staff and school leaders The social and academic outcomes for pupils with special educational needs Lessons learned from inclusive practices Ideal for researchers, lecturers, and advanced students in the field of inclusive education, Establishing Pathways to Inclusion is an important contribution from leading researchers in this vital field of study.
Instant New York Times Bestseller Uncover the evidence-based science to slowing the effects of aging, from the New York Times bestselling author of the How Not to Die series When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don’t need Big Pharma to keep us feeling young—we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies’ cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent “zombie” cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of “blue zone” regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity.
50th Anniversary Edition of the groundbreaking case-based pharmacotherapy text, now a convenient two-volume set. Celebrating 50 years of excellence, Applied Therapeutics, 12th Edition, features contributions from more than 200 experienced clinicians. This acclaimed case-based approach promotes mastery and application of the fundamentals of drug therapeutics, guiding users from General Principles to specific disease coverage with accompanying problem-solving techniques that help users devise effective evidence-based drug treatment plans. Now in full color, the 12th Edition has been thoroughly updated throughout to reflect the ever-changing spectrum of drug knowledge and therapeutic approaches. New chapters ensure contemporary relevance and up-to-date IPE case studies train users to think like clinicians and confidently prepare for practice.
* Provides a sound background in the basic mechanisms of congenital heart disease * Includes guidelines for evaluating newborns with suspected heart disease * Offers advice on treatment and drug therapy guidelines
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