It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.
The Performer's Voice, Second Edition presents a comprehensive approach to the prevention, diagnosis, and treatment of voice disorders as well as up-to-date voice care and injury prevention information--specifically related to actors, singers, and other voice professionals. This second edition is completely updated with six new chapters and contributions from leading voice professionals. Written in an accessible, straightforward style, The Performer's Voice, Second Editionappeals to medical professionals, vocal coaches, and professional performers. This text not only serves as an effective resource for practitioners and clinicians who provide state-of-the-art treatment to voice professionals, but also provides professional vocalists and coaches with insight into what to look for when seeking treatment. The authors have dedicated their careers to voice disorders and prevention of voice injury as well as education and research to advance the science and art of voice care. The diversity of authors' backgrounds supports the importance of a multidisciplinary approach in the care of voice disorders.
Covering preventive, non-invasive, and natural treatments, Textbook of Natural Medicine, 4th Edition offers more than just alternative medicine. It promotes an integrated practice that can utilize natural medicine, traditional Western medicine, or a combination of both in a comprehensive, scientific treatment plan. Based on a combination of philosophy and clinical studies, Textbook of Natural Medicine helps you provide health care that identifies and controls the underlying causes of disease, is supportive of the body's own healing processes, and is considerate of each patient's unique biochemistry. Internationally known authors Joseph Pizzorno and Michael Murray include detailed pharmacologic information on herbs and supplements, plus evidence-based coverage of diseases and conditions to help you make accurate diagnoses and provide effective therapy. - Comprehensive, unique coverage makes this book the gold standard in natural medicine. - A scientific presentation includes the science behind concepts and treatments, and discusses Western medical treatments and how they can work with natural medicine in a comprehensive treatment plan; if natural medicine is not effective, this book recommends the Western treatment. - Coverage of pharmacology of natural medicines includes the uses and potential dangers of nearly 80 herbal medicines, special nutrients, and other natural agents, addressing topics such as general information, chemical composition, history, pharmacology, clinical applications dosage, and toxicology. - In-depth, evidence-based coverage of 73 diseases and conditions includes key diagnostic criteria, pathophysiology of diseases, and therapeutic rationales. - Coverage of potential interactions between drugs, herbs, and supplements ensures the safest possible use for each of 79 herbs and supplements. - Diagnostic procedures include practical, easy-to-follow descriptions of evidence-based techniques plus discussions of clinical application of diet analysis, food allergy testing, immune function assessment, fatty acid profiling, hair mineral analysis, and other diagnostic approaches. - Common therapeutic modalities are described and reviewed, including botanical medicine, nutritional therapy, therapeutic fasting, exercise therapy, hydrotherapy, counseling, acupuncture, homeopathy, and soft tissue manipulation. - Coverage of syndromes and therapies helps in understanding the underlying causes of diseases by discussing topics such as food reactions, functional toxicology, sports nutrition, stress management, and breathing pattern disorders. - Coverage of the philosophy of natural medicine includes its history and background, with discussions of toxicity, detoxification, and scientific documentation of the healing actions of nature and natural substances. - Internationally known authors Joseph Pizzorno and Michael Murray and more than 90 expert contributors provide material that is up to date, accurate, and informed. - More than 10,000 research literature citations show that the content is based on science rather than opinions or anecdotes. - 13 useful appendices offer quick lookup of frequently used charts, handouts, and information.
Offering a one-stop guide to recognition and therapeutic decision making, Diagnosis and Treatment of Rare Gynecologic Cancers fills a gap in the medical literature on uncommon ovarian, uterine, cervical, and vulvovaginal cancers and trophoblastic diseases. This authoritative text, edited by Drs. Michael Frumovitz, Mario Leitao, and Preetha Ramalingam, has been authored by internationally recognized experts from top institutions such as MD Anderson Cancer Center and Memorial Sloan Kettering Cancer Center. Each chapter covers different cancer subtypes and has been reviewed by an oncologist and a pathologist. - Provides up-to-date clinical guidance on assessment and therapeutic options for patients with rare gynecologic malignancies. - Presents information in a templated, easy-to-read format. Each chapter includes an introductory clinical case followed by epidemiology of disease, pathologic assessment, basic science/molecular/translational research, work-up of newly diagnosed disease, staging, treatment of newly diagnosed disease, treatment of recurrent disease, potential therapeutic targets, and a case resolution. - Includes diagnostic and treatment algorithms for each form of cancer. - Contains numerous anatomical figures, radiographs, photographs, and tables for quick visual reference.
Perry’s The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.
This book serves as a basis for the exploration of language in a more systematic way. By surveying the several major divisions of language (phonology, morphology, syntax, lexis, tropology) and explicating the way in which sound and meaning cohere in them, this text lays bare––for students, scholars and advanced readers alike––the lineaments of an understanding of what makes language the sign system par excellence, in the service of its most important function as the instrument of cognition and of communication. This book is intended as a companion volume to Shapiro’s The Speaking Self: Language Lore and English Usage. The two volumes taken in tandem will provide a solid grounding in the observational science of linguistics, linking theory with practice in a way that will expand one’s understanding of language as a global phenomenon.
Merriam Press World War 2 History Series. A History of the 316th Troop Carrier Group, 1942-1945. Complete history utilizing the author's personal recollections and those of his comrades along with extensive archival research. Encompasses Headquarters, 36th, 37th, 44th and 45th Squadrons, the Group was part of the 52nd Troop Carrier Wing, Ninth Air Force, participating in the airborne/glider operations in Sicily, Italy, Normandy, Holland and Germany. 91 photos, 30 maps, 13 appendices, 428 footnotes, bibliography, index.
During the past 20 years, there has been enormous productivity in theoretical as well as computational integration. Some attempts have been made to find an optimal or best numerical method and related computer code to put to rest the problem of numerical integration, but the research is continuously ongoing, as this problem is still very much open-
The first book entirely dedicated to the topic emphasizes the relation between basic research and actual processing technologies. As such, it covers complex microstructures down to the nanometer scale, structure/property relationships and potential applications in key industries. From the contents: * Constitution * Thermophysical Constants * Phase Transformations and Microstructures * Deformation Behaviour * Strengthening Mechanisms * Creep * Fracture Behaviour * Fatigue * Oxidation Resistance and Related Issues * Alloy Design * Ingot Production and Component Casting * Powder Metallurgy * Wrought Processing * Joining * Surface Hardening * Applications and Component Assessment
For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.
50th Anniversary Edition of the groundbreaking case-based pharmacotherapy text, now a convenient two-volume set. Celebrating 50 years of excellence, Applied Therapeutics, 12th Edition, features contributions from more than 200 experienced clinicians. This acclaimed case-based approach promotes mastery and application of the fundamentals of drug therapeutics, guiding users from General Principles to specific disease coverage with accompanying problem-solving techniques that help users devise effective evidence-based drug treatment plans. Now in full color, the 12th Edition has been thoroughly updated throughout to reflect the ever-changing spectrum of drug knowledge and therapeutic approaches. New chapters ensure contemporary relevance and up-to-date IPE case studies train users to think like clinicians and confidently prepare for practice.
The keystone of Christianity is Jesus’s physical, bodily resurrection. Present-day scholars can be significantly challenged as they forage through voluminous documents on the resurrection of Jesus. The literature measures well over seven thousand sources in English-language books alone. This makes finding specific sources that are most relevant for specific scholarly purposes an arduous task. Even when a specific book is relevant, finding the parts of the book that are most relevant to the resurrection rather than other topics often requires additional effort. A Thematic Access-Oriented Bibliography of Jesus’s Resurrection addresses these challenges in several ways. First, the bibliography organizes more than seven thousand English sources into twelve main categories and then thirty-four subcategories, which are designed to help you find the most relevant literature quickly and efficiently. Embedded are pro and con arguments which support efficient access through brief annotations and then annotate the diversity and complexity of the field of religion by including sources that represent a diverse range of views: theistic (e.g., Christian, Jewish, Muslim, etc.), agnostic, and nontheistic. The objective of this bibliography is to provide convenient access to relevant sources from a variety of perspectives, allowing you to browse or find the one source accurately and with ease.
The plant hormone ethylene is one of the most important, being one of the first chemicals to be determined as a naturally-occurring growth regulator and influencer of plant development. It was also the first hormone for which significant evidence was found for the presence of receptors. This important new volume in Annual Plant Reviews is broadly divided into three parts. The first part covers the biosynthesis of ethylene and includes chapters on S-adenosylmethionine and the formation and fate of ACC in plant cells. The second part of the volume covers ethylene signaling, including the perception of ethylene by plant cells, CTR proteins, MAP kinases and EIN2 / EIN3. The final part covers the control by ethylene of cell function and development, including seed development, germination, plant growth, cell separation, fruit ripening, senescent processes, and plant-pathogen interactions. The Plant Hormone Ethylene is an extremely valuable addition to Wiley-Blackwell's Annual Plant Reviews. With contributions from many of the world's leading researchers in ethylene, and edited by Professor Michael McManus of Massey University, this volume will be of great use and interest to a wide range of plant scientists, biochemists and chemists. All universities and research establishments where plant sciences, biochemistry, chemistry, life sciences and agriculture are studied and taught should have access to this important volume.
Global Health: Diseases, Programs, Systems, and Policies, Fourth Edition brings together contributions from the world's leading authorities into a single comprehensive text. It thoroughly examines the wide range of global health challenges facing low- and middle-income countries today and the various approaches nations adopt to deal with them. These challenges include measurement of health status, infectious and chronic diseases, injuries, nutrition, reproductive health, global environmental health, and complex emergencies. The book also explores the financing and management of emerging health systems as well as the roles of nation states, international agencies, the private sector, and nongovernmental organizations in promoting health. Designed for graduate-level students, this text provides an expansive view of today's issues and challenges in global health and be an invaluable resource in the years to come. Updated throughout to reflect new and emerging issues, the Fourth Edition o
Widely considered to be the most comprehensive and accessible textbook in the field of Cognitive Psychology Emphasis on applied cognition with ‘in the real world’ case studies and examples Comprehensive companion website including access to Primal Pictures’ interactive 3D atlas of the brain, test simulations of key experiments, multiple choice questions, glossary flashcards and instructor PowerPoint slides Simple, clear pedagogy in every chapter to highlight key terms, case studies and further reading Updated references throughout the textbook to reflect the latest research
Frontiers in Electronics is divided into four sections: advanced terahertz and photonics devices; silicon and germanium on insulator and advanced CMOS and MOSHFETs; nanomaterials and nanodevices; and wide band gap technology for high power and UV photonics. This book will be useful for nano-microelectronics scientists, engineers, and visionary research leaders. It is also recommended to graduate students working at the frontiers of the nanoelectronics and microscience.
In your practice, you require advanced knowledge of the obstetrical, medical, genetic and surgical complications of pregnancy and their effects on the mother and fetus. With both basic science and clinical information, six new chapters, and an updated color design, you need look no further than the 6th edition of this long-time best seller. Includes both basic science and clinical information to give you comprehensive knowledge of the biology of pregnancy. Acts as an excellent resource for OB/GYNs studying for their Maternal-Fetal Medicine boards — and for practitioners who need quick access to practical information. Provides an updated and focused reference list to keep you up to date on the standards of care in maternal-fetal medicine today. Keeps you current with a new section: Disorders at the Maternal-Fetal Interface...and 6 new chapters: Biology of Parturition, Developmental Origins of Health and Disease, Intrapartum Assessment of Fetal Health, Pathogenesis of Pre-term Birth, Maternal and Fetal Infectious Disorders, and Benign Gynecological Conditions of Pregnancy. Features over 50% new authorship with increased focus on international perspectives. Includes the following hot topics in Maternal-Fetal Medicine: o Biology of Parturition o Fetal Growth o Prenatal Genetic Screening and Diagnosis o Fetal Cardiac Malformations and Arrhythmias o Thyroid Disease and Pregnancy o Management of Depression and Psychoses during Pregnancy and the Puerperium Focuses on evidence based medicine, the current best practice in MFM for diagnosing and treating high risk pregnancies. Includes new illustrations and an updated, color design.
Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.
In the last decades, various mathematical problems have been solved by computer-assisted proofs, among them the Kepler conjecture, the existence of chaos, the existence of the Lorenz attractor, the famous four-color problem, and more. In many cases, computer-assisted proofs have the remarkable advantage (compared with a “theoretical” proof) of additionally providing accurate quantitative information. The authors have been working more than a quarter century to establish methods for the verified computation of solutions for partial differential equations, mainly for nonlinear elliptic problems of the form -∆u=f(x,u,∇u) with Dirichlet boundary conditions. Here, by “verified computation” is meant a computer-assisted numerical approach for proving the existence of a solution in a close and explicit neighborhood of an approximate solution. The quantitative information provided by these techniques is also significant from the viewpoint of a posteriori error estimates for approximate solutions of the concerned partial differential equations in a mathematically rigorous sense. In this monograph, the authors give a detailed description of the verified computations and computer-assisted proofs for partial differential equations that they developed. In Part I, the methods mainly studied by the authors Nakao and Watanabe are presented. These methods are based on a finite dimensional projection and constructive a priori error estimates for finite element approximations of the Poisson equation. In Part II, the computer-assisted approaches via eigenvalue bounds developed by the author Plum are explained in detail. The main task of this method consists of establishing eigenvalue bounds for the linearization of the corresponding nonlinear problem at the computed approximate solution. Some brief remarks on other approaches are also given in Part III. Each method in Parts I and II is accompanied by appropriate numerical examples that confirm the actual usefulness of the authors’ methods. Also in some examples practical computer algorithms are supplied so that readers can easily implement the verification programs by themselves.
A full-color, case-based guide to effectively managing airway difficulties—updated to reflect the latest guidelines, devices, and techniques Written by the creators of the Difficult Airway Course: AnesthesiaTM and presented in full-color, this trusted resource covers the latest guidelines, leading-edge principles, tools, and procedures of airway assessment and management. Multidisciplinary in scope, the book encompasses the key areas of anesthesia, hospitalists, intensivists, emergency medicine, and paramedicine. Updated and revised, this fourth edition includes the most current review available of the many innovations that been introduced since publication of the previous edition. This is accompanied by a thorough review of the pharmacology of airway management designed to help you understand how to achieve the desired effects on ventilation and muscle strength. You'll find expert advice and strategies for treating patients in a range of settings, from pre-hospital care to the ER, as well as proven techniques for special patient populations. Hung's Management of the Difficult and Failed Airway, Fourth Edition features: Skill-building, case-based approach that highlights that the right tools and techniques Comprehensive review of the difficult or failed airway Chapter-ending questions that reinforce learning and allow you to assess your knowledge Dozens of airway management vignettes covering the intensive care unit, operating room, pediatric population, emergency room, and more New: 15 additional chapters New: Coverage on managing COVID-19 patients New: Content focused on standard of care in a global crisis in critical care Full-color illustrations
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