Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.
A celebration of Jewish men's voices in prayer—to strengthen, to heal, to comfort, to inspire from the ancient world up to our own day. "An extraordinary gathering of men—diverse in their ages, their lives, their convictions—have convened in this collection to offer contemporary, compelling and personal prayers. The words published here are not the recitation of established liturgies, but the direct address of today's Jewish men to ha-Shomea Tefilla, the Ancient One who has always heard, and who remains eager to receive, the prayers of our hearts." —from the Foreword by Rabbi Bradley Shavit Artson, DHL This collection of prayers celebrates the variety of ways Jewish men engage in personal dialogue with God—with words of praise, petition, joy, gratitude, wonder and even anger—from the ancient world up to our own day. Drawn from mystical, traditional, biblical, Talmudic, Hasidic and modern sources, these prayers will help you deepen your relationship with God and help guide your journey of self-discovery, healing and spiritual awareness. Together they provide a powerful and creative expression of Jewish men’s inner lives, and the always revealing, sometimes painful, sometimes joyous—and often even practical—practice that prayer can be. Jewish Men Pray will challenge your preconceived ideas about prayer. It will inspire you to explore new ways of prayerful expression, new paths for finding the sacred in the ordinary and new possibilities for understanding the Jewish relationship with the Divine. This is a book to treasure and to share.
The remarkable excavation of a previously unidentified city in Israel from the time of King David, shedding new light on the link between the bible and history King David is a pivotal figure in the Bible, which tells his life story in detail and gives stirring accounts of his deeds, including the slaying of the Philistine giant Goliath and the founding of his capital in Jerusalem. But no certain archaeological finds from the period of his reign or of the kingdom he ruled over have ever been uncovered—until now. In this groundbreaking account, the excavators of Khirbet Qeiyafa in the Valley of Elah, where the Bible says David fought Goliath, reveal how seven years of exhaustive investigation have uncovered a city dating to the time of David— the late eleventh and early tenth century BCE—surrounded by massive fortifications with impressive gates and a clear urban plan, as well as an abundance of finds that tell us much about the inhabitants. Discussing the link between the Bible, archaeology, and history In the Footsteps of King David explains the significance of these discoveries and how they shed new light on David’s kingdom. The topic is at the center of a controversy that has raged for decades, but these findings successfully challenge scholars disputing the historicity of the Bible and the chronology of the events recounted in it.
Fully revised and updated, the second edition of this authoritative guide is a comprehensive, scholarly and systematic review of modern English. In one volume the book presents a description of both the linguistic structure of present-day English and its geographical, social, gender, and ethnic variations. Covering new developments such as the impact of email on language and corpus-based grammars, this accessible text has been extensively rewritten and brings the survey of modern English right up to date. It also offers new examples and suggestions for further reading.
**Selected for Doody’s Core Titles® 2024 in Dentistry** Learn and master a range of clinical techniques and achieve therapeutic goals with Newman and Carranza’s Clinical Periodontology and Implantology, 14th Edition! Unmatched for its comprehensive approach, this resource provides detailed, up-to-date information on the etiology and pathogenesis of periodontal disease. Basic and advanced evidence-based information on the various treatment modalities employed in periodontics and implantology is presented in an easy-to-read format, with callout boxes throughout the text highlighting the clinical relevance of foundational basic science information. Full-color photos and radiographic images depict periodontal conditions and procedures, and the Atlas of Periodontal Pathology is one of the most comprehensive ever compiled in a periodontal textbook. Written by a team of leading experts led by Michael G. Newman, this text not only demonstrates how to perform periodontal procedures but explains the evidence supporting each treatment and provides knowledge on how to achieve the best possible outcomes of periodontal therapy and implant treatment. An eBook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud. The eBook version included with print purchase also includes Periopixel 3D color illustrations, a periodontal classification calculator and interactive learning tool, review questions, case studies, videos, 3D animations, and more! This edition features new chapters on Precision Medicine, Pocket Reduction Therapy, Periodontal Referral, and Digital Implant Workflows, as well as an updated glossary of terms linked to the eBook. It also features first-of-its-kind content on the effects of COVID-19 on treatment from key opinion leaders in this area. Case studies reflect the new format of the Integrated National Board Dental Exam (INBDE). Full-color photos, illustrations, radiographs, animations, simulations, and videos demonstrate how to perform periodontal and implant procedures. Current information on clinical techniques in periodontology and the latest advances in basic science. Evidence-based treatment planning provides knowledge on how to achieve the best possible outcomes of periodontal therapy and implant treatment. Extensive color atlas of periodontal pathology Internationally known experts contribute chapters on their areas of specialty. An eBook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud.
A vital, timely text on the viruses that cause pandemics and how to face them, by the New York Times bestselling author of How Not to Die. As the world grapples with the devastating impact of COVID-19, Dr Michael Greger reveals not only what we can do to protect ourselves and our loved ones during a pandemic, but also what human society must rectify to reduce the likelihood of even worse catastrophes in the future. From tuberculosis to bird flu and HIV to coronavirus, these infectious diseases share a common origin story: human interaction with animals. Otherwise known as zoonotic diseases for their passage from animals to humans, these pathogens – both pre-existing ones and those newly identified – emerge and re-emerge throughout history, sparking epidemics and pandemics that have resulted in millions of deaths around the world. How did these diseases come about? And what – if anything – can we do to stop them and their fatal march into our countries, our homes, and our bodies? In How to Survive a Pandemic, Dr Michael Greger, physician and internationally-recognized expert on public health issues, delves into the origins of some of the deadliest pathogens the world has ever seen. Tracing their evolution from the past until today, Dr Greger spotlights emerging flu and coronaviruses as he examines where these pathogens originated, as well as the underlying conditions and significant human role that have exacerbated their lethal influence to large, and even global, levels.
A vital, timely text on the viruses that cause pandemics and how to face them, by the New York Times bestselling author of How Not to Die. From tuberculosis to bird flu and HIV to coronavirus, these infectious diseases share a common origin story: human interaction with animals. Otherwise known as zoonotic diseases for their passage from animals to humans, these pathogens—both pre-existing ones and those newly identified—emerge and re-emerge throughout history, sparking epidemics and pandemics that have resulted in millions of deaths around the world. How did these diseases come about? And what—if anything—can we do to stop them and their fatal march into our countries, our homes, and our bodies? In How to Survive a Pandemic, Dr. Michael Greger, physician and internationally-recognized expert on public health issues, delves into the origins of some of the deadliest pathogens the world has ever seen. Tracing their evolution from the past until today, Dr. Greger spotlights emerging flu and coronaviruses as he examines where these pathogens originated, as well as the underlying conditions and significant human role that have exacerbated their lethal influence to large, and even global, levels. As the world grapples with the devastating impact of the novel coronavirus 2019, Dr. Greger reveals not only what we can do to protect ourselves and our loved ones during a pandemic, but also what human society must rectify to reduce the likelihood of even worse catastrophes in the future.
More than 50 years ago, President Kennedy gave an address to Congress that launched the community mental health movement in the U.S. This movement involved a vast and complex effort to replace the wholesale institutionalization of people with serious mental illnesses with community mental health centers, public education on mental illness, and prevention efforts. The mission and main thrust of this new movement, however, were quite simple: we would provide effective mental health treatment to people in their home communities and provide the conditions for them to have 'a life in the community.' Starting in the 1990s with Jim, a person who was homeless and initially refused help from outreach workers, Citizenship & Mental Health tells a 20-year story of practice, theory, and research to support the full participation of persons with mental illnesses who, in many cases, have also been homeless, have criminal charges in their past, and are poor. As the first of its kind, this book addresses the concept of citizenship as an applied theory for fulfilling the promise of the community mental health center movement. Citizenship is defined as a strong connection to the 5 R's of rights, responsibilities, roles, resources, and relationships that society offers to its members, and a sense of belonging that comes from others' recognition of one's valued membership in society. The citizenship model supports the strengths, hopes, and aspirations of people with mental illnesses to become neighbors, community members, and citizens.
Some of the world's leading research scientists in the field have contributed to this new book on malaria vaccine development. The book examines various strategies being pursued against the different stages of the parasite (the sporozoite, asexual erythrocytic stages, and sexual stages). It describes vaccines that combat the parasite directly, vaccines aimed at preventing disease, vaccines based on attenuated parasites, and vaccines based on small, carefully defined synthetic peptides. The book provides a compendium of current approaches, lists of preferred antigens, and the results of vaccine trials to date. Molecular immunology involved with both the natural immune response to parasites and with the constraints on inducing immunity are emphasized throughout the book. Views on how vaccines may be tested and then integrated into malaria control programs are also discussed. Molecular Immunological Considerations in Malaria Vaccine Development will be useful for researchers and students in immunology, parasitology, biotechnology, vaccine design, and tropical and public health.
Campus Power Struggle traces the explosive evolution of the student political movement from the Berkeley Free Speech Movement of 1964 to armed confrontation at Cornell in 1969. From campus conflict as a microcosm of larger political struggles for self-determination, to student concern about infringements upon personal liberties, the studies in this book provide authoritative insight into unrest on American campuses. This volume represents sociology as the ""big news"" in its most impressive and involved style. No.l in the series.Contents: Introduction - The Struggle for Power on the Campus (Howard S. Becker). Beyond Berkeley (Joseph Gusfleld). Columbia: The Dynamics of a Student Revolution (Ellen Kay Tnmberger). The Crisis at San Francisco State (James McEvoy and Abraham Miller). Confrontation at Cornell (William H. Fried/and and Harry Edwards'). The Phantom Racist (Rita James Simon and James Carey). Dynamic Young Fogies-Rebels on the Right (Lawrence F. Schiff). Ending Campus Drug Incidents (Howard S. Becker). The Psychiatrist as Double Agent (Thomas Szasz). Student Power in Action (Arlie Hochschild).
Researchers examine the existing state of knowledge regarding surprises (effects that are not natural extensions of existing trends) and nonlinearities (responses disproportionate to changes in stimuli that may threaten adaptive capacities) in natural and socioeconomic systems confronted with human-induced climatic change.
In Legal Pragmatism, Michael Sullivan looks closely at the place of the individual and community in democratic society. After mapping out a brief history of American legal thinking regarding rights, from communitarianism to liberalism, Sullivan gives a rich and nuanced account of how pragmatism worked to resolve conflicts of self-interest and community well-being. Sullivan's view of pragmatism provides a comprehensive framework for understanding democracy, as well as issues such as health care, education, gay marriage, and illegal immigration that will determine its character in the future. Legal Pragmatism is a bold, carefully argued book that presents a unique understanding of contemporary society, law, and politics.
The infonnation revolution is upon us. Whereas the industrial revolution heralded the systematic augmentation of human physical limitations by har nessing external energy sources, the infonnation revolution strives to augment human memory and mental processing limitations by harnessing external computational resources. Computers can accumulate. transmit and output much more infonnation and in a more timely fashion than more con ventional printed or spoken media. Of greater interest, however, is the computer's ability to process, classify and retrieve infonnation selectively in response to the needs of each human user. One cannot drink from the fire hydrant of infonnation without being immediately flooded with irrelevant text. Recent technological advances such as optical character readers only exacerbate the problem by increasing the volume of electronic text. Just as steam and internal combustion engines brought powerful energy sources under control to yield useful work in the industrial revolution, so must we build computational engines that control and apply the vast infonnation sources that they may yield useful knowledge. Information science is the study of systematic means to control, classify, process and retrieve vast amounts of infonnation in electronic fonn. In par ticular, several methodologies have been developed to classify texts manually by annies of human indexers, as illustrated quite clearly at the National Library ofMedicine, and many computational techniques have been developed to search textual data bases automatically, such as full-text keyword searches. In general.
This valuable resource prepares graduate-level students in social work and other helping professions to provide integrated behavioral health services in community-based health and mental healthcare settings. Responding to the increasing prevalence of behavioral health issues in the general U.S. population and the resulting additional responsibilities for social workers and health professionals, this textbook describes the latest evidence-based practices and interventions for common behavioral health disorders as well as issues related to suicide, violence, substance use, and trauma. Detailed case studies help illustrate the effects of a range of interventions, inviting readers to consider how best to implement behavioral health assessment and treatment practices that are evidence-based, trauma-informed, and recovery-oriented. In addition to outlining integrated behavioral health service models and assessment tools, chapters address specific topics such as: Public health approaches to addressing interpersonal violence Intersections of social, behavioral, and physical health Achieving recovery and well-being from behavioral health disorders Motivating clients to achieve and maintain recovery from addiction Stage-based treatments for substance use disorders Cognitive behavioral approaches to treating anxiety and depressive disorders Evidence-based approaches to treating the effects of trauma and PTSD Integrated Behavioral Health Practice equips graduate students and health professionals alike to provide sensitive and informed interprofessional care for patients and families while consistently engaging in practices that emphasize recovery and well-being.
Based on the paradigm of model-driven security, the authors of this book show how to systematically design and realize security-critical applications for SOAs. In a second step, they apply the principles of model-driven security to SOAs.
How can classroom teachers effectively differentiate learning and teaching programs to provide for the needs of every student in their class? Inclusion in Action begins by asking, “Why include all students in regular classrooms?” and then shows how this can be done. It outlines the philosophy of inclusive education and focuses on the use of individualised planning and effective teaching practices to maximise learning outcomes within positive and productive environments. This sixth edition is grounded in evidence-based practices, Universal Design for Learning (UDL), and Response to Intervention. Expansion and focus on these educational frameworks and approaches is in line with the research evidence about what works for students with diverse abilities across different education settings. Premium online teaching and learning tools are available on the MindTap platform. Learn more about the online tools au.cengage.com/mindtap
GaAs devices and integrated circuits have emerged as leading contenders for ultra-high-speed applications. This book is intended to be a reference for a rapidly growing GaAs community of researchers and graduate students. It was written over several years and parts of it were used for courses on GaAs devices and integrated circuits and on heterojunction GaAs devices developed and taught at the University of Minnesota. Many people helped me in writing this book. I would like to express my deep gratitude to Professor Lester Eastman of Cornell University, whose ideas and thoughts inspired me and helped to determine the direction of my research work for many years. I also benefited from numerous discussions with his students and associates and from the very atmosphere of the pursuit of excellence which exists in his group. I would like to thank my former and present co-workers and colleagues-Drs. Levinstein and Gelmont of the A. F. Ioffe Institute of Physics and Technology, Professor Melvin Shaw of Wayne State University, Dr. Kastalsky of Bell Communi cations, Professor Gary Robinson of Colorado State University, Professor Tony Valois, and Dr. Tim Drummond of Sandia Labs-for their contributions to our joint research and for valuable discussions. My special thanks to Professor Morko.;, for his help, his ideas, and the example set by his pioneering work. Since 1978 I have been working with engineers from Honeywell, Inc.-Drs.
From basic science and fundamental procedures to the latest advanced techniques in reconstructive, esthetic, and implant therapy, Newman and Carranza's Clinical Periodontology, 13th Edition is the resource you can count on to help master the most current information and techniques in periodontology. Full color photos, illustrations, and radiographs show you how to perform periodontal procedures, while renowned experts from across the globe explain the evidence supporting each treatment and lend their knowledge on how to best manage the outcomes. UNIQUE! Expert Consult platform offers a versatile print and digital resources that help bring text information to life. UNIQUE! Bonus content on Expert Consult includes multiple-choice self-assessment questions with instant feedback, chapter review PowerPoint slides, videos clips, case studies, and more. UNIQUE! Periodontal Pathology Atlas contains the most comprehensive collection of cases found anywhere. Full-color photos and anatomical drawings clearly demonstrate core concepts and reinforce important principles. UNIQUE! Chapter opener boxes in the print book alert readers when more comprehensive coverage of topics is available in the online version of the text. NEW! Chapters updated to meet the current exam requirements for the essentials in periodontal education. NEW! Case-based clinical scenarios incorporated throughout the book mimic the new patient case format used in credentialing exams. NEW! Additional tables, boxes, and graphics highlight need-to-know information. NEW! Virtual microscope on Expert Consult offers easy access to high-resolution views of select pathology images. NEW! Two new chapters cover periimplantitis and resolving inflammation. NEW! Section on evidence-based practice consists of two chapters covering evidence-based decision making and critical thinking.
Largely reorganised and much expanded in this second edition, Practice and Procedures brings together in a single volume general methods of pain assessment and presents the wide range of therapies that can be provided by a range of health care disciplines. Authored by a multidisciplinary team of experts, chapters can stand alone for readers looking
Blome-Tillmann puts forth an innovative account of epistemic contextualism based on the idea that pragmatic presuppositions play a central role in the semantics of knowledge attributions. Using the resulting theory, he establishes its significance for a variety of issues within epistemology and the philosophy of language.
Was David a good man ruined by the negative influence of the evil villain Joab or was David himself the villain who cast his dark shadow wrongfully over Joab? The depth and complexity of David's character is more clearly observed and appreciated through this careful reading of the texts describing Joab as his foil. This book provides a wealth of information regarding character studies, a new perspective on David, and a groundbreaking study of Joab. Courses in biblical studies, especially literary or historical, will find this text most helpful.
Political science has been described as a jigsaw puzzle with many specializations and subfields that do not talk to one another. This book offers a solution that will advance the field from mid-level theory to engage in cross-fertilization through metatheoretical paradigms. The book begins with a history of political science from the nineteenth century to the present, followed by a paradigmatic history of political science including 6 metatheories in the pre-behavioral era, 12 in the behavioral era, and the 4 major and several minor paradigms being developed today. The book advances the goal of David Easton by proposing a neobehavioral political science including multimethodological innovations, cross-testing of paradigms, and tenets of a new political science that can rise to become a truly theoretical science. Each paradigm is diagramed to demonstrate the key concepts and their causal interconnections. Political Science Revitalized: Filling the Jigsaw Puzzle with Paradigms poses an exciting and provocative argument for the future of the vast field of political science.
In American Maelstrom, Michael A. Cohen captures the full drama of this watershed election, establishing 1968 as the hinge between the decline of political liberalism and the ascendancy of conservative populism and the anti-government attitudes that continue to dominate the nation's political discourse, taking us to the source of the politics of division.
To this day Jewish thinkers struggle to articulate the appropriate response to the unprecedented catastrophe of the Holocaust. Here, Morgan offers the first comprehensive overview of Post-Holocaust Jewish theology, quoting extensively from and interpreting all of the significant American writings of the movement. Morgan's lucid analysis clarifies the background of the movement in the postwar period, its origins, its character, and its legacy for subsequent thinking, theological and otherwise. Ultimately, Morgan's primary purpose is to tell the story of the movement, to illuminate its real, deep point, and to demonstrate its continuing relevance today.
This is the first comprehensive study of U.S. policy toward China during the presidency of Lyndon Johnson, a critical phase of the Cold War immediately preceding the dramatic Sino-American rapprochement of the early 1970s. Based on a wide array of recently declassified government documents, this study challenges the popular view that Johnson’s approach to China was marked by stagnation and sterility, exploring the administration's relationship to both the Vietnam War and the Cultural Revolution. By documenting Johnson’s contributions to the decision-making process Lumbers offers a new perspective on both his capacity as a foreign policy leader and his role in the further development of the Cold War. A major contribution to our understanding of both Sino-American relations and the Vietnam War, this book will be of great interest to students of the Cold War, U.S. foreign relations, Asian Politics and the Johnson Presidency.
An updated examination of what's weakening the U.S. economy, and how to fix it The Committee to Destroy the World: Inside the Plot to Unleash a Super Crash on the Global Economy is a passionate and informed analysis of the struggling global economy. In this masterfully conceived and executed work, Michael Lewitt, one of Wall Street's most respected market strategists and money managers, updates his groundbreaking examination of the causes of the 2008 crisis and argues that economic and geopolitical conditions are even more unstable today. His analysis arrives in time for the impending economic and geopolitical debates of the 2016 election season. Lewitt explains in detail how debt has now overrun the world's capacity, how federal policies of the past few decades have created a downward vortex sapping growth and vitality from the American economy, and how greed and corruption are preventing reform. The financial crisis created tens of trillions of debt, leaving investors to pay a huge price for these policy failures: The highest asset inflation we've seen in our lifetimes, although the government claims there isn't enough inflation More than $2 trillion of stock buybacks funded with low cost debt that are artificially inflating stock prices The Federal Reserve and other global central banks becoming the largest buyers of government debt in order to suppress interest rates An M&A boom resulting from companies needing to find growth outside of their core businesses While the financial media misses the story, Lewitt pulls no punches explaining how all of these trends are leading to the brink of another crisis. Lewitt lays out a survival plan for the average investor to protect their assets when the debt bubble bursts. The first edition of this book expressed hope that policymakers would not let the financial crisis go to waste. This book urges investors to learn from the crushed hope and take action before the next crisis.
This Brochure on E-education, Nr. 1, focuses the Web in education, in particular E-education (Electronically Enhanced Education). The text accomplishes many thoughts and observations laid down in the four 2004-2006 Volumes on The Principles of E-education. E-education could not emerge without the Web as an icon for electronic communication and technique. Together with the Net, cyberspace's concepts shaped major domains of modern society, including norms as well as thought patterns and behaviors. E-education covers one of the most influential cultural complexities-intergenerational transference-and is by no means identical with the Web or the Internet. This is one of the interesting perspectives of the Brochure. Students and teachers who experience 'being online', and develop a positive attitude in that regard, are not unbalanced involved in or even enslaved by the Web. E-education integrates Web elements, its data and its Internet provisions with non-electronic devices. Those form a specific Education Environment that sustains the acquiring of a variety of skills, insights and attitudes, which are ultimately the outset of a well-educated citizen. Their establishment of Intranet Sites is a special form of using the Web, with many guarantees not to become involved in the Internet mediated Web vices. The brochure explains how parental fears that their kids will via E-education automatically enter problematic sites, spend time in Internet-driven chat boxes or mail systems, or operate Internet-related handhelds with inappropriate films and texts, are misled in not appreciating the difference between an education Intranet and the Web-related Internet.
This filmography (including television and music video appearances) chronicles the career of Caroline Munro, a woman of humble beginnings whose chance entry in a "Face of the Year" photo competition propelled her to international fame as a model and actress, and whose work in genre cinema has won her the well-earned title of "First Lady of Fantasy." It provides complete technical and cast credits for each film, a synopsis, reviews and notes, and a foreword by Caroline Munro.
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