The first two chapters provide an introduction to functional groups; these are followed by chapters reviewing basic organic transformations (e.g. oxidation, reduction). The book then looks at carbon-carbon bond formation reactions and ways to 'disconnect' a bigger molecule into simpler building blocks. Most chapters include an extensive list of questions to test the reader's understanding. There is also a new chapter outlining full retrosynthetic analyses of complex molecules which highlights common problems made by scientists.
This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.
Senior level/graduate level text/reference presenting state-of-the- art numerical techniques to solve the wave equation in heterogeneous fluid-solid media. Numerical models have become standard research tools in acoustic laboratories, and thus computational acoustics is becoming an increasingly important branch of ocean acoustic science. The first edition of this successful book, written by the recognized leaders of the field, was the first to present a comprehensive and modern introduction to computational ocean acoustics accessible to students. This revision, with 100 additional pages, completely updates the material in the first edition and includes new models based on current research. It includes problems and solutions in every chapter, making the book more useful in teaching (the first edition had a separate solutions manual). The book is intended for graduate and advanced undergraduate students of acoustics, geology and geophysics, applied mathematics, ocean engineering or as a reference in computational methods courses, as well as professionals in these fields, particularly those working in government (especially Navy) and industry labs engaged in the development or use of propagating models.
This is the first publication to describe the evolution of fluid dynamics as a major field in modern science and engineering. It contains a description of the interaction between applied research and application, taking as its example the history of fluid mechanics in the 20th century. The focus lies on the work of Ludwig Prandtl, founder of the aerodynamic research center (AVA) in Göttingen, whose ideas and publications have influenced modern aerodynamics and fluid mechanics in many fields. While suitable for others, this book is intended for natural scientists and engineers as well as historians of science and technology.
In this book, through a distinctive evangelical and critical approach, Michael Bird explores the historical development of the four canonical Gospels. He shows how the memories and faith of the earliest believers formed the Gospel accounts of Jesus that got written and, in turn, how these accounts further shaped the early church. Bird's study clarifies the often confusing debates over the origins of the canonical Gospels. Bird navigates recent concerns and research as he builds an informed case for how the early Christ followers wrote and spread the story of Jesus -- the story by which they believed they were called to live. The Gospel of the Lord is ideal for students or anyone who wants to know the story behind the four Gospels. Watch an interview with Michael Bird from our Eerdmans Author Interview Series:
This comprehensive, detailed reference provides readers with both a working knowledge of Mathematica in general and a detailed knowledge of the key aspects needed to create the fastest, shortest, and most elegant implementations possible. It gives users a deeper understanding of Mathematica by instructive implementations, explanations, and examples from a range of disciplines at varying levels of complexity. The three volumes - Programming, Graphics, and Mathematics - each with a CD, total 3,000 pages and contain more than 15,000 Mathematica inputs, over 1,500 graphics, 4,000+ references, and more than 500 exercises. This second volume covers 2 and 3D graphics, providing a detailed treatment of creating images from graphic primitives such as points, lines, and polygons. It also shows how to graphically display functions that are given either analytically or in discrete form and a number of images from the Mathamatica graphics gallery. The use of Mathematicas graphics capabilities provides a very efficient and instructive way to learn how to deal with the structures arising in solving complicated problems.
A "z pinch" is a deceptively simple plasma configuration in which a longitudinal current produces a magnetic field that confines the plasma. Z-pinch research is currently one of the fastest growing areas of plasma physics, with revived interest in z-pinch controlled fusion reactors along with investigations of new z-pinch applications, such as very high power x-ray sources, high-energy neutrons sources, and ultra-high magnetic fields generators. This book provides a comprehensive review of the physics of dense z pinches and includes many recent experimental results.
This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entired field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost im anyone person to stay informed on this subject by reading the possible for At the same time it is becoming increasingly apparent that primary literature. these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony-stimulating factors," was quite artifactual; they are in fact the basis of a common language for intercellular communication. As a set they affect es sentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research.
Language can help lift or limit students. Based on brain research and authentic classroom experience, this book will help you get back to the optimism of teaching by reconnecting with the possibility of each student. From classroom practice to systemwide policies, readers will find strategies for shifting the way we approach teaching to cultivate the gifts each student has to offer. Teachers and leaders will: Understand how limiting language stifles student growth and academic success Utilize figures and other resources to better recognize limiting language and replace it with positive language Reflect on the culture of your own school and improve collaborative work Access and analyze data that will equip you to better handle obstacles in developing your professional learning community Improve communication among all classrooms within your school or district Contents: Foreword by Anthony Muhammad Introduction Part 1: What We Say About Students Chapter 1: Talking About Underserved Students Chapter 2: Talking About Expectations for Students Chapter 3: Talking About Student Motivation Chapter 4: Talking About Student Data Part 2: What We Say About Colleagues Chapter 5: Talking About Taking Responsibility Chapter 6: Talking About Research and Best Practices Chapter 7: Talking About Teacher Individuality Chapter 8: Talking About Collaboration Chapter 9: Talking About Trust Epilogue
Being a Scientist is a comprehensive introduction to the many aspects of scientific life beyond the classroom and laboratory. Written with undergraduate science majors in mind, the book covers ethics, the philosophical bases of scientific methods, library research, reading, peer review, creativity, proposal and paper writing, and oral and poster presentations. In contrast to other texts in the field, which often take a simple prescriptive approach to these topics, Being a Scientist connects them to the historical and philosophical roots of modern science, as well as the common experiences of all people. Written in a conversational style, the book makes use of metaphor, historical anecdote, and hypothetical research about everyday household questions. This approach helps undergraduates learn basic research skills without being too intimidated by the advanced concepts, vocabulary, and methods which are encountered in looking at the current scientific literature. Being a Scientist is a textbook for a semester-long course devoted to teaching research and communication skills to undergraduate science majors, but it can be adapted for use in summer research experiences, capstone research courses, and other courses throughout the undergraduate curriculum.
Fungi are ubiquitous in the world and responsible for driving the evolution and governing the sustainability of ecosystems now and in the past. Fossil Fungi is the first encyclopedic book devoted exclusively to fossil fungi and their activities through geologic time. The book begins with the historical context of research on fossil fungi (paleomycology), followed by how fungi are formed and studied as fossils, and their age. The next six chapters focus on the major lineages of fungi, arranging them in phylogenetic order and placing the fossils within a systematic framework. For each fossil the age and provenance are provided. Each chapter provides a detailed introduction to the living members of the group and a discussion of the fossils that are believed to belong in this group. The extensive bibliography (~ 2700 entries) includes papers on both extant and fossil fungi. Additional chapters include lichens, fungal spores, and the interactions of fungi with plants, animals, and the geosphere. The final chapter includes a discussion of fossil bacteria and other organisms that are fungal-like in appearance, and known from the fossil record. The book includes more than 475 illustrations, almost all in color, of fossil fungi, line drawings, and portraits of people, as well as a glossary of more than 700 mycological and paleontological terms that will be useful to both biologists and geoscientists. - First book devoted to the whole spectrum of the fossil record of fungi, ranging from Proterozoic fossils to the role of fungi in rock weathering - Detailed discussion of how fossil fungi are preserved and studied - Extensive bibliography with more than 2000 entries - Where possible, fungal fossils are placed in a modern systematic context - Each chapter within the systematic treatment of fungal lineages introduced with an easy-to-understand presentation of the main characters that define extant members - Extensive glossary of more than 700 entries that define both biological, geological, and mycological terminology
Seismic waves – generated both by natural earthquakes and by man-made sources – have produced an enormous amount of information about the Earth's interior. In classical seismology, the Earth is modeled as a sequence of uniform horizontal layers (or sperical shells) having different elastic properties and one determines these properties from travel times and dispersion of seismic waves. The Earth, however, is not made of horizontally uniform layers, and classic seismic methods can take large-scale inhomogeneities into account. Smaller-scale irregularities, on the other hand, require other methods. Observations of continuous wave trains that follow classic direct S waves, known as coda waves, have shown that there are heterogeneities of random size scattered randomly throughout the layers of the classic seismic model. This book focuses on recent developments in the area of seismic wave propagation and scattering through the randomly heterogeneous structure of the Earth, with emphasis on the lithosphere. The presentation combines information from many sources to present a coherent introduction to the theory of scattering in acoustic and elastic materials and includes analyses of observations using the theoretical methods developed.
Covering preventive, non-invasive, and natural treatments, Textbook of Natural Medicine, 4th Edition offers more than just alternative medicine. It promotes an integrated practice that can utilize natural medicine, traditional Western medicine, or a combination of both in a comprehensive, scientific treatment plan. Based on a combination of philosophy and clinical studies, Textbook of Natural Medicine helps you provide health care that identifies and controls the underlying causes of disease, is supportive of the body's own healing processes, and is considerate of each patient's unique biochemistry. Internationally known authors Joseph Pizzorno and Michael Murray include detailed pharmacologic information on herbs and supplements, plus evidence-based coverage of diseases and conditions to help you make accurate diagnoses and provide effective therapy. Comprehensive, unique coverage makes this book the gold standard in natural medicine. A scientific presentation includes the science behind concepts and treatments, and discusses Western medical treatments and how they can work with natural medicine in a comprehensive treatment plan; if natural medicine is not effective, this book recommends the Western treatment. Coverage of pharmacology of natural medicines includes the uses and potential dangers of nearly 80 herbal medicines, special nutrients, and other natural agents, addressing topics such as general information, chemical composition, history, pharmacology, clinical applications dosage, and toxicology. In-depth, evidence-based coverage of 73 diseases and conditions includes key diagnostic criteria, pathophysiology of diseases, and therapeutic rationales. Coverage of potential interactions between drugs, herbs, and supplements ensures the safest possible use for each of 79 herbs and supplements. Diagnostic procedures include practical, easy-to-follow descriptions of evidence-based techniques plus discussions of clinical application of diet analysis, food allergy testing, immune function assessment, fatty acid profiling, hair mineral analysis, and other diagnostic approaches. Common therapeutic modalities are described and reviewed, including botanical medicine, nutritional therapy, therapeutic fasting, exercise therapy, hydrotherapy, counseling, acupuncture, homeopathy, and soft tissue manipulation. Coverage of syndromes and therapies helps in understanding the underlying causes of diseases by discussing topics such as food reactions, functional toxicology, sports nutrition, stress management, and breathing pattern disorders. Coverage of the philosophy of natural medicine includes its history and background, with discussions of toxicity, detoxification, and scientific documentation of the healing actions of nature and natural substances. Internationally known authors Joseph Pizzorno and Michael Murray and more than 90 expert contributors provide material that is up to date, accurate, and informed. More than 10,000 research literature citations show that the content is based on science rather than opinions or anecdotes. 13 useful appendices offer quick lookup of frequently used charts, handouts, and information. New chapters are included on hot topics such as female infertility, medicinal mushrooms, natural products and quality control, pregnancy health and primary prevention, and Vitamin K; new appendices include a supplier certification questionnaire and cervical escharotics treatment. Thorough updates ensure that you use only the most current research and provide the most effective treatment of patients. Tabs in Specific Health Problems section separate more than 70 alphabetized diseases/conditions. One convenient volume replaces the cumbersome two-volume set for easy, convenient reference. Electronic access is available via Pageburst, making it easy to search topics, drugs, herbs and supplements, and diseases and conditions. Sold separately.
This book describes the exciting discovery of every isotope observed on earth to date, which currently numbers some 3000. The discoveries are arranged in chapters according to the observation techniques or production methods. Each chapter contains tables listing the first authors of the first publication as well as details about the production and detection methods used. At the end, a comprehensive table lists all isotopes sorted by elements. The book is based on individual paragraphs for each isotope, which were published over the last few years as separate articles in the journal “Atomic Data and Nuclear Data Tables”. The work re-evaluates all prior assignments judging them with a uniform set of criteria. In addition, the author includes over 100 new isotopes which have been discovered since the articles published. This book is a source of information for researchers as well as enthusiastic laymen alike. From the prepublication review: “The explanations focus on the essentials, which makes the various chapters pleasingly compact. The phrasing is well understandable also for non-experts. This makes the book easy to read, even thrilling. I have to confess that parts of the manuscript I was even reading as an evening lecture in the bed, so exciting was the history of isotope discoveries.” Sigurd Hofmann, Helmholtz Professor at GSI Darmstadt, Germany, and a leading expert in superheavy nuclei
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
Originally published in 1985, this book analyses the development of private rented housing in Britain, France, the former West Germany, the Netherlands and the USA. The book shows that the changing fortunes of the private rented sector are seen in some measure to be connected with the social, economic and political conditions which surrounded the rapid industrialisation and urbanisation of the 19th Century.
Although less common than α-amino acids, non-α-amino acids—where the amino group is not on the carbon immediately adjacent to the carboxyl group but is attached to another carbon in the chain (for example, the β, γ, δ carbon)—are components of biologically important molecules, are significant in the pharmaceutical industry, and are useful starting materials for many areas of organic chemistry. Since the publication of the first edition of this book nearly 20 years ago, synthetic work devoted to the preparation of non- α-amino acids has expanded greatly. Methods of Non-α-Amino Acid Synthesis, Second Edition has been extensively rewritten and reorganized, providing an up-to-date review of strategies and methods for non-α-amino acid synthesis, particularly those amino acids that are key synthetic intermediates or important compounds in their own right. It focuses on acyclic amino acids of C3–C10, but also aminoalkanoic carboxylic acids, aminoalkenoic acids, and aminoalkynoic acids. The new edition contains many updated references and has a greater emphasis on the biological importance of non-α-amino acids. In addition to an array of synthetic methods, the book offers discussions on why non-α-amino acids are important. The book covers synthetic methods that rely on substituent refunctionalization, the conversion of cyclic precursors to acyclic amino acids, conjugate addition reactions, and enolate anion reactions and condensation reactions that lead to non-α-amino acids. It also examines reactions and strategies that lead to good diastereoselectivity and enantioselectivity during synthesis. A chapter devoted to biologically important amino acids includes separate sections on GABA, GABOB, carnitine, DAVA, statine, and other significant amino acids as well as a new section on peptides and proteins that contain non-α-amino acids. The final chapter addresses aminocyclic and heterocyclic amino acids.
This monograph presents a comprehensive taxonomic revision of the hyperdiverse Neotropical beetle genus Operclipygus Marseul. Operclipygus occurs almost throughout the Americas, but there are few species that extend beyond the diverse tropical regions.ÿ The genus was originally defined very narrowly, for just a single unusual species (the type species O. sulcistrius). However, evolutionary considerations have led to a much broader conception of the genus, and it is now one of the largest in the entire family Histeridae, containing 177 species. In this paper 138 species are described as new. Identification keys are presented to allow identification of all the species, and most species are illustrated by color photographs and drawings of diagnostic characteristics. Natural history details for species of Operclipygus are scant, as most specimens have been collected through the use of passive flight interception traps. They are known to be predaceous, and many are probably generally associated with decaying vegetation and leaf litter, where they prey on small arthropods. But a small proportion are known to be inquilines, living in symbiotic relationships with social insects such as ants and termites, and also with some burrowing mammals, such as Tuco-tucos.
Enteropathogenic Escherichia coli (EPEC) strains are a leading cause of diarrhea among infants in developing countries. These bacteria spread via fecal–oral transmission and colonize the small intestine. Typical EPEC differs from atypical strains in that they possess the bfp operon and generate a type IV-B class of fimbriae known as the bundle-forming pilus (BFP). EPEC uses BFP to attach to intestinal epithelium. Upon attachment, EPEC translocates effector proteins into the host cell via a type 3 secretion system, which is encoded on a pathogenicity island known as the locus of enterocyte effacement. Translocated effectors modulate the host response in a number of ways, including subversion of immune responses and hijacking of the cytoskeletal system. By inducing actin rearrangement, EPEC causes the formation of actin pedestals onto which it sits, and leads to the effacement of microvilli, giving this bacterium a characteristic attaching and effacing phenotype. EPEC infections are typically self-limiting, with rehydration therapy constituting primary treatment, but they can be protracted and lethal. Breastfeeding provides a great protective effect, validating the use of a vaccine to induce a humoral response in mother or child as a potential means of preventative action. This chapter provides a detailed discussion on EPEC pathogenesis and host cell responses and summarizes the current detection and treatment options available.
Covering preventive, non-invasive, and natural treatments, Textbook of Natural Medicine, 4th Edition offers more than just alternative medicine. It promotes an integrated practice that can utilize natural medicine, traditional Western medicine, or a combination of both in a comprehensive, scientific treatment plan. Based on a combination of philosophy and clinical studies, Textbook of Natural Medicine helps you provide health care that identifies and controls the underlying causes of disease, is supportive of the body's own healing processes, and is considerate of each patient's unique biochemistry. Internationally known authors Joseph Pizzorno and Michael Murray include detailed pharmacologic information on herbs and supplements, plus evidence-based coverage of diseases and conditions to help you make accurate diagnoses and provide effective therapy. - Comprehensive, unique coverage makes this book the gold standard in natural medicine. - A scientific presentation includes the science behind concepts and treatments, and discusses Western medical treatments and how they can work with natural medicine in a comprehensive treatment plan; if natural medicine is not effective, this book recommends the Western treatment. - Coverage of pharmacology of natural medicines includes the uses and potential dangers of nearly 80 herbal medicines, special nutrients, and other natural agents, addressing topics such as general information, chemical composition, history, pharmacology, clinical applications dosage, and toxicology. - In-depth, evidence-based coverage of 73 diseases and conditions includes key diagnostic criteria, pathophysiology of diseases, and therapeutic rationales. - Coverage of potential interactions between drugs, herbs, and supplements ensures the safest possible use for each of 79 herbs and supplements. - Diagnostic procedures include practical, easy-to-follow descriptions of evidence-based techniques plus discussions of clinical application of diet analysis, food allergy testing, immune function assessment, fatty acid profiling, hair mineral analysis, and other diagnostic approaches. - Common therapeutic modalities are described and reviewed, including botanical medicine, nutritional therapy, therapeutic fasting, exercise therapy, hydrotherapy, counseling, acupuncture, homeopathy, and soft tissue manipulation. - Coverage of syndromes and therapies helps in understanding the underlying causes of diseases by discussing topics such as food reactions, functional toxicology, sports nutrition, stress management, and breathing pattern disorders. - Coverage of the philosophy of natural medicine includes its history and background, with discussions of toxicity, detoxification, and scientific documentation of the healing actions of nature and natural substances. - Internationally known authors Joseph Pizzorno and Michael Murray and more than 90 expert contributors provide material that is up to date, accurate, and informed. - More than 10,000 research literature citations show that the content is based on science rather than opinions or anecdotes. - 13 useful appendices offer quick lookup of frequently used charts, handouts, and information.
The completely revised and updated, definitive resource for students and professionals in organic chemistry The revised and updated 8th edition of March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions The opening chapters of March's Advanced Organic Chemistry, 8th Edition deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms. This edition: Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017 Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction The 8th edition of March's Advanced Organic Chemistry proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields. Winner of the Textbook & Acadmic Authors Association 2021 McGuffey Longevity Award.
Nanocharacterization by Atom Probe Tomography is a practical guide for researchers interested atomic level characterization of materials with atom probe tomography. Readers will find descriptions of the atom probe instrument and atom probe tomography technique, field ionization, field evaporation and field ion microscopy. The fundamental underlying physics principles are examined, in addition to data reconstruction and visualization, statistical data analysis methods and specimen preparation by electropolishing and FIB-based techniques. A full description of the local electrode atom probe – a new state-of-the-art instrument – is also provided, along with detailed descriptions and limitations of laser pulsing as a method to field evaporate atoms. Valuable coverage of the new ionization theory is also included, which underpins the overall technique.
Annotation. Spectroscopic Properties of Inorganic and Organometallic Compounds provides a unique source of information on an important area of chemistry. Divided into sections mainly according to the particular spectroscopic technique used, coverage in each volume includes: NMR (with reference to stereochemistry, dynamic systems, paramagnetic complexes, solid state NMR and Groups 13-18); nuclear quadrupole resonance spectroscopy; vibrational spectroscopy of main group and transition element compounds and coordinated ligands; and electron diffraction. Reflecting the growing volume of published work in this field, researchers will find this Specialist Periodical Report an invaluable source of information on current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading experts in their specialist fields, this series is designed to help the chemistry community keep current with the latest developments in their field. Each volume in the series is published either annually or biennially and is a superb reference point for researchers. www.rsc.org/spr
Creatine and Creatine Phosphate: Scientific and Clinical Perspectives is an up-to-date summary of both the scientific and medical aspects of creatine and creatine phosphate metabolism and therapy.It covers in detail the basic biochemistry, bioenergetics and biophysics of these agents with particular emphasis on their role on the cardiovascular and muscle systems. Modern in vivo myocardial and skeletal muscle measurements are outlined, and the importance of the molecules in cardiovascular medicine, sport science and cardiac surgery are highlighted.This book is designed for those interested in the basic scientific background to creatine and creatine phosphate, and also for physicians treating or studying heart and vascular disease. The book will also be vital for sports scientists who wish to acquire a comprehensive knowledge of the molecule which is currently being promoted for performance and exercise programmes.
The central purpose of this book is to impart knowledge, skills and practical - plementation methods for the planning and operation of adaptable production - cilities and factories. It addresses planning methods and procedures for various types of production facility up to and including entire factories, and is aimed at practicing factory planners and students alike. The book provides facts and demonstrates practical processes using case studies for the purposes of illustration, so that ultimately skills can be acquired that make independent practical implementation and app- cation possible. It is based on up-to-the-minute practical experience and univ- sally applicable knowledge of the planning and technological design of adaptable production facilities (manufacturing and assembly) and factories. In comparison to existing, thematically-similar reference books, what is in- vative about this manual is that it provides the impulse for a more flexible pl- ning approach for the efficient design of adaptable production facilities using - sponsive, unconventional planning and organizational solutions. The book aims to provide a way of integrating systematic and situation-driven planning methods in a meaningful way. Situation-driven planning is becoming increasingly important to production facilities in these fast-moving times of change, in particular in terms of resource and energy efficiency. Existing technical and organizational course of action in terms of resources (both human and technical) need to be selected for the specific case at hand, and changes (to workshops, products, processes and equ- ment) need to be managed.
This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entire field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost impossible for anyone person to stay informed on this subject by reading the primary literature. At the same time it is becoming increasingly apparent that these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony stimulating factors," was quite artifactual; they are in fact the basis of a com mon language for intercellular communication. As a set they affect essentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research. This treatise is divided into four main sections. After three introductory chapters, its principal focus is the detailed description of each of the major peptide growth factors in 26 individual chapters.
The basic thesis for this study was that the telencephalon is needed to make decisions in new situations. Subsidary hypotheses were that the telencephalon consists of: (a) a sensorimotor system which generates motor activity from sensory input and (b) a selection system which makes choices from possible motor programs. It was postulated that the selection system should fulfil the following requirements: be accessible for past and present events, have the capacity to process this information in a nondetermined way with a possibility for ordering, and have access to motor-affecting systems (the sensorimotor system). The ability of the selection system to correlate information in a nonpredetermined way was considered most important. In short: The selection system should be able to associate any information in any combination, and have the capability for internal control of neuronal activity and external selection of motor programs (see Fig. IA. ) Xenopus laevis was chosen as a subject, since it has a relatively simple tel encephalon, with characteristics that it shares with "primitive" species of different vertebrate classes, and because it is easy to maintain as a laboratory animal. The main method used was the determination of connections with HRP. The pallium was in the focus of attention, since it was considered to be the core of the selection system. Immunohistochemistry was used as an additional parameter to compare Xenopus laevis forebrain with those of other vertebrates.
Although empires have shaped the political development of virtually all the states of the modern world, "imperialism" has not figured largely in the mainstream of scholarly literature. This book seeks to account for the imperial phenomenon and to establish its importance as a subject in the study of the theory of world politics. Michael Doyle believes that empires can best be defined as relationships of effective political control imposed by some political societies--those called metropoles--on other political societies--called peripheries. To build an explanation of the birth, life, and death of empires, he starts with an overview and critique of the leading theories of imperialism. Supplementing theoretical analysis with historical description, he considers episodes from the life cycles of empires from the classical and modern world, concentrating on the nineteenth-century scramble for Africa. He describes in detail the slow entanglement of the peripheral societies on the Nile and the Niger with metropolitan power, the survival of independent Ethiopia, Bismarck's manipulation of imperial diplomacy for European ends, the race for imperial possession in the 1880s, and the rapid setting of the imperial sun. Combining a sensitivity to historical detail with a judicious search for general patterns, Empires will engage the attention of social scientists in many disciplines.
Chemistry in Nonaqueous Ionizing Solvents: Volume II — Part 1 investigates the chemical and physico-chemical properties of substances dissolved or suspended in non-aqueous ionizing solvents (also known as water-like solvents). This volume is concerned with chemistry in anhydrous hydrogen cyanide and with inorganic chemistry in liquid hydrogen fluoride. This book is comprised of 35 chapters that cover topics ranging from commercial preparation of hydrogen fluoride to laboratory preparation of pure hydrogen fluoride as well as deuterium and tritium fluorides. Experimental techniques and the apparatus used in investigations of liquid hydrogen fluoride are also described. Subsequent chapters explore health risks and first aid with respect to handling hydrogen fluoride; physical properties of the pure solvent; inorganic solvates; solubilities and reactions of inorganic compounds; and acids and bases and their reactions with each other. The last two chapters are devoted to fluorides of the lanthanides and actinides in hydrogen fluoride. This monograph will be of interest to chemists.
In this intriguing book, Petrus C. van Duyne and Michael Levi introduce the reader to an ever-unfolding series of problems, from mind-influencing substances to the complications of international drug regulation and the interaction between markets
Need the go-to reference on adult bone and joint injuries? Get the definitive guide on fracture treatment, written by the world’s top orthopaedic surgeons: Rockwood and Green’s Fractures in Adults. This fully updated and expanded 8th edition offers up-to-the-minute research and recommendations from more than 80 leading orthopaedic experts from around the world. An essential resource on fractures for every orthopaedic surgeon or resident.. Features: NEW chapters on: Management of the Geriatric or Elderly Patient; Management of Bone Defects;; Psychological Aspect of Trauma NEW authors from countries including India, China, Columbia, Greece, and Denmark NEW 10 new full length videos added to the video library. All videos feature easy navigation so you can go directly to specific steps in the procedure, or watch the entire procedure from start to finish Pearls and Pitfalls and preventive measures listed for all procedures NEW Time-saving outline template for easy quick-reference “Before the Case” checklists of all necessary equipment for each surgical procedure Preferred Technique section provides algorithms explaining each author’s choice of preferred procedure Full-color operative photos, tables, x-rays, diagrams, and more than 500 line drawings of surgical procedures
Spectral Data for Steroids provides a comprehensive compilation of spectral data for 211 steroids. The compounds are arranged on the basis of their molecular structures:
This work provides a comprehensive overview of, and the most common and useful methods for, the synthesis of non-alpha-amino acids, particularly amino acids that are key synthetic intermediates or important compounds in their own right. Attention is paid to acyclic amino acids C3-C10 including amino alkanoic carboxylic acids, aminoalkenoic acids and aminoalkynoic acids.
Surgery is a constantly evolving specialty in medicine – research and technological advances have made surgical procedures safer and more effective and offer shorter recovery times. Recent Advances in Surgery 39 is the latest volume in the annually-publishing series that reviews current topics in general surgery and its major subspecialties. Divided into eight sections, the book begins with topics of generic interest to surgeons, followed by discussion on subspecialty surgeries including upper and lower gastro-intestinal, hepato-pancreato-biliary, and vascular. This new volume features practical notes on surgical management conditions, advanced novel technologies such as radiotherapy techniques for LGI surgeries, and new developments including 3D printing in surgery. The final section describes clinical trials. With contributions from recognised experts, the majority from throughout the UK, this new volume covers all the latest developments in surgery, providing excellent revision material for professional examinations, and helping consultant surgeons keep up to date across the specialty. Key points Latest volume in series bringing postgraduates and surgeons up to date with the latest advances in general surgery and its subspecialties Features new developments such as 3D printing and advanced novel technologies Includes review of recent randomised clinical trials Recognised editor and author team, based mainly in the UK
Despite its recognized significance in social life, leadership is a notoriously elusive subject that generates a host of different points of explanatory focus. This is particularly so in the field of political leadership, which has been afflicted by an enduring split between the biographical idiosyncrasies of individual leaders and the specialist contributions from an array of social science disciplines. This new study is designed to establish an improved balance between this often myopic and confusing bifurcation of approaches. It engages with an expansive range of empirical, theoretical, and interpretive research into the issue of leadership but does so in a way that ensures that the political character of the subject is kept securely in the foreground. The project is therefore designed to maintain a clear emphasis upon leaders embedded in their political contexts and viscerally connected to high level issues of political location and status, political power and legitimacy, and political functions and contingencies. The book has a cumulative design that moves from an in-depth analysis of the basic components of political leadership to an examination of a series of key dimensions relating to leadership activity and development—namely the themes of representation, communication, marketing, business practice, and the issue of women leaders. It goes on to survey the developmental properties of the international sphere before concluding with a substantive review of the changing landscapes of contemporary leadership activity and the different ways that we come to terms with the theme of political leadership in an increasingly complex world.
Challenged by the teaching of Vatican II about the "seeds of the Word" in non-Christian religions, this book investigates the sacred character of the Saddharmapuṇḍarika Sūtra and its relation to the fundamental theological category of scriptural inspiration. In applying the methods of modern exegesis, the Sūtra in its ingenious composition is disclosed as a religious drama about the inspirational experience of the Buddha. The draft of a theology of inspiration along the guide lines of the Dogmatic Constitution Dei Verbum of Vatican II elaborates a 'christology of the Word' as its core, which allows an extension of inspiration in analogical manner to non-Biblical scriptures. The contrast of Christ, the "Word incarnate", and Buddha, the "Inspired One", offers a new contribution to an inter- religious dialogue.
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