Shape UP: Strategies for Health Awareness Through Preaching and Empowerment by Dr. Michael Thomas Scott, Sr. is a must read for Pastors, Preachers, Health Educators and Community Leaders of all churches and denominations. There is a tremendous need for health awareness through preaching within the African-American community because many African- Americans continue to make bad choices that often lead to disease and infirmity. Preaching has always been and always will be the catalyst to motivate people and the source of inspiration to inspire people to continue to move forward when their progress has been impeded or stopped because of some opposing opposition. Health Awareness Ministry is an application of the hands on approach. This insightful book is a practical resource tool for the implementation of an effective Health Awareness Ministry for the local church.
During the Civil War, the state of Missouri witnessed the most widespread, prolonged, and destructive guerrilla fighting in American history. With its horrific combination of robbery, arson, torture, murder, and swift and bloody raids on farms and settlements, the conflict approached total war, engulfing the whole populace and challenging any notion of civility. Michael Fellman's Inside War captures the conflict from "inside," drawing on a wealth of first-hand evidence, including letters, diaries, military reports, court-martial transcripts, depositions, and newspaper accounts. He gives us a clear picture of the ideological, social, and economic forces that divided the people and launched the conflict. Along with depicting how both Confederate and Union officials used the guerrilla fighters and their tactics to their own advantage, Fellman describes how ordinary civilian men and women struggled to survive amidst the random terror perpetuated by both sides; what drove the combatants themselves to commit atrocities and vicious acts of vengeance; and how the legend of Jesse James arose from this brutal episode in the American Civil War.
This edition of the History of Libraries in the Western World represents a substantial revision of the earlier edition, taking into account the "information revolution" that has swept the West since 1945 and the political revolution that swept across Europe beginning in 1986. In addition, recent scholarship has been incorporated throughout the text, with special emphasis on the work centered around the "new history of the book." The bibliographies at the end of each of the twelve chapters have been thoroughly revised to reflect the very considerable new work on library and book history.
Introduces human sexuality, describes the changes brought about by puberty, and discusses sexual abuse, sexually transmitted diseases, AIDS, and pregnancy.
The American negroes are the only people in the history of the world. . . . that ever became free without any effort on their own." W. E. Woodward stated this in his biography of General Ulysses S. Grant. Nothing could be farther from the truth as will be seen in this history which will show that the African Americans fighting in the Civil War may have been the deciding factor in determining the outcome.
Armstrong's Handbook of Human Resource Management Practice is the classic text for all students and practitioners of HRM. Providing a complete resource for understanding and implementing HR in relation to the needs of the business as a whole, it contains in-depth coverage of all the key areas essential to the HR function, including performance, reward, employee engagement and HR policy. This fully revised and updated thirteenth edition contains an entirely new part covering the increasingly important subject of international human resource management. Other new chapters have been added on rewarding special groups and on employment law, and the chapters on HRM, motivation and engagement have been completely revised. Armstrong's Handbook of Human Resource Management Practice has also been brought up to date by reference to the findings of a number of significant research projects and other investigations of how HRM operates in practice. Comprehensive online support material for the instructor, student and practitioner is provided, offering a complete resource for teaching and self-learning. Online supporting resources include lecture slides, an instructor's manual, a student's manual complete with multiple-choice practice questions and case studies and a glossary of terms.
The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.
In Victory Without Triumph: The Wilderness May 6th & 7th, 1864, John Priest meticulously details the vicious infantry fighting along the Plank Road, Longstreet's counterstrike against the II Corps, the cavalry operations of both armies near Todd's Tavern, and John B. Gordon's daring assault against the Army of the Potomac's right flank. Embellished with 38 detailed, two-color maps, Victory Without Triumph enables the reader to follow the Army of the Potomac and the Army of Northern Virginia through the last two days of the campaign which signaled the advent of Ulysses S. Grant into the Eastern theater of the war. John Priest has turned meticulous research into a gripping story that engages the reader from the very first page. No civil war studies collection can be considered complete without the acquisition of Victory Without Triumph.
This volume examines the interrelationship of ecology, subsistence pat terns, and the observed genetic variation in human populations. Hence, the book is divided conceptually into the following categories: nonhuman primates, hunters and gatherers, nomads, swidden agriculturalists, peas ant farmers, religious isolates, and modern and urban aggregates. While many of these populations have experienced (and are experiencing) ac culturation as a result of contact with technologically more advanced groups, the genetic structures described in this volume attempt to recon struct the traditional patterns as well as genetic changes because of con tact. Most chapters also integrate biological (genetic), social, and de mographic data within an ecological frame thus presenting a holistic view of the population structures of ecologically distinct groups. The first chapter examines the body of early nonhuman primate lit erature that emphasized ecological determinism in effecting the popula tion structure of our primate ancestors-relatives. It also examines more recent literature (since 1970) in which it became apparent that greater flexibility exists in primate social structure within specific environmental frameworks. Thus, it appears that our nonhuman primate evolutionary heritage is not one of ecological determinism in social organization but one of flexibility and rapid change suggesting the evolutionary success of our species is based upon a system of flexibility and that social ad aptations can be accomplished in a number of diverse ways.
A detailed history of the Confederate retreat after the Battle of Gettysburg and the Union effort to destroy the enemy during the American Civil War. The three-day Battle of Gettysburg left 50,000 casualties in its wake, a battered Southern army far from its base of supplies, and a rich historiographic legacy. Thousands of books and articles cover nearly every aspect of the battle, but One Continuous Fight is the first detailed military history of Lee’s retreat and the Union effort to destroy the wounded Army of Northern Virginia. Against steep odds and encumbered with thousands of casualties, Confederate commander Robert E. Lee’s post-battle task was to successfully withdraw his army across the Potomac River. Union commander George G. Meade’s equally difficult assignment was to intercept the effort and destroy his enemy. The responsibility for defending the exposed Southern columns belonged to cavalry chieftain James Ewell Brown (Jeb) Stuart. If Stuart fumbled his famous ride north to Gettysburg, his generalship during the retreat more than redeemed his flagging reputation. The long retreat triggered nearly two dozen skirmishes and major engagements, including fighting at Granite Hill, Monterey Pass, Hagerstown, Williamsport, Funkstown, Boonsboro, and Falling Waters. President Abraham Lincoln was thankful for the early July battlefield victory, but disappointed that General Meade was unable to surround and crush the Confederates before they found safety on the far side of the Potomac. Exactly what Meade did to try to intercept the fleeing Confederates, and how the Southerners managed to defend their army and ponderous 17-mile long wagon train of wounded until crossing into western Virginia on the early morning of July 14, is the subject of this study. One Continuous Fight draws upon a massive array of documents, letters, diaries, newspaper accounts, and published primary and secondary sources. These long ignored foundational sources allow the authors, each widely known for their expertise in Civil War cavalry operations, to carefully describe each engagement. The result is a rich and comprehensive study loaded with incisive tactical commentary, new perspectives on the strategic role of the Southern and Northern cavalry, and fresh insights on every engagement, large and small, fought during the retreat. The retreat from Gettysburg was so punctuated with fighting that a soldier felt compelled to describe it as “One Continuous Fight.” Until now, few students fully realized the accuracy of that description. Complete with 18 original maps, dozens of photos, and a complete driving tour with GPS coordinates of the army’s retreat and the route of the wagon train of wounded, One Continuous Fight is an essential book for every student of the American Civil War in general, and for the student of Gettysburg in particular.
Reward management deals with the strategies, policies and processes required to ensure that the value of people and the contribution they make to achieving organizational, departmental and team goals is recognized and rewarded. Armstrong's Handbook of Reward Management Practice is the definitive guide to understanding, developing and implementing effective reward systems. It is aimed at HR practitioners involved in employee reward, and at students who need to understand the importance of reward and how it can be successfully applied across organizations. Updated to reflect the practical implications of the most recent research and discussion on reward management, this edition includes new case studies and chapters on evidence-based reward management, reward risk management and ethical approaches to reward management. This authoritative and engaging book is accompanied by extensive online resources, including PowerPoint slides and notes for tutors, and exercises to help students to test their learning. It is also closely aligned to the CIPD's standards in Reward Management, making it an ideal companion for both practitioners and students undertaking a professional qualification.
Michael H. Day's Guide to Fossil Man is the standard reference work on hominid remains found at the major palaeolithic sites throughout the world. This fourth edition now includes details of fifteen new sites, as well as new evidence from thirty-four previously known sites featured in earlier editions of the book. Day begins with an introduction to the anatomy of human fossils. He then describes the forty-nine sites in Europe, the Near East, Africa, the Middle East, Asia, and Oceania that have yielded the most significant information on the development of hominid species and the appearance of early man. Grouped geographically, each site description includes data on the hominid remains, other finds such as tools and animal bones, the local geology and contemporary geomorphology and ecology, and dating and other references. Sites featured for the first time in this edition include Kow Swamp and Mungo in Australia; Dali and Maba in China; and West Turkana in Kenya, which contained the almost complete skeleton of a boy determined to be 1,600,000 years old. Short essays on problems associated with neandertal, australpithecine, and Homo erectus remains are included, as well as a glossary, a geological time scale, charts and comprehensive illustrations. Day's Guide to Fossil Man is invaluable not only for working palaeontologists, palaeolithic archaeologists, and physical anthropologists, but also for anyone interested in human evolution.
Radical abolitionist and freedom-fighter John Brown inspired literary America to confrontation during his short but dramatic career as a public figure in antebellum America. Emerging from obscurity during the violent struggle to determine how Kansas would enter the Union in 1856, John Brown captured the imagination of the most prominent Eastern literary figures following his dramatic, though failed raid on Harper’s Ferry. Impressed by Brown’s forthright defense of his attempt to initiate the end of slavery, Whittier, Whitman, Melville, Longfellow, and Howells responded to the abolitionist with poetic tributes suggesting that Brown was a liberating hero, while Emerson and Thoreau celebrated his effort to inspire the nation to a new moral awareness of the common humanity of all men. Responses, however, were not uniform, as these and other figures debated the merits and meanings of Brown’s actions. This exceptional book sheds new light on how John Brown inspired America’s most significant intellects to take a public stand against the inertia of moral compromise and social degeneracy, bringing the nation to the brink of civil war.
The Battle of Petersburg was the culmination of the Virginia Overland campaign, which pitted the Army of the Potomac, led by Ulysses S. Grant and George Gordon Meade, against Robert E. Lee’s Army of Northern Virginia. In spite of having outmaneuvered Lee, after three days of battle in which the Confederates at Petersburg were severely outnumbered, Union forces failed to take the city, and their final, futile attack on the fourth day only added to already staggering casualties. By holding Petersburg against great odds, the Confederacy arguably won its last great strategic victory of the Civil War. In The Battle of Petersburg, June 15–18, 1864, Sean Michael Chick takes an in-depth look at an important battle often overlooked by historians and offers a new perspective on why the Army of the Potomac’s leadership, from Grant down to his corps commanders, could not win a battle in which they held colossal advantages. He also discusses the battle’s wider context, including politics, memory, and battlefield preservation. Highlights include the role played by African American soldiers on the first day and a detailed retelling of the famed attack of the First Maine Heavy Artillery, which lost more men than any other Civil War regiment in a single battle. In addition, the book has a fresh and nuanced interpretation of the generalships of Grant, Meade, Lee, P. G. T. Beauregard, and William Farrar Smith during this critical battle.
This bestselling reference bridges the gap between the introductory and highly specialized books dealing with aspects of food biochemistry for undergraduate and graduate students, researchers, and professionals in the fi elds of food science, horticulture, animal science, dairy science and cereal chemistry. Now fully revised and updated, with contributing authors from around the world, the third edition of Biochemistry of Foods once again presents the most current science available. The first section addresses the biochemical changes involved in the development of raw foods such as cereals, legumes, fruits and vegetables, milk, and eggs. Section II reviews the processing of foods such as brewing, cheese and yogurt, oilseed processing as well as the role of non-enzymatic browning. Section III on spoilage includes a comprehensive review of enzymatic browning, lipid oxidation and milk off-flavors. The final section covers the new and rapidly expanding area of rDNA technologies. This book provides transitional coverage that moves the reader from concept to application. - Features new chapters on rDNA technologies, legumes, eggs, oilseed processing and fat modification, and lipid oxidation - Offers expanded and updated material throughout, including valuable illustrations - Edited and authored by award-winning scientists
Psychology is the science that will determine who wins and who loses the wars of the 21st century, just as physics ultimately led the United States to victory in World War II. Changes in the world's political landscape coupled with radical advances in the technology of war will greatly alter how militaries are formed, trained, and led. Leadership under fire--and the traits and skills it requires--is also changing. Grant, Lee, Pershing, Patton--these generals would not succeed in 21st century conflicts. In Head Strong: How Psychology is Revolutionizing War, Michael D. Matthews explores the many ways that psychology will make the difference for wars yet to come, from revolutionary advances in soldier selection and training to new ways of preparing soldiers to remain resilient in the face of horror and to engineering the super-soldier of the future. These advancements will ripple out to impact on the lives of all of us, not just soldiers. Amputees will have "intelligent" life-like prosthetics that simulate the feel and function of a real limb. Those exposed to trauma will have new and more effective remedies to prevent or treat post-traumatic stress disorder. And a revolution in training--based heavily in the military's increasing reliance on immersive simulations--will radically alter how police, fire, and first-responder personnel are trained in the future. The revised and expanded edition of Head Strong includes significant advances that have occurred in military psychology since its publication in 2013. Many of the predictions made in the first edition have come true, and exciting new developments in military psychology have emerged. The revised and expanded edition updates the existing chapters with important new developments, and adds new chapters on character and human performance optimization--both topics of significant interest in today's military. Authored by a West Point military psychologist, this book is one of the first to expose us to the smarter wars, and the world around them, to come.
From the 1905 opening of the wildly popular, eponymous Nickelodeon in the city's downtown to the subsequent outgrowth of nickel theaters in nearly all of its neighborhoods, Pittsburgh proved to be perfect for the movies. Its urban industrial environment was a melting pot of ethnic, economic, and cultural forces—a "wellspring" for the development of movie culture—and nickelodeons offered citizens an inexpensive respite and handy escape from the harsh realities of the industrial world.Nickelodeon City provides a detailed view inside the city's early film trade, with insights into the politics and business dealings of the burgeoning industry. Drawing from the pages of the Pittsburgh Moving Picture Bulletin, the first known regional trade journal for the movie business, Michael Aronson profiles the major promoters in Pittsburgh, as well as many lesser-known ordinary theater owners, suppliers, and patrons. He examines early film promotion, distribution, and exhibition, and reveals the earliest forms of state censorship and the ensuing political lobbying and manipulation attempted by members of the movie trade. Aronson also explores the emergence of local exhibitor-based cinema, in which the exhibitor assumed control of the content and production of film, blurring the lines between production, consumption, and local and mass media. Nickelodeon City offers a fascinating and intimate view of a city and the socioeconomic factors that allowed an infant film industry to blossom, as well as the unique cultural fabric and neighborhood ties that kept nickelodeons prospering even after Hollywood took the industry by storm. 9.5
Widely praised upon publication and now considered a classic study, Southern Labor and Black Civil Rights chronicles the southern industrial union movement from the Great Depression to the Cold War, a history that created the context for the sanitation workers' strike that brought Dr. Martin Luther King, Jr. to Memphis in April 1968. Michael K. Honey documents the dramatic labor battles and sometimes heroic activities of workers and organizers that helped to set the stage for segregation's demise. Winner of the Charles S. Sydnor Award, given by the Southern Historical Association, 1994. Winner of the James A. Rawley Prize given by the Organization of American Historians, 1994. Winner of the Herbert G. Gutman Award for an outstanding book in American social history.
Discover how the latest computational tools are building our understanding of particle interactions and leading to new applications With this book as their guide, readers will gain a new appreciation of the critical role that particle interactions play in advancing research and developing new applications in the biological sciences, chemical engineering, toxicology, medicine, and manufacturing technology The book explores particles ranging in size from cations to whole cells to tissues and processed materials. A focus on recreating complex, real-world dynamical systems helps readers gain a deeper understanding of cell and tissue mechanics, theoretical aspects of multiscale modeling, and the latest applications in biology and nanotechnology. Following an introductory chapter, Multiscale Modeling of Particle Interactions is divided into two parts: Part I, Applications in Nanotechnology, covers: Multiscale modeling of nanoscale aggregation phenomena: applications in semiconductor materials processing Multiscale modeling of rare events in self-assembled systems Continuum description of atomic sheets Coulombic dragging and mechanical propelling of molecules in nanofluidic systems Molecular dynamics modeling of nanodroplets and nanoparticles Modeling the interactions between compliant microcapsules and patterned surfaces Part II, Applications in Biology, covers: Coarse-grained and multiscale simulations of lipid bilayers Stochastic approach to biochemical kinetics In silico modeling of angiogenesis at multiple scales Large-scale simulation of blood flow in microvessels Molecular to multicellular deformation during adhesion of immune cells under flow Each article was contributed by one or more leading experts and pioneers in the field. All readers, from chemists and biologists to engineers and students, will gain new insights into how the latest tools in computational science can improve our understanding of particle interactions and support the development of novel applications across the broad spectrum of disciplines in biology and nanotechnology.
This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.
This work is a general and synthetic study of the post-industrial era and its implications for library and information services in the United States. Since Daniel Bell promulgated his post-industrial metaphor in the early 1970s, it has become one of the most dominant metaphors in contemporary America. His ideas on the nature of the era, especially his articulation of what he refers to as the information society have influenced the ways in which government officials, corporate leaders, and citizens think about the future of political, social and economic life in America. This text examines how this influence has also been felt in the library and information field.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction - Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle - Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol
As more and more people crowd onto less and less land, incidences of human-wildlife conflicts will only increase. A comprehensive overview of this emerging field, Resolving Human-Wildlife Conflicts: The Science of Wildlife Damage Management discusses the issues facing wildlife managers and anyone else dealing with interactions between wildlife and
Written in a conversational style and presented in an innovative handbook format, The Interpersonal Communication Playbook empowers students to take an active role in the development of their communication skills in both physical and digital arenas. Bestselling authors Teri Kwal Gamble and Michael W. Gamble provide students with ample opportunities to make personal observations, examine personal experiences, and assess their personal growth across interpersonal contexts. The Second Edition features a new chapter on The Cultural Dynamics of Interpersonal Communication in response to the COVID-19 pandemic and lessons learned on adapting communication skills to changing conditions, ways to develop communication resiliency, and the value in practicing mindfulness. This title is accompanied by a complete teaching and learning package. Contact your SAGE representative to request a demo. Learning Platform / Courseware SAGE Vantage is an intuitive learning platform that integrates quality SAGE textbook content with assignable multimedia activities and auto-graded assessments to drive student engagement and ensure accountability. Unparalleled in its ease of use and built for dynamic teaching and learning, Vantage offers customizable LMS integration and best-in-class support. It’s a learning platform you, and your students, will actually love. Learn more. Assignable Video with Assessment Assignable video (available in SAGE Vantage) is tied to learning objectives and curated exclusively for this text to bring concepts to life. Watch a sample video now. LMS Cartridge: Import this title’s instructor resources into your school’s learning management system (LMS) and save time. Don’t use an LMS? You can still access all of the same online resources for this title via the password-protected Instructor Resource Site. Learn more.
A guide to promoting literacy in the digital age With young children gaining access to a dizzying array of games, videos, and other digital media, will they ever learn to read? The answer is yes—if they are surrounded by adults who know how to help and if they are introduced to media designed to promote literacy, instead of undermining it. Tap, Click, Read gives educators and parents the tools and information they need to help children grow into strong, passionate readers who are skilled at using media and technology of all kinds—print, digital, and everything in between. In Tap, Click, Read authors Lisa Guernsey and Michael H. Levine envision a future that is human-centered first and tech-assisted second. They document how educators and parents can lead a new path to a place they call 'Readialand'—a literacy-rich world that marries reading and digital media to bring knowledge, skills, and critical thinking to all of our children. This approach is driven by the urgent need for low-income children and parents to have access to the same 21st-century literacy opportunities already at the fingertips of today's affluent families.With stories from homes, classrooms and cutting edge tech labs, plus accessible translation of new research and compelling videos, Guernsey and Levine help educators, parents, and America's leaders tackle the questions that arise as digital media plays a larger and larger role in children's lives, starting in their very first years of life. Tap, Click, Read includes an analysis of the exploding app marketplace and provides useful information on new review sites and valuable curation tools. It shows what to avoid and what to demand in today's apps and e-books—as well as what to seek in community preschools, elementary schools and libraries. Peppered with the latest research from fields as diverse as neuroscience and behavioral economics and richly documented examples of best practices from schools and early childhood programs around the country, Tap, Click, Read will show you how to: Promote the adult-child interactions that help kids grow into strong readers Learn how to use digital media to build a foundation for reading and success Discover new tools that open up avenues for creativity, critical thinking, and knowledge-building that today's children need The book's accompanying website keeps you updated on new research and provides vital resources to help parents, schools and community organizations.
The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black's H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.
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