In the end, we must acknowledge that we have been held spellbound by a master storyteller. Highly recommended."--Library Journal Starred Review "A truly fine novel. It's filled with exactitude of place and people, taking us into a world that seethes with dangerous secrets. On that treacherous journey, Michael Genelin makes unfamiliar worlds seem knowable, and does so with great style."--Pete Hamill, author of North River "A terrific novel by a man who knows crime, knows Europe, and knows how to write. Siren of the Waters is a genuine pleasure."--Thomas Perry, author of Silence Jana Matinova entered the Czechoslovak police force as a young woman, married an actor, and became a mother. The regime destroyed her husband, their love for one another, and her daughter's respect for her. But she has never stopped being a seeker of justice. Now, as a commander in the Slovak police force, she liaises with colleagues across Europe as they track the mastermind of an international criminal operation involved in, among other crimes, human trafficking. Her investigation takes her from Ukraine to Strasbourg, from Vienna to Nice, in a hunt for a ruthless killer and the beautiful young Russian woman he is determined either to capture or destroy. Michael Genelin, a graduate of UCLA and the UCLA Law School, has served in the LA District Attorney's Office and the US Department of Justice in Central Europe. He has written for film and has been an adviser to television series. He now lives with his wife and daughter in Paris.
The second Jana Matinova mystery sees the detective investigate a corrupt politician. One day, Jana finds an enormous diamond dangling from a string fixed to the ceiling of her living room. Where did it come from? And why was it left for her to find? The search for the answer leads Jana across Europe, into a criminal conspiracy involving her hapless, impulsive friend Sofia and, ultimately, to the criminal mastermind behind it all - a one-time Communist Party boss.
Devastated by her lover's death in an explosion--on the same day an indigent student was shot and killed in sleepy Bratislava--Jana Mantiova is transferred to The Hague, headquarters of the international police force Europol. On the flight she encounters a retired magician, the dead student's uncle, who is determined to help Jana investigate his nephew's death. And his help is indeed needed as Jana faces an international criminal conspiracy emanating from Europol itself.
In the end, we must acknowledge that we have been held spellbound by a master storyteller. Highly recommended."--Library Journal Starred Review "A truly fine novel. It's filled with exactitude of place and people, taking us into a world that seethes with dangerous secrets. On that treacherous journey, Michael Genelin makes unfamiliar worlds seem knowable, and does so with great style."--Pete Hamill, author of North River "A terrific novel by a man who knows crime, knows Europe, and knows how to write. Siren of the Waters is a genuine pleasure."--Thomas Perry, author of Silence Jana Matinova entered the Czechoslovak police force as a young woman, married an actor, and became a mother. The regime destroyed her husband, their love for one another, and her daughter's respect for her. But she has never stopped being a seeker of justice. Now, as a commander in the Slovak police force, she liaises with colleagues across Europe as they track the mastermind of an international criminal operation involved in, among other crimes, human trafficking. Her investigation takes her from Ukraine to Strasbourg, from Vienna to Nice, in a hunt for a ruthless killer and the beautiful young Russian woman he is determined either to capture or destroy. Michael Genelin, a graduate of UCLA and the UCLA Law School, has served in the LA District Attorney's Office and the US Department of Justice in Central Europe. He has written for film and has been an adviser to television series. He now lives with his wife and daughter in Paris.
The second Jana Matinova mystery sees the detective investigate a corrupt politician. One day, Jana finds an enormous diamond dangling from a string fixed to the ceiling of her living room. Where did it come from? And why was it left for her to find? The search for the answer leads Jana across Europe, into a criminal conspiracy involving her hapless, impulsive friend Sofia and, ultimately, to the criminal mastermind behind it all - a one-time Communist Party boss.
Sal Mineo is probably most well-known for his unforgettable, Academy Award–nominated turn opposite James Dean in Rebel Without a Cause and his tragic murder at the age of thirty-seven. Finally, in this riveting new biography filled with exclusive, candid interviews with both Mineo’s closest female and male lovers and never-before-published photographs, Michael Gregg Michaud tells the full story of this remarkable young actor’s life, charting his meteoric rise to fame and turbulent career and private life. One of the hottest stars of the 1950s, Mineo grew up as the son of Sicilian immigrants in a humble Bronx flat. But by age eleven, he appeared on Broadway in Tennessee Williams’s The Rose Tattoo, and then as Prince Chulalongkorn in the original Broadway production of The King and I starring Yul Brynner and Gertrude Lawrence. This sultry-eyed, dark-haired male ingénue of sorts appeared on the cover of every major magazine, thousands of star-struck fans attended his premieres, and millions bought his records, which included several top-ten hits. His life offstage was just as exhilarating: full of sports cars, motor boats, famous friends, and some of the most beautiful young actresses in Hollywood. But it was fourteen-year-old Jill Haworth, his costar in Exodus—the film that delivered one of the greatest acting roles of his life and earned him another Academy Award nomination and a Golden Globe win—with whom he fell in love and moved to the West Coast. But by the 1960s, a series of professional missteps and an increasingly tumultuous private life reversed his fortunes. By the late sixties and early seventies, grappling with the repercussions of publicly admitting his homosexuality and struggling to reinvent himself from an aging teen idol, Mineo turned toward increasingly self-destructive behavior. Yet his creative impulses never foundered. He began directing and producing controversial off-Broadway plays that explored social and sexual taboos. He also found personal happiness in a relationship with male actor Courtney Burr. Tragically, on the cusp of turning a new page in his life, Mineo’s life was cut short in a botched robbery. Revealing a charming, mischievous, creative, and often scandalous side of Mineo few have known before now, Sal Mineo is an intimate, moving biography of a distinctive Hollywood star.
MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.
Need the go-to reference on adult bone and joint injuries? Get the definitive guide on fracture treatment, written by the world’s top orthopaedic surgeons: Rockwood and Green’s Fractures in Adults. This fully updated and expanded 8th edition offers up-to-the-minute research and recommendations from more than 80 leading orthopaedic experts from around the world. An essential resource on fractures for every orthopaedic surgeon or resident.. Features: NEW chapters on: Management of the Geriatric or Elderly Patient; Management of Bone Defects;; Psychological Aspect of Trauma NEW authors from countries including India, China, Columbia, Greece, and Denmark NEW 10 new full length videos added to the video library. All videos feature easy navigation so you can go directly to specific steps in the procedure, or watch the entire procedure from start to finish Pearls and Pitfalls and preventive measures listed for all procedures NEW Time-saving outline template for easy quick-reference “Before the Case” checklists of all necessary equipment for each surgical procedure Preferred Technique section provides algorithms explaining each author’s choice of preferred procedure Full-color operative photos, tables, x-rays, diagrams, and more than 500 line drawings of surgical procedures
Since its first edition over 60 years ago, Rockwood and Green’s Fractures in Adults has been the go-to reference for treating a wide range of fractures in adult patients. The landmark, two-volume tenth edition continues this tradition with two new international editors, a refreshed mix of contributors, and revised content throughout, bringing you fully up to date with today’s techniques and technologies for treating fractures in orthopaedics. Drs. Paul Tornetta III, William M. Ricci, Robert F. Ostrum, Michael D. McKee, Benjamin J. Ollivere, and Victor A. de Ridder lead a team of experts who ensure that the most up-to-date information is presented in a comprehensive yet easy to digest manner.
The latest knowledge for all those dealing with arthroscopic diagnosis and treatment. A standardised structure of the individual chapters facilitates the retrieval of information: diagnosis, therapeutic management including decision-making for conservative and operative treatment, arthroscopic results and surgical techniques. The latter are described in a practical step-by-step manner. 2,000 brilliant figures illustrate each operative step. This comprehensive manual includes rare conditions and provides detailed information on tricks and pitfalls.
Devastated by her lover's death in an explosion--on the same day an indigent student was shot and killed in sleepy Bratislava--Jana Mantiova is transferred to The Hague, headquarters of the international police force Europol. On the flight she encounters a retired magician, the dead student's uncle, who is determined to help Jana investigate his nephew's death. And his help is indeed needed as Jana faces an international criminal conspiracy emanating from Europol itself.
In the rapidly advancing science of genetics, currency and accuracy are critical in any book. This book presents the most up-to-date developments in genetics as well as the fundamental principles. It stresses how genetics is done and provides historical and biographical insights to the people and events that have made genetics a pre-eminent science. The new edition incorporates organizational changes to make the book more modern, including earlier DNA coverage. A new design also highlights numerous practice problems that help reinforce important concepts. * Provides a comprehensive and balanced view of both Classical Mendelian topics and modern Molecular topics. * Incorporates the latest findings from Genomics and Proteomics. * Includes numerous high-quality illustrations with stepped-out art to help readers visualize complex processes. * Offers the analytical tools that readers will need for problem solving.
Convert the latest genomic data to the most effective patient management and treatment approaches Clinical Genomics helps healthcare providers translate the vast amount of new genomic data into successful clinical application. It is a comprehensive textbook and practical guide to the use of this information across a broad spectrum of adult diseases – from individual differences in drug responses, cardiac andcancer risks to Alzheimer's and other neurological and psychiatric disorders. While traditional textbooks on medical genetics focus on classic Mendelian disorders, Clinical Genomics discusses the everyday application of genetic assessment and the diagnostic, therapeutic, and preventiveimplications to the most common adult diseases that healthcare providers encounter. Covering approximately 200 conditions, it is a true clinical text for use across all of internal medicine. Coverage of each condition is presented in a consistent,clinically relevant manner and includes: Key Points Diagnostic Criteria and Clinical Characteristics Screening and C ounseling Management and Treatment Molecular Genetics and Molecular Mechanism Supplementary Information More than ten valuable appendices, include Genetic Privacy; Race, Ancestry, and Genetics; Personalized Medicine in Clinical Practice; Clinical Interpretationof Genomic Data; and Genetic Risk Profiling in the Genomics Era. Clinical Genomics is essential for internists, primary care physicians, and other healthcare providers who wish to increase their knowledge of the gene-and-protein level care of patients in a clinical setting.
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