Shortly after Wolfgang Amadeus Mozart's death, his widow Constanze sent a manuscript copy of one of his most beloved operas, Die Zauberflste, to the court of the Elector of Cologne. It was eventually published by Nicolaus Simrock in 1814 as the first full-score edition. However, the question still remains as to why this early copy in her possession diverges from Mozart's autograph in so many libretto details. The Authentic Magic Flute Libretto: Mozart's Autograph or the First Full-Score Edition? investigates the origin and claim to authenticity of the first full-score edition of Die Zauberflste, drawing attention to the close bond between words and music. Michael Freyhan brings the subtlety of the first edition word setting to the attention of scholars, musicians, and opera-lovers, setting out the evidence for its authenticity and detailing the quest, pursued in 15 countries, for the earliest possible historical sources. Freyhan examines the differences between the first edition and the autograph, discussing the quality of the word-setting_supported by 32 musical examples_and evaluating the relationship of the two texts in terms of language and literature. The following chapters discuss the early history of the autograph, focusing on four alleged owners, its market value, and the misleading catalogue numbering systems seen on the first page. Details of the performance and publication history of the first edition text are followed by a new perspective on the disputed authorship of the libretto, in light of the possible existence of two authentic texts. A concluding chapter discusses Mozart's sketches and working methods, while an appendix traces the character and career of Karl Ludwig Giesecke, one of the writers who claimed ownership of the opera's libretto. The book also includes several photos and the complete first edition libretto, in German and with literal English translation, providing a side-by-side text comparison with the autograph text.
In the nineteenth century, Jewish merchants created a thriving niche economy in the cotton trade, positioning themselves at the forefront of capitalist expansion. Jewish involvement in the cotton industry transformed both Jewish communities and their broader economic restructuring of the South. Cotton Capitalists analyzes this niche economy, revealing how Jewish merchants' status as a minority fostered ethnic economic networks, which became the key to the merchant's success. Michael R. Cohen argues that Jewish merchants in the Gulf South, faced with anti-Jewish prejudice in an era where business relationships were based primarily upon trust, used ethnic ties with other Jewish-owned firms across the globe to sidestep those prejudices. Following the Civil War, they relied on these connections to direct Northern credit and goods to the economically devastated South. These relationships allowed them to survive the volatility of the Reconstruction Era while many of their non-Jewish competitors went under. Beyond the story of American Jewish success and integration, this book demonstrates the role of ethnicity in the development of global capitalism."--Dust jacket.
Conceptual Issues in Psychological Medicine is a collection of papers written by the celebrated psychiatrist, Michael Shepherd, who was one of the originators of psychiatric epidemiology in the UK and a leading social psychiatrist of his generation. He designed and implemented some of the first systematic studies into what are now widely recognised clinical syndromes. His extensive research experience and his advocacy of a scientific approach to social psychiatry form the basis of the essays contained in this book. Covering such issues as the development of research strategy and the difficulties involved in completing psychiatric studies, Shepherd's papers address many of the issues currently facing professionals in this field. He writes authoritatively and engagingly on clinical syndromes, the history of ideas and the use of the epidemiological approach in psychiatry. Conceptual Issues in Psychological Medicine stimulates and informs the reader in equal measure; it will be a welcome addition to the bookshelf of any practitioner of medicine.
The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black's H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.
This book analyses how the early Greek whole-Bible manuscripts (pandects) change and preserve the text. Dormandy refutes the method based on singular readings and so investigates all the ways in which each pandect differs from the initial text, both changes introduced by its own scribe and by the scribes of earlier manuscripts. He surveys sample chapters in John, Romans, Revelation, Sirach and Judges (including discussing the “new finds” of Sinaiticus). Dormandy’s observations of Codex Ephraemi challenge accepted transcriptions. Dormandy argues that Sinaiticus and Vaticanus may plausibly have been made in response to commissions by Constantine and Constans. Dormandy concludes that generally, across all the Biblical books considered, the pandects preserve the initial text well. Transcriptional and linguistic variations are more common than harmonisations or changes of content. The more precise profiles of each manuscript vary between Biblical books. The pandects thus create bibliographic unity from textual diversity. This shows their significance in the history of the Christian Bible: they reflect in bibliographic form the hermeneutical move to consider all the books of the Christian Bible as one corpus.
Within months of the start of the First World War, Germany began to run out of the raw materials it needed to make explosives. As Germany faced imminent defeat, chemists such as Fritz Haber and Carl Bosch came to the rescue with Nobel Prize winning discoveries that overcame the shortages and enabled the country to continue in the war. Similarly, Britain could not have sustained its war effort for four years had it not been for chemists like Chaim Weizmann who was later to become the first president of the State of Israel. Michael Freemantle tells the stories of these and many other chemists and explains how their work underpinned and shaped what became known as The Chemists’ War. He reveals: • how chemistry contributed to the care of the sick and wounded and to the health and safety of troops; • how coal not only powered the war but was also an important source of the chemicals needed for the manufacture of explosives, dyes, medicines and antiseptics; • how Britain’s production of propellants relied on the slaughter of tens of thousands of whales; • how a precious metal played a critical role in the war; • how poisonous chemicals were used as weapons of mass destruction for the first time in the history of warfare and how chemists developed gas masks for protection against these weapons; • how the British naval blockade of Germany imperilled agricultural production in the United States. The book will appeal to the general reader as well as the many scientists and historians interested in the Great War.
This study shows how politics and art intermingled in the life and works of one of the most renowned playwrights of German Expressionism, a man who was in many senses paradigmatic of the non-communist Left in the Weimar Republic. Toller sought to preserve the sanctity of the individual against collectivist assaults from the Right and from the Left, but at the same time to meet the needs of a complex society. Ossar demonstrates that the playwright arrived at solutions that were anarchist in nature, deriving from a long European tradition. This is the first in-depth book-length study of Toller and his plays published in English.
Psychotic disorders are common and important psychiatric conditions, and patients suffering from psychosis can be challenging to assess and manage. In this new monograph, experts in schizophrenia and related psychoses review the current state of science in this area, and provide a practical and readable overview of the how to diagnose and treat individuals presenting with these disorders. This pocket-sized text features call-out boxes, case descriptions, practical tips, and general guidelines that should be ideal for medical students, residents, young mental health professionals, and trainees in other fields. Beginning with a history of psychosis, the authors proceed to explore the phenomenology of symptoms and experiences and how these can be used in clinical assessment. Diagnostic criteria are reviewed, along with common conditions in the differential diagnosis. Subsequent chapters tackle epidemiology, course and prognosis, and the neurobiology of psychotic disorders. The book concludes with chapters on treatment, both somatic and psychosocial, including discussion of novel interventional approaches and service delivery. The authors of this text are a mix of clinician-educators and scientific investigators, all with experience teaching trainees; this pocket-sized book has been developed to help young professionals easily gain a basic understanding of the complexities and challenges of psychotic disorders. Self-assessment questions, resources, and references will assist, but what really sets this book apart is the accessibility and concision of the text, ideal for individuals learning about or reviewing psychosis.
For many years, schizophrenia was considered to be a deep and profound mystery. It was generally viewed as unknown and unknowable-beyond the reach of science.
With the remarkable expansion in the use of antipsychotics, concerns about their immediate, intermediate, and long-term adverse effects have intensified. Despite this, studies consistently show that monitoring of patients taking antipsychotics can be inadequate, haphazard, or worse. This book provides a comprehensive review of the adverse effects of this pharmacologically complex therapeutic class, covering all commonly used conventional and atypical agents. In the first section, each chapter provides background information about an adverse effect, reviews the evidence linking the effect to various antipsychotics, and provides specific detection and monitoring recommendations. The second section provides unique monitoring guides for each antipsychotic. The third section provides the clinician with a program to monitor patients over the long-term. By supporting rational treatment decisions and systematic adverse effect monitoring, Antipsychotics and their Side Effects provides the clinician with the necessary information and tools for optimizing the safe and effective long-term use of antipsychotic drugs.
Shortly after Wolfgang Amadeus Mozart's death, his widow Constanze sent a manuscript copy of one of his most beloved operas, Die Zauberflste, to the court of the Elector of Cologne. It was eventually published by Nicolaus Simrock in 1814 as the first full-score edition. However, the question still remains as to why this early copy in her possession diverges from Mozart's autograph in so many libretto details. The Authentic Magic Flute Libretto: Mozart's Autograph or the First Full-Score Edition? investigates the origin and claim to authenticity of the first full-score edition of Die Zauberflste, drawing attention to the close bond between words and music. Michael Freyhan brings the subtlety of the first edition word setting to the attention of scholars, musicians, and opera-lovers, setting out the evidence for its authenticity and detailing the quest, pursued in 15 countries, for the earliest possible historical sources. Freyhan examines the differences between the first edition and the autograph, discussing the quality of the word-setting_supported by 32 musical examples_and evaluating the relationship of the two texts in terms of language and literature. The following chapters discuss the early history of the autograph, focusing on four alleged owners, its market value, and the misleading catalogue numbering systems seen on the first page. Details of the performance and publication history of the first edition text are followed by a new perspective on the disputed authorship of the libretto, in light of the possible existence of two authentic texts. A concluding chapter discusses Mozart's sketches and working methods, while an appendix traces the character and career of Karl Ludwig Giesecke, one of the writers who claimed ownership of the opera's libretto. The book also includes several photos and the complete first edition libretto, in German and with literal English translation, providing a side-by-side text comparison with the autograph text.
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