One of Wall Street Journal's "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell's ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body's trillions of cells. But some of our cells don't age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.
We are at the beginning of a new scientific revolution. Dramatic life extension - even age reversal - has moved from science fiction to real possibility. The Telomerase Revolution reveals the latest research on human ageing and the enzyme telomerase which is starting to be used to slow the rate at which our cells - and we - age.
AARP Digital Editions offer you practical tips, proven solutions, and expert guidance. Based on Nobel Prize–winning genetic research, AARP The Immortality Edge provides a simple plan to keep your telomeres healthy for better health and longevity. Telomeres play an important role in protecting our chromosomes from critical damage. The shortening of the telomere disrupts vital cellular function and promotes the previously seemingly inevitable onset of aging and various diseases, including cancer and Alzheimer's. Drawing from the groundbreaking discoveries about telomeres that won the 2009 Nobel Prize in Medicine, this book includes a highly prescriptive program that shows you how to live longer by slowing telomere shortening and rejuvenating your cells through relatively simple alterations in nutrition habits and other lifestyle changes. Written by authors with extensive knowledge of genetics, telomeres, and longevity Offers a simple action plan you can start using immediately Includes a revolutionary new eating plan Recommends individualized supplement programs Shares a diet and exercise approach grounded in solid scientific research The exciting recent discoveries about telomeres promise to revolutionize our approach to anti-aging much as antioxidants did ten years ago. Unlike trendy diet and fitness books with no basis in science, The Immortality Edge targets health at its innermost level by laying out a realistic, lifelong plan using easy steps that can fit into any busy schedule-steps that can improve the length and quality of your life.
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
Consistently lauded for its comprehensiveness and full-color color presentation, the latest edition of Rheumatology by Marc C. Hochberg, MD, MPH et al. continues the tradition of excellence of previous editions. Designed to meet the needs of the practicing clinician, it provides extensive, authoritative coverage of rheumatic disease from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Find the critical answers you need quickly and easily thanks to a consistent, highly user-friendly format covering all major disorders of the musculoskeletal system in complete, self-contained chapters. Get trusted perspectives and insights from chapters co-authored by internationally renowned leaders in the field, 25% of whom are new to this edition. Track disease progression and treat patients more effectively with the most current information, including 22 new chapters on genetic findings, imaging outcomes, and cell and biologic therapies as well as rheumatoid arthritis and SLE. Incorporate the latest findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.
Equally important, Rose surveys the entire field, offering colorful portraits of many leading scientists and shedding light on research findings from around the world. We learn that rodents given fifteen to forty percent fewer calories live about that much longer, and that volunteers in Biosphere II, who lived on reduced caloric intake for two years, all had improved vital signs. Perhaps most interesting, we discover that aging hits a plateau and stops - at least, it does so in fruit flies."--Jacket.
Produced biennially, The World's Water is the most comprehensive and up-to-to date source of information and analysis on freshwater resources. Each new volume examines critical global trends and offers the best data available on a variety of topics related to water. Volume 7 features chapters on U.S. water policy, transboundary waters, and the effects of fossil fuel production on water resources, among other timely issues. Water briefs provide concise updates on topics including bottled water, The Great Lakes Water Agreement, and water and security. The World's Water is coauthored by MacArthur "genius" Peter H. Gleick and his colleagues at the world-renowned Pacific Institute. Since the first volume was published in 1998, the series has become an indispensable resource for professionals in government agencies and nongovernmental organizations, researchers, students, and anyone concerned with water and its use.
Organic Synthesis 5e provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature.? There have been advancements in organic reactions, particularly organometallic reactions, and there is a need to show how these advancements have influenced current organic synthesis. The goal is to revise and update the examples of reaction examples taken from the synthesis literature from about 2017-2023. The reactions illustrate those that are used most often in modern organic synthesis, but recent examples will show their current relevance.? Where new approaches and new reactions have been developed for organic synthesis, examples will be added as new material. - Provides new content, reaction examples, and study problems from recent research? - Features improved organization, new art, and new chapter content on process chemistry and green organic chemistry - Includes revised homework for each chapter, with new examples and questions?
A Certain Kind of Wisdom In Plato’s Apology, the Greek philosopher Socrates is on trial to defend himself against the allegation of corrupting the youth of Athens. Socrates denies this charge and offers an alternate reason for why he is on trial. He explains, “[w]hat has caused my reputation is none other than a certain kind of wisdom. What kind of wisdom? Human wisdom, perhaps(1). ” He proceeds to tell the story of his friend Chaerophon, who once asked the Oracle at Delphi whether there was anyone wiser than Socrates. The Oracle answered that there was not. Socrates did not agree and thought that he would try to prove the Oracle wrong. And so he set about seeking out Athenians with a reputation for wisdom in various regards in order to test their claims to knowledge through questioning. He discovered many with false claims to knowledge and none with genuine wisdom and ultimately concluded that he was the wisest. He reached this conclusion not because of any special knowledge he possessed that others did not, but rather because he recognized his own lack of knowledge and strived to learn more, while others thought that they were kno- edgeable but were not. Socrates’ conclusion that there is wisdom in recognizing the limitations of accepted knowledge represents the motivation for this book.
This book considers the problems of death and the hereafter and how these ages-old problems ought to be addressed in light of our continuing progress. A materialistic viewpoint of reality is assumed, denying the likelihood of supernatural or other superhuman assistance. Death, however, is not seen as inevitable or even irreversible; it is maintained that the problem can and should be addressed scientifically in all of its aspects. The book thus follows recent, immortalist thinking that places hopes in future advances in our understanding and technology. A functionalist, reductionist argument is developed for the possibility of resurrecting the dead through the eventual creation of replicas and related constructs. Meanwhile, it is urged, medical advances leading to the conquest of biological death should be pursued, along with cryonics: freezing the newly deceased for possible, eventual reanimation. A common ground thus is sought between two hitherto largely independent strands of scientific immortalism, the one based on hopes in a remote but hyperadvanced future, the other on the nearer-term prospects of presently advancing technology. The resulting philosophy, encompassing both past and future, is directed toward the long-term interests of each sentient being, and it thereby acquires a moral dimension. The immortalization of humans and other life-forms is seen as a great moral project and labor of love that will unite us in a common cause and provide a meaningful destiny. A rational and thorough exploration of human potential. Few have considered, much less visualized, the profound changes set to occur over the next few decades through exponential advances in science and philosophy. Mike Perry has, and he shares his vision with eloquence. --Jim Halperin, author of The Truth Machine and The First Immortal.
Every orthopedic surgeon faces complications in the management of fractures. Drs. Michael T. Archdeacon, Jeffrey O. Anglen, Robert F. Ostrum, and Dolfi Herscovici, Jr. have created Prevention and Management of Common Fracture Complications, a comprehensive reference dedicated entirely to the prevention and management of fracture complications. Prevention and Management of Common Fracture Complications is arranged on an anatomic basis with contributions from more than 45 orthopedic surgeons. Each contributor is considered an expert on the topic covered in their respective sections of the book. Some Chapters Include:• The etiological factors for each complication • Strategies for preventing the complication • Surgical techniques • Reduction and implant selection • Strategies required to successfully manage the complication Prevention and Management of Common Fracture Complications also includes more than 300 images and more than 45 tables. Prevention and Management of Common Fracture Complications offers a single and complete resource to readily answer all fracture complication questions and is ideal for orthopedic surgeons, orthopedic residents, and medical students interested in orthopedic surgery.
Dost thou love life? Then do not squander time, for that's the stuff life is made oj': Benjamin Franklin This book describes the technical principles and applications of echo-planar imaging (EPI) which, as much as any other technique, has shaped the develop ment of modern magnetic resonance imaging (MRI). The principle of EPI, namely, the acquisition of multiple nuclear magnetic resonance echoes from a single spin excitation, has made it possible to shorten the previously time-con suming MRI data acquisition from minutes to much less than a second. Interest ingly, EPI is one of the oldest MRI techniques, conceived in 1976 by Sir Peter Mansfield only 4 years after the initial description of the principles of MRI. One of the inventors of MRI himself, Mansfield realized that fast data acquisition would be paramount in bringing medical applications of MRI to full fruition. The technological challenges in implementing EPI, however, were formidable. Until the end of the 1980s few people believed that EPI would be clinically useful, since its complexity was far greater than that of "conventional" MRI methods.
Non-Animal Techniques in Biomedical and Behavioral Research and Testing features the contributions of noted experts describing the application of non-animal methods in a wide variety of research and testing situations, including computer modeling/graphics, protein sequence analysis, behavioral analysis, drug design/testing, cosmetic and household products testing, toxicological testing, clinical testing, chemical identification and analysis, and disease investigations. Many of the alternatives covered have applications in behavioral as well as biomedical research and testing. Topics examined include in vitro techniques, molecular genetics, structure-activity relationships, physicochemical methods, computer-assisted drug designs, nutrition, epidemiology, autopsies, neural networks, ethology, image scanning devices, and medical microbiology. Future applications for non-animal methods are also explored. The book will appeal to toxicologists, pharmacologists, cosmetic and household product researchers, epidemiologists, medical microbiologists, biopsychiatrists, biomedical and psychological educators, biochemists, molecular geneticists, and other scientists interested in alternative testing methods.
Creatine and Creatine Phosphate: Scientific and Clinical Perspectives is an up-to-date summary of both the scientific and medical aspects of creatine and creatine phosphate metabolism and therapy.It covers in detail the basic biochemistry, bioenergetics and biophysics of these agents with particular emphasis on their role on the cardiovascular and muscle systems. Modern in vivo myocardial and skeletal muscle measurements are outlined, and the importance of the molecules in cardiovascular medicine, sport science and cardiac surgery are highlighted.This book is designed for those interested in the basic scientific background to creatine and creatine phosphate, and also for physicians treating or studying heart and vascular disease. The book will also be vital for sports scientists who wish to acquire a comprehensive knowledge of the molecule which is currently being promoted for performance and exercise programmes.
Brigham and Women's Experts' Approach to Rheumatology is for physicians in training, primary care physicians. and any healthcare professional caring for patients with rheumatologic disorders. Rheumatic symptoms are often vague and difficult to diagnose. Brigham and Women's Experts' Approach to Rheumatology helps clinicians navigate the myriad disorders and makes recommendations for treatmentall in one concise reference book.
The latest edition of this in-depth look at athletic injuries of the shoulder has been updated to feature 16 new chapters, additional illustrations and algorithms, an added focus on arthroscopic treatments, and pearls that highlight key information. Additional contributing authors give you a fresh spin on new and old topics from rehabilitation exercises to special coverage of female athletes, pediatrics, and golfers. This book offers coverage of arthroscopy, total joint replacement, instability, football, tennis, swimming, and gymnastic injuries, rotator cuff injuries, and much, much more! The large range of topics covered in this text ensures that it's a great resource for orthopaedists, physical therapists, athletic trainers, and primary care physicians. - Presents a multidisciplinary approach to the care of the shoulder, combining contributions from the leaders in the field of orthopedic surgery, physical therapy, and athletic training. - Demonstrates which exercises your patients should perform in order to decrease their chance of injury or increase strength following an injury through illustrated exercises for rehabilitation and injury prevention. - Illustrates how the shoulder is affected during activity of certain sports with a variety of tables and graphs. - Covers a large range of topics including all shoulder injuries to be sufficiently comprehensive for both orthopaedists and physical therapists/athletic trainers.Features 16 new chapters, including Internal Impingement, Bankarts: Open vs. Arthroscopy, Adhesive Capsulitis of the Shoulder, Cervicogenic Shoulder Pain, Proprioception: Testing and Treatment, and more. - Details current surgical and rehabilitation information for all aspects of shoulder pathology to keep you up-to-date. - Organizes topics into different sections on anatomy, biomechanics, surgery, and rehabilitation for ease of reference.
In his most ambitious work yet, Shermer sets out to discover what drives humans' belief in life after death, focusing on recent scientific attempts to achieve immortality by radical life extentionists, extropians, transhumanists, cryonicists, and mind-uploaders, along with utopians who have attempted to create heaven on earth. For millennia, religions have concocted numerous manifestations of heaven and the afterlife, the place where souls go after the death of the physical body. Religious leaders have toiled to make sense of this place that a surprising 74% of Americans believe exists, but from which no one has ever returned to report what it is really like. Heavens on Earth concludes with an uplifting paean to purpose and progress and what we can do in the here-and-now, whether or not there is a hereafter" --
The Orthopaedic Clinical Handbook is a pocket guide for students in any orthopedic course, including physicians, physical therapists and assistants, chiropractors, and athletic trainers. This useful resource is organized in a manner that is helpful for both students and clinicians. the reader will find the information they need easily, as the information is organized by body regions, and includes medical screening differential diagnosis tables, origin, insertion, nerve supply and action of muscles. Suggestions for evaluation, post surgical rehab protocols, and evidence-based parameters for mod
Significantly revised and updated, the new edition of this highly regarded reference on the shoulder continues to impress. A multitude of leading international authorities—30% new to this 4th edition—present today’s most comprehensive, in-depth view of the current state of shoulder practice, all in a beautifully illustrated, full-color 2-volume masterwork. They deliver the most up-to-date coverage of shoulder function and dysfunction, along with practical approaches for patient evaluation and balanced discussions of treatment alternatives—open and arthroscopic, surgical and nonsurgical. Greatly expanded and visually enhanced coverage of arthroscopy, as well as many new chapters, provide expert guidance on the latest minimally invasive approaches. New “Critical Points summary boxes highlight key technical tips and pearls, and two DVDs deliver new videos that demonstrate how to perform open and arthroscopic procedures. And now, as an Expert Consult title, this thoroughly updated 4th edition comes with access to the complete fully searchable contents online, as well as videos of arthroscopic procedures from the DVDs—enabling you to consult it rapidly from any computer with an Internet connection. Includes tips and pearls from leaders in the field, as well as their proven and preferred methods. Offers scientifically based coverage of shoulder function and dysfunction to aid in the decision-making process. Provides a balance between open and arthroscopic techniques so you can chose the right procedures for each patient. Includes the entire contents of the book online, fully searchable, as well as procedural videos from the DVDs, for quick, easy anywhere access. Features 30% new expert contributors and new chapters, including Effectiveness Evaluation and the Shoulder, Revision of Rotator Cuff Problems, Management of Complications of Rotator Cuff Surgery, Management of Infected Shoulder Prosthesis, and others, providing you with abundant fresh insights and new approaches. Provides new and expanded material on the management of advanced arthritis and CTA, infected arthroplasty, procedures to manage the stiff shoulder, and much more keeping you on the cusp of the newest techniques. Offers enhanced coverage of shoulder arthroscopy, including basic and advanced techniques and complications, for expert advice on all of the latest minimally invasive approaches. Devotes an entire new chapter to research frontiers to keep you apprised of what’s on the horizon. Incorporates “Critical Points summary boxes that highlight key technical tips and pearls. Uses a new full-color design for optimal visual guidance of arthroscopic views and procedures. Presents new videos on arthroscopic procedures on 2 DVDs to help you master the latest techniques.
A facsimile reprint of the Second Edition (1994) of this genealogical guide to 25,000 descendants of William Burgess of Richmond (later King George) County, Virginia, and his only known son, Edward Burgess of Stafford (later King George) County, Virginia. Complete with illustrations, photos, comprehensive given and surname indexes, and historical introduction.
The completely revised and updated, definitive resource for students and professionals in organic chemistry The revised and updated 8th edition of March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions The opening chapters of March's Advanced Organic Chemistry, 8th Edition deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms. This edition: Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017 Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction The 8th edition of March's Advanced Organic Chemistry proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields. Winner of the Textbook & Acadmic Authors Association 2021 McGuffey Longevity Award.
Now in one convenient volume, Atlas of Amputations and Limb Deficiencies: Surgical, Prosthetic, and Rehabilitation Principles, Fifth Edition, remains the definitive reference on the surgical and prosthetic management of acquired and congenital limb loss. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Joseph Ivan Krajbich, MD, FRCS(C), Michael S. Pinzur, MD, FAAOS, COL Benjamin K. Potter, MD, FAAOS, FACS, and Phillip M. Stevens, MEd, CPO, FAAOP, it discusses the most recent advances and future developments in prosthetic technology with in-depth treatment and management recommendations for adult and pediatric conditions. With coverage of every aspect of this complex field from recognized experts in amputation surgery, rehabilitation, and prosthetics, it is an invaluable resource for surgeons, physicians, prosthetists, physiatrists, therapists, and all others with an interest in this field.
Clinical Mechanics and Kinesiology provides a solid foundation in physical therapy, occupational therapy, and athletic training so that students understand biomechanics and functional anatomy as they relate to both normal and abnormal movement. Written by active clinicians with more than 40 combined years of clinical and teaching experience, this text is also a practical reference for rehabilitation professionals working with a range of populations and pathologies. Taking a clinical approach not found in other texts, Clinical Mechanics and Kinesiology follows a logical progression from biomechanical and physiological concepts all the way to full-body movement patterns such as jumping and cutting.
A groundbreaking book about the medical advances that will definitively prevent aging. In a startling glimpse of our possible future, we see how we may live for two to three hundred years longer, how age-related diseases will be eradicated, and how the aging press will be prevented if not reversed. Illus.
Orthopedic Clinical Examination With Web Resource provides readers with fundamental knowledge for developing proficiency at performing orthopedic evaluations and diagnosing conditions. Michael P. Reiman, who is internationally respected for his teaching, clinical practice, and research focused on orthopedic assessment and treatment methods, presents an evidence-based guide on the process of conducting tests and making diagnoses.
The key contribution of the approach to x-ray mammographic image analysis developed in this monograph is a representation of the non-fatty compressed breast tissue that we show can be derived from a single mammogram. The importance of the representation, called hint, is that it removes all those changes in the image that are due only to the particular imaging conditions (for example, the film speed or exposure time), leaving just the non-fatty 'interesting' tissue. Normalising images in this way enables them to be enhanced and matched, and regions in them to be classified more reliably, because unnecessary, distracting variations have been eliminated. Part I of the monograph develops a model-based approach to x-ray mammography, Part II shows how it can be put to work successfully on a range of clinically-important tasks, while Part III develops a model and exploits it for contrast-enhanced MRI mammography. The final chapter points the way forward in a number of promising areas of research.
Michael H. Weisman, Michael Weinblatt, James S Louie, and Ronald Van Vollenhoven offer their unique insights into choosing the correct pharmacological and non-pharmacological therapies for your patients. Chapters cover the full breadth of rheumatic diseases, rheumatoid arthritis, lupus, connective tissue diseases, osteoporosis, regional pain disorders, and fibromyalgia. The full-color design presents detailed clinical photographs and treatment algorithms for visual guidance and easy reference. Covers the treatment of pediatric patients as well as adults so that you can properly address the particular needs of any patient you see. Features the guidance and specific recommendations of experts from United States and Europe for a state-of-the-art approach to the variety of treatments currently in use. Displays the clinical manifestations of rheumatic diseases in full color, along with treatment algorithms for easy at-a-glance reference.
Fully updated with completely updated content, exciting new authors, and commentary by national and international experts in the field, Rockwood and Matsen’s The Shoulder, 5th Edition continues its tradition of excellence as the cornerstone reference for effective management of shoulder disorders. This masterwork provides how-to guidance on the full range of both tried-and-true and recent surgical techniques, including both current arthroscopic methods and the latest approaches in arthroplasty. An outstanding editorial team headed by Drs. Charles A. Rockwood, Jr. and Frederick A. Matsen III ensures that you have the tools you need to achieve optimal patient outcomes for any shoulder challenge you encounter. Throughout the book the authors focus on the value of the procedures to patients, showing ways that expense and risk can be minimized. Combines the ‘how to’ for ‘tried and true’ shoulder procedures along with the latest arthroscopic methods for managing shoulder disorders. Focuses on the most challenging open procedures, including those often overlooked in training programs, yet thoroughly reviews the rationale for using minimally invasive arthroscopic techniques whenever possible. Offers scientifically based coverage of shoulder function and dysfunction to aid in the decision-making process. Features new commentaries from international authorities – including dissenting and alternative viewpoints -- and final comments by our editorial experts. Covers new approaches, including reverse total shoulder, the latest rotator cuff repair methods, and the "ream and run" procedure, as well as emerging imaging methods.
Blending the latest technical and clinical skills of hand surgery and hand therapy, Hand and Upper Extremity Rehabilitation: A Practical Guide, 4th Edition walks you through the treatment of common medical conditions affecting the upper extremities and highlights non-surgical and surgical procedures for these conditions. This expanded fourth edition presents the latest research in hand and upper extremity rehabilitation and provides the purpose and rationale for treatment options. Clinical outcomes included in each chapter relate clinical expectations to the results of clinical research trials, providing you with the expected range of motion and function based on evidence in the literature. Highly structured organization makes information easy to find, allowing the text to function as a quick reference in the clinical setting. Contributors from a variety of clinical settings like hand therapy clinics, hospitals, and outpatient clinics means you get to learn from the experience of clinicians working in diverse clinical contexts like yourself. Over 400 line drawings and clinical photographs delineate important concepts described in text. Chapters divided into eight parts - Wound Management, Nerve Injuries, Tendon Injuries, Shoulder, Elbow, Wrist and Distal Radial Ulnar Joint, Hand, and Special Topics - so information can be located quickly. 51 leading experts offer fresh insight and authoritative guidance on therapeutic approaches for many common diagnoses. Treatment guidelines presented for each stage of recovery from a wide range of upper extremity conditions. NEW! Authoritative quick reference guide to surgical and non-surgical procedures for hand and all upper extremity conditions. NEW! Updated information and references offers the latest information and research in the areas of hand and upper extremity rehabilitation. NEW! Larger trim size and new design accommodates a two-column format that is easier to follow.
One of Wall Street Journal's "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell's ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body's trillions of cells. But some of our cells don't age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.
The leading introductory textbook on geriatrics – completely updated and revised A Doody’s Core Title for 2024 & 2021! Essentials of Clinical Geriatrics is an engagingly written, up-to-date introductory guide to the core topics in geriatric medicine. Since 1984, its goal has remained unchanged: to help clinicians do a better job of caring for their older patients. You will find thorough and authoritative coverage of all the important issues in geriatrics, along with concise, practical guidance on the diagnosis and treatment of the diseases and disorders most commonly encountered in an elderly patient. Presented in full-color, this classic features a strong focus on the field’s must-know concepts, from the nature of clinical aging to differential diagnosis of important geriatric syndromes to drug therapy and health services. The Eighth Edition has been completely revised to provide the most current updates on the assessment and management of geriatric care. FEATURES: Numerous tables and figures that summarize conditions, values, mechanisms, therapeutics, and more Thorough coverage of preventive services and disease screening Eight chapters devoted to general management strategies Important chapters on ethical issues and palliative care Appendix of Internet resources on geriatrics Essentials of Clinical Geriatrics, Eighth Edition is the best resource available to help healthcare professionals provide the innovative, cost-effective, and person-centered care that older people and their caregivers deserve.
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