A giant, ancient statue of Buddha is blown to pieces in Afghanistan, and there is one man to blame: terrorist Habib Khadr. Following this magnificent display of his power, Habib is quiet for decades until he surfaces again in Mexico. He has successfully evaded Interpol, and he now plans to cross the Sierra Madre Plateau into America. Habib leaves a trail of murders in his wake, but he arrives in North Dakota, where he is reunited with his notoriously powerful wife. Together, they form a plot to rescue their son from Americanization and destroy Mount Rushmore. Meanwhile, private investigators-and spouses-Ryan Moar and Joanne Sutter have their own problems. They investigate a young man named Moe Fouzi, who is about to marry an American heiress, although his intentions are not clear. Moe is not who he appears to be, and their investigation soon takes the detectives into the bloody path of Habib Khadr. Now, in the Black Hills of South Dakota, Ryan and Joanne must fight to save America's most prized monument and their own lives.
For Fargo-based private investigator Ryan Moar, the island of Zanzibar is longer a laid-back tropical paradiseit has become a sinister and violent place. On this exotic East African island, the most unlikely target imaginable is economics professor Jomo Willow gunned down outside a seedy bar, a cold execution by an unknown assassin. Ryan pays a brutal price for saving Aisling Quinn from drowning in Zanzibars harbor. The rescue of the enigmatic Irish woman, plunges Ryan into a maelstrom of manipulations by a notorious crime tsar known only as Shark. The head of an international rogue organization, Shark is bent on expanding his empire at a frightening pace, eliminating anyone who stands in his way. When Ryan finds out Aisling has transmitted Sharks secret files to Ireland, the PI is compelled to find the incriminating documents no matter what the cost. Ryan is soon embroiled in a deadly duel against one of the worlds most diabolical criminals. While staying one-step ahead of teams of deadly assassins, the hunt for Dr. Willows killer takes Ryan from the narrow back alleys of Zanzibar to the gritty streets and stately homes of Dublin.
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
Over the last decade, the study of cycles as a model for the earth's changing climate has become a new science. Earth Systems Science is the basis for understanding all aspects of anthropogenic global change, such as chemically forced global climate change. The work is aimed at those students interested in the emerging scientific discipline.Earth Systems Science is an integrated discipline that has been rapidly developing over the last two decades. New information is included in this updated edition so that the text remains relevant. This volume contains five new chapters, but of special importance is the inclusion of an expanded set of student exercises.The two senior authors are leading scientists in their fields and have been awarded numerous prizes for their research efforts. * First edition was widely adopted* Authors are highly respected in their field* Global climate change, integral to the book, is now one of the most important issues in atmospheric sciences and oceanography
This book provides a comprehensive, cutting-edge look at the problems that impact the way we conduct intervention and treatment for youth in crisis today—an indispensable resource for practitioners, students, researchers, policymakers, and faculty working in the area of juvenile justice. Understanding Juvenile Justice and Delinquency provides a concise overview of the most compelling issues in juvenile delinquency today. It covers not only the range of offenses but also the offenders themselves as well as those impacted by crime and delinquency. All of the chapters contain up-to-date research, laws, and data that accurately frame discussions on youth violence, detention, and treatment; related issues such as gangs and drugs; the consequences for scholars, teachers, and students; and best practices in intervention methods. The book's organization guides readers logically from the broader definitions and parameters of the study of juveniles to the more specific. The volume leads with an explanation of the relationship between victimization and juvenile behavior and sets up boundaries of the arenas of delinquency—from the family to the streets to cyberspace. The book then focuses on more specific populations of offenders and offenses, including recent, emerging issues, offering the most accurate information available and cutting-edge insight into the issues that affect youth in custody and in our communities.
Coping with Work Stress: A Review and Critique highlights current research relating to the coping strategies of individuals and organizations, and provides best practice techniques for dealing with the growing epidemic of stress and lack of overall well-being at work. Reviews and critiques the most current research focusing on workplace stress Provides 'best practice' techniques for dealing with stress at the workplace Extends beyond stress to cover broader issues of well-being at work
This book offers practical guidance on possible solutions to communication problems, featuring a number of examples related to the construction industry.
Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death. Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer’s Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer’s is initially a problem of amyloid, the neuron, or of the blood-brain barrier Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer’s
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