Medical microbiology concerns the nature, distribution and activities of microbes and how they impact on health and wellbeing, most particularly as agents of infection. Infections remain a major global cause of mortality and in most hospitals around one in ten of those admitted will suffer from an infection acquired during their stay. The evolution of microbes presents a massive challenge to modern medicine and public health. The constant changes in viruses such as influenza, HIV, tuberculosis, malaria and SARS demand vigilance and insight into the underlying process. Building on the huge success of previous editions, Medical Microbiology 18/e will inform and inspire a new generation of readers. Now fully revised and updated, initial sections cover the basic biology of microbes, infection and immunity and are followed by a systematic review of infective agents, their associated diseases and their control. A final integrating section addresses the essential principles of diagnosis, treatment and management. An unrivalled collection of international contributors continues to ensure the relevance of the book worldwide and complementary access to the complete online version on Student Consult further enhances the learning experience. Medical Microbiology is explicitly geared to clinical practice and is an ideal textbook for medical and biomedical students and specialist trainees. It will also prove invaluable to medical laboratory scientists and all other busy professionals who require a clear, current and most trusted guide to this fascinating field.
50th Anniversary Edition of the groundbreaking case-based pharmacotherapy text, now a convenient two-volume set. Celebrating 50 years of excellence, Applied Therapeutics, 12th Edition, features contributions from more than 200 experienced clinicians. This acclaimed case-based approach promotes mastery and application of the fundamentals of drug therapeutics, guiding users from General Principles to specific disease coverage with accompanying problem-solving techniques that help users devise effective evidence-based drug treatment plans. Now in full color, the 12th Edition has been thoroughly updated throughout to reflect the ever-changing spectrum of drug knowledge and therapeutic approaches. New chapters ensure contemporary relevance and up-to-date IPE case studies train users to think like clinicians and confidently prepare for practice.
A powerful challenge to contemporary economics and a new agenda for global finance In the wake of the global financial crisis that began in 2007, faith in the rationality of markets has lost ground to a new faith in their irrationality. The problem, Roman Frydman and Michael Goldberg argue, is that both the rational and behavioral theories of the market rest on the same fatal assumption—that markets act mechanically and economic change is fully predictable. In Beyond Mechanical Markets, Frydman and Goldberg show how the failure to abandon this assumption hinders our understanding of how markets work, why price swings help allocate capital to worthy companies, and what role government can and can't play. The financial crisis, Frydman and Goldberg argue, was made more likely, if not inevitable, by contemporary economic theory, yet its core tenets remain unchanged today. In response, the authors show how imperfect knowledge economics, an approach they pioneered, provides a better understanding of markets and the financial crisis. Frydman and Goldberg deliver a withering critique of the widely accepted view that the boom in equity prices that ended in 2007 was a bubble fueled by herd psychology. They argue, instead, that price swings are driven by individuals' ever-imperfect interpretations of the significance of economic fundamentals for future prices and risk. Because swings are at the heart of a dynamic economy, reforms should aim only to curb their excesses. Showing why we are being dangerously led astray by thinking of markets as predictably rational or irrational, Beyond Mechanical Markets presents a powerful challenge to conventional economic wisdom that we can't afford to ignore.
Posing a major challenge to economic orthodoxy, Imperfect Knowledge Economics asserts that exact models of purposeful human behavior are beyond the reach of economic analysis. Roman Frydman and Michael Goldberg argue that the longstanding empirical failures of conventional economic models stem from their futile efforts to make exact predictions about the consequences of rational, self-interested behavior. Such predictions, based on mechanistic models of human behavior, disregard the importance of individual creativity and unforeseeable sociopolitical change. Scientific though these explanations may appear, they usually fail to predict how markets behave. And, the authors contend, recent behavioral models of the market are no less mechanistic than their conventional counterparts: they aim to generate exact predictions of "irrational" human behavior. Frydman and Goldberg offer a long-overdue response to the shortcomings of conventional economic models. Drawing attention to the inherent limits of economists' knowledge, they introduce a new approach to economic analysis: Imperfect Knowledge Economics (IKE). IKE rejects exact quantitative predictions of individual decisions and market outcomes in favor of mathematical models that generate only qualitative predictions of economic change. Using the foreign exchange market as a testing ground for IKE, this book sheds new light on exchange-rate and risk-premium movements, which have confounded conventional models for decades. Offering a fresh way to think about markets and representing a potential turning point in economics, Imperfect Knowledge Economics will be essential reading for economists, policymakers, and professional investors.
This engaging and highly practical title is designed to support healthcare professionals in providing the best possible care for their patients with migraine. Developed by two leading authorities in the field who bring wit and warmth to their writing, the book combines the valuable wisdom of their clinical expertise with cutting edge scientific synthesis and helpful clinical pearls. Replete with a plethora of instructional aids and clinical tools (such as patient handouts, questionnaires, checklists, video clips, and quick-reference boxes), Discussing Migraine with Your Patients: A Common Sense Guide for Clinicians reviews migraine treatment in an evidence-based manner -- according to the empirical data and FDA and consensus-based guidelines. Discussion topics include acute and preventive pharmacotherapy, medical interventions and devices, behavioral and psychological nonpharmacologic therapies, education, trigger management, healthy lifestyle practices, stress management, neutraceuticals, and alternative medicine offerings. In addition, this easy-to-read title covers genetics and pathophysiology, symptoms and comorbidities, and a range of essential clinical skills that are useful in achieving the best possible outcomes with patients. In invaluable addition to the literature, this title will serve as the ultimate go-to resource for primary care clinicians and trainees. Headache specialists, too, will find value in this work.
This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entired field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost im anyone person to stay informed on this subject by reading the possible for At the same time it is becoming increasingly apparent that primary literature. these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony-stimulating factors," was quite artifactual; they are in fact the basis of a common language for intercellular communication. As a set they affect es sentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research.
Today, the Bay Area is home to the most successful knowledge economy in America, while Los Angeles has fallen progressively further behind its neighbor to the north and a number of other American metropolises. Yet, in 1970, experts would have predicted that L.A. would outpace San Francisco in population, income, economic power, and influence. The usual factors used to explain urban growth—luck, immigration, local economic policies, and the pool of skilled labor—do not account for the contrast between the two cities and their fates. So what does? The Rise and Fall of Urban Economies challenges many of the conventional notions about economic development and sheds new light on its workings. The authors argue that it is essential to understand the interactions of three major components—economic specialization, human capital formation, and institutional factors—to determine how well a regional economy will cope with new opportunities and challenges. Drawing on economics, sociology, political science, and geography, they argue that the economic development of metropolitan regions hinges on previously underexplored capacities for organizational change in firms, networks of people, and networks of leaders. By studying San Francisco and Los Angeles in unprecedented levels of depth, this book extracts lessons for the field of economic development studies and urban regions around the world.
This document, which consists of approximately 2900 lecture slides, offers a wealth of information on many topics relevant to programming in C++, including coverage of the C++ language itself, the C++ standard library and a variety of other libraries, numerous software tools, and an assortment of other programming-related topics. The coverage of the C++ language and standard library is current with the C++20 standard. C++ PROGRAMMING LANGUAGE. Many aspects of the C++ language are covered from introductory to more advanced. This material includes: the preprocessor, language basics (objects, types, values, operators, expressions, control-flow constructs, functions, namespaces, and comparison), classes, templates (function, class, variable, and alias templates, variadic templates, template specialization, and SFINAE), concepts, lambda expressions, inheritance (run-time polymorphism and CRTP), exceptions (exception safety and RAII), smart pointers, memory management (new and delete operators and expressions, placement new, and allocators), rvalue references (move semantics and perfect forwarding), coroutines, concurrency (memory models, and happens-before and synchronizes-with relationships), modules, compile-time computation, and various other topics (e.g., copy elision and initialization). C++ STANDARD LIBRARY AND VARIOUS OTHER LIBRARIES. Various aspects of the C++ standard library are covered including: containers, iterators, algorithms, ranges, I/O streams, time measurement, and concurrency support (threads, mutexes, condition variables, promises and futures, atomics, and fences). A number of Boost libraries are discussed, including the Intrusive, Iterator, and Container libraries. The OpenGL library and GLSL are discussed at length, along with several related libraries, including: GLFW, GLUT, and GLM. The CGAL library is also discussed in some detail. SOFTWARE TOOLS. A variety of software tools are discussed, including: static analysis tools (e.g., Clang Tidy and Clang Static Analyzer), code sanitizers (e.g., ASan, LSan, MSan, TSan, and UBSan), debugging and testing tools (e.g., Valgrind, LLVM XRay, and Catch2), performance analysis tools (e.g., Perf, PAPI, Gprof, and Valgrind/Callgrind), build tools (e.g., CMake and Make), version control systems (e.g., Git), code coverage analysis tools (e.g., Gcov, LLVM Cov, and Lcov), online C++ compilers (e.g., Compiler Explorer and C++ Insights), and code completion tools (e.g., YouCompleteMe, and LSP clients/servers). OTHER TOPICS. An assortment of other programming-related topics are also covered, including: data structures, algorithms, computer arithmetic (e.g., floating-point arithmetic and interval arithmetic), cache-efficient algorithms, vectorization, good programming practices, software documentation, software testing (e.g., static and dynamic testing, and structural coverage analysis), and compilers and linkers (e.g., Itanium C++ ABI).
This document, which consists of approximately 2500 lecture slides, offers a wealth of information on many topics relevant to programming in C++, including coverage of the C++ language itself, the C++ standard library and a variety of other libraries, numerous software tools, and an assortment of other programming-related topics. The coverage of the C++ language and standard library is current with the C++17 standard.
This is a comprehensive and up-to-date presentation of the processes by which biological systems, most notably the nervous system, affect behaviour. A fantastic art program, an applauded accessible writing style and a host of pedagogical features make the text relevant to the lives of the students taking biological psychology.
Globally Competent Governance explores promising policies and practices developed by local governments and other community leaders across the United States and beyond in their efforts to build welcoming and inclusive communities and globally competent governments. Cities of the future, be they large, regional metropolitan centers of commerce and political power, regional hubs that service central metropolitan regions, or smaller suburban or rural centers that cater to agriculture or regional commerce, will continue to evolve. Globalization and global mobility have greatly increased the cultural, ethnic, linguistic, and religious diversity in cities and communities around the globe and demand local governments build welcoming and inclusive communities for all residents, particularly newcomers. Leaders, both in and out of government, must be prepared to respond to changing needs and manage any potential challenges this may create. To better understand what local officials are facing and what they are doing to manage change, the author presents data collected through surveys and individual interviews of local officials and other community influencers. Based on these findings, the book analyzes the current state of cities and makes policy recommendations for moving forward. This book will be of interest to advanced undergraduate and postgraduate students, researchers, and academics in the fields of public policy, governance, immigration, community engagement, social welfare, and political science, as well as professionals in government and nongovernmental organizations. It will also interest professionals working with immigrants and in immigration policy.
Describing the diagnosis and management of maxillofacial and associated traumatic injuries step by step, Oral and Maxillofacial Trauma, 4th Edition takes you beyond the surgical management of head and neck trauma to cover the general management of traumatic injuries, systemic evaluation of the trauma patient, and special considerations associated with maxillofacial trauma patient care. New to this edition are over 700 full-color illustrations showing details of traumatic injuries and their treatment. Edited by head and neck trauma expert Dr. Raymond J. Fonseca, along with over 80 highly respected contributors, this comprehensive reference provides all of the information you need to offer the best care possible to maxillofacial trauma patients. One-of-a-kind, comprehensive chapters cover current research literature with topics including advances in maxillofacial trauma surgery, nonpenetrating chest trauma, metabolic response to trauma, maxillofacial prosthetics, and the societal impact of maxillofacial trauma. Coverage of emerging topics includes firearm injuries, neurologic injuries (the leading cause of death from trauma), wound healing, airway management, shock, and nasal fractures, so you can work confidently with team members from other disciplines such as neurologists, anesthesiologists, and orthopedists. Over 80 expert contributors represent the specialties of oral and maxillofacial surgery, anesthesiology, and otolaryngology. UPDATED content reflects current thinking and the latest techniques in the management of traumatic injuries. NEW full-color illustrations and design highlight clinical areas and show details of injuries and their treatment. NEW! Streamlined, single-volume format makes information easier to access and the book easier to carry.
Finally, a multi-disciplinary approach that covers both the surgical and non-surgical interventions for sleep apnea and snoring. From the editor of Operative Techniques in Otolaryngology, this new reference will quickly become the standard in surgery for this key area within otolaryngology. ., Full-color line drawings illustrate key concepts and create a comprehensive way of learning surgical techniques. Provides consistent, templated chapters and a contemporary, full-color format for quick, easy access to the most up-to-date surgical and non surgical interventions for sleep apnea and snoring. Includes contributions from leaders in neurology, pulmonology, psychiatry, otolaryngology, and oral & maxillofacial surgery. to create a truly multi-disciplinary approach. Covers new and innovative procedures including ZPP (Zeta palatopharyngoplasty), Transpalatal Advancement Pharyngoplasty and Minimally invasive submucosal glossectomy Details when and why surgery is necessary, and how to perform a successful operation for snoring and sleep apnea.
This is a very comprehensive book on the subject matter with references that users can access and follow through. It is well structured and the writing style is appropriate for a wide range of students." Mo Nowrung, University of East Anglia, UK We are facing an epidemic of work stress. But why should problems at work which previously led to industrial disputes and political activity now be experienced as a cause of physical or mental illness? This book combines a critique of the scientific evidence relating to work stress, with an account of the social, historical and cultural changes that produced this phenomenon. The analysis is grounded in workers' accounts of their experiences of work stress, derived from the authors' qualitative research. Sociological theories of embodiment, emotions and medicalization are employed to explore the role of subjectivity in mediating the relationship between work and ill health. This book concludes with an exploration of the consequences of adopting the passive identity of 'work stress victim', and the extent to which individuals resist the medicalization of their problems. It will be of interest to a range of students and researchers in the social sciences, particularly those with an interest in medical sociology, sociology of work, management studies and industrial relations.
After the Cosmopolitan? argues that both racial divisions and intercultural dialogue can only be understood in the context of the urbanism through which they are realized. All the key debates in cultural theory and urban studies are covered in detail: the growth of cultural industries and the marketing of cities social exclusion and violence the nature of the ghetto the cross-disciplinary conceptualization of cultural hybridity the politics of third-way social policy. In considering the ways in which race is played out in the world's most eminent cities, Michael Keith shows that neither the utopian naiveté of some invocations of cosmopolitan democracy, nor the pessimism of multicultural hell can adequately make sense of the changing nature of contemporary metropolitan life. Authoritative and informative, this book will be of interest to advanced undergraduates, postgraduates and researchers of anthropology, cultural studies, geography, politics and sociology.
THE DEFINITIVE ILLUSTRATED GUIDE TO ABDOMINAL OPERATIONS FOR GENERAL, COLORECTAL, AND GASTROINTESTINAL SURGEONS--NOW IN FULL COLOR! With each edition, Maingot's Abdominal Operations has built a legacy of expertise, currency, and clinical rigor acclaimed by surgical trainees and practicing surgeons. Presented in full-color for the first time, the 63 streamlined chapters of the twelfth edition offer a concise, yet complete, survey of the diagnosis and management of benign and malignant digestive diseases. This authoritative resource has everything you need to understand congenital, acquired, and neoplastic disorders--and optimize surgical outcomes for any type of abdominal procedure. FEATURES Contemporary focus on operative procedures, and new concepts in the diagnosis and management of abdominal disease Convenient organ/procedure presentation provides a seamless review of surgical protocols, as well as pre- and postoperative strategies and techniques Thirteen new "Perspective" chapters feature expert commentary and alternative viewpoints on the most clinically relevant topics Added chapters on gastrointestinal bleeding, abdominal trauma, and abdominal vascular emergencies--along with minimally invasive surgery chapters woven throughout the text--present current, ready-to-use insights designed to enhance surgical care and recovery More than 1,250 illustrations (most in full color)
The definitive survey of diagnostic dermatopathology—and the single-best resource for addressing differential diagnosis at the microscopic level For virtually every kind of skin lesion, this skill-sharpening resource has everything clinicians need to successfully perform differential diagnosis at the microscopic level. Dermatopathology features a systematic, algorithmic approach that cuts through the complexity of the discipline’s traditional disease-oriented focus, providing a ready-to-use diagnostic tool that puts the entire world of dermatopathology into perspective. This classic has won acclaim as the only dermatology pathology resource that is valuable for both teaching and for clinical practice and differential diagnosis. While other references may be more exhaustive, denser, or larger, none are more clinically useful as Dermatopathology. With 25% of the dermatology board and recertification examination consisting of dermatopathology topics, this is also an outstanding board review tool. Filled with hundreds of color photomicrographs, the book features a clear five-part organization and nearly forty detailed chapters—each reflecting the scientifically rigorous, up-to-date insights of authors who are acknowledged experts in the field. The book’s vast scope encompasses all skin disease processes—inflammatory, non-inflammatory, infections, and proliferations (harmatomas, hyperplasias, and neoplasms, plus disorders of nails and oral mucosa). •Includes Online Image Bank containing all the images in the book•Increased number of full-color images•Numerous tables assist clinicians differentiate similar conditions from one another•NEW CHAPTERS on laboratory methods and stains, and updated immunohistochemistry content
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