MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
This text provides a pioneering and comprehensive analysis of over one hundred international organizations. After introducing the broad historical and contextual settings, the book covers the full range of international organizations including those th
The rapid growth of the electronic products market has created an increasing need for affordable, reliable, high-speed and high-density multi-layer printed circuit boards (PCBs). This book presents the technologies, algorithms, and methodologies for engineers and others developing the next generation of electronic products. A vision of the future in advanced electronics Advanced Routing of Electronic Modules provides both fundamental theory and advanced technologies for improving routing. Beginning chapters discuss approaches to approximate a minimum rectilinear Steiner tree from a minimum spanning tree and introduce ways to avoid obstacles for routing simple multi-terminal nets sequentially in a workspace. Timing delay, clock skew, and noise control requirements in signal integrity are described as well as computer-aided approaches to managing these requirements in high-speed PCB/MCM routing. Later chapters present the two-layer wiring problem, rip-up and reroute approaches, and parallel routing, including global routing, boundary crossing placement, and detailed maze routing in hardware acceleration. Data structures, data management, and algorithms for parallel routing in a multiple-processor hardware systems are also covered.
As one of the foremost contemporary public intellectuals and scholars of our time, Hamid Dabashi's interests and writings span subjects ranging from Islamic philosophy and political ideology to Iranian art and Persian literature; from Sufism and Orientalism to Iranian and world cinema and contemporary Arab and Muslim visual arts; and from postcolonial theory and globalization to imperialism and public affairs. There is a direct connection between his theoretical innovations and the angle of his public interventions on the urgent global issues of the day. This book brings together some of his most important writings, especially those that offer new ways of understanding Islam, Iran, Islamist ideology, global art, and the condition of global modernity. The book shows the underlying conceptual themes that unify Dabashi's wide-ranging and brilliantly insightful corpus. Book jacket.
This monograph evolved over a period of nine years from a series of papers and presentations addressing the subject of passive vibration control of mechanical s- tems subjected to broadband, transient inputs. The unifying theme is Targeted - ergy Transfer – TET, which represents a new and unique approach to the passive control problem, in which a strongly nonlinear, fully passive, local attachment, the Nonlinear Energy Sink – NES, is employed to drastically alter the dynamics of the primary system to which it is attached. The intrinsic capacity of the properly - signed NES to promote rapid localization of externally applied (narrowband) - bration or (broadband) shock energy to itself, where it can be captured and dis- pated, provides a powerful strategy for vibration control and the opens the pos- bility for a wide range of applications of TET, such as, vibration and shock i- lation, passive energy harvesting, aeroelastic instability (?utter) suppression, se- mic mitigation, vortex shedding control, enhanced reliability designs (for ex- ple in power grids) and others. The monograph is intended to provide a thorough explanation of the analytical, computational and experimental methods needed to formulate and study TET in mechanical and structural systems. Several prac- cal engineering applications are examined in detail, and experimental veri?cation and validation of the theoretical predictions are provided as well. The authors also suggest a number of possible future applications where application of TET seems promising. The authors are indebted to a number of sponsoring agencies.
This text introduces students to the theory and practice of differential equations, which are fundamental to the mathematical formulation of problems in physics, chemistry, biology, economics, and other sciences. The book is ideally suited for undergraduate or beginning graduate students in mathematics, and will also be useful for students in the physical sciences and engineering who have already taken a three-course calculus sequence. This second edition incorporates much new material, including sections on the Laplace transform and the matrix Laplace transform, a section devoted to Bessel's equation, and sections on applications of variational methods to geodesics and to rigid body motion. There is also a more complete treatment of the Runge-Kutta scheme, as well as numerous additions and improvements to the original text. Students finishing this book will be well prepare
In this engaging and accessible sociological study of white and black Christian beliefs, Jason E. Shelton and Michael O. Emerson push beyond establishing that there are racial differences in belief and practice among members of American Protestantism to explore why those differences exist.
Much of the received wisdom about the world of work emphasizes the marketization of the employment relationship; the decline of class-based forms of inequality, and the individualization of employment relations. Non-standard forms of employment, the delayering of organizational hierarchies, and the use of individual performance-based payment systems are all held up as examples of a new neo-liberal order in which employers and employees no longer feel a sense of obligation to each other. Drawing on a range of employee and employer surveys, including the authors own Working in Britain 2000 survey, this ambitious study presents a comprehensive examination of the conditions, attitudes, and experiences of British employees from the mid-1980s to the early years of this century. The authors' analyses provides a compelling critique of the received wisdom, while also providing an original, alternative account of recent developments in work and labour markets. Along the way, the book covers such topical issues as the changing nature of trade union membership, the consequences of Britain's 'long hours' culture', and the apparent inability of women to ask for pay rises. Significantly, the authors seek to reposition debates about the future of work by restoring the concepts of contracts and social class to the analysis of the employment relationship. Based on the ESRC funded Future of Work research programme this book is destined to shape our understanding of employment in Britain for the foreseeable future.
The fifth edition of this leading authority continues to provide comprehensive analysis of the law and practice of sale of goods under English and international law. It is an indispensable resource for practitioners, scholars, and postgraduate students.
California State University, San Bernardino opened in 1965 in San Bernardino. This chronological history records the major and minor developments in the history of the campus, between 1960, when it was created by the California Legislature, to the end of the 2009/10 academic year. Includes tables of major administrators, plus a detailed index.
The exhibition "Assyria to Iberia at the Dawn of the Classical Age" (The Metropolitan Museum of Art, New York, 2014) offered a comprehensive overview of art and cultural exchange in an era of vast imperial and mercantile expansion. The twenty-seven essays in this volume are based on the symposium and lectures that took place in conjunction with the exhibition. Written by an international group of scholars from a wide variety of disciplines, they include reports of new archaeological discoveries, illuminating interpretations of material culture, and innovative investigations of literary, historical, and political aspects of the interactions that shaped art and culture in the in the early first millennium B.C. Taken together, these essays explore the cultural encounters of diverse populations interacting through trade, travel, and migration, as well as war and displacement, in the ancient world. Assyria to Iberia: Art and Culture in the Iron Age contributes significantly to our understanding of the epoch-making exchanges that spanned the Near East and the Mediterranean and exerted immense influence in the centuries that followed.
In The Populist Persuasion, the distinguished historian Michael Kazin guides readers through the expressions of conflict between powerful elites and "the people" that have run through our civic life, filling it with discord and meaning from the birth of the United States until the present day. Kazin argues persuasively that the power of populism lies in its adaptable nature. Across the political spectrum, commentators paste the label on forces and individuals who really have just one big thing in common: they are effective at blasting "elites" or "the establishment" for harming the interests and betraying the ideals of "the people" in nations that are committed, at least officially, to democratic principles. Kazin’s classic book has influenced debates over populism since its publication. The new preface to this edition brings the story up to date by charting the present resurgence of populist discourse, which was front and center in the 2016 elections and in the Brexit debate.
Who killed the economy? A page-turning, true-crime exposé of the subprime salesmen and Wall Street alchemists who produced the biggest financial scandal in American history "It's hard to have a guilty conscience if you don't have a conscience. Anything that benefited production - that benefited me and benefited my wallet - I'd do it." The sales force at Ameriquest Mortgage took this philosophy to heart. They watched the Hollywood white-collar-crime flick "Boiler Room" as a training tape, studying how to pitch overpriced deals to unsuspecting home owners. They learned how to forge signatures on mortgage paperwork and create fake documents in "cut-and-paste" operations they dubbed "The Lab" or "The Art Department." In this stunning narrative, award-winning reporter Michael W. Hudson reveals the story of the rise and fall of the subprime mortgage business by chronicling the rise and fall of two corporate empires: Ameriquest and Lehman Brothers. As the biggest subprime lender and Wall Street's biggest patron of subprime, Ameriquest and Lehman did more than any other institutions to create the feeding frenzy that emboldened mortgage pros to flood the nation with high-risk, high-profit home loans. It's a tale populated by a remarkable cast of the characters: a shadowy billionaire who created the subprime industry out of the ashes of the 1980s S&L scandal; Wall Street executives with an insatiable desire for product; struggling home owners ensnared in the most ingenious of traps; lawyers and investigators who tried to expose the fraud; politicians and bureaucrats who turned a blind eye; and, most of all, the drug-snorting, high-living salesmen who tell all about the money they made, the lies they told, the deals they closed. Provocative and gripping, The Monster is a searing exposé of the bottom-feeding fraud and top-down greed that fueled the financial collapse.
As this volume indicates, the issues facing black America are diverse, and the tools needed to understand these phenomena cross disciplinary boundaries. In this anthology, the authors address a wide range of topics including race, gender, class, sexual orientation, globalism, migration, health, politics, culture, and urban issues-from a diversity of disciplinary perspectives.
Managing performance is a critical focus of HR activity. Well-designed strategies to recognise and improve performance and focus individual effort can have a dramatic effect on bottom-line results. The problem is to determine what the processes, tools and delivery mechanisms are that will improve performance in your organisation, as well as determine which ones are best avoided. The authors have tracked performance management processes over the past seven years, and their comprehensive survey reveals what leading organisations are doing to manage their employees' performance and how they are delivering results.With detailed illustrations from the real world, and clear practical advice, this text shows you how to improve the management of your employees' performance. "Managing Performance" will help you: design performance management processes that reflect the context and nature of the organisation; create supportive delivery mechanisms for performance management; and, evaluate and continuously develop performance management strategies to reflect the changing business environment.
Winner of the Herbert Feis Award from the American Historical Association and named one of the best religion books of the year by Publishers Weekly, D. Michael Quinn's Same-Sex Dynamics among Nineteenth-Century Americans has elicited critical acclaim as well as controversy. Using Mormonism as a case study of the extent of early America's acceptance of same-sex intimacy, Quinn examines several examples of long-term relationships among Mormon same-sex couples and the environment in which they flourished before the onset of homophobia in the late 1950s.
Here's a one-of-a-kind sourcebook on who's who and what's what in American business today. Arranged alphabetically by type of company, it offers a diverse assortment of listings crucial in reaching CEOs, VPs, and other key executives in the nation's top 1,000 companies.
A unique approach to human behavior that integrates and interprets the latest research from cell to society Incorporating principles and findings from molecular biology, neuroscience, and psychological and sociocultural sciences, Human Behavior employs a decidedly integrative biosocial, multiple-levels-of-influence approach. This approach allows students to appreciate the transactional forces shaping life course opportunities and challenges among diverse populations in the United States and around the world. Human Behavior includes case studies, Spotlight topics, and Expert's Corner features that augment the theme of each chapter. This book is rooted in the principles of empirical science and the evidence-based paradigm, with coverage of: Genes and behavior Stress and adaptation Executive functions Temperament Personality and the social work profession Social exchange and cooperation Social networks and psychosocial relations Technology The physical environment Institutions Belief systems and ideology Unique in its orientation, Human Behavior proposes a new integrative perspective representing a leap forward in the advancement of human behavior for the helping professions.
More people were killed by smallpox during the twentieth century--over 300 million--than by all of the wars of that period combined. In 1918 and 1919, influenza virus claimed over 50 million lives. A century later, influenza is poised to return, ongoing plagues of HIV/AIDS and hepatitis infect millions, and Ebola, Zika, and West Nile viruses cause new concern and panic. The overlapping histories of humans and viruses are ancient. Earliest cities became both the cradle of civilization and breeding grounds for the first viral epidemics. This overlap is the focus of virologist/immunologist Michael Oldstone in Viruses, Plagues and History. Oldstone explains principles of viruses and epidemics while recounting stories of viruses and their impact on human history. This fully updated second edition includes engrossing new chapters on hepatitis, Zika, and contemporary threats such as the possible return of a catastrophic influenza, and the impact of fear of autism on vaccination efforts. This is a fascinating panorama of humankind's longstanding conflict with unseen viral enemies, both human successes--such as control of poliomyelitis, measles, smallpox and yellow fever, and continued dangers--such as HIV and Ebola. Impeccably researched and accessibly written, Viruses, Plagues and History will fascinate all with an interest in how viral illnesses alter the course of human history.
Sport Nutrition, Third Edition, uses a physiological basis to provide an in-depth look at the science supporting nutrition recommendations. Students will come away with an understanding of nutrition as it relates to sport and the influence of nutrition on performance, training, and recovery.
In this book, we examine the past and present research and theory on the motivations (the why), the situations and contexts (the when), the individual difference variables and traits (the who), and the affective and cognitive processes (the how) that lead to stereotyping and prejudice. The intent is to provide an in-depth and broad-ranging analysis of stereotyping and prejudice. The text focuses on understanding the issues, theories, and important empirical experiments that bear upon each problem in stereotyping and prejudice and to understand the most up-to-date research, theories, and conclusions of the leading researchers in the field. Stereotyping and prejudice are indeed complex in their origin, and one of the main goals of this book is to provide a coherent picture of the conditions under which stereotyping and prejudice are more (or less) likely to occur. Another primary focus is to examine whether (and how) stereotyping and prejudice can be reduced or eliminated"--
This book examines the topic of excess in modern Irish writing in terms of mysticism, materialism, myth and language. The study engages ideas of excess as they appear in works by major thinkers from Hegel, Kierkegaard and Marx through to Nietzsche, Bataille, Derrida and, more recently, Badiou. Poems, plays and fiction by a wide range of Irish authors are considered. These include works by Oscar Wilde, W. B. Yeats, G. B. Shaw, Patrick Pearse, James Joyce, Sean O’Casey, Louis MacNeice, Samuel Beckett, Elizabeth Bowen, Roddy Doyle, Seamus Heaney, Marina Carr and Medbh McGuckian. The readings presented illustrate how Matthew Arnold’s nineteenth-century idea of the excessive character of the Celt is itself exceeded within the modernity of twentieth-century Irish writing.
Increasing global competition, combined with shrinking budgets, are forcing managers to find new ways of operating. To compete successfully, companies must now use technology and resources (particularly human resources) to their full potential. Much of the research in the area of performance management has suggested that, while it has great potential to contribute dramatically to the bottom line, it rarely works. The third edition of Managing Performance Improvement looks at why performance systems fail, and explores the tools and techniques to overcome this failure. This best selling text provides practical, specific advice to managers and students enabling them to plan for, and then manage, performance improvement.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
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