Soon to be a major motion picture starring Jim Parsons, this is a “heartbreaking but often surprisingly hilarious memoir” (People) about the lessons, love, and laughter of the fourteen years a respected TV columnist shared with his late husband before he succumbed to cancer. Perfect for fans of Bettyville and No Happy Endings. For over a decade, TV fans have counted upon Michael Ausiello’s insider knowledge to get the scoop on their favorite shows and stars. From his time at Soaps In Depth and Entertainment Tonight to his influential stints at TV Guide and Entertainment Weekly to his current role as cofounder of the wildly popular website TVLine, Michael has established himself as the go-to expert when it comes to our most popular form of entertainment. What many of his fans don’t know, however, is that while his professional life was in full swing, Michael had to endure the greatest of personal tragedies: his longtime boyfriend, Kit Cowan, was diagnosed with a rare and very aggressive form of neuroendocrine cancer. Over the course of eleven months, Kit and Michael did their best to combat the deadly disease, but Kit succumbed to his illness in 2015. In this heartbreaking and darkly hilarious memoir, Michael tells the story of his harrowing and challenging last year with Kit while revisiting the thirteen years that preceded it, and how the undeniably powerful bond between him and Kit carried them through all manner of difficulties—always with laughter front and center in their relationship. “Engrossing, poignant, tragic, and hilarious” (Jenny Lawson, #1 New York Times bestselling author), Spoiler Alert: The Hero Dies is “a story about love and loss, joy and heartbreak. And in the midst of personal turmoil, we learn that bravery comes in many forms” (The Washington Post).
Software Engineer's Pocket Book provides a concise discussion on various aspects of software engineering. The book is comprised of six chapters that tackle various areas of concerns in software engineering. Chapter 1 discusses software development, and Chapter 2 covers programming languages. Chapter 3 deals with operating systems. The book also tackles discrete mathematics and numerical computation. Data structures and algorithms are also explained. The text will be of great use to individuals involved in the specification, design, development, implementation, testing, maintenance, and quality assurance of software.
In your practice, you require advanced knowledge of the obstetrical, medical, genetic and surgical complications of pregnancy and their effects on the mother and fetus. With both basic science and clinical information, six new chapters, and an updated color design, you need look no further than the 6th edition of this long-time best seller. Includes both basic science and clinical information to give you comprehensive knowledge of the biology of pregnancy. Acts as an excellent resource for OB/GYNs studying for their Maternal-Fetal Medicine boards — and for practitioners who need quick access to practical information. Provides an updated and focused reference list to keep you up to date on the standards of care in maternal-fetal medicine today. Keeps you current with a new section: Disorders at the Maternal-Fetal Interface...and 6 new chapters: Biology of Parturition, Developmental Origins of Health and Disease, Intrapartum Assessment of Fetal Health, Pathogenesis of Pre-term Birth, Maternal and Fetal Infectious Disorders, and Benign Gynecological Conditions of Pregnancy. Features over 50% new authorship with increased focus on international perspectives. Includes the following hot topics in Maternal-Fetal Medicine: o Biology of Parturition o Fetal Growth o Prenatal Genetic Screening and Diagnosis o Fetal Cardiac Malformations and Arrhythmias o Thyroid Disease and Pregnancy o Management of Depression and Psychoses during Pregnancy and the Puerperium Focuses on evidence based medicine, the current best practice in MFM for diagnosing and treating high risk pregnancies. Includes new illustrations and an updated, color design.
A comprehensive introduction to interval logic and duration calculus for modelling, analysing and verifying real-time systems. The Duration Calculus (DC) represents a logical approach to formal design of real-time systems. In DC real numbers are used to model time and Boolean-valued (i.e. {0,1}-valued) functions over time to model states of real-time systems. The duration of a state in a time interval is the accumulated presence time of the state in the interval. DC extends interval logic to a calculus to specify and reason about properties of state durations. The text covers theory (completeness, decidability, undecidability, model-checking), results, as well as case studies (Deadline Driven Scheduler).
This latest volume in the Current Topics in Medical Mycology series brings together internationally recognized researchers to summarize current topics of interest to medical mycologists and other scientists who are working in microbiology and immunology. A blend of contemporary, authoritative reviews and summaries of new advancements and future directions, Volume 3 aims to promote the interdisciplinary use of medically important fungi in pathogenesis, epidemiology, mycotoxins, taxonomy, and other areas where basic, applied, and clinical science are used.
Cases in Interventional Cardiology, by Dr. Michael Ragosta, offers practical, clinical guidance on coronary and peripheral interventional cardiology through 100 well-presented case histories. Brief clinical presentations, representative illustrations, and dynamic online videos of angiograms, aortograms, and intravascular echos optimize your understanding of these procedures and help you better recognize and manage a wide array of conditions. You'll find valuable advice on patient selection, complications, complex lesion subsets, management dilemma controversies, and much more. Through expertconsult.com you’ll have convenient access to the full text, illustrations, and videos online. Access the fully searchable text online at expertconsult.com and view videos of the angiograms, aortograms, and intravascular echos relevant to each case. See how to manage a wide range of coronary lesions via 100 case studies illustrating a wide range of clinical scenarios you may experience. Get unparalleled visual guidance with high-quality clinical images that help you recognize the characteristic appearance of coronary and peripheral lesions. Improve patient care with advice on patient selection, complications, complex lesion subsets, management dilemma controversies, and more Find what you need quickly thanks to a practical, consistent chapter-to-chapter format.
The updated edition of Atlas of Pelvic Anatomy and Gynecologic Surgery richly illustrates pelvic anatomy and surgical operations through full-color anatomic drawings, correlative surgical artwork with step-by-step photographs, and computer-assisted hybrid photo illustrations. Covering a compendium of gynecologic operations, including major and minor procedures and approaches, the techniques described feature a myriad of laparotomy, laparoscopic, robotic, hysteroscopic, vaginal, vulvar and cystoscopic operations. It is a truly comprehensive resource that's well suited for practicing obstetricians-gynecologists, obstetrics-gynecology residents, general surgeons, subspecialists, nurses, and medical students with an interest in gynecology. Half-tone images and four-color clinical photographs aid in comprehending complex anatomic relationships. Comprehensive coverage of conventional and endoscopic surgeries helps you master the full spectrum of surgical procedures. Brand-new chapters include a third chapter on Pelvic Anatomy, A Comprehensive Atlas of Vulvar Disorders, Avoiding and Managing Mesh Complications, and Appropriate Use of Mesh for Pelvic Organ Prolapse. Correlative drawings and full-color illustrations provide the clearest and best visual understanding on the market. New Robotic Surgery chapter authored by Javier Magrina, renowned minimally invasive and robotic gynecologic surgeon. Medicine eBook is accessible on a variety of devices.
Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.
Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk was selected for The First Clinical Research Bookshelf - Essential reading for clinical research professionals by the Journal of Clinical Research Best Practices. Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk provides drug safety/pharmacovogilance professionals, pharmaceutical and clinical research scientists, statisticians, programmers, medical writers, and technicians with an accessible, practical framework for the analysis, summary and interpretation of drug safety data. The only guide of its kind, Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk is an invaluable reference for pre- and post-marketing risk assessment. With decades of pharmaceutical research and drug safety expertise, authors Dr. Klepper and Dr. Cobert discuss how quality planning, safety training, and data standardization result in significant cost, time, and resource savings. Through illustrative, step-by-step instruction, Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk is the definitive guide to drug safety data analysis and reporting. Key features include: * Step-by-step instruction on how to analyze, summarize and interpret safety data for mandatory governmental safety reports * Pragmatic tips...and mistakes to avoid * Simple explanations of what safety data are collected, and what the data mean * Practical approaches to determining a drug effect and understanding its clinical significance * Guidance for determining risk throughout the lifecycle of a drug, biologic or nutraceutical * Examples of user-friendly data displays that enhance safety signal identification * Ways to improve data quality and reduce the time, resources and costs involved in mandatory safety reporting * Relevant material for the required training of drug safety/pharmacovigilance professionals * SPECIAL FEATURE: Actual examples of an Integrated Analysis of Safety (IAS) -used in the preparation of the Integrated Summary of Safety (ISS) and the Summary of Clinical Safety (SCS) reports -, and the Periodic Safety Update Report (PSUR)
Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You'll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors-such as heavy metals and pesticides-and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. And, Expert Consult functionality allows you to access the full text of the book online, from any Internet connection. Provides a complete listing of neurotoxic agents-from manufactured to environmental-so you get comprehensive, clinical coverage. Covers how toxins manifest themselves according to age and co-morbidity so that you can address the needs of all your patients. Offers broad and in-depth coverage of toxins from all over the world through contributions by leading authorities and up-and-coming clinical neurotoxicologists. Features discussion of controversial and unusual topics such as Gulf War Syndrome, Parkinson's Disease, motor neuron disease, as well as other issues that are still in question. Includes access to www.expertconsult.com, a companion website where you can quickly search the complete contents of the book. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.
Case Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, followed by clinical presentation, diagnosis and treatment. Five core sets of questions are posed in each case. What is the nature of the infectious agent, how does it gain access to the body, what cells are infected, and how does the organism spread? What are the host defense mechanisms against the agent and how is the disease caused? What are the typical manifestations of the infection and the complications that can occur? How is the infection diagnosed and what is the differential diagnosis? How is the infection managed, and what preventative measures can be taken to avoid infection? This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms, fully integrating microbiology and immunology throughout.
The study of multi-agent systems (MAS) focuses on systems in which many intelligent agents interact with each other. These agents are considered to be autonomous entities such as software programs or robots. Their interactions can either be cooperative (for example as in an ant colony) or selfish (as in a free market economy). This book assumes only basic knowledge of algorithms and discrete maths, both of which are taught as standard in the first or second year of computer science degree programmes. A basic knowledge of artificial intelligence would useful to help understand some of the issues, but is not essential. The book’s main aims are: To introduce the student to the concept of agents and multi-agent systems, and the main applications for which they are appropriate To introduce the main issues surrounding the design of intelligent agents To introduce the main issues surrounding the design of a multi-agent society To introduce a number of typical applications for agent technology After reading the book the student should understand: The notion of an agent, how agents are distinct from other software paradigms (e.g. objects) and the characteristics of applications that lend themselves to agent-oriented software The key issues associated with constructing agents capable of intelligent autonomous action and the main approaches taken to developing such agents The key issues in designing societies of agents that can effectively cooperate in order to solve problems, including an understanding of the key types of multi-agent interactions possible in such systems The main application areas of agent-based systems
In subvolume 27C1 magnetic and related properties of binary lanthanide oxides have been compiled. This subvolume covers data obtained since 1980 and can therefore be regarded as supplement to volume III/12c. While in the previous volume the majority of magnetic data was obtained either from magnetometric measurements or from neutron diffraction, for the present data the main emphasis is devoted to 'related' properties without which, however, the understanding of classical magnetic properties is impossible. A second part 27C2 will deal with binary oxides of the actinide elements.
The idea of this book grew out of a symposium that was held at Stony Brook in September 2012 in celebration of David S.Warren's fundamental contributions to Computer Science and the area of Logic Programming in particular. Logic Programming (LP) is at the nexus of Knowledge Representation, Artificial Intelligence, Mathematical Logic, Databases, and Programming Languages. It is fascinating and intellectually stimulating due to the fundamental interplay among theory, systems, and applications brought about by logic. Logic programs are more declarative in the sense that they strive to be logical specifications of "what" to do rather than "how" to do it, and thus they are high-level and easier to understand and maintain. Yet, without being given an actual algorithm, LP systems implement the logical specifications automatically. Several books cover the basics of LP but focus mostly on the Prolog language with its incomplete control strategy and non-logical features. At the same time, there is generally a lack of accessible yet comprehensive collections of articles covering the key aspects in declarative LP. These aspects include, among others, well-founded vs. stable model semantics for negation, constraints, object-oriented LP, updates, probabilistic LP, and evaluation methods, including top-down vs. bottom-up, and tabling. For systems, the situation is even less satisfactory, lacking accessible literature that can help train the new crop of developers, practitioners, and researchers. There are a few guides onWarren’s Abstract Machine (WAM), which underlies most implementations of Prolog, but very little exists on what is needed for constructing a state-of-the-art declarative LP inference engine. Contrast this with the literature on, say, Compilers, where one can first study a book on the general principles and algorithms and then dive in the particulars of a specific compiler. Such resources greatly facilitate the ability to start making meaningful contributions quickly. There is also a dearth of articles about systems that support truly declarative languages, especially those that tie into first-order logic, mathematical programming, and constraint solving. LP helps solve challenging problems in a wide range of application areas, but in-depth analysis of their connection with LP language abstractions and LP implementation methods is lacking. Also, rare are surveys of challenging application areas of LP, such as Bioinformatics, Natural Language Processing, Verification, and Planning. The goal of this book is to help fill in the previously mentioned void in the LP literature. It offers a number of overviews on key aspects of LP that are suitable for researchers and practitioners as well as graduate students. The following chapters in theory, systems, and applications of LP are included.
This comprehensive and self-contained textbook presents an accessible overview of the state of the art of multivariate algorithmics and complexity. Increasingly, multivariate algorithmics is having significant practical impact in many application domains, with even more developments on the horizon. The text describes how the multivariate framework allows an extended dialog with a problem, enabling the reader who masters the complexity issues under discussion to use the positive and negative toolkits in their own research. Features: describes many of the standard algorithmic techniques available for establishing parametric tractability; reviews the classical hardness classes; explores the various limitations and relaxations of the methods; showcases the powerful new lower bound techniques; examines various different algorithmic solutions to the same problems, highlighting the insights to be gained from each approach; demonstrates how complexity methods and ideas have evolved over the past 25 years.
Case Studies in Infectious Disease: Clostridium difficile presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.
Minimize complications with Creasy and Resnik's Maternal-Fetal Medicine. This medical reference book puts the most recent advances in basic science, clinical diagnosis, and management at your fingertips, equipping you with the up-to date evidence-based guidelines and knowledge you need to ensure the best possible outcomes in maternal-fetal medicine. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Apply today’s best practices in maternal-fetal medicine with an increased emphasis on evidence-based medicine. Find dependable, state-of-the-art answers to any clinical question with comprehensive coverage of maternal-fetal medicine from the foremost researchers and practitioners in obstetrics, gynecology and perinatology. Take advantage of the most recent diagnostic advances with a new section on Obstetrical Imaging, complemented by online ultrasound clips as well as cross references and links to genetic disorder databases. Stay on top of rapidly evolving maternal-fetal medicine through new chapters on Recurrent Spontaneous Abortion, Stillbirth, Patient Safety, Maternal Mortality, and Substance Abuse, as well as comprehensive updates on the biology of parturition, fetal DNA testing from maternal blood, fetal growth, prenatal genetic screening and diagnosis, fetal cardiac malformations and arrhythmias, thyroid disease and pregnancy, management of depression and psychoses during pregnancy and the puerperium, and much more. Access the complete contents online at Expert Consult.
Cooperative game theory is a branch of (micro-)economics that studies the behavior of self-interested agents in strategic settings where binding agreements among agents are possible. Our aim in this book is to present a survey of work on the computational aspects of cooperative game theory. We begin by formally defining transferable utility games in characteristic function form, and introducing key solution concepts such as the core and the Shapley value. We then discuss two major issues that arise when considering such games from a computational perspective: identifying compact representations for games, and the closely related problem of efficiently computing solution concepts for games. We survey several formalisms for cooperative games that have been proposed in the literature, including, for example, cooperative games defined on networks, as well as general compact representation schemes such as MC-nets and skill games. As a detailed case study, we consider weighted voting games: a widely-used and practically important class of cooperative games that inherently have a natural compact representation. We investigate the complexity of solution concepts for such games, and generalizations of them. We briefly discuss games with non-transferable utility and partition function games. We then overview algorithms for identifying welfare-maximizing coalition structures and methods used by rational agents to form coalitions (even under uncertainty), including bargaining algorithms. We conclude by considering some developing topics, applications, and future research directions.
Direct and Allosteric Control of Glutamate Receptors describes in detail recent research that has demonstrated that glutamate receptors are subject to numerous modulatory controls. Significant new insights into the physiology and pathophysiology of the nervous system have been obtained by these discoveries. The sites on the receptor proteins where modulation occurs have provided a platform of opportunities for medicinal chemists to design new therapeutic modalities. These new drugs will be of major significance in treating diseases (such as stroke, Alzheimer's, epilepsy, Parkinson's, Huntington's, neurotrauma, schizophrenia, pain, and anxiety) associated with abnormal excitatory amino acid neurotransmission and function.
With your heavy case load, you can't afford to waste time searching for answers. Cardiology, 3rd Edition, by Drs. Crawford, DiMarco, and Paulus, offers you just the practical, problem-based guidance you need to quickly overcome any clinical challenge. 8 color-coded sections cover the 8 major clinical syndromes of cardiovascular disease—each section a virtual "mini textbook" on its topic! 40 new chapters keep you up to date with the latest advances in the field, while more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs capture clinical manifestations as they present in practice. It’s current, actionable information that you can put to work immediately for your patients! Offers a problem-based approach that integrates basic science, diagnostic investigations, and therapeutic management in one place for each cardiovascular disease so you can quickly find all of the actionable knowledge you need without flipping from one section to another. Features introductory bulleted highlights in each chapter that present the most pertinent information at a glance. Presents abundant algorithms to expedite clinical decision making. Includes more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs that capture clinical manifestations as they present in practice, and promote readability and retention. Includes 40 new chapters including Inherited Arrhythmia Syndromes, Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy in CHD, Management of the Cyanotic Patient with CHD, Special Problems for the Cardiology Consultant Dealing with Bariatric/Gastric Bypass — and many more — that equip you with all of the latest knowledge. Presents "Special Problem" sections—many new to this edition—that provide practical advice on problems that can be difficult to treat.
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. Discusses today’s key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer.
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