This comprehensive history shows how France coupled the pursuit of power and the furtherance of European integration over a 60 year period, from the close of the Second World War to the hesitation caused by the French electorate's referendum rejection of the European Union's constitutional treaty in 2005.
Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neuron, synapse, circuit, or entire network, and dysregulation at some or all of these levels may contribute to neuropsychiatric disorders, intellectual disability, and epilepsy. Greater mechanistic understanding of homeostatic plasticity will provide key insights into the etiology of these disorders, which may result from network instability and synaptic dysfunction. Over the past 15 years, the molecular mechanisms of this form of plasticity have been intensely studied in various model organisms, including invertebrates and vertebrates. Though once thought to have a predominantly postsynaptic basis, emerging evidence suggests that homeostatic mechanisms act on both sides of the synapse through mechanisms such as retrograde signaling, to orchestrate compensatory adaptations that maintain stable network function. These trans-synaptic signaling systems ultimately alter neurotransmitter release probability by a variety of mechanisms including changes in vesicle pool size and calcium influx. These adaptations are not expected to occur homogenously at all terminals of a pre-synaptic neuron, as they might synapse with neurons in non-overlapping circuits. However, the factors that govern the homeostatic control of synapse-specific plasticity are only beginning to be understood. In addition to our limited molecular understanding of pre-synaptic homeostatic plasticity, very little is known about its prevalence in vivo or its physiological and disease relevance. In this research topic, we aim to fill the aforementioned void by covering a broad range of topics that include: - Identification of signaling pathways and mechanisms that operate globally or locally to induce specific pre-synaptic adaptations - The nature of pre-synaptic ion channels relevant to this form of plasticity and their synapse-specific modulation and trafficking - Development and utilization of new tools or methods to study homeostatic plasticity in axons and pre-synaptic terminals - Novel mechanisms of homeostatic adaptations in pre-synaptic neurons - Postsynaptic sensors of activity and retrograde synaptic signaling systems - A comprehensive analysis of the kinds of pre-synaptic adaptations in diverse neural circuits and cell types - Identification of physiological or developmental conditions that promote pre-synaptic homeostatic adaptations - How activity-dependent (Hebbian) and homeostatic synaptic changes are integrated to both permit sufficient flexibility and maintain stable activity - Relevance of pre-synaptic homeostatic plasticity to the etiology of neuropsychiatric disorders - Computational modeling of pre-synaptic homeostatic plasticity and network stability.
Image Correlation for Shape, Motion and Deformation Measurements provides a comprehensive overview of data extraction through image analysis. Readers will find and in-depth look into various single- and multi-camera models (2D-DIC and 3D-DIC), two- and three-dimensional computer vision, and volumetric digital image correlation (VDIC). Fundamentals of accurate image matching are described, along with presentations of both new methods for quantitative error estimates in correlation-based motion measurements, and the effect of out-of-plane motion on 2D measurements. Thorough appendices offer descriptions of continuum mechanics formulations, methods for local surface strain estimation and non-linear optimization, as well as terminology in statistics and probability. With equal treatment of computer vision fundamentals and techniques for practical applications, this volume is both a reference for academic and industry-based researchers and engineers, as well as a valuable companion text for appropriate vision-based educational offerings.
The definitive biography and assessment of the wily and formidable prince who unexpectedly became monarch-the most infamous king in British history. The reign of Richard III, the last Yorkist king and the final monarch of the Plantagenet dynasty, marked a turning point in British history. But despite his lasting legacy, Richard only ruled as king for the final two years of his life. While much attention has been given to his short reign, Michael Hicks explores the whole of Richard's fascinating life and traces the unfolding of his character and career from his early years as the son of a duke to his violent death at the battle of Bosworth. Hicks explores how Richard-villainized for his imprisonment and probable killing of the princes-applied his experience to overcome numerous setbacks and adversaries. Richard proves a complex, conflicted individual whose Machiavellian tact and strategic foresight won him a kingdom. He was a reformer who planned big changes, but lost the opportunity to fulfill them and to retain his crown."--Provided by publisher.
Atlas and Synopsis of Lever's Histopathology of the Skin provides a systematic approach to diagnosing skin diseases. Written for trainees as well as experienced dermatopathologists, this text classifies skin diseases by location, reaction patterns, and cell type, if applicable. Revised and updated based on the 10th edition of Lever's Histopathology of the Skin, it greatly expands the concept of pattern recognition in differential diagnosis.
Originally published in 1974 this book examines the problems confronting the London public transport system in the 1970s. After a brief historical introduction the book then pays particular attention to planning, capital investment, co-ordination, the relationship between transport and housing, the competition between road and rail and the grants paid by central government. There are 15 case studies of significant topics ranging from station car parks to bus lanes, new tube trains to facilities for pedestrians. Although the focus is on London, many of the issues are common to other UK cities and across the world.
Between 1455 and 1485, 15th century England was ravaged by war. The dynastic struggle was between supporters of two rival branches of the royal House of Plantagenet: the houses of Lancaster and York The "Red" and "White" Roses. These books are of people and places, listing them and trying to locate their situations on maps of the counties ( Shires ).
25 ADDITIONAL CHAPTERS AVAILABLE ONLINE THE LANDMARK TEXT ON HOW TO ACHIEVE OPTIMAL PATIENT OUTCOMES THROUGH EVIDENCE-BASED MEDICATION THERAPY Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories. This edition is enriched by more than 300 expert contributors, and every chapter has been revised and updated to reflect the latest evidence-based information and recommendations. Important features such as Key Concepts at the beginning of each chapter, Clinical Presentation tables that summarize disease signs and symptoms, and Clinical Controversies boxes that examine the complicated issues faced by students and clinicians in providing drug therapy make this text an essential learning tool for students, patient-focused pharmacists, and other health care providers. NEW TO THIS EDITION: A section on personalized pharmacotherapy appears in most sections All diagnostic flow diagrams, treatment algorithms, dosing guideline recommendations, and monitoring approaches have been updated in full color to clearly distinguish treatment pathways New drug monitoring tables have been added Most of the disease-oriented chapters have incorporated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches Twenty-five online-only chapters are available at www.pharmacotherapyonline.com
The most comprehensive text available on the use of evidence-based medication therapies for optimal patient outcomes – updated with the latest breakthroughs and guidelines A Doody's Core Title for 2019! Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories. Presented in full-color, the Tenth Edition is enriched by more than 300 expert contributors, and every chapter has been updated to reflect the latest in evidence-based information and recommendations. This sweeping updates include tables, charts, algorithms, and practice guidelines. This edition is also enhanced by a timely all-new chapter on Travel Health. Here’s why this is the perfect learning tool for students, patient-focused pharmacists, and other health care providers: • All chapters have been updated to provide the most current, reliable, and relevant information possible • Key Concepts at the beginning of each chapter • Clinical Presentation Tables summarize disease signs and symptoms • Clinical Controversies Boxes examine the complicated issues faced by students and clinicians in providing drug therapy • Color coded diagnostic flow diagram, treatment algorithms, dosing recommendations, and monitoring approaches clearly distinguish treatment pathways • Most disease-oriented chapters include updated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches Edition after trusted edition, Pharmacotherapy: A Pathophysiologic Approach has been unmatched in its ability to clearly and impartially impart core pathophysiological and therapeutic elements that students and practitioners must be familiar with.
The Progressive Era, a few brief decades around the turn of the last century, still burns in American memory for its outsized personalities: Theodore Roosevelt, whose energy glinted through his pince-nez; Carry Nation, who smashed saloons with her axe and helped stop an entire nation from drinking; women suffragists, who marched in the streets until they finally achieved the vote; Andrew Carnegie and the super-rich, who spent unheard-of sums of money and became the wealthiest class of Americans since the Revolution. Yet the full story of those decades is far more than the sum of its characters. In Michael McGerr's A Fierce Discontent America's great political upheaval is brilliantly explored as the root cause of our modern political malaise. The Progressive Era witnessed the nation's most convulsive upheaval, a time of radicalism far beyond the Revolution or anything since. In response to the birth of modern America, with its first large-scale businesses, newly dominant cities, and an explosion of wealth, one small group of middle-class Americans seized control of the nation and attempted to remake society from bottom to top. Everything was open to question -- family life, sex roles, race relations, morals, leisure pursuits, and politics. For a time, it seemed as if the middle-class utopians would cause a revolution. They accomplished an astonishing range of triumphs. From the 1890s to the 1910s, as American soldiers fought a war to make the world safe for democracy, reformers managed to outlaw alcohol, close down vice districts, win the right to vote for women, launch the income tax, take over the railroads, and raise feverish hopes of making new men and women for a new century. Yet the progressive movement collapsed even more spectacularly as the war came to an end amid race riots, strikes, high inflation, and a frenzied Red scare. It is an astonishing and moving story. McGerr argues convincingly that the expectations raised by the progressives' utopian hopes have nagged at us ever since. Our current, less-than-epic politics must inevitably disappoint a nation that once thought in epic terms. The New Deal, World War II, the Cold War, the Great Society, and now the war on terrorism have each entailed ambitious plans for America; and each has had dramatic impacts on policy and society. But the failure of the progressive movement set boundaries around the aspirations of all of these efforts. None of them was as ambitious, as openly determined to transform people and create utopia, as the progressive movement. We have been forced to think modestly ever since that age of bold reform. For all of us, right, center, and left, the age of "fierce discontent" is long over.
This volume collects together Michael Freeman's work on the family and society, and the part law plays in defining, structuring and controlling it. He questions the role of family law and its interface with family values, as well as the rights and best interests of children. Responsible parenthood is examined as well as the relationship between family law and medical law, examining surrogacy and saviour siblings. On adult relations the volume centres on domestic violence, same sex marriage, and alternative dispute resolution. Finally he examines the relationship between law and religion, focusing on Jewish divorce and the role of the state. The book is essential reading for scholars and students of family law, as well as those interested in gender and patriarchy, law and feminism, rights, and dispute resolution.
On an August morning more that five hundred years ago, to the sound of thundering hooves, gunshot, the clash of steel and the cries of men in battle, Richard III, King of England, lost his life and the Plantagenet name came to an end. But what do we really know of the battle which became known as Bosworth Field? How do we separate fact from legend when our knowledge is based on sources which by any reckoning are meagre, garbled or partisan?In this classic account Michael Bennett provides as detailed and authoritative a reconstruction of the battle, and the events that led up to it, as is possible. It is an enthralling detective story uncovering the real facts behind one of the most famous of British battles.
If you administer a DNS server under Windows NT, this book will help you: understand the Domain Name System (DNS) and how it works; enhance your understanding of WINS, the Windows Internet Name Service; design your own DNS services; install and configure a DNS server; integrate DNS with WINS; create primary and secondary DNS servers; establish forwarding, caching, and slave DNS servers; configure clients for reliable name resolution; and troubleshoot DNS using tools and utilities."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
The definitive survey of diagnostic dermatopathology—and the single-best resource for addressing differential diagnosis at the microscopic level A Doody's Core Title for 2023 & 2024! For virtually every kind of skin lesion, this skill-sharpening resource has everything clinicians need to successfully perform differential diagnosis at the microscopic level. Barnhill's Dermatopathology features a systematic, algorithmic approach that cuts through the complexity of the discipline’s traditional disease-oriented focus, providing a ready-to-use diagnostic tool that puts the entire world of dermatopathology into perspective. This classic has won acclaim as the only dermatology pathology resource that is valuable for both teaching and for clinical practice and differential diagnosis. While other references may be more exhaustive, denser, or larger, none are more clinically useful as Barnhill's Dermatopathology. With 15% of the dermatology board and recertification examination consisting of dermatopathology topics, this is also an outstanding board review tool. Filled with hundreds of color photomicrographs, the book features a clear five-part organization and nearly forty detailed chapters—each reflecting the scientifically rigorous, up-to-date insights of authors who are acknowledged experts in the field. The book’s vast scope encompasses all skin disease processes—inflammatory, non-inflammatory, infections, and proliferations (harmatomas, hyperplasias, and neoplasms, plus disorders of nails and oral mucosa). Includes Online Bonus Content Increased number of full-color images Numerous tables assist clinicians differentiate similar conditions from one another NEW CHAPTERS on laboratory methods and stains, and updated immunohistochemistry content
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