Architects today are increasingly subject to the dictates of the free market, globalism, and the gradual privatization of state institutions. Indeed, pressure to alter their projects to conform to market forces and popular taste has never been greater. Must successful design correspond to the wishes of the masses? On what exactly are the trends and expectations of the general public based? Is design always a response against popular trends or can adapting to popular tendencies also generate the potential to create a better living environment?What People Want is an examination of the concept of populism by internationally known contributors such as Diller - Scofidio, Kas Oosterhuis, Bill Moggridge (IDEO), and bestselling author Thomas Frank.
What wants to be is in the process of becoming - this basic assumption reminds us that self-development cannot be forced. It should also inspire people to take the path into the open, to trust their longing for the whole and to look at the dark sides of the soul in the light of the sun. This self-experience is a journey to the heart - and from there into the open. Only when man follows the longing, he can unfold as it corresponds to his own destiny. In essay form, Michael Worsch illuminates the round horizon of his practical experiences as a psychotherapist and theater director with a view to symbolization processes.
Designed for major and non-major students taking an introductory level microbiology lab course. Whether your course caters to pre-health professional students, microbiology majors or pre-med students, everything they need for a thorough introduction to the subject of microbiology is right here.
The official tie-in to the third instalment in the legendary Planet Earth franchise Few places on Earth remain untouched by humans, creating challenges for the wildlife we share it with. We have entered a new age, and we must look at the splendour of the natural world through a different lens. From the depths of our oceans, to scorching deserts and the most remote jungles, Planet Earth III features spectacular places and surprising animal behaviours from all corners of our world. And for the first time, a human element is introduced to each landscape, highlighting how, in the age of the Anthropocene, today's planet has been forever changed by humanity and that wildlife now faces new challenges in our crowded, modern world. Featuring over 250 beautiful full-colour photographs, Planet Earth III reveals the wonders and trials of life on an increasingly fragile planet, bringing you closer than ever before to our world’s most intriguing species, unseen landscapes and natural phenomena.
This latest volume in the Current Topics in Medical Mycology series brings together internationally recognized researchers to summarize current topics of interest to medical mycologists and other scientists who are working in microbiology and immunology. A blend of contemporary, authoritative reviews and summaries of new advancements and future directions, Volume 3 aims to promote the interdisciplinary use of medically important fungi in pathogenesis, epidemiology, mycotoxins, taxonomy, and other areas where basic, applied, and clinical science are used.
This newest addition to the best-selling Microbiology: Laboratory Theory & Application series of manuals provides an excellent value for courses where lab time is at a premium or for smaller enrollment courses where customization is not an option. The Essentials edition is intended for courses populated by nonmajors and allied health students and includes exercises selected to reflect core microbiology laboratory concepts.
Get the most from your study time, and experience a realistic USMLE simulation with Rapid Review Microbiology and Immunology, 3rd Edition, by Drs. Ken S. Rosenthal and Michael J. Tan. This new reference in the highly rated Rapid Review Series is formatted as a bulleted outline with photographs, tables and figures that address all the microbiology and immunology information you need to know for the USMLE. And with Student Consult functionality, you can become familiar with the look and feel of the actual exam by taking a timed or a practice test online that includes 400 USMLE-style questions. Access all the information you need to know quickly and easily with a user-friendly, two-color outline format that includes High-Yield Margin Notes. Take a timed or a practice test online with more than 400 USMLE-style questions and full rationales for why every possible answer is right or wrong. Review the most current information with completely updated chapters, images, and questions, including a new chapter on Laboratory Tests for Diagnosis. Profit from the guidance of series editor, Dr. Edward Goljan, a well-known author of medical study references, who is personally involved in content review. Study and take notes more easily with the new, larger page size. Practice with a new testing platform on USMLE Consult that gives you a realistic review experience and fully prepares you for the exam. Review your understanding of how to interpret lab results in a new chapter on Laboratory Tests for Diagnosis.
Drawing on the work of the Roundtable on Evidence-Based Medicine, the 2007 IOM Annual Meeting assessed some of the rapidly occurring changes in health care related to new diagnostic and treatment tools, emerging genetic insights, the developments in information technology, and healthcare costs, and discussed the need for a stronger focus on evidence to ensure that the promise of scientific discovery and technological innovation is efficiently captured to provide the right care for the right patient at the right time. As new discoveries continue to expand the universe of medical interventions, treatments, and methods of care, the need for a more systematic approach to evidence development and application becomes increasingly critical. Without better information about the effectiveness of different treatment options, the resulting uncertainty can lead to the delivery of services that may be unnecessary, unproven, or even harmful. Improving the evidence-base for medicine holds great potential to increase the quality and efficiency of medical care. The Annual Meeting, held on October 8, 2007, brought together many of the nation's leading authorities on various aspects of the issues - both challenges and opportunities - to present their perspectives and engage in discussion with the IOM membership.
This volume examines the fortunes of social democracy in Western and East-Central Europe and the policy challenges it faces. By arguing that social democracy is a way of reconciling market capitalism with social inclusion and equality, they show that it h
Lippincott® Connect Featured Title Purchase of the new print edition of this Lippincott® Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. Known for generations as the most comprehensive foundational text on medical microbiology, Schaechter's Mechanisms of Microbial Disease delivers a thorough understanding of microbial agents and the pathophysiology of microbial diseases. This trusted text is universally praised for "telling the story of a pathogen" in an engaging way, facilitating learning and recall by emphasizing unifying principles and paradigms. Content is uniquely organized by microbial class and by organ system, making it equally at home in traditional and systems-based curricula. This updated 6th Edition reflects the latest advances in the field, including significant enhancements to the coverage of serious threats to global health, respiratory and childhood viruses, and sexually transmitted diseases. New illustrations and additional learning features further clarify concepts, reinforce understanding, and help users confidently prepare for board exams and beyond.
There has been an enormous advance in our understanding of the regulation of the cell division cycle in the last five years. The leap in understanding has centered on the cell cycle control protein p34cdc2 and its congeners and on the cyclins. The most important insight to emerge has been that cell cycle control mechanisms and their participating proteins are very well-conserved through evolution. This has created a spectacular growth in knowledge as data from one organism have been readily applied to another. In this volume, there are sea urchin and frog eggs, as well as mammalian cells and yeast. There is also an illustration of how fruitful the genetic approach can be in other organisms than yeast with a chapter on Aspergillus nidulans. The cell cycle kinase has been well-characterized and has also been well-exposed in numerous proceedings volumes and collections. In this issue of Advances in Molecular Cell Biology, the cell cycle kinase is ever present, but in the early chapters it has a supporting role. Center stage are the regulatory mechanisms that control the kinase. The contribution that the centrosome (the organelle of cell division) makes to cell cycle regulation are described. The part played by calcium and calcium-controlled regulatory proteins is emphasized. The importance of phosphatase as well as kinase activity to cell cycle regulation is stressed. The last words are reserved for the mitotic kinase: the last chapters describe its effects and its regulation in cell-free systems.
Have you ever wondered what could happen when we discover another communicating species outside the Earth? This book addresses this question in all its complexity. In addition to the physical barriers for communication, such as the enormous distances where a message can take centuries to reach its recipient, the book also examines the biological problems of communicating between species, the problems of identifying a non-Terrestrial intelligence, and the ethical, religious, legal and other problems of conducting discussions across light years. Most of the book is concerned with issues that could impinge on your life: how do we share experiences with ETI? Can we make shared laws? Could we trade? Would they have religion? The book addresses these and related issues, identifying potential barriers to communication and suggesting ways we can overcome them. The book explores this topic through reference to human experience, through analogy and thought experiment, while relying on what is known to-date about ourselves, our world, and the cosmos we live in.
Safe Water in Healthcare: A Practical and Clinical Guide enables users from different disciplines to understand all types of waterborne hazards that can pose a risk to those who might be exposed, the events which cause them to be present, what may precipitate an increase in their levels that may cause harm, and how they can be avoided or managed to reduce risk. The handbook highlights microorganisms that can cause infections, modes of transmission, the infections they cause, and risks. The book's authors draw from their extensive practical experience assisting with day-to-day problems that range from minor issues to outbreaks. The book includes case studies on the growth of biofilms and where they cause problems in water systems as well as providing practical answers to a majority of issues that arise in healthcare water and drainage systems. This is an accessible handbook that fills the gaps for those without technical knowledge for a complex but important area of infection control. It provides practical guidance for professionals who are required to design, manage and maintain water systems and help them manage associated infection outbreaks. - Discusses waterborne pathogens, their detection, identification and surveillance and describes the extent and range of recognized and emerging waterborne microorganisms as well as the diseases that occur and consequences to patients and staff - Covers hazards that can cause harm within water systems and associated equipment, the circumstances or factors that increase the risks, and the multiple modes of transmission of waterborne pathogens - Explains the importance of good design, including the type of design, management, hardware and software that can help manage and control the presence of waterborne pathogens. - Highlights who needs to be involved at each stage to ensure that patients are kept safe from waterborne pathogens, taking into account current legislation and best practices guidance
This issue of Clinics in Chest Medicine, edited by Dr. Michael Niederman, focuses on Pneumonia, with topics including: Inflammation and Pneumonia; The Lung Microbiome's Role in Pneumonia; Biomarkers for the Management of Pneumonia; Influenza and Viral Pneumonia; Guidelines to Manage Community-Acquired Pneumonia (CAP); Vaccines to Prevent CAP; Adjunctive Therapies for CAP; Healthcare Associated Pneumonia; Rapid Diagnostic Methods for Pneumonia; Airway Devices in VAP Pathogenesis and Prevention; Management of VAP; Distinguishing Ventilator-Associated Tracheobronchitis from VAP; Practical Approaches to VAP Prevention; Optimizing Antibiotic Administration for Pneumonia; New Antibiotics for Pneumonia; and Personalized Approach to Pneumonia Management.
Exercises for the Microbiology Laboratory, Fourth Edition by Michael J. Leboffe and Burton E. Pierce is an inexpensive, black-and-white manual that provides a concise and flexible alternative to other large microbiology laboratory manuals. It can be used by itself as a required lab text, but is also designed to be used in conjunction with A Photographic Atlas for the Microbiology Laboratory.
Case Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, followed by clinical presentation, diagnosis and treatment. Five core sets of questions are posed in each case. What is the nature of the infectious agent, how does it gain access to the body, what cells are infected, and how does the organism spread? What are the host defense mechanisms against the agent and how is the disease caused? What are the typical manifestations of the infection and the complications that can occur? How is the infection diagnosed and what is the differential diagnosis? How is the infection managed, and what preventative measures can be taken to avoid infection? This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms, fully integrating microbiology and immunology throughout.
The Handbook of Environmental Health-Biological, Chemical and Physical Agents of Environmentally Related Disease, Volume 1, Fourth Edition includes twelve chapters on a variety of topics basically following a standard chapter outline where applicable with the exception of chapters 1, 2 and 12. The outline is as follows:1. Background and status2. Sc
This work looks at the process of European integration by focusing on interest intermediation in the European Community. In order to characterize and explain various patterns of interest intermediation, the author employs a modified, neo-institutionalist approach. This framework provides a coherent picture of interest intermediation and explains the variety of bargaining patterns and interest group participation in EC policy-making. This study also looks at issues important to the future of the European Union, focusing on policy-making, governance, and fair distribution of costs and benefits of integration. Euro-Corporation? will interest students and scholars of international relations, regional integration, European politics and European integration, interest groups, and industrial relations.
Case Studies in Infectious Disease: Neisseria meningitidis presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.
Clinical Chemistry: Principles, Techniques, and Correlations, Enhanced Eighth Edition demonstrates the how, what, why, and when of clinical testing and testing correlations to help you develop the interpretive and analytic skills you’ll need in your future career.
Case Studies in Infectious Disease: Staphylococcus aureus presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.
Covering the latest advances in CNS drug development, this bookwill guide all those involved in pre-clinical to early clinicaltrials. The authors describe how recent innovations can acceleratethe development of novel CNS compounds, improve early detection ofefficacy and toxicity signals, and increase the safety oflater-stage clinical trials. The current crisis in the drug development industry iscritically reviewed, as well as the steps needed to correct theproblems, including new government-backed regulations andindustry-based innovations designed to accelerate CNS drugdevelopment in the future. Animal-based models of major CNS disorders are described indetail, and the ability of the latest in vitro and computer-basedmodels to simulate CNS disease states and predict drug efficacy andside-effects are examined. Particular attention is given tothe growing use of biomarkers and how they can be used effectivelyin early human trials as signals of potential drug efficacy, aswell as the increasingly important role of imaging studies to guidedose selection. Cognitive assessments that can be useful indicatorsof effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drugtrials for over 20 years, and based on a wealth of drug developmentand clinical trial experience, Critical Pathways to Success inCNS Drug Developmentis full of practical advice forsuccessfully designing and executing CNS drug trials, avoidingpotential pitfalls, and complying with government regulations
50th Anniversary Edition of the groundbreaking case-based pharmacotherapy text, now a convenient two-volume set. Celebrating 50 years of excellence, Applied Therapeutics, 12th Edition, features contributions from more than 200 experienced clinicians. This acclaimed case-based approach promotes mastery and application of the fundamentals of drug therapeutics, guiding users from General Principles to specific disease coverage with accompanying problem-solving techniques that help users devise effective evidence-based drug treatment plans. Now in full color, the 12th Edition has been thoroughly updated throughout to reflect the ever-changing spectrum of drug knowledge and therapeutic approaches. New chapters ensure contemporary relevance and up-to-date IPE case studies train users to think like clinicians and confidently prepare for practice.
Advances in Pediatrics reviews the most current practices in pediatrics. A distinguished editorial board, headed by Dr.Michael Kappy, identifies key areas of major progress and controversy and invites expert pediatricians to contribute original articles devoted to these topics. These insightful overviews bring concepts to a clinical level and explore their everyday impact on patient care. Topics such as fetal diagnosis and surgical intervention, updates in pharmacology, and fatty liver disease are represented, highlighting the most current and relevant information in the field.
Case Studies in Infectious Disease: Streptococcus pneumoniae presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.
A reassessment of the military's role in developing the Western territories moves beyond combat stories and stereotypes to focus on more non-martial accomplishments such as exploration, gathering scientific data, and building towns.
The Fifth Edition of Greenfield's Surgery has been thoroughly revised, updated, and refocused to conform to changes in surgical education and practice. Reflecting the increasingly clinical emphasis of residency programs, this edition features expanded coverage of clinical material and increased use of clinical algorithms. Key Points open each chapter, and icons in the text indicate where Key Points are fully discussed. Many of the black-and-white images from the previous edition have been replaced by full-color images. This edition has new chapters on quality assessment, surgical education, and surgical processes in the hospital. Coverage of surgical subspecialty areas is more sharply focused on topics that are encountered by general surgeons and included in the current general surgery curriculum and ABSITE exam. The vascular section has been further consolidated. A new editor, Diane M. Simeone, MD, PhD, has joined the editorial team. This edition is available either in one hardbound volume or in a four-volume softbound set. The lightweight four-volume option offers easy portability and quick access. Each volume is organized by organ system so you can find the facts you need within seconds. The companion website presents the fully searchable text, an instant-feedback test bank featuring over 800 questions and answers, and a comprehensive image bank. Unique to this new edition's website are 100 "Morbidity and Mortality" case discussions. Each case reviews a specific surgical complication, how the complication was addressed, and reviews the literature on approaches and outcomes.
The two-volume Handbook of Environmental Health, Fourth Edition provides a comprehensive but concise discussion of important environmental health areas, including energy, ecology and people, environmental epidemiology, risk assessment and risk management, environmental law, air quality management, food protection, insect control, rodent control, pe
Observations Plus Recipes It has been said that science is the orderly collection of facts about the natural world. Scientists, however, are wary of using the word ‘fact. ’ ‘Fact’ has the feeling of absoluteness and universality, whereas scientific observations are neither ab- lute nor universal. For example, ‘children have 20 deciduous [baby] teeth’ is an observation about the real world, but scientists would not call it a fact. Some children have fewer deciduous teeth, and some have more. Even those children who have exactly 20 deciduous teeth use the full set during only a part of their childhood. When they are babies and t- dlers, children have less than 20 visible teeth, and as they grow older, children begin to loose their deciduous teeth, which are then replaced by permanent teeth. ‘Children have 20 deciduous [baby] teeth’ is not even a complete scientific sta- ment. For one thing, the statement ‘children have 20 deciduous teeth’ does not tell us what we mean by ‘teeth. ’ When we say “teeth,” do we mean only those that can seen be with the unaided eye, or do we also include the hidden, unerupted teeth? An observation such as ‘children have 20 deciduous teeth’ is not a fact, and, by itself, it is not acceptable as a scientific statement until its terms are explained: scientifically, ‘children have 20 deciduous teeth’ must be accompanied by definitions and qualifiers.
Tap into the gold standard on central nervous system infections: Infections of the Central Nervous System, 4e is now fully revised and updated to accommodate the wealth of new CNS information discovered over the past decade. More than 90 leading experts contribute chapters, providing comprehensive, up-to-date information. With a broad scope and thorough detail, the text addresses pathogenesis, clinical manifestations, diagnosis, and therapy of various CNS infections and related conditions. Features: Every chapter has been extensively revised and updated, nearly half with new author teams NEW chapter on acute encephalitis NEW clinical information on treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease NEW color design and color images Numerous diagrams, figures, tables, illustrations and photographs demonstrate the content Evidence-based references
Enzymes as Targets for Drug Design is a collection of scientific discussions related to enzyme inhibitors that show the many facets of the drug discovery process from the basic sciences through clinical applications. Topics include the biogenesis of phosphatidylinositol glycosyl membrane proteins, structure and catalytic function of ADP-ribose polymerase (ADPRT), and modulation of the dopaminergic system in cardiovascular therapeutics. The therapeutic utility of selected enzyme-activated irreversible inhibitors, the role of proteinases in the fibrosis of systemic sclerosis, and therapeutic opportunities in eicosanoid biosynthesis are also discussed. This book consists of 18 chapters and begins with examples of enzymes whose activities have recently been elucidated, or for which newer insights have been gleaned, but which do not yet have selective or potent inhibitors. The second part provides examples of enzymes where inhibitors have been identified but it is still not clear whether or not such an enzymatic blockade will be therapeutically beneficial. The final section describes clinical studies of newer, and not so new, enzyme inhibitors that are clearly of therapeutic importance. The therapeutic activity of monoamine oxidase inhibitors and the associated clinical issues are considered. This book is intended for clinicians as well as basic scientists in biochemistry, chemistry, pharmacology, and cell biology.
This issue of Orthopedics Clinics will be surveying a broad range of topics across sub-specialty areas on Evidence-based Medicine in Orthopedics. Each issue in the series is edited by an experienced team of surgeons from the Campbell Clinic. Articles will discuss the following topics, among others: Use of Tourniquets in Limb Trauma Surgery; Cerebral Palsy; Injection therapies for rotator cuff disease; Antibiotic prophylaxis in shoulder and elbow surgery; venous thromboembolism prophylaxis in shoulder surgery; Patient Reported Outcomes in Foot and Ankle Surgery; and VTED prophylaxis in foot and ankle surgery.
For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.
Highly regarded by anesthesiologists, residents, and nurse anesthetists, Essence of Anesthesia Practice, 4th Edition by Drs. Lee A. Fleisher, Michael F. Roizen, and Jeffrey Roizen, is a trusted resource for point-of-care anesthesia management. Concise, easy-to-find summaries cover a single clinical topic for both common and rare conditions. A renewed focus on diseases and drugs makes this edition even more useful when formulating anesthesia plans and mastering the core knowledge of anesthesia practice. - Features a unique, easy-to-follow, consistent format that covers a single clinical topic on each page, with a review of its problems, causes, comorbidities, and anesthesia implications. - Helps you understand the interactions of common drugs and alternative medicine so that you can develop effective anesthesia plans. - Includes more than 105 new disease topics (with more coverage of rarer diseases) and new drug information featuring 20 new drugs that patients take on an outpatient basis. - Offers fresh insights on nearly 550 topics – many authored by new contributors to this edition. - Keeps you current with the latest perioperative anesthetic implications including anticipated problems, drug interactions, and special concerns. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. - Provides a single source of information on lung epithelial junctions and transporters - Discusses of the role of the epithelium in lung homeostasis and disease - Includes capsule summaries of main conclusions as well as highlights of future directions in the field - Covers the mechanistic basis for lung disease for a range of audiences
Encyclopedic presentation of the clinical applications of biomaterials from markets and advanced concepts to pharmaceutical applications and blood compatibility.
This concise textbook of dermatology is aimed at medical students, those preparing for the MRCP and MRCGP examinations and specialist nurses. The information is presented in a highly accessible format, using double page spreads for each topic. Extensive use of colour for both clinical photographs and graphics makes for a superb appearance. For review for examination preparation key point boxes are provided. In this fourth edition extensive revision has been made to the contents to reflect changes in the understanding of dermatological conditions at a molecular level and the changes in clinical practice. In addition the use of the internet for dermatological information by both doctors and patients is reviewed. Information presented in easy to access double-page spreads. Highly illustrated with full colour photographs and graphics. Summary boxes for examination preparation. Covers the subject from basic molecular mechanisms through to the principles of medical and surgical treatment. Gives references to internet URLs for further information. Includes a glossary of dermatological terms. New co-author introduced for the fifth edition.
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