Thermodynamics of Membrane Receptors and Channels synthesizes a wealth of new information regarding the biophysics of membrane proteins. New insights provided by molecular genetics, single channel recording, and high resolution structural techniques are discussed from a conceptual perspective. Basic theoretical topics are introduced, developed, and then extensively illustrated with recent results from the literature or data from the authors' own laboratories. Theoretical and experimental information is incorporated into in-depth discussions of ion permeation mechanisms, ion channel and receptor conformational changes, aggregate activity of complexes of lipids and proteins, and how coupling is achieved between different energy modes in the many transduction systems residing in biomembranes. Thermodynamics of Membrane Receptors and Channels will be valuable both as a learning aid and a reference for biophysicists, neuroscientists, cell biologists, physiologists, and other researchers investigating any aspects of biomembranes.
The study of the biological effects of foreign chemicals (whether therapeutic drugs or chemicals present at work or in the environment) interests the biologist from a number of different and complementary viewpoints. Apart from the more obvious pharmacological and toxicological interest, the experimentalist often uses foreign chemicals to produce in experimental animals disease states similar to naturally occurring diseases, so that their pathogenetic mechanisms and therapy can be studied under controlled conditions. In addition - as Claude Bernard pointed out over a century ago - foreign chemicals can be employed as instruments to analyze the most delicate vital processes; much can be learned about the physiological processes themselves by a careful study of the mechanisms by which these are altered by chemicals. The field of heme and hemoproteins offers an example of the interplay of these different approaches. Their metabolism can be altered by therapeutic drugs and other foreign chemicals and this results in a variety of biological responses that transcend the boundaries of pharmacology into the confines of clinical medi cine, genetics, toxicology, biochemistry and physiology. In this book a multidisciplinary approach to the study of heme metabolism is presented including the effect of chemicals on heme metabolism in patients, the results of experimental work in the whole animal, as well as in vitro studies.
The bestselling business book from award-winning restauranteur Danny Meyer, of Union Square Cafe, Gramercy Tavern, and Shake Shack Seventy-five percent of all new restaurant ventures fail, and of those that do stick around, only a few become icons. Danny Meyer started Union Square Cafe when he was 27, with a good idea and hopeful investors. He is now the co-owner of a restaurant empire. How did he do it? How did he beat the odds in one of the toughest trades around? In this landmark book, Danny shares the lessons he learned developing the dynamic philosophy he calls Enlightened Hospitality. The tenets of that philosophy, which emphasize strong in-house relationships as well as customer satisfaction, are applicable to anyone who works in any business. Whether you are a manager, an executive, or a waiter, Danny’s story and philosophy will help you become more effective and productive, while deepening your understanding and appreciation of a job well done. Setting the Table is landmark a motivational work from one of our era’s most gifted and insightful business leaders.
First published in 1989: State-of-the-art information on the topic of clinical thrombosis, including an introductory portion dealing with the principles of hemostasis and the pathogenesis of thrombosis, is presented in this text. The use of thrombolytic therapy in acute myocardial infarction is discussed. Other significant advances, such as the identification and understanding of the risk factors contributing to thrombosis such as Protein C and S deficiency, lupus anticoagulants, immune heparin-induced thrombocytopenia, new diagnostic techniques and newer modalities of therapy, are described. Clinical and pathophysiologic features of thrombosis disorders and special situations involving multiple organs are covered. This book also clarifies and updates the usefulness of the various diagnostic techniques.
Blood is more than a fluid solution of cells, platelets and plasma. It is a symbol for the most basic of human concerns--life, death and family find expression in rituals surrounding everything from menstruation to human sacrifice. Comprehensive in its scope and provocative in its argument, this book examines beliefs and rituals concerning blood in a range of regional and religious contexts throughout human history. Meyer reveals the origins of a wide range of blood rituals, from the earliest surviving human symbolism of fertility and the hunt, to the Jewish bris, and the clitoridectomies given to young girls in parts of Africa. The book also explores how cultural practices influence gene selection and makes a connection with the natural sciences by exploring how color perception influences the human proclivity to create blood symbols and rituals.
The mystery of life puzzles all of us. Marianne Meyer had her first out-of-body experience at age two. Not being able to make herself understood led to a seeker's life. The confusing n o t h i n g called time drifts us relentless toward the end. As long as the brain makes connections we can leap back and forth in time. From infancy to middle age and back, the author scavenges tidbits from those times and transfers them to the presence. Shortly after moving from Frankfurt to L. A., Marianne met her great-grandfather on a higher level of consciousness. She was told he had migrated to USA, took on the last name Victor and lived in the Carmel area. He had left his homeland after creating the child of love on Christmas 1901. Wilhelmina Meckes was married in a hurry, in vindication of honor, and on October 5, Maria Hörr was born as a credited 7 month child. A few years ago, Marianne learned about her mother's family relationship with the Carmel resident Doris Day! Both their grandmothers descended from J. J. Mann and M. E. Nollert and grew up in Neckarhäuserhof, a tiny village near Heidelberg. The synchronicity of both her parents' relatives living in Carmel Mrs. Meyer views as an appeal to go forward with searching for her father's family members. She still has a clear vision of her incorporeal ancestor. Will she find a picture of him in photo albums of a Victor family living in or near Carmel? Enthralling, Marianne portrays her exciting life in India, USA, South Pacific, Africa and Europe. Proving prophecy, past lives and synchronizes, Dr. Meyer presents metaphysics as the true science and shows how she heals herself and her pets. She also uncovers how she cracks the mysterious water code via exploring water crystal photos. Marianne wishes men to fast progress on the way of knowledge. That would be likely if scientists would go out on a limb, rid themselves of blinders and examine life without preconceptions just like children. She is inspired by a pioneering spirit and a passionate dedication on the well-being of the people and the animals. Therefore, 50 cents of each sold copy goes to DDAF and two pounds.
Molecular and Cellular Biophysics provides advanced undergraduate and graduate students with a foundation in the basic concepts of biophysics. Students who have taken physical chemistry and calculus courses will find this book an accessible and valuable aid in learning how these concepts can be used in biological research. The text provides a rigorous treatment of the fundamental theories in biophysics and illustrates their application with examples. Conformational transitions of proteins are studied first using thermodynamics, and subsequently with kinetics. Allosteric theory is developed as the synthesis of conformational transitions and association reactions. Basic ideas of thermodynamics and kinetics are applied to topics such as protein folding, enzyme catalysis and ion channel permeation. These concepts are then used as the building blocks in a treatment of membrane excitability. Through these examples, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems.
Poverty among the elderly is sharply gendered—women over sixty-five are twice as likely as men to live below the poverty line. Older women receive smaller Social Security payments and are less likely to have private pensions. They are twice as likely as men to need a caregiver and twice as likely as men to be a caregiver. Recent efforts of some in Washington to reduce and privatize social welfare programs threaten to exacerbate existing gender disparities among older Americans. They also threaten to exacerbate inequality among women by race, class, and marital status. Madonna Harrington Meyer and Pamela Herd explain these disparities and assess how proposed policy reforms would affect inequality among the aged. Market Friendly or Family Friendly? documents the cumulative disadvantages that make it so difficult for women to achieve economic and health security when they retire. Wage discrimination and occupational segregation reduce women's lifetime earnings, depressing their savings and Social Security benefits. While more women are employed today than a generation ago, they continue to shoulder a greater share of the care burden for children, the disabled, and the elderly. Moreover, as marriage rates have declined, more working mothers are raising children single-handedly. Women face higher rates of health problems due to their lower earnings and the high demands associated with unpaid care work. There are also financial consequences to these family and work patterns. Harrington Meyer and Herd contrast the impact of market friendly programs that maximize individual choice, risk, and responsibility with family friendly programs aimed at redistributing risks and resources. They evaluate popular policies on the current agenda, considering the implications for inequality. But they also evaluate less discussed policy proposals. In particular, minimum benefits for Social Security, as well as credits for raising children, would improve economic security for all, regardless of marital status. National health insurance would also reduce inequality, as would reforms to Medicare, particularly increased coverage of long term care. Just as important are policies such as universal preschool and paid family leave aimed at reducing the disadvantages women face during their working years. The gender gaps that women experience during their work and family lives culminate in income and health disparities between men and women during retirement, but the problem has received scant attention. Market Friendly or Family Friendly? is a comprehensive introduction to this issue, and a significant contribution to the debate over the future of America's entitlement programs. A Volume in the American Sociological Association's Rose Series in Sociology
In Nicholas Meyer's The Return of the Pharaoh, Sherlock Holmes returns in an adventure that takes him to Egypt in search of a missing nobleman, a previously undiscovered pharaoh's tomb, and a conspiracy that threatens his very life. With his international bestseller, The Seven Per Cent Solution, Nicholas Meyer brought to light a previously unpublished case of Sherlock Holmes that reinvigorated the world's interest in the first consulting detective. Now, many years later, Meyer is given exclusive access to Dr. Watson's unpublished journal, wherein he details a previously unknown case. In 1910, Dr. John Watson travels to Egypt with his wife Juliet. Her tuberculosis has returned and her doctor recommends a stay at a sanitarium in a dry climate. But while his wife undergoes treatment, Dr. Watson bumps into an old friend--Sherlock Holmes, in disguise and on a case. An English Duke with a penchant for egyptology has disappeared, leading to enquiries from his wife and the Home Office. Holmes has discovered that the missing duke has indeed vanished from his lavish rooms in Cairo and that he was on the trail of a previous undiscovered and unopened tomb. And that he's only the latest Egyptologist to die or disappear under odd circumstances. With the help of Howard Carter, Holmes and Watson are on the trail of something much bigger, more important, and more sinister than an errant lord.
“A well-researched and thorough book examining what the author finds to be a unique facet of film music of the late 1940s and early 1950s.” —Soundtrax Lavish musical soundtracks contributed a special grandeur to the new widescreen, stereophonic sound movie experience of postwar biblical epics such as Samson and Delilah, Ben-Hur, and Quo Vadis. In Epic Sound, Stephen C. Meyer shows how music was utilized for various effects, sometimes serving as a vehicle for narrative plot and at times complicating biblical and cinematic interpretation. In this way, the soundscapes of these films reflected the ideological and aesthetic tensions within the genre, and more generally, within postwar American society. By examining key biblical films, Meyer adeptly engages musicology with film studies to explore cinematic interpretations of the Bible during the 1940s through the 1960s. “A major contribution to the field of film music studies and ought to be widely read by musicologists with an interest in film. Really, it ought to be read by film scholars as well: although the depth of Meyer’s engagement with the music is felt on almost every page, this is also a powerfully sustained exploration of the biblical epic as a film genre.” —American Music “Meyer’s clear and articulate study promises to be a welcome addition to the reading list of anyone interested not just in film but in mid-century music history.” —Journal of the Society for American Music “An ambitious and fascinating book.” —James Buhler, The University of Texas at Austin
This book brings together information on fear and anxiety disorders from many disciplines, including ethology, genetics, biochemistry, physiology, pharmacology, psychology, and psychiatry.
Rediscover the simple pleasures of a day trip with Day Trips from Kansas City. Packed with full trip-planning information for hundreds of exciting things for locals and vacationers to do, see, and discover—all within a two-hour drive of the Kansas City metro area—Day Trips from Kansas City helps locals and vacationers make the most of a brief getaway.
In the first years of the existence of this series of monographs, during the so-called "Golden Age" of drug research, the majority of the pa pers published were mainly concerned with the traditional domains of drug research, namely chemistry, pharmacology, toxicology and pre clinical investigations. The series' aim was to give coverage to impor tant areas of research, to introduce new active substances with thera peutic potential and to call attention to unsolved problems. This objective has not changed. The table of contents of the present volume makes evident, however, that the search for new medicines has become increasingly complex, and additional, new disciplines have entered the research arena. The series now includes reviews on bio chemical, biological, immunological, physiological and medicinal aspects of drug research. Researchers actively engaged in the various scientific fields forming the entity of drug research can benefit from the wealth of knowledge and experience of the respective authors, and will be assisted in their endeavour to discover new pharmaceutical agents. Those simply wanting to keep abreast of new developments in the complex, multi-discipline science can turn to the "Progress in Drug Research" volumes as an almost encyclopaedic source of information without having to consult the innumerable original publications. Volume 32 contains 12 reviews, a subject index, an index for the close to 400 articles published in the series so far, and an author and titles index for all 32 volumes.
Racism in Contemporary America is the largest and most up-to-date bibliography available on current research on the topic. It has been compiled by award-winning researcher Meyer Weinberg, who has spent many years writing and researching contemporary and historical aspects of racism. Almost 15,000 entries to books, articles, dissertations, and other materials are organized under 87 subject-headings. In addition, there are author and ethnic-racial indexes. Several aids help the researcher access the materials included. In addition to the subject organization of the bibliography, entries are annotated whenever the title is not self-explanatory. An author index is followed by an ethnic-racial index which makes it convenient to follow a single group through any or all the subject headings. This is a source book for the serious study of America's most enduring problem; as such it will be of value to students and researchers at all levels and in most disciplines.
This is a book that needed to be written. Eric Cantor’s defeat was not only shocking but it runs against everything we teach in our election courses. By extracting the lessons from Cantor’s defeat, Slingshot helps to inform our more general understanding of campaigns & elections." -Professor Kirby Goidel, Texas A&M University Incumbents don′t lose. So how did nationally prominent House Majority Leader Eric Cantor lose a primary battle to college professor David Brat, an unknown political rookie? In Slingshot: The Defeat of Eric Cantor, authors Lauren Cohen Bell, David Elliot Meyer and Ronald Keith Gaddie take advantage of exceptional behind-the-scenes access to the Brat campaign to explain the challenger’s victory. They examine the essential need for elected officials to maintain strong support in their home districts and just how Cantor’s focus on climbing the party ranks in Washington contributed to his loss. They also show how local "rules of the game" —particularly voter mobilization in this case—affect elections, and they explore the continuing impact of the Tea Party and its role in the factionalism of current Southern politics.
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