This collection of essays from Nobel Laureate Max Perutz explores a wide range of scientific and personal topics with insight and lucidity. It includes lively anecdotes about key figures in 20th-century science.
Linus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphous replacement with heavy atoms which led to the first protein structures, haemoglobin and its simpler relative myoglobin. Later papers deal with the stereochemistry of the cooperative effects of haemoglobin, with the relationships between the structures and impaired functions of abnormal haemoglobin, with species adaptation of haemoglobin, and with its action as a drug receptor and as an oxygen sensor. The final papers deal with amino acid repeats which act as polar zippers and their role in certain inherited neurodegenerative diseases.
This collection of essays from Nobel Laureate Max Perutz explores a wide range of scientific and personal topics with insight and lucidity. It includes lively anecdotes about key figures in 20th-century science.
This work offers succinct, medically-oriented coverage of biochemistry, examining biologically important materials and presenting the properties of nucleic acids as well as nucleic acid metabolism. Each metabolic process is integrated in a review of overall energy metabolism, diabetes and starvation. A solutions manual is available to instructors only.
The first substantial history and analysis of the To-Day and To-Morrow series which published 110 books from 1923 to 1931 and included works by J. B. S. Haldane, Bertrand Russell, Vernon Lee, Robert Graves, Vera Brittain, Sylvia Pankhurst, Hugh MacDiarmid, James Jeans, J. D. Bernal, Winifred Holtby, and Andre Maurois.
Max Perutz, who won the Nobel Prize for chemistry in 1962 has made major contributions in the field of molecular biology, and particularly on the structure and functions of proteins and nucleic acids. In this book, aimed at the general reader, he examines the role of science in society, and makes a powerful case for the essential benevolence and humanizing influence of the scientific process in its approach to the great problems of our world. He takes us into the three main areas in which science and human problems interact, the areas of food-production, health and medicine, and energy. In each case the problems we face - for example the endemic undernourishment and near-starvation throughout the third world, the unsolved problems of cancer and heart disease, the total dependence of our civilization on dwindling fossil-fuel supplies - are still, in his view, susceptible to scientific solutions.
Linus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphous replacement with heavy atoms which led to the first protein structures, haemoglobin and its simpler relative myoglobin. Later papers deal with the stereochemistry of the cooperative effects of haemoglobin, with the relationships between the structures and impaired functions of abnormal haemoglobin, with species adaptation of haemoglobin, and with its action as a drug receptor and as an oxygen sensor. The final papers deal with amino acid repeats which act as polar zippers and their role in certain inherited neurodegenerative diseases.
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