Linus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphous replacement with heavy atoms which led to the first protein structures, haemoglobin and its simpler relative myoglobin. Later papers deal with the stereochemistry of the cooperative effects of haemoglobin, with the relationships between the structures and impaired functions of abnormal haemoglobin, with species adaptation of haemoglobin, and with its action as a drug receptor and as an oxygen sensor. The final papers deal with amino acid repeats which act as polar zippers and their role in certain inherited neurodegenerative diseases.
Corden has written a charming and insightful account of his professional and personal life, from his childhood in Breslau, Germany, until his retirement in Melbourne. The book is divided into two parts. Part I considers Corden's early life, from a young boy growing up in Nazi Germany, to his immigration from England to Australia and what that means for the author's self-identity. Part II addresses Corden's work on the Australian Protection Policy for which he is perhaps best known, before reflecting upon the author's time at Oxford University and the Australian National University, and, finally, moving on to review contributions made at the IMF, Johns Hopkins University, and The World Bank. This book will be of interest to all aspiring economists, as well as established economists familiar with Corden's work. It is an inspiring and profound record of the intellectual journey made by one of Australia's best known economists.
This unique resource provides practice tested forms and up-to-date expert guidance for successfully launching private placement investment transactions. The authors illustrate a variety of proven techniques for raising capital and explain ways to accommodate the investor's demands for protection while maintaining the flexibility necessary for efficient operation and growth in today's business and regulatory environment.Raising Capital: Private Placement Forms, Third Edition contains a wealth of essential forms, entity formation agreements, investment agreements and instruments, debt financing forms, investor agreements, and materials relating to the federal securities laws. This book also includes a chapter addressing environmental concerns, and a new chapter on privacy concerns, as well as chapters on: IncorporationStock ProvisionsExemptions for Registration Under Federal Securities laws: Regulati
As the first decade of the twenty-first century has made brutally clear, the very definitions of war and the enemy have changed almost beyond recognition. Threats to security are now as likely to come from armed propagandists, popular militias, or mercenary organizations as they are from conventional armies backed by nation-states. In this timely book, national security expert Max G. Manwaring explores a little-understood actor on the stage of irregular warfare—the gang. Since the end of the Cold War, some one hundred insurgencies or irregular wars have erupted throughout the world. Gangs have figured prominently in more than half of those conflicts, yet these and other nonstate actors have received little focused attention from scholars or analysts. This book fills that void. Employing a case study approach, and believing that shadows from the past often portend the future, Manwaring begins with a careful consideration of the writings of V. I. Lenin. He then scrutinizes the Piqueteros in Argentina, gangs in Colombia, private armies in Mexico, Hugo Chavez’s use of popular militias in Venezuela, and the looming threat of Al Qaeda in Western Europe. As conventional warfare is increasingly eclipsed by these irregular and “uncomfortable” wars, Manwaring boldly diagnoses the problem and recommends solutions that policymakers should heed.
New insights for understanding and combating Al Qaeda and other contemporary security threats Wars were once fought mainly between nations—a presumption put to rest on September 11, 2001. Al Qaeda showed that nonstate actors could threaten a traditional nation-state and pursue strategic objectives without conventional weaponry, thereby altering the nature of war and often rendering military firepower meaningless. National security expert Max G. Manwaring examines the emergence of nonstate actors in a geopolitical world. Manwaring invites policy makers to look past familiar insurgencies such as those in Vietnam and Iraq and consider global security problems from multiple perspectives. He concludes that the use of calculated political and psychological power may be the most effective response in many situations. The power to make war no longer rests solely in the hands of traditional governments. Manwaring analyzes the context, conduct, and outcome of today’s irregular wars and applies proven methods of effective response to seven case studies: Colombia, Al Qaeda, Portugal, Uruguay, Venezuela, Italy, and Central American gangs and criminal organizations. Insurgency, Terrorism, and Crime translates the cogent lessons of recent events into workable strategies for tomorrow’s leaders. This book is required reading for students of national security policy and foreign-policy analysis.
In "Migräne, Mörderpuppe - Bericht einer Schmerzpille" begleiten wir den zielstrebigen Max, der von Migräne geplagt wird und in die Fänge einer Tablettenabhängigkeit gerät. Auf dem Höhepunkt seiner Sucht landet er in einer Schmerzklinik. Dort trifft er auf unkonventionelle Mitpatient*innen und begegnet der rätselhaften Mörderpuppe. Ein einzigartiger Twist: Die Geschichte wird aus der Sicht von Almo, einer aufgeweckten Schmerztablette, erzählt. Kann Max seine Sucht überwinden und sein Leben umkrempeln?
Departing from conventional policy rhetoric on the unconventional "new world disorder," Max G. Manwaring, Wm. J. Olson, and their colleagues here build upon Ambassador David C. Miller, Jr.'s three pillars of success for foreign policy and military management. They provide a sound intellectual road map through the dense fog of the contemporary inter
A comprehensive reference on diabetes mellitus, covering basic biochemistry, physiology, and pathogenesis, as well as clinical diagnosis and treatment. The Sixth Edition includes five new chapters, plus new material on the genetic basis of the disease, new hypoglycemic drugs, mechanisms of hormone action, and regulation of hormone secretion.
The Oxford Handbook of Complementary Medicine presents evidence-based information on CAM in an easily accessible form, thereby enabling hospital doctors, GPs, nurses, medical students and other healthcare professionals to competently advise patients about CAM treatments. The book covers definitions, cost, safety, regulation, legal and ethical questions and a range of practical issues, diagnostic techniques, and risk-benefit assessments of CAM modalities. The main part of the book is organised by condition, outlining for each the CAM treatments available, ranked according to level of evidence of effectiveness, followed by a concise clinical bottom line assessing risks and benefits, also in relation to conventional treatment. The information is presented in a concise, matter-of-fact fashion, avoiding the obscure jargon sometimes used in CAM. Many issues surrounding CAM remain controversial and this handbook discusses them openly and critically.
The Oxford Handbook of Palliative Care covers all aspects of palliative care in a concise and succinct format suited to busy professionals who need to access key information in their daily care of patients. This new edition is revised throughout, with an additional emphasis on the nursing aspects of Palliative Care. The authors have included new sections on international palliative care, self care and liaison palliative care in acute hospitals. There is also extended material on the use of antibiotics, palliative care research and quality of life issues. The second edition of the Oxford Handbook of Palliative Care continues to be an invaluable resource for all health professionals working with adults, children and families with palliative care needs.
This is the fifth edition of a comprehensive textbook on the immune system and its mechanisms. With this edition, the tradition established by Max Samter is carried on by his colleagues and former students, along with leading scientists, researchers and physicians from the USA, UK, France, Spain, Austria and Israel. Firm editorial control has ensured that this text is a current resource: the extensive reference lists are up-to-date as of 1993 and the book has been revised and reorganized throughout to reflect the changing face of immunology.
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