This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.
The author of the Commissario Ricciardi series “manages to conjure up the terrifying darkness at the heart of a serial killer in this chilling procedural” (Publishers Weekly, starred review). The chaotic, shadowy city of Naples proves the perfect hunting ground for a killer dubbed “The Crocodile” by the press. Like a crocodile, when he devours his own children, he cries. And like a crocodile he is a perfect killing machine: He waits and watches until his prey is within range, and then he strikes. Three young people with very diverse backgrounds have been found murdered in three different neighborhoods, each shot with a single bullet, execution style. While his colleagues see little or no connection, Inspector Giuseppe Lojacono, smells a rat. Once an esteemed member of the mobile unit of the Agrigento police force, Lojacono was accused of leaking sensitive information to the mob and has now lost everything—first and foremost the love of his wife and daughter. But now he’s been given a second chance and a shot at clearing his name. A young magistrate has heard of his preternatural skills and his incredible powers of observation and she thinks a man like him is needed in Naples. So it is that Inspector Lojacono is charged with finding the link between the three dead bodies. At the root of these murders, he will discover, is a pain that still burns, a sense of guilt than cannot be purged, and one all-consuming love. “A wonderfully suspenseful novel in which de Giovanni restores life to the cliché of the world-weary detective.” —Kirkus Reviews (starred review) “Offers an elegant narrative and vividly rendered characters. It’s genuinely seductive.” —Booklist
The hospitality model called "Albergo Diffuso" (AD), or "scattered hotel," has been engneered by Mr Giancarlo Dall'Ara and described by The New York Times as a way of bringing life back to historic towns and rural hamlets by utilizing unused rooms for tourism. This "simple but genial" model devised in Italy in the mid-90's received an award from the UNDP for its sustainability, but despite the spread of AD's, no peer-reviewed books have previously been published in English focusing on this innovation. In this book, the author therefore begins by exploring the AD as a community-based hospitality model, examining both its pros and cons. He then considers conviviality, sense of security, and other factors that Hans Magnus Enzensberger referred to as luxuries of our time for urban dwellers. These represent the key pre-requisites a location must possess to be deemed suitable for this innovation. Next, investors and co-interested private, public and not-for-profit associations are provided with a structured framework to help them achieve a defensible competitive advantage by harnessing the economic potential of valuable, rare, inimitable and non-substitutable (VRIN) resources. The final section assesses the AD as a business model, evaluating various aspects at the heart of any business plan.
Economics has not given sufficient attention to the microeconomic analysis of innovation and technological change. Counteracting this imbalance, The Microeconomics of Product Innovation considers how the use of economic analysis can guide and inform the search for insight in the generation and adoption of new products synonymously labelled product innovation. Written in an accessible tone and restricting its analysis to the use of microeconomics, this book encompasses the definition of product innovation. It explores means of measurement and revealed patterns of the extent of product innovation; the economic analysis of the forces driving the demand for, the supply of, and incentives to generate new products; empirical evidence upon the determinants of the extent of product innovation; the diffusion of product innovations; product innovation and firm performance; price measurement under product innovation; product innovation and welfare; and public policy and product innovation.
Classical mechanics is the basis for any university-level study of technical-scientific disciplines. But most existing manuals use a technological and engineering approach, with basic aspects sometimes insufficiently highlighted. This book introduces the concepts and applications of classical mechanics into Newtonian formalism. Newtonian dynamics is useful for solving applied physics and engineering problems, but also a fascinating theory anchored in questions posed since the times of the Greek philosophers, regarding space, the flow of time, measurable physical quantities, the physical principles with the mathematical structure needed to describe the Universe, etc. The author aims to encourage students to think about these fundamental aspects and how they will be addressed in modern physics, including the successes and limitations of Newton's mechanics. The book is designed to mirror the progress of the students using it, with earlier chapters assuming no more than basic high school instruction and later ones geared toward subsequent enhanced understanding. The book is designed for students of undergraduate programs in physics, mathematics, chemistry, and engineering who will deal with modern physics, as they will benefit from an approach in which the aspects of classical mechanics are introduced in a propaedeutic approach towards relativistic physics and quantum mechanics.
Tutti i tabellini del Torino anno per anno, dal 1887 al 2019 compreso: squadre, avversari, risultati, giocatori, marcatori, giocatori sostituiti, giocatori subentrati, stagione per stagione, allenatori, presidenti, 150 pagine di facile consultazione.
However you view the present time, it is a new century, a new world, and also a new humanity - in fact, humanity is not something that was ever defined once and for all, but remains an open project. For several decades we have been witnessing a revolution. However, unlike the political and ideological revolutions that took place around the First World War, this is a technological and much more radical one that does not depend on people's beliefs, but rather on the tireless labour of machines. The rise of automation has brought about a revelation of something that had hitherto remained hidden in the workshops of homo faber. That is, there are very few functions, apart from consumption, where a machine cannot replace a human being, be these material or spiritual - machines need energy, but they can also do without it, whereas humans die if deprived of it, or one can imagine a machine producing symphonies, but not enjoying them. So while human beings are still needed, their roles and scopes have to be reconsidered. Workers may be superfluous, but humans are still needed, including those who until recently only recognised themselves as producers. The exclusion of workers from production does not discount humans being able to produce value in the form of consumption. Recognising this will enable us to conceive the "Webfare" - a new digital system that will teach us to find new names and new forms, more tolerance and room for traditional human needs. Above all, it will teach us how to transform the time given to us by automation into an opportunity for progress.
The Massachusetts General Hospital is widely respected as one of the world's premier psychiatric institutions. Now, preeminent authorities from MGH present the newly updated edition of Massachusetts General Hospital Comprehensive Clinical Psychiatry, a unique medical reference book that continues to simplify your access to the current clinical knowledge you need - both in print and online! It provides practical approaches to a wide variety of clinical syndromes and settings, aided by stunning graphics and hundreds of questions and answers geared to each chapter. You'll have convenient access to all the authoritative answers necessary to overcome any clinical challenge. User-friendly, highly templated organization with abundant boxed summaries, bulleted points, case histories, algorithms, references, and suggested readings. Peerless, hands-on advice from members of the esteemed MGH Department of Psychiatry helps you put today's best approaches to work for your patients. Interactive and downloadable Q&As for each chapter allow you to test your retention of the material covered. In-depth coverage of many unique areas, including Psychiatric and Substance Use Disorders in Transitioning Adolescents and Young Adults; Neuroanatomical Systems Relevant to Neuropsychiatric Disorders; Legal and Ethical Issues in Psychiatry; Military Psychiatry; and Approaches to Collaborative Care and Primary Care Psychiatry. Features full, new DSM-5 criteria; new art, tables, and key points; and new Alzheimer's Disease guidelines. Highlights recent developments in the field, such as neurotherapeutics, new psychotropics, military psychiatry, collaborative care, ensuring your knowledge is thoroughly up to date. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
How Machiavelli's Christianity shaped his political thought To many readers of The Prince, Machiavelli appears to be deeply un-Christian or even anti-Christian, a cynic who thinks rulers should use religion only to keep their subjects in check. But in Machiavelli's God, Maurizio Viroli, one of the world's leading authorities on Machiavelli, argues that Machiavelli, far from opposing Christianity, thought it was crucial to republican social and political renewal—but that first it needed to be renewed itself. And without understanding this, Viroli contends, it is impossible to comprehend Machiavelli's thought. Viroli places Machiavelli in the context of Florence's republican Christianity, which was founded on the idea that the true Christian is a citizen who serves the common good. In this tradition, God participates in human affairs, supports and rewards those who govern justly, and desires men to make the earthly city similar to the divine one. Building on this tradition, Machiavelli advocated a religion of virtue, and he believed that, without this faith, free republics could not be established, defend themselves against corruption, or survive. Viroli makes a powerful case that Machiavelli, far from being a pagan or atheist, was a prophet of a true religion of liberty, a way of moral and political living that would rediscover and pursue charity and justice. The translation of this work has been funded by SEPS—Segretariato Europeo per le Pubblicazioni Scientifiche.
This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.
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